LOCUS       NM_001106460            2747 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type
            22 (Ptpn22), mRNA.
ACCESSION   NM_001106460 XM_001068074 XM_215658
VERSION     NM_001106460.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Lioger B, Rollin J, Vayne C, Perret-Gallix K, Pouplard C, Godeau B,
            Michel M and Gruel Y.
  TITLE     No impact of PTPN22, PTPRJ and ACP1 genes polymorphisms on the risk
            of immune thrombocytopenia in French adult patients
  JOURNAL   Thromb Res 144, 76-78 (2016)
   PUBMED   27309885
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M and Battaglia
            M.
  TITLE     PTPN22 controls virally-induced autoimmune diabetes by modulating
            cytotoxic T lymphocyte responses in an epitope-specific manner
  JOURNAL   Clin Immunol 156 (2), 98-108 (2015)
   PUBMED   25513733
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   Sarmiento J, Wallis RH, Ning T, Marandi L, Chao G, Veillette A,
            Lernmark A, Paterson AD and Poussier P.
  TITLE     A functional polymorphism of Ptpn22 is associated with type 1
            diabetes in the BioBreeding rat
  JOURNAL   J Immunol 194 (2), 615-629 (2015)
   PUBMED   25505293
  REMARK    GeneRIF: These findings are consistent with a role for rat Ptpn22
            allelic variation within Iddm26.2 in the regulation of T cell
            responses, and subsequently the risk for development of T1D.
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Xu YB, Wang NZ, Yang LL, Cui HD, Xue HX and Zhang N.
  TITLE     Expression of peptidylarginine deiminase 4 and protein tyrosine
            phosphatase nonreceptor type 22 in the synovium of collagen-induced
            arthritis rats
  JOURNAL   Chin Med Sci J 29 (2), 85-90 (2014)
   PUBMED   24998229
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Spalinger MR, Lang S, Vavricka SR, Fried M, Rogler G and Scharl M.
  TITLE     Protein tyrosine phosphatase non-receptor type 22 modulates
            NOD2-induced cytokine release and autophagy
  JOURNAL   PLoS One 8 (8), e72384 (2013)
   PUBMED   23991106
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M,
            MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS,
            Comings D and Mustelin T.
  TITLE     A functional variant of lymphoid tyrosine phosphatase is associated
            with type I diabetes
  JOURNAL   Nat Genet 36 (4), 337-338 (2004)
   PUBMED   15004560
REFERENCE   7  (bases 1 to 2747)
  AUTHORS   Hasegawa K, Martin F, Huang G, Tumas D, Diehl L and Chan AC.
  TITLE     PEST domain-enriched tyrosine phosphatase (PEP) regulation of
            effector/memory T cells
  JOURNAL   Science 303 (5658), 685-689 (2004)
   PUBMED   14752163
REFERENCE   8  (bases 1 to 2747)
  AUTHORS   Gjorloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh
            P, Williams S, Schnitzer J and Mustelin T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   9  (bases 1 to 2747)
  AUTHORS   Cohen S, Dadi H, Shaoul E, Sharfe N and Roifman CM.
  TITLE     Cloning and characterization of a lymphoid-specific, inducible
            human protein tyrosine phosphatase, Lyp
  JOURNAL   Blood 93 (6), 2013-2024 (1999)
   PUBMED   10068674
REFERENCE   10 (bases 1 to 2747)
  AUTHORS   Cloutier JF and Veillette A.
  TITLE     Association of inhibitory tyrosine protein kinase p50csk with
            protein tyrosine phosphatase PEP in T cells and other hemopoietic
            cells
  JOURNAL   EMBO J 15 (18), 4909-4918 (1996)
   PUBMED   8890164
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215658.4, XM_001068074.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMN06680412 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2747
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /note="protein tyrosine phosphatase, non-receptor type 22"
                     /db_xref="GeneID:295338"
                     /db_xref="RGD:1307992"
     exon            1..199
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2527
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /EC_number="3.1.3.48"
                     /note="protein tyrosine phosphatase, non-receptor type 8;
                     protein tyrosine phosphatase, non-receptor type 22
                     (lymphoid)"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     22"
                     /protein_id="NP_001099930.1"
                     /db_xref="GeneID:295338"
                     /db_xref="RGD:1307992"
                     /translation="MDQREILQQLLKEAQKKKINREEFANEFLKLKRQSTKYKADKIY
                     PTTVAQRPKNIKKNRYKDILPYDHSLVELSLLTSDEDSSYINASFIKGVYGPRAYIAT
                     QGPLSTTLLDFWRMIWEYRVLVIVMACMEFEMGKKKCERYWAEPGETQLQFGPFSISC
                     ETEKKKSDYKIRTLKAKFNSETRIVYQFHYKNWPDHDVPSSIDPILQLIWDMRCYQED
                     DCVPLCIHCSAGCGRTGVICAVDYTWMLLKDGIIPKNFSVFNLIQEMRTQRPSLVQTQ
                     EQYELVYSAVLELFKRHVDIISDNHREREIQAECSIPEQKLTIEADSYPLDFPKNAVR
                     DAKMTNQQSKQGAEAESTEVSSFGLRTSKISAKEELVLHSKSSPSFDCLELNCECNKA
                     VITRNGQARASLVVGEPLQKYQSLDFGSILFGSCPSALPINTASRCHNSKGPVKRTKS
                     TPFELIQQRKTNELAVEDGSSCLESQLLEHGLMELQAQKVAHASSEELNYSLPRACER
                     PACDASCVPQDGPGALREHLCMSLAEDPYFSSSPPNSAGSKMSFDLPEKQDGATSPGA
                     QLPASSAASSSYSNPRDSLMESTLTSFPPPINQETAIEATSARTDDEIPPPLPERTPE
                     SFIVAEAAGEPSPSITESLPLAGKSGVTLECGGTSESQSHDLVAFTSSKNVELGSPKS
                     DQHQDGSPPPPLPERTLESFFLADEDCIQAQPMKPSSISYPETTEISTSSKQTLKTPG
                     KSFTRSKSLKIFRNMKKSVCNSPSPSKPTECVQPKNSSSFLNFGFGTRFSKPKGPRNP
                     PSTWNI"
     exon            200..308
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            309..385
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            386..481
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            482..520
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            521..592
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            593..652
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            653..795
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            796..862
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            863..940
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1027
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1104
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1925
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2009
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2131
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2159
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2237
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2353
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2384
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2462
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2747
                     /gene="Ptpn22"
                     /gene_synonym="Ptpn8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctccagcac gcccggctca tgcagcagtg gtggcttctt ggtggtgtct tggccatgac
       61 acatatttga catgccctcc cttaacccac tcacagactc ttgctctacg gcatggacca
      121 aagagaaatt ctgcagcagc tactgaaaga ggcccagaaa aagaaaatta acagggagga
      181 gtttgccaat gaatttctga agctgaaaag gcaatctacc aagtacaagg cagacaaaat
      241 atatcctaca accgtggctc agaggcccaa gaatatcaag aaaaacagat acaaggatat
      301 tttgccctat gatcacagcc tggtagagct gtctctgtta acgtccgatg aggactccag
      361 ttacatcaat gccagcttta ttaagggtgt ctatgggccc agggcttata ttgccactca
      421 gggtccttta tctacaactc tcctggactt ctggaggatg atctgggaat accgtgtctt
      481 ggtcatcgtc atggcatgta tggagttcga aatgggaaag aaaaagtgtg agcgttattg
      541 ggctgagcca ggagaaacac agctgcaatt tggccccttt tctatatcct gtgaaactga
      601 gaaaaagaaa tctgattata aaatcaggac tctgaaagcc aagttcaata gtgaaactcg
      661 aattgtttac cagtttcatt ataagaattg gccggaccat gatgtgcctt cctctataga
      721 ccctatcctt cagctcatct gggatatgcg gtgttaccaa gaagacgact gcgttcctct
      781 atgcattcat tgcagtgccg gctgcggaag gacgggggtc atttgtgctg ttgattatac
      841 atggatgttg ctgaaagatg ggataattcc taagaacttc agtgttttta atttgattca
      901 ggaaatgcga acacagaggc cttcgctagt tcaaactcag gaacagtacg aactggtcta
      961 cagcgctgtg ttggaactgt ttaagaggca cgtggacatt atctctgata atcaccgtga
     1021 aagagagatt caagcagaat gttcaattcc tgaacaaaag ctcactatag aagctgactc
     1081 ttatcctctg gattttccaa aaaacgccgt gagagatgca aaaatgacaa accagcagag
     1141 caaacaaggg gcggaagcgg agagcaccga agtgtcttcc tttggcctta gaacttctaa
     1201 gataagtgcc aaggaagagt tggttttgca ctctaaatct agcccttctt ttgactgttt
     1261 agagctaaac tgtgagtgta acaaggctgt cataaccagg aacgggcagg cgagggcttc
     1321 tctggtcgtg ggagagccgc ttcagaagta tcaaagtctg gacttcggtt ccatattgtt
     1381 tgggtcgtgt cctagtgctc tgcccataaa cacagcgagc agatgtcaca actcaaaggg
     1441 gccagtaaaa cggaccaaat caactccttt cgaactgatt cagcagagga aaacaaacga
     1501 gttagctgtg gaagacggtt cttcatgctt ggaatctcag ctgctcgagc acggtctcat
     1561 ggagttgcag gcgcaaaaag tggcccatgc ttcttcagaa gaactgaact attcattgcc
     1621 gcgtgcctgc gaacgcccgg catgtgatgc atcttgtgta ccgcaggacg gccccggtgc
     1681 tttgagagag catttgtgta tgtctttagc ggaagatcct tacttttcat catcccctcc
     1741 aaatagtgct ggttctaaga tgtcttttga tctgcctgag aaacaagatg gagccacttc
     1801 tcctggtgct cagctgccag cctcttctgc agcctcctct tcttatagta acccacggga
     1861 ttccttaatg gagagcactc taaccagctt tcccccgcca ataaaccaag agacagctat
     1921 agaagccact tctgcaagga cagatgatga aatccccccg ccactccctg aacggacacc
     1981 tgagtccttc attgtggccg aagcagccgg agagccctcg ccaagcatta ctgagtcctt
     2041 acctctggca ggaaaatctg gagtgacact ggaatgcggg ggaacatctg agtcacagag
     2101 ccatgacttg gtggcgttta cgtcaagcaa gaatgtggaa ctcggaagtc ccaaatcaga
     2161 tcaacatcag gatggttctc ctccacctcc actcccagaa agaactctgg agtccttctt
     2221 tcttgctgac gaggactgta tacaggccca acccatgaaa ccttcctcta ttagctatcc
     2281 tgaaaccaca gagatctcca catcttctaa gcaaacattg aagaccccag gaaaaagttt
     2341 cacaaggagc aagagtttga agattttccg aaatatgaaa aaaagtgttt gtaattctcc
     2401 ctcaccaagc aagcctacag aatgtgttca gccaaaaaat tccagctcct ttctgaattt
     2461 tggttttgga actcgttttt caaaacccaa aggaccaagg aacccaccat caacttggaa
     2521 tatttaacaa cctccggatt tataagaata tttgctaaaa ttgtgcctgc aaataaagct
     2581 actggaatac tgctagaata atatctgtaa tgacgacatc tgtaatgacg acatattgtc
     2641 aatgaagagg gaagcagtgt gtggaaactt ccagcaatca tgtattttca tattccttct
     2701 gttttattgg gaactgccaa taaagtttgt acttcagttt atgtttc
//
