LOCUS       NM_053908               2168 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type 6
            (Ptpn6), mRNA.
ACCESSION   NM_053908
VERSION     NM_053908.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2168)
  AUTHORS   Wang,Y.Y., Gao,B., Yang,Y., Jia,S.B., Ma,X.P., Zhang,M.H.,
            Wang,L.J., Ma,A.Q. and Zhang,Q.N.
  TITLE     Histone deacetylase 3 suppresses the expression of SHP-1 via
            deacetylation of DNMT1 to promote heart failure
  JOURNAL   Life Sci 292, 119552 (2022)
   PUBMED   33932446
  REMARK    GeneRIF: Histone deacetylase 3 suppresses the expression of SHP-1
            via deacetylation of DNMT1 to promote heart failure.
REFERENCE   2  (bases 1 to 2168)
  AUTHORS   Lu,L., Cao,L., Liu,Y., Chen,Y., Fan,J. and Yin,Y.
  TITLE     Angiotensin (ang) 1-7 inhibits ang II-induced atrial fibrosis
            through regulating the interaction of proto-oncogene
            tyrosine-protein kinase Src (c-Src) and Src homology region 2
            domain-containing phosphatase-1 (SHP-1))
  JOURNAL   Bioengineered 12 (2), 10823-10836 (2021)
   PUBMED   34872449
  REMARK    GeneRIF: Angiotensin (ang) 1-7 inhibits ang II-induced atrial
            fibrosis through regulating the interaction of proto-oncogene
            tyrosine-protein kinase Src (c-Src) and Src homology region 2
            domain-containing phosphatase-1 (SHP-1)).
REFERENCE   3  (bases 1 to 2168)
  AUTHORS   Zhuang,X., Ma,J., Xu,S., Sun,Z., Zhang,R., Zhang,M. and Xu,G.
  TITLE     SHP-1 suppresses endotoxin-induced uveitis by inhibiting the
            TAK1/JNK pathway
  JOURNAL   J Cell Mol Med 25 (1), 147-160 (2021)
   PUBMED   33207073
  REMARK    GeneRIF: SHP-1 suppresses endotoxin-induced uveitis by inhibiting
            the TAK1/JNK pathway.
            Erratum:[J Cell Mol Med. 2022 Jul;26(13):3808. doi:
            10.1111/jcmm.17446.. PMID: 35793029]
REFERENCE   4  (bases 1 to 2168)
  AUTHORS   Cao,X., Zhu,N., Zhang,Y., Chen,Y., Zhang,J., Li,J., Hao,P., Gao,C.
            and Li,L.
  TITLE     Y-box protein 1 promotes hypoxia/reoxygenation- or
            ischemia/reperfusion-induced cardiomyocyte apoptosis via
            SHP-1-dependent STAT3 inactivation
  JOURNAL   J Cell Physiol 235 (11), 8187-8198 (2020)
   PUBMED   31967332
  REMARK    GeneRIF: Y-box protein 1 promotes hypoxia/reoxygenation- or
            ischemia/reperfusion-induced cardiomyocyte apoptosis via
            SHP-1-dependent STAT3 inactivation.
REFERENCE   5  (bases 1 to 2168)
  AUTHORS   Yang,L., Bai,H.H., Zhang,Z.Y., Liu,J.P., Suo,Z.W., Yang,X. and
            Hu,X.D.
  TITLE     Disruption of SHP1/NMDA receptor signaling in spinal cord dorsal
            horn alleviated inflammatory pain
  JOURNAL   Neuropharmacology 137, 104-113 (2018)
   PUBMED   29758384
  REMARK    GeneRIF: Results revealed a specific regulation by SHP1 of
            GluN2A-dependent pain transmission. Authors provided evidence that
            interference with SHP1/GluN2A interaction in spinal dorsal horn
            generated an effective analgesic action against inflammatory pain.
REFERENCE   6  (bases 1 to 2168)
  AUTHORS   Jiao,H., Berrada,K., Yang,W., Tabrizi,M., Platanias,L.C. and Yi,T.
  TITLE     Direct association with and dephosphorylation of Jak2 kinase by the
            SH2-domain-containing protein tyrosine phosphatase SHP-1
  JOURNAL   Mol Cell Biol 16 (12), 6985-6992 (1996)
   PUBMED   8943354
REFERENCE   7  (bases 1 to 2168)
  AUTHORS   Pani,G., Fischer,K.D., Mlinaric-Rascan,I. and Siminovitch,K.A.
  TITLE     Signaling capacity of the T cell antigen receptor is negatively
            regulated by the PTP1C tyrosine phosphatase
  JOURNAL   J Exp Med 184 (3), 839-852 (1996)
   PUBMED   9064344
REFERENCE   8  (bases 1 to 2168)
  AUTHORS   Kon-Kozlowski,M., Pani,G., Pawson,T. and Siminovitch,K.A.
  TITLE     The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1
            in hematopoietic cells
  JOURNAL   J Biol Chem 271 (7), 3856-3862 (1996)
   PUBMED   8632004
REFERENCE   9  (bases 1 to 2168)
  AUTHORS   Ghalaut,P.S., Mahajan,S.K., Mahajan,K.K. and Kumar,M.
  TITLE     Effect of treatment on pulmonary functions in chronic severe
            anaemia
  JOURNAL   Indian J Chest Dis Allied Sci 34 (3), 137-140 (1992)
   PUBMED   1302222
REFERENCE   10 (bases 1 to 2168)
  AUTHORS   Clark,E.A., Shultz,L.D. and Pollack,S.B.
  TITLE     Mutations in mice that influence natural killer (NK) cell activity
  JOURNAL   Immunogenetics 12 (5-6), 601-613 (1981)
   PUBMED   6971254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 1, 2020 this sequence version replaced NM_053908.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099824.1, SRR26643284.6580.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000004.1  159236890-159237069 c
            181-303             JAXUCZ010000004.1  159224904-159225026 c
            304-498             JAXUCZ010000004.1  159224468-159224662 c
            499-688             JAXUCZ010000004.1  159220526-159220715 c
            689-805             JAXUCZ010000004.1  159220289-159220405 c
            806-919             JAXUCZ010000004.1  159220077-159220190 c
            920-1016            JAXUCZ010000004.1  159219853-159219949 c
            1017-1096           JAXUCZ010000004.1  159219484-159219563 c
            1097-1246           JAXUCZ010000004.1  159219145-159219294 c
            1247-1378           JAXUCZ010000004.1  159217290-159217421 c
            1379-1533           JAXUCZ010000004.1  159217005-159217159 c
            1534-1601           JAXUCZ010000004.1  159213605-159213672 c
            1602-1753           JAXUCZ010000004.1  159213359-159213510 c
            1754-1845           JAXUCZ010000004.1  159213172-159213263 c
            1846-1988           JAXUCZ010000004.1  159212675-159212817 c
            1989-2168           JAXUCZ010000004.1  159212320-159212499 c
FEATURES             Location/Qualifiers
     source          1..2168
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2168
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /note="protein tyrosine phosphatase, non-receptor type 6"
                     /db_xref="GeneID:116689"
                     /db_xref="RGD:620660"
     exon            1..180
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1960
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /EC_number="3.1.3.48"
                     /note="SH2 phosphatase 1; protein-tyrosine phosphatase
                     SHP-1"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     6"
                     /protein_id="NP_446360.2"
                     /db_xref="GeneID:116689"
                     /db_xref="RGD:620660"
                     /translation="MLSRGWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLS
                     VRVDDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPL
                     NCSDPTSERWYHGHMSGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGP
                     GSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYAT
                     RVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKN
                     RYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATV
                     NDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNCKEHDTAEY
                     KLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGP
                     IIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYK
                     FIYVAIAQFIETTKKKLEIIQSQRGQESEYGNITYPPALRSAHAKASRTSSKHKEEVY
                     ENVHSKNKKEEKVKKQRSADKEKNKGSLKRK"
     exon            181..303
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..498
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..688
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..805
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..919
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1016
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1096
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1246
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1378
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1533
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1601
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1753
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1845
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1988
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2168
                     /gene="Ptpn6"
                     /gene_synonym="Ptph6; Shp-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggcttgg cctcaaagtg ccattggttt gacaggctgg atgaggagga agtggccgaa
       61 accgaaatat tcttcctgaa ggtctggatc cccgaacagc tgtgccactc gattggcccc
      121 gcccctgtcg ccctttgcct gtgacttccc ccactcctcc agggagatgc tgtcccgcgg
      181 gtggtttcac cgggacctca gtgggcctga tgccgagacc ctgctcaagg gccggggagt
      241 ccctgggagc ttcctggctc ggcccagtcg caagaaccag ggtgacttct ccctctcagt
      301 cagggtggat gaccaggtga ctcatattcg gatccagaac tcaggggact tctatgacct
      361 gtatggaggg gagaagtttg cgacgttgac agagctggtg gagtattaca ctcagcagca
      421 gggcatcctg caggaccgag acggcaccat catccacctc aagtacccac tgaactgctc
      481 ggaccccacc agcgagaggt ggtatcatgg tcacatgtct ggagggcagg cagagtcact
      541 gctgcaggcc aagggcgagc cctggacatt tcttgtgcgt gagagtctca gccaacctgg
      601 tgattttgtg ctctctgtgc tcaatgacca gcccaaggct ggcccgggtt ccccgctcag
      661 ggtcacgcac atcaaggtta tgtgtgaggg tggacgatac actgtgggtg gctcagagac
      721 attcgacagc ctcacagacc tggtggagca cttcaagaag acggggattg aggaggcctc
      781 aggtgccttt gtctacctga ggcagcctta ctatgccact cgggtaaatg cagcagacat
      841 tgagaaccgg gtcttggaac tgaacaagaa gcaggagtca gaggacacag ccaaggccgg
      901 cttctgggag gagtttgaga gtctgcaaaa gcaagaggta aagaacttgc accagcgtct
      961 ggaagggcag cggccggaga acaagagcaa gaaccgctac aagaacattc ttccctttga
     1021 ccacagccga gtgatcctgc agggacgtga cagtaacatc ccagggtctg attacatcaa
     1081 tgccaactac gttaagaacc agctgctagg tccggatgag aactctaaga cctacatcgc
     1141 cagtcagggc tgtctggacg ctaccgtcaa tgacttctgg cagatggctt ggcaggagaa
     1201 cactcgtgtc atcgtcatga ctaccagaga ggtggagaaa ggccggaaca aatgtgtccc
     1261 atactggcct gaggtgggca ctcagcgcgt ctatgggctc tactctgtga ccaactgtaa
     1321 agagcatgac acagcagagt acaaacttcg aacattgcag atctccccac tggacaatgg
     1381 ggacctggtt cgggagatat ggcactacca gtacctgagc tggcctgacc atggggttcc
     1441 cagtgagcct ggaggtgtcc tcagcttcct ggatcagatc aaccagcggc aggaaagttt
     1501 gcctcacgcg gggcccatca ttgtgcattg cagcgctggc atcggccgca cgggcaccat
     1561 catcgtcatt gatatgctca tggagagcgt ctccaccaag gggctagact gtgacattga
     1621 catccagaag accatccaga tggtacgggc acagcgctct ggcatggtgc agacagaggc
     1681 acagtacaag tttatttatg tggccatcgc ccagttcatc gaaacaacca agaagaaact
     1741 ggagatcata caatcccaga ggggccagga gtcggagtat gggaacatca cctaccctcc
     1801 ggctttgagg agtgcccacg ccaaagcctc ccgtacctcc tccaaacaca aggaggaggt
     1861 gtacgaaaac gtgcatagca agaacaagaa ggaagagaaa gtaaagaagc agcgatcggc
     1921 agacaaggag aagaacaaag gttctctcaa gaggaagtga gctgggtatt cgtctgcagg
     1981 tggccatgca tcagccttac tccgtgcaga ggcctccgct gggcagacag agacctgtag
     2041 tccacaccac ccccatcttg ttgtaattta agtgaccgtg gtcctctgaa cctgtatatg
     2101 gctcagcaag cctcagggag agtcagaccc ttctcttctt gtaaataaag cccctggaca
     2161 actgtgta
//
