LOCUS       NM_012763               2925 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, receptor type, A
            (Ptpra), mRNA.
ACCESSION   NM_012763
VERSION     NM_012763.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2925)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   2  (bases 1 to 2925)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 2925)
  AUTHORS   Wang,P.S., Wang,J., Xiao,Z.C. and Pallen,C.J.
  TITLE     Protein-tyrosine phosphatase alpha acts as an upstream regulator of
            Fyn signaling to promote oligodendrocyte differentiation and
            myelination
  JOURNAL   J Biol Chem 284 (48), 33692-33702 (2009)
   PUBMED   19812040
REFERENCE   4  (bases 1 to 2925)
  AUTHORS   Huang,J., Huang,A., Zhang,Q., Lin,Y.C. and Yu,H.G.
  TITLE     Novel mechanism for suppression of hyperpolarization-activated
            cyclic nucleotide-gated pacemaker channels by receptor-like
            tyrosine phosphatase-alpha
  JOURNAL   J Biol Chem 283 (44), 29912-29919 (2008)
   PUBMED   18768480
  REMARK    GeneRIF: RPTPalpha plays a critical role in HCN channel function
            via tyrosine dephosphorylation
REFERENCE   5  (bases 1 to 2925)
  AUTHORS   Lin,D., Kamsteeg,E.J., Zhang,Y., Jin,Y., Sterling,H., Yue,P.,
            Roos,M., Duffield,A., Spencer,J., Caplan,M. and Wang,W.H.
  TITLE     Expression of tetraspan protein CD63 activates protein-tyrosine
            kinase (PTK) and enhances the PTK-induced inhibition of ROMK
            channels
  JOURNAL   J Biol Chem 283 (12), 7674-7681 (2008)
   PUBMED   18211905
  REMARK    GeneRIF: CD63 plays a role in the regulation of ROMK channels
            through its association with RPTPalpha, which in turn interacts
            with and activates Src family PTK, thus reducing ROMK activity.
REFERENCE   6  (bases 1 to 2925)
  AUTHORS   Lei,G., Xue,S., Chery,N., Liu,Q., Xu,J., Kwan,C.L., Fu,Y.P.,
            Lu,Y.M., Liu,M., Harder,K.W. and Yu,X.M.
  TITLE     Gain control of N-methyl-D-aspartate receptor activity by
            receptor-like protein tyrosine phosphatase alpha
  JOURNAL   EMBO J 21 (12), 2977-2989 (2002)
   PUBMED   12065411
REFERENCE   7  (bases 1 to 2925)
  AUTHORS   Calera,M.R., Vallega,G. and Pilch,P.F.
  TITLE     Dynamics of protein-tyrosine phosphatases in rat adipocytes
  JOURNAL   J Biol Chem 275 (9), 6308-6312 (2000)
   PUBMED   10692429
REFERENCE   8  (bases 1 to 2925)
  AUTHORS   Helmke,S., Lohse,K., Mikule,K., Wood,M.R. and Pfenninger,K.H.
  TITLE     SRC binding to the cytoskeleton, triggered by growth cone
            attachment to laminin, is protein tyrosine phosphatase-dependent
  JOURNAL   J Cell Sci 111 (Pt 16), 2465-2475 (1998)
   PUBMED   9683640
REFERENCE   9  (bases 1 to 2925)
  AUTHORS   Su,J., Batzer,A. and Sap,J.
  TITLE     Receptor tyrosine phosphatase R-PTP-alpha is
            tyrosine-phosphorylated and associated with the adaptor protein
            Grb2
  JOURNAL   J Biol Chem 269 (29), 18731-18734 (1994)
   PUBMED   7518443
REFERENCE   10 (bases 1 to 2925)
  AUTHORS   Moriyama,T., Fujiwara,Y., Imai,E., Takenaka,M., Kawanishi,S.,
            Inoue,T., Noguchi,T., Tanaka,T., Kamada,T. and Ueda,N.
  TITLE     cDNA cloning of rat LRP, a receptor like protein tyrosine
            phosphatase, and evidence for its gene regulation in cultured rat
            mesangial cells
  JOURNAL   Biochem Biophys Res Commun 188 (1), 34-39 (1992)
   PUBMED   1417854
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081828.1.
            
            On Dec 8, 2007 this sequence version replaced NM_012763.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2925
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2925
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /note="protein tyrosine phosphatase, receptor type, A"
                     /db_xref="GeneID:25167"
                     /db_xref="RGD:3450"
     exon            1..259
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            260..338
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..2656
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /EC_number="3.1.3.48"
                     /note="receptor-type tyrosine-protein phosphatase alpha;
                     R-PTP-alpha; protein tyrosine phosphatase alpha"
                     /codon_start=1
                     /product="receptor-type tyrosine-protein phosphatase alpha
                     precursor"
                     /protein_id="NP_036895.2"
                     /db_xref="GeneID:25167"
                     /db_xref="RGD:3450"
                     /translation="MDSWFILILFGSGLIHISANNTTTVSPSLGTTRLIKTSTTESAK
                     EENKTSNSTSSVISLSVTPTFSPNLTLEPTYVTTVNSSHSDNGTKRAASTESGGTTIS
                     PNGTYGTWLTDNQFTDARTEPWEGNSSTAATTPETFPPADETPIIAVMVALSSLLVIV
                     FIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKFPPLPVD
                     KLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRV
                     HLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT
                     NLKERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTNRKPQR
                     LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID
                     AMLDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSL
                     DTHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEF
                     NRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIV
                     MLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ
                     IRQFHFHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALS
                     TVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK"
     exon            339..689
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            690..774
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            775..848
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            849..985
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1076
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1153
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1190
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1288
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1408
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1575
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1711
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1861
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1955
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2032
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2167
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2293
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2445
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2581
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2900
                     /gene="Ptpra"
                     /gene_synonym="LRP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgagtga ggcgctgaca gggactcacg ggggcatctt gcacagaccc ctggaccacg
       61 ccgccatcgc agcctcccgc ccagtcctct ctctgctgct tctcctcgcc atggaggcga
      121 ggccgccgcc gccgccgcgg ggcttcgagc agcggaccgg gcggcggccc tgaggggagc
      181 ggcgggccga gacgccgccg cggtgctgag gcggagctgc cgtgcgcgtc ccccgcggtc
      241 ccgcccagcg ccgggctcgg tcagcatgga ttcctggttc attcttatcc tgtttggcag
      301 tggtctaata cacattagtg ccaacaacac tactacagtt tcaccttctt taggaactac
      361 aagattaatt aaaacatcaa caacagaatc ggctaaggaa gagaataaaa cttcaaattc
      421 aacctcttca gtaatttctc tttctgtgac accaacattc agcccaaatc taactctgga
      481 acccacctat gtgactactg ttaattcttc acactctgac aatgggacca agagagcagc
      541 cagcacggaa tctggaggca ctaccatttc accaaacgga acatacggaa catggcttac
      601 tgataaccag ttcacggatg ccagaacaga accctgggag gggaattcca gcactgcagc
      661 aaccactcca gaaaccttcc cccctgcaga tgagacacca atcattgcgg tgatggtggc
      721 cctgtcctct ctgctagtaa ttgtgtttat tattatagtt ctgtacatgt taaggtttaa
      781 gaaatacaag caagctggga gccattccaa ttctttccgc ctgtcaaatg gccgcacaga
      841 ggatgtggag ccccaaagtg taccacttct ggccaggtcc ccgagcacca acaggaagtt
      901 cccaccactg cctgtggaca agctggaaga ggagattaac cggagaatgg ctgatgacaa
      961 taagctcttc agagaggaat tcaacgccct ccctgcctgt ccaatccagg ccacctgtga
     1021 ggctgcctcc aaggaagaaa acaaggaaaa aaaccgatat gtaaacatcc tgccttatga
     1081 ccactccaga gtgcacctga cgcctgtgga aggggttcca gattctgatt acatcaacgc
     1141 ctcattcatt aatggctacc aggaaaagaa caaattcatt gctgcacaag gaccaaaaga
     1201 agaaacggtg aatgatttct ggagaatgat atgggaacag aacacagcca ccattgtcat
     1261 ggtgaccaac ctgaaggaga gaaaggagtg taaatgtgcc cagtattggc cagaccaagg
     1321 ctgctggacc tatgggaatg tccgtgtgtc tgtcgaggat gtgactgttc tggtggacta
     1381 cacagtacgg aaattctgca tccagcaggt gggcgacgtc accaacagga agccacagcg
     1441 cctcatcact cagttccatt tcaccagctg gccagacttt ggggtgcctt ttaccccaat
     1501 tggcatgctc aagttcctca agaaggtgaa agcctgtaac cctcagtatg caggggctat
     1561 cgtggtccac tgcagtgcag gtgtagggcg cactggcacc tttgttgtca tcgatgccat
     1621 gctggacatg atgcattcgg agcgcaaagt ggatgtatat gggtttgtga gccggatccg
     1681 ggcccagcgc tgccagatgg tccagacaga catgcagtac gtcttcatat accaggccct
     1741 tctggagcat tatctatatg gcgacacaga gctggaagtg acttccctag acacccacct
     1801 gcaaaaaatt tataacaaga tcccaggaac tagcaacaat ggactagagg aggaatttaa
     1861 gaaattaact tcaatcaaaa tccaaaatga caagatgcgt acgggaaacc ttccagccaa
     1921 catgaagaag aaccgagttt tacagatcat tccatatgaa tttaacagag tgatcattcc
     1981 agtcaaacgg ggcgaagaga acacagacta tgtgaacgca tccttcattg atggctaccg
     2041 gcagaaagat tcctacatcg ccagccaggg ccctcttctc cacacaattg aggacttctg
     2101 gcgaatgatc tgggaatgga agtcctgctc cattgtaatg ctaacagaac tggaagaaag
     2161 aggccaggag aagtgtgccc agtactggcc atctgatggc ctggtgtcct atggagacat
     2221 cacagttgag ctgaagaagg aggaggaatg tgagagctac actgtccgag acctcctggt
     2281 caccaacacc agggagaaca agagtcggca gatccggcag ttccacttcc acggctggcc
     2341 tgaggtgggc atccccagcg atgggaaggg tatgatcaac atcattgcag cagtgcagaa
     2401 gcagcagcag cagtcaggga accatcccat cactgtgcac tgcagtgccg gggcaggacg
     2461 gacagggacc ttttgtgcct tgagcacagt cctggagcgc gtgaaagcag aaggaatttt
     2521 ggatgtcttc caaactgtca agagcctgcg gctgcagagg ccacacatgg tccagacact
     2581 ggaacagtat gaattctgct acaaggtggt acaggagtac atcgatgcct tctcagatta
     2641 tgccaacttc aagtgacagg ggacaaggcc cacagacagg agaattgcct ttaatatttt
     2701 gtaatattct gttttgttaa tatacccaaa attgtatata tcttataact gttttagaaa
     2761 tggcacatag gcttctatta cctattaggt ggagattttg tatgtaaatg tgttagcact
     2821 atagtccttt tccagtgttt tattggggaa ttaaatagtg tgatatttga gttgatttaa
     2881 tgaagtcctt agcctggaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
