LOCUS       NM_001398605            3328 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type 5
            (Ptpn5), mRNA.
ACCESSION   NM_001398605 XM_006229252
VERSION     NM_001398605.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Paramasivam,P., Choi,S.W., Poddar,R. and Paul,S.
  TITLE     Impairment of neuronal tyrosine phosphatase STEP worsens
            post-ischemic inflammation and brain injury under hypertensive
            condition
  JOURNAL   J Neuroinflammation 21 (1), 271 (2024)
   PUBMED   39438980
  REMARK    GeneRIF: Impairment of neuronal tyrosine phosphatase STEP worsens
            post-ischemic inflammation and brain injury under hypertensive
            condition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Telegina,D.V., Kulikova,E.A., Kozhevnikova,O.S., Kulikov,A.V.,
            Khomenko,T.M., Volcho,K.P., Salakhutdinov,N.F. and Kolosova,N.G.
  TITLE     Alterations of STEP46 and STEP61 Expression in the Rat Retina with
            Age and AMD-Like Retinopathy Development
  JOURNAL   Int J Mol Sci 21 (15), 5182 (2020)
   PUBMED   32707818
  REMARK    GeneRIF: Alterations of STEP46 and STEP61 Expression in the Rat
            Retina with Age and AMD-Like Retinopathy Development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Xu,J., Kurup,P., Nairn,A.C. and Lombroso,P.J.
  TITLE     Synaptic NMDA Receptor Activation Induces Ubiquitination and
            Degradation of STEP61
  JOURNAL   Mol Neurobiol 55 (4), 3096-3111 (2018)
   PUBMED   28466270
  REMARK    GeneRIF: activation of synaptic NMDAR by bicuculline or D-serine
            results in the ubiquitination and proteasomal degradation of
            STEP61, and increased surface localization of GluN1/GluN2B
            receptors.
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Tian,M., Xu,J., Lei,G., Lombroso,P.J., Jackson,M.F. and
            MacDonald,J.F.
  TITLE     STEP activation by Galphaq coupled GPCRs opposes Src regulation of
            NMDA receptors containing the GluN2A subunit
  JOURNAL   Sci Rep 6, 36684 (2016)
   PUBMED   27857196
  REMARK    GeneRIF: findings suggest that Src and STEP recruitment is
            contingent on differing intracellular Ca(2+) dynamics that dictate
            whether NMDAR function is augmented or depressed following M1R
            stimulation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Rajagopal,S., Deb,I., Poddar,R. and Paul,S.
  TITLE     Aging is associated with dimerization and inactivation of the
            brain-enriched tyrosine phosphatase STEP
  JOURNAL   Neurobiol Aging 41, 25-38 (2016)
   PUBMED   27103516
  REMARK    GeneRIF: It is involved in the etiology of several age-associated
            neurologic disorders linked to oxidative stress and is also known
            to play a role in neuroprotection by modulating glutamatergic
            transmission.
REFERENCE   6  (bases 1 to 3328)
  AUTHORS   Pulido,R., Zuniga,A. and Ullrich,A.
  TITLE     PTP-SL and STEP protein tyrosine phosphatases regulate the
            activation of the extracellular signal-regulated kinases ERK1 and
            ERK2 by association through a kinase interaction motif
  JOURNAL   EMBO J 17 (24), 7337-7350 (1998)
   PUBMED   9857190
REFERENCE   7  (bases 1 to 3328)
  AUTHORS   Bult,A., Zhao,F., Dirkx,R. Jr., Sharma,E., Lukacsi,E., Solimena,M.,
            Naegele,J.R. and Lombroso,P.J.
  TITLE     STEP61: a member of a family of brain-enriched PTPs is localized to
            the endoplasmic reticulum
  JOURNAL   J Neurosci 16 (24), 7821-7831 (1996)
   PUBMED   8987810
REFERENCE   8  (bases 1 to 3328)
  AUTHORS   Boulanger,L.M., Lombroso,P.J., Raghunathan,A., During,M.J.,
            Wahle,P. and Naegele,J.R.
  TITLE     Cellular and molecular characterization of a brain-enriched protein
            tyrosine phosphatase
  JOURNAL   J Neurosci 15 (2), 1532-1544 (1995)
   PUBMED   7869116
REFERENCE   9  (bases 1 to 3328)
  AUTHORS   Lombroso,P.J., Naegele,J.R., Sharma,E. and Lerner,M.
  TITLE     A protein tyrosine phosphatase expressed within dopaminoceptive
            neurons of the basal ganglia and related structures
  JOURNAL   J Neurosci 13 (7), 3064-3074 (1993)
   PUBMED   8331384
REFERENCE   10 (bases 1 to 3328)
  AUTHORS   Lombroso,P.J., Murdoch,G. and Lerner,M.
  TITLE     Molecular characterization of a protein-tyrosine-phosphatase
            enriched in striatum
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 7242-7246 (1991)
   PUBMED   1714595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 20, 2021 this sequence version replaced XM_006229252.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211673.1, SRR26643298.3065.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               JAXUCZ010000001.1  106815707-106816134 c
            429-520             JAXUCZ010000001.1  106799742-106799833 c
            521-680             JAXUCZ010000001.1  106796720-106796879 c
            681-757             JAXUCZ010000001.1  106796110-106796186 c
            758-948             JAXUCZ010000001.1  106771092-106771282 c
            949-1056            JAXUCZ010000001.1  106770463-106770570 c
            1057-1140           JAXUCZ010000001.1  106770150-106770233 c
            1141-1382           JAXUCZ010000001.1  106769488-106769729 c
            1383-1572           JAXUCZ010000001.1  106768239-106768428 c
            1573-1657           JAXUCZ010000001.1  106765831-106765915 c
            1658-1737           JAXUCZ010000001.1  106762616-106762695 c
            1738-1875           JAXUCZ010000001.1  106762289-106762426 c
            1876-1986           JAXUCZ010000001.1  106760942-106761052 c
            1987-2147           JAXUCZ010000001.1  106758475-106758635 c
            2148-2261           JAXUCZ010000001.1  106758273-106758386 c
            2262-3328           JAXUCZ010000001.1  106756896-106757962 c
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3328
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /note="protein tyrosine phosphatase, non-receptor type 5"
                     /db_xref="GeneID:29644"
                     /db_xref="RGD:3448"
     exon            1..428
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            429..520
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            521..680
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..2355
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine-phosphatase non-receptor 5;
                     neural-specific protein-tyrosine phosphatase;
                     protein-tyrosine phosphatase striatum-enriched;
                     striatum-enriched protein-tyrosine phosphatase"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     5"
                     /protein_id="NP_001385534.1"
                     /db_xref="GeneID:29644"
                     /db_xref="RGD:3448"
                     /translation="MCTSSSSSLSSSSSSLTKESGDRMAQWSEKESQAADDSKGGTLD
                     MCCSKRLLGLPQPVEMGGLDEGEGLPSKQRELPPPPPSPPSEPAQKLPPQGAGSHSLT
                     VRSSLCLFAASQLLLACGVLWLSGHGHSWLQTTTDLIFSSLTVLNHLGPAAWLGSGTW
                     GTPSLLLVSLTVSLGIITTLVWHLLKTPPEPPVPLPPEDRRQSVSRQPSFTYSEWMEE
                     KVEDDFLDLDAVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPG
                     CNEEGFGYLVSPREESAHEYLLSASRVLRAEELHEKALDPFLLQAEFFEIPMNFVDPK
                     EYDIPGLVRKNRYKTILPNPHSRVRLTSPDPEDPLSSYINANYIRGYNGEEKVYIATQ
                     GPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPEEQVVHDGVEITVQKVIH
                     TEDYRLRLISLRRGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHC
                     SPIIVHCSAGIGRTGCFIATSICCQQLRREGVVDILKTTCQLRQDRGGMIQTCEQYQF
                     VHHAMSLYEKQLSLQSSE"
     exon            681..757
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            758..948
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1056
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1140
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1382
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1572
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1657
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1737
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1875
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1986
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2147
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2261
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..3328
                     /gene="Ptpn5"
                     /gene_synonym="STEP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaggagatg ggatccgatg ttaagggtct gtggtccacc ccctagagct ctaggcgatg
       61 ccggagctcc ccacccccac cccgccaagc cggcgagccc tgcgcaattc ccggggagcg
      121 gcgcaagccc gtccgggggc ggggcggagc ccgggctggg ggtgccaaac ggacccggca
      181 gctgtgcccg cgactctgta gtccaggcgc atttggtggg gcgactgggc agggagcagg
      241 caaggagagc gggactgagg actccgcgga cagaccgaca gacggacgcc cccgcatacg
      301 cagacgcacc gagctccgca cggcccctgt cacacacaga cagggacaca cgcagacacg
      361 cacactcgcg cgctcacatc ctcccgccag cctgcttgtc cgccggcgcc tggagcccgc
      421 tctggccgtt tgctttttgc tgaggaaaac tcccagtcct ggccccagat ggcacctttc
      481 cccacctgga taccttggga atgaagtttg agggaattag gggtgctctt atagtaaagc
      541 aagttcagga ttcagagact tctcaacccc aattcccctg gcccctactt tagcagtcaa
      601 atgtgcacat catcatcatc gtcgttgtcg tcgtcatcat catcactaac aaaggaatca
      661 ggagacagaa tggcacagtg gagtgagaaa gagagccagg ctgctgatga ctccaaggga
      721 gggaccctgg acatgtgctg tagtaagagg ctgttgggtc tgccccagcc agtagagatg
      781 ggaggtctgg acgagggcga aggactcccc agcaagcaga gagagctgcc acccccgcca
      841 ccctcaccgc cctctgagcc agctcagaag ctgccacctc aaggtgccgg gagccactcc
      901 ctcacagtca gaagcagcct gtgcctgttt gctgcctctc agttactgct tgcctgtggg
      961 gtgctctggc tcagtggcca tggccactcc tggctgcaga ccaccacaga cctcatcttc
     1021 tcctcgctca ccgtgttgaa ccacctggga cctgcagcct ggctaggttc tgggacctgg
     1081 gggacaccaa gtctgctgtt agtctctctg actgtgagcc tgggcatcat caccaccctg
     1141 gtgtggcacc ttctcaagac acccccagag ccacctgtcc cactgccccc agaggacaga
     1201 cgacaatcag tgagccggca gccctccttc acttactcag agtggatgga ggagaaggta
     1261 gaggatgact ttctggacct ggacgcagtg ccggagacac ccgtgtttga ctgtgtgatg
     1321 gacatcaagc ctgaggctga tcccacctcg ttgactgtca agtccatggg tctgcaggag
     1381 aggaggggct ccaatgtctc cttgaccctg gacatgtgta ctcctggctg caatgaggag
     1441 ggctttggct acctggtgtc cccacgagag gagtcagccc atgaatacct gctcagtgcc
     1501 tcccgtgtcc tccgggcaga ggagctgcac gaaaaggccc tggacccttt cttgctgcag
     1561 gcggaattct ttgaaatccc catgaacttt gtggatccaa aagaatatga catcccaggg
     1621 ctggtacgga agaatcggta caaaaccatc cttcccaatc ctcacagcag ggtacgtctg
     1681 acgtcaccag accctgaaga tcctctgagt tcctacatca atgccaacta catccggggc
     1741 tacaatgggg aggagaaggt gtacatcgcc acccagggac ccatcgtcag cactgtggcc
     1801 gacttctggc gcatggtgtg gcaggagcgc acacccatca tcgtcatgat caccaacatc
     1861 gaggagatga acgagaagtg cacggaatat tggccagaag agcaggtcgt ccacgatggc
     1921 gtagagatca ctgtgcagaa agtcatccac acagaggact accggctgcg acttatctcc
     1981 ctcaggagag ggactgaaga gagaggcttg aagcattact ggttcacatc ctggcctgac
     2041 cagaagaccc ccgaccgggc acccccactc ctgcacctgg tacgggaggt ggaggaggca
     2101 gcccagcaag agggacccca ctgttccccg atcattgttc actgcagtgc agggattggg
     2161 agaaccgggt gcttcatcgc caccagcatc tgctgccagc agctgcgacg tgagggcgtg
     2221 gtagacatcc taaagaccac gtgccagctc cgtcaggaca ggggcggcat gatccaaaca
     2281 tgcgaacagt atcagtttgt gcaccacgcc atgagcctct atgagaagca gctatccctc
     2341 cagtcctcag agtgaccaca ctcttcctct gagatccact gggcactgcc gagtctgagg
     2401 ctggggcttc accccaacta cccaaggtct taccttgggt cctgggcctg ttccctggct
     2461 ctccccttca gtctgccccc atctgttgtc ctggcctggt ccctacccca agcctagctc
     2521 ttctactgta catactgcag agttcgggag ggcaggggag gaatgtgcca ggccaggcct
     2581 ggggcccctg ggcctgaccc acactatata gacctggggc ctcagtttta accatgattc
     2641 cacagctact tggtccaaaa tgttttcatg ccacacccca agtgtcctac cacaacatgt
     2701 tctgtctgtc catccatcac agctatctgt accaaacact gtgtcccctc agccaggaaa
     2761 ggagtactga tctgagctct cacccctcag ccctcaccca catcgctatt cccagacacc
     2821 caccctgctc cccaggcaga gatgtctacc aatctctggc ctcacaggat gtggatggtg
     2881 gagaccaggc agaggagaat gtggtggttg accgagatcc cagctgagaa ggttcccggg
     2941 caagggtggg catctctggc ctatgagaca ctggagagaa agaggacaga tatagtggga
     3001 aaccctaagg atctgagccc tgagggggcc ctccaagagt agggtgggga cagctccaga
     3061 cctgcgaggc atctttctgt gtcactatgg gaaaccccaa atgtctcctc gctacatgtt
     3121 gctccgtgtg ttcccttgtc catgtgtgtg ttgagagccc atgagcaggg catgcatgac
     3181 tctttggcaa catgtgttat cttggagcca cgtgttttta tcgctgactt taaatattta
     3241 ttccacggca tacagagaca tttggtgtct ttttataatc tgctcgtggt cattgaatag
     3301 agcaataaac agagcatttt gagcaaaa
//
