LOCUS       NM_001013040            2089 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type 9
            (Ptpn9), mRNA.
ACCESSION   NM_001013040 XM_236280
VERSION     NM_001013040.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Zhang,D., Marlin,M.C., Liang,Z., Ahmad,M., Ashpole,N.M.,
            Sonntag,W.E., Zhao,Z.J. and Li,G.
  TITLE     The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and
            Signal Transduction of Tropomyosin Receptor Kinase A
  JOURNAL   J Biol Chem 291 (46), 23895-23905 (2016)
   PUBMED   27655914
  REMARK    GeneRIF: As a result, overexpression of PTP-MEG2 down-regulates
            NGF/TrkA signaling and blocks neurite outgrowth and differentiation
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Barr,A.J., Ugochukwu,E., Lee,W.H., King,O.N., Filippakopoulos,P.,
            Alfano,I., Savitsky,P., Burgess-Brown,N.A., Muller,S. and Knapp,S.
  TITLE     Large-scale structural analysis of the classical human protein
            tyrosine phosphatome
  JOURNAL   Cell 136 (2), 352-363 (2009)
   PUBMED   19167335
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Wang,X., Huynh,H., Gjorloff-Wingren,A., Monosov,E., Stridsberg,M.,
            Fukuda,M. and Mustelin,T.
  TITLE     Enlargement of secretory vesicles by protein tyrosine phosphatase
            PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells
  JOURNAL   J Immunol 168 (9), 4612-4619 (2002)
   PUBMED   11971009
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082041.1.
            
            On Apr 20, 2005 this sequence version replaced XM_236280.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2089
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /note="protein tyrosine phosphatase, non-receptor type 9"
                     /db_xref="GeneID:266611"
                     /db_xref="RGD:628726"
     exon            1..85
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1804
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     9"
                     /protein_id="NP_001013058.1"
                     /db_xref="GeneID:266611"
                     /db_xref="RGD:628726"
                     /translation="MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSW
                     NVAVKFLMARKFDVLRAVELFHCYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVR
                     DPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNY
                     ANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILK
                     TSEVTQHLPRECLPENLGGYIKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWD
                     SVHVPGPHAMTIQELVDYVNTRQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYG
                     DVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWE
                     QKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIQFGFLTVTNLGVENMNHYKKTTLEIH
                     NTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRSQQSMAVGSLGARSKGQCPE
                     PPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYF
                     CYKAILEFAEREGMVPSGHSLLAMDGQ"
     exon            86..229
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            230..319
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            320..444
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..550
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..661
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..990
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1084
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1151
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1230
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1381
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1589
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..2059
                     /gene="Ptpn9"
                     /gene_synonym="Meg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctgcctc ggcggcggcg ggatggagcc ggcgaccgcg ccccggccgg acatggcgcc
       61 ggagctgacc cccgaggagg agcaggctac caagcagttt cttgaagaga tcaacaagtg
      121 gacagtacag tataatgttt ctcctctttc ttggaacgtg gctgtcaagt tcctcatggc
      181 cagaaagttt gatgtgctcc gtgctgtaga gctgtttcac tgctacagag aaacaagacg
      241 gaaggaaggc attgtgaagc tgaagcctca tgaggagccg ctccgttctg agatcctcag
      301 cgggaagttc accatcttga atgttcgaga cccaactgga gcctccattg cccttttcac
      361 tgccaggtta caccatcccc acaagtctgt ccaacatgtg gtactccaag ccttgtttta
      421 cctgctagac agagctgtgg acagttttga aactcaaagg aatggactgg tgttcatcta
      481 tgatatgtgt gggtctaatt atgccaactt tgagctagat ctcggcaaga aagtcttaaa
      541 cctgctgaag ggagcatttc cagctcgact gaagaaggtg ctgattgtag gagcacccat
      601 atggttccga gtgccctatt ctatcatcag cctgctcttg aaggataaag tccgggagag
      661 gattcagata ttaaagacat ctgaagttac ccagcacctg ccgagggaat gccttcccga
      721 aaatctgggt gggtacatca aaattgacct cgccacttgg aatttccagt tcctgcccca
      781 agtgaacggc catccagatc ccttcgatga gatcatcctg ttttccctac ctcctgcctt
      841 agactgggac tcagtacatg ttccaggtcc tcatgccatg accatccaag agttggtaga
      901 ctatgttaac accaggcaaa agcagggcat ctatgaggag tatgaagaca ttcgtcgtga
      961 gaaccctgtt ggcactttcc actgttctat gtctccagga aacctagaga aaaacagata
     1021 tggagatgta ccctgcctgg accaaacacg tgtgaagctg acaaaacgaa gtggtcacac
     1081 tcagacagat tacatcaatg ccagtttcat ggatggctac aagcagaaga atgcttacat
     1141 tggtacacaa ggtcctttgg agaacaccta tcgtgacttc tggctcatgg tttgggagca
     1201 aaaagttttg gtgattgtca tgaccacccg ctttgaggaa ggcggcagga gaaaatgtgg
     1261 ccagtactgg cctttagaaa aagactcccg gatccaattt ggcttcctca cggtgactaa
     1321 tctaggagtg gagaacatga accattataa gaaaacaact ctagaaattc acaacacaga
     1381 ggagcggcag aaacgccagg taacccactt ccagttccta agctggccag actatggtgt
     1441 cccttcctca gctgcttccc tcattgactt cctgagagtg gtcagaagcc agcagagcat
     1501 ggccgtaggc agcctgggag cacgctccaa agggcagtgt cctgagccac ccattgtggt
     1561 ccattgcagt gccggcattg gcaggacagg taccttctgc tcactggaca tctgcctggc
     1621 acagctggag gagcttggca cccttaatgt gttccagaca gtgtcacgaa tgaggaccca
     1681 gagggccttc agtatccaga cccctgagca gtactacttt tgctacaagg ccattctgga
     1741 gtttgcagag agggaaggca tggttccctc tggtcacagc ctgttggcca tggatggtca
     1801 ataactgttt cacaagtttc cacttgctgg tcagccttcc ttaaactacc ctggacactg
     1861 ctgagcctat aggctgccat cagttatgct gaagccatgg atcaacctct ttcttgtgtc
     1921 tcccagcgca catgtgcacg caaggcagcc tttccctttg gctagataaa tgtggtgaac
     1981 ttgccactag aaagggccag cagcaatatg ttcttaattc ctagcacctg ctatcaaagt
     2041 gtgccttatc aaaaccaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
