LOCUS       NM_133545               5543 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type
            21 (Ptpn21), mRNA.
ACCESSION   NM_133545
VERSION     NM_133545.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5543)
  AUTHORS   Cui,N., Lu,H., Li,M. and Yan,Q.
  TITLE     PTPN21 protects PC12 cell against oxygen-glucose deprivation by
            activating cdk5 through ERK1/2 signaling pathway
  JOURNAL   Eur J Pharmacol 814, 226-231 (2017)
   PUBMED   28843827
  REMARK    GeneRIF: PTPN21 protects PC12 cell against oxygen-glucose
            deprivation by activating cdk5 through ERK1/2 signaling pathway
REFERENCE   2  (bases 1 to 5543)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Expression of Ptpn21 decreases 8-fold at night in the rat
            pineal gland relative to day values.  This appears to reflect
            negative effects of norepinephrine acting through a cyclic AMP
            mechanism.
REFERENCE   3  (bases 1 to 5543)
  AUTHORS   L'Abbe,D., Banville,D., Tong,Y., Stocco,R., Masson,S., Ma,S.,
            Fantus,G. and Shen,S.H.
  TITLE     Identification of a novel protein tyrosine phosphatase with
            sequence homology to the cytoskeletal proteins of the band 4.1
            family
  JOURNAL   FEBS Lett 356 (2-3), 351-356 (1994)
   PUBMED   7805871
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133545.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U17971.1, SRR26643429.24845.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000006.1  123727715-123727809 c
            96-444              JAXUCZ010000006.1  123723748-123724096 c
            445-614             JAXUCZ010000006.1  123705522-123705691 c
            615-712             JAXUCZ010000006.1  123695418-123695515 c
            713-780             JAXUCZ010000006.1  123694202-123694269 c
            781-851             JAXUCZ010000006.1  123693487-123693557 c
            852-939             JAXUCZ010000006.1  123690959-123691046 c
            940-1028            JAXUCZ010000006.1  123690122-123690210 c
            1029-1116           JAXUCZ010000006.1  123686069-123686156 c
            1117-1196           JAXUCZ010000006.1  123685034-123685113 c
            1197-1257           JAXUCZ010000006.1  123679153-123679213 c
            1258-1342           JAXUCZ010000006.1  123678478-123678562 c
            1343-2778           JAXUCZ010000006.1  123673986-123675421 c
            2779-2916           JAXUCZ010000006.1  123669525-123669662 c
            2917-3138           JAXUCZ010000006.1  123668590-123668811 c
            3139-3267           JAXUCZ010000006.1  123666433-123666561 c
            3268-3502           JAXUCZ010000006.1  123666029-123666263 c
            3503-3663           JAXUCZ010000006.1  123665240-123665400 c
            3664-5543           JAXUCZ010000006.1  123662783-123664662 c
FEATURES             Location/Qualifiers
     source          1..5543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..5543
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /note="protein tyrosine phosphatase, non-receptor type 21"
                     /db_xref="GeneID:171070"
                     /db_xref="RGD:620216"
     exon            1..95
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            96..444
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..3792
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase 2E"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     21"
                     /protein_id="NP_598229.2"
                     /db_xref="GeneID:171070"
                     /db_xref="RGD:620216"
                     /translation="MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVEST
                     GQESLEAVAQRLELREITYFSLWYYNKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVV
                     FYVPSVSQLQQEITRYQYYLQLKKDVLEGNLPCTLEQAIQLAGLAVQADFGDFDQYES
                     QDFLQKFALLPVGWLQDEKLLEEAAQKVALLHQKYRGLTAPEAEMLYMQEVERMDGYG
                     EESYPAKDSQGSDISIGACLDGIFVKHKNGRPPVVFRWHDIANMSHNKSFFALELANK
                     EETIQFQTEDMETAKYVWRLCVARHKFYRLNQCNLQTQAATLNSVRRGSSSRMSLPKP
                     QPYAMPPPPQLHYNGHYTEPFASSQDNVFVPNKNGFYCHSQTSLDRTQIDLSGRIRNG
                     SVYSAHSTNSLNTPQPYLQPSPMSSNPSIPGSDVMRPDYIPSHRHSALIPPSYRPTPD
                     YESVMKRLNRGMVHADRHSHSLRNLNIGSSYAYSRPDALVYSQPEIREHPHLASPQSA
                     HYPFNLNYSFHSQAPYPYPVERRPVVGAVSVPELTNVQLQAQDYPAPNIMRTQVYRPP
                     PPYPYPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPL
                     TAARHAHLQKRNSIEIAGLTHGFEGLRLKERTMSASAADVAPRTFSAGSQSSVFSDKV
                     KQEGTEEQGSGGYSHKKSLSDATMLIHSSEEDEDLEDDSSREHAVSEPRLTAAFSQEQ
                     QLNYPCASVTPVTGPLHIFEPKSHVTEPEKRAKDISPVHLVMETHQPRRHGLLTPSMS
                     ESDLTTSGRYRARRDSLKKRPVSDLLSGKKNTVEGLPPLGGMKKTRADAKKIGPLKLA
                     ALNGLSLSRLPLPDEGKEVSTRATNDERCKVLEQRLEQGTVFTEYERILKKRLVDGEC
                     STARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGIEWDYIATQ
                     GPLQNTCQDFWQMVWEQGVAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKIT
                     TRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSV
                     RRHTNSTSEPRSPNPPLLVHCSAGVGRTGVVILSEIMVACLEHNEVLDIPRVLELLRQ
                     QRMMLVQTLSQYTFVYRVLIQFLKSSRLI"
     exon            445..614
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            615..712
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            713..780
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            781..851
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            852..939
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1028
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1116
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1196
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1257
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1342
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..2778
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2916
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3138
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3267
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3502
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..3663
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..5543
                     /gene="Ptpn21"
                     /gene_synonym="Ptp2E"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcgagcg ctagcggccg cggcggccgc gcggaaccca gggaggcggg acgcagagcc
       61 ggagcgcggc cccgaccagg cgggagcccg agcagcgctg gcgtggatgc tcccatcgct
      121 tggtcgttgg agactcggtt gctttttaat ggcagcagcg gctgttggat gactagagtt
      181 tgttttgact ggagggtcgc ttttgcttgg cactataact gctggattgg tccttcctgg
      241 cccttccact gttgaaggga gaagatgcca ctgccatttg ggttgaaatt gaaacgcacc
      301 cggcgctaca ctgtgtccag caagagctgc ctggttgcac ggatccagct gctcaataat
      361 gagtttgtgg agttcactct gtccgtggag agcactggcc aggagagcct agaagctgtg
      421 gcccaacgcc tggagctgag agagatcacg tacttcagcc tctggtacta caacaagcag
      481 aatcagcgtc gctgggtgga tttggagaaa cccctgaaga agcagctgga caagcacgcg
      541 ctggagccca ccgtctactt tggagtggtg ttttatgtgc cctctgtttc ccagctgcag
      601 caggagatca ccaggtacca gtattacctg cagctgaaga aggatgttct ggaaggaaac
      661 cttccctgca cattggagca agccattcag ctggctggct tagctgttca agctgatttt
      721 ggcgactttg atcagtatga atcccaagat tttcttcaga aattcgcctt gctccctgtg
      781 gggtggctac aggatgaaaa actgctggaa gaagcagccc aaaaagtggc cttgctgcat
      841 cagaaataca gagggctcac agctcctgag gccgagatgc tgtacatgca ggaggtagag
      901 cggatggacg gctatggaga ggagagctac cctgccaagg acagccaagg aagtgacata
      961 tccattggtg cttgtctcga tggcatcttt gtgaagcaca agaatgggag gcctcccgtg
     1021 gtgttcaggt ggcacgacat tgctaacatg tcacacaata agtccttttt tgcgttagaa
     1081 ctggcaaata aagaggagac catccagttt caaactgaag acatggaaac agcaaagtac
     1141 gtgtggaggc tgtgtgtggc acgccacaaa ttttacagac tgaaccagtg taacctgcaa
     1201 actcaggctg ccacgttgaa ctccgtcagg aggggctcat cgtccaggat gtctctgcct
     1261 aaaccccagc cctatgcgat gcctccccca ccccagctgc attataatgg acattataca
     1321 gagccatttg cttcttccca agacaatgtc tttgtgccca acaagaatgg attctattgc
     1381 cactcccaga caagtttgga cagaacccaa attgacctca gtggccgcat ccgcaacggc
     1441 agcgtgtaca gtgcacacag tacgaactcc ttaaacacac ctcagcccta cctgcagccc
     1501 tcccctatgt cctccaaccc cagtattcca ggcagcgatg tcatgagacc tgactacatc
     1561 ccatcccacc ggcacagcgc cttgattccc ccatcctacc gcccgacccc tgactacgag
     1621 agcgtgatga agcggctcaa cagaggcatg gtgcatgcag acaggcatag ccactcgctc
     1681 aggaacctca acattggcag ttcctatgca tacagcaggc ccgacgcctt ggtctacagc
     1741 cagcctgaga ttcgggaaca cccacacctc gcctctcccc agtcagccca ctacccattt
     1801 aacttgaact acagtttcca cagccaggct ccgtatccat accctgtgga gaggcggcct
     1861 gtggtgggcg ctgtgagtgt ccctgagctg accaatgtgc agctgcaggc ccaggactac
     1921 ccagctccaa acattatgag gacccaggtg taccggccgc ccccgccata tccttaccca
     1981 agacctgcca acagcacccc ggacctatcg cggcacctct acatcagcag cagcaatcca
     2041 gatctcatca ccagacgcgt ccatcactcg gtgcagacct tccaggagga cagcttgccc
     2101 gtggctcact ctctgcagga ggtgagtgag cccctcacag cagctcggca tgcacaccta
     2161 cagaagagga acagtattga aatcgcaggg ctcacacatg gtttcgaagg cctgaggctc
     2221 aaggagagga cgatgtcagc ctcagccgca gacgtggccc ccaggacctt ctcagcaggc
     2281 tcccagtcca gcgtcttctc tgacaaagtg aagcaggagg gaaccgaaga gcaggggagt
     2341 ggtgggtaca gtcacaagaa gtccctttct gatgccacca tgctgattca cagcagcgag
     2401 gaggatgagg acttagaaga cgacagcagc agagaacacg ctgtgtctga gccccgcctt
     2461 acggccgctt tctctcagga acaacagcta aactacccct gtgcttcagt gactccggtc
     2521 actggccctc tgcatatttt cgagcccaag tcccatgtta cggagcctga gaagagggca
     2581 aaggacatca gccctgtcca cctggttatg gagactcatc agccccgaag acatggactg
     2641 ctgaccccct ccatgtccga gtcagacctc acgacgtcag ggaggtaccg agctaggagg
     2701 gactctctca agaagaggcc agtgtcagat ctcctctctg ggaagaagaa cactgtggaa
     2761 ggacttccgc cactaggggg aatgaaaaag actcgagcag atgcaaaaaa aattggcccc
     2821 ctcaagctgg cagccctcaa tggactctcc ctgtcccggc tgcccctgcc tgacgaaggc
     2881 aaagaagtgt ccaccagagc gacaaatgac gagaggtgta aagttctgga gcagcggtta
     2941 gagcaaggaa cggtcttcac cgagtatgag aggattctga aaaagcggct ggttgatggc
     3001 gagtgctcaa cagctcggct ccctgaaaat gcagagagaa accgattcca agatgtgctc
     3061 ccctacgatg atgccagagt ggagttggtg ccaaccaagg agaacaacac tggctatatc
     3121 aatgcgtcac acattaaggt ctctgtcagc ggaattgaat gggattatat tgccacacag
     3181 ggaccattac aaaatacctg ccaggacttt tggcagatgg tgtgggaaca gggagtcgca
     3241 attatagcaa tggtgacagc ggaagaggag ggaggtcggg agaagagctt taggtattgg
     3301 ccacggcttg gctccaggca caacactgtc acctatggaa ggtttaagat cacaactcgc
     3361 ttccgcacgg actcgggctg ctacgccacc acaggtttga agatgaagca ccttctcaca
     3421 gggcaggaga ggacagtttg gcatctccag tacacagact ggcctgaaca tggctgtccc
     3481 gaagacctca agggattttt atcatacctt gaagagatcc agtcagttcg acgtcataca
     3541 aacagtacaa gtgaacccag aagtcccaac cccccgctgc tggtgcactg cagtgctggc
     3601 gtgggaagaa ctggggttgt cattctgtca gagatcatgg tggcctgtct ggaacacaat
     3661 gaggtgctgg acatccccag agtgctggag ctgctgaggc agcagaggat gatgctggtg
     3721 cagacactta gccagtacac gttcgtgtac cgggtgctca ttcagttcct gaagagctct
     3781 aggctcatct aagctccacc acctttctat ggggacccaa tcatgtgatg tgtttacagc
     3841 tttaaaaaga aaaaggaaag aaaagagtgc agctcccact ttgttcccag gagtccatgt
     3901 ggagacctca acaggaagtg tgtaagagct gaagaagcta agcatggggc tgaggagtct
     3961 ggggacctgg gagaggccga ggaggcaggt gctgccctgg ccacatctgc ctggtttgct
     4021 gcacttgcac aagttttgga gattgtattt tctagacagt tctctgtcgt actgaagctg
     4081 cctgggcagt cccagccagc acttaaggca cacagacttc tatcttaaac tcatatttga
     4141 taatgcaatt ttatgactaa atagggcttt ttctttttta gctagaagct gaacttttct
     4201 gtgggacatc cacagaccgt gtggttcttg agtacctgta tttaaaacca ttattagctt
     4261 ttgtttaaga acaaaaacca tgggggaact aagtgtttta ttcatgaaat ccaaaactaa
     4321 agaaaatcta aaagtgttat tttgaaacat agaaagcatt tttatattca gaatgttttt
     4381 ttaaaagtta tatatttgta ccttctatat tttccaaata agagctccat tgttatgaca
     4441 ctgagtcaat gtaaagttgg ggataaaggc acattattta aaaatctaag aatcagattc
     4501 actatttttt cagtattatt agtaagcgta aaatgagttt gatttttttg aacatgaaag
     4561 agcaattgca taggatggtt ttaagcactt ttttgttaaa aatgagttta atatatgtgg
     4621 ctttatattt aagcaacagt ggacactatt tcaaagagaa gggctctgag tacgttcgat
     4681 gactagggga agaggaagtg ctctcggggc tcacccggaa ggtgtggtca ttacacaaat
     4741 gcagtattac ctatgctcac tcgagcgaga gcgagagctg agatggcgtg gaactcaagg
     4801 cctgctaccg tgatgacggg ctttgctgcc tggggttctt cctgtctttc ttccccccac
     4861 agacaagtcc aggcttacat taccattaga gacccccgaa gaggctttgt ttcctttagg
     4921 ttgaaaggag gaaatagtta acgaggttcc tttccctgaa ccacagccca aacttgtggg
     4981 gccaccagaa attgctgtgg tgttcagggg gtacttgaat ttagcaccgt aatcctgtcc
     5041 tcccccaggg tcagttctag gtacttggtc tccctttcca tcccatttgg gcacattctc
     5101 tattgatcag aacccaggct tgaagtggaa agtgctgttc ttggaggaca agctggcacc
     5161 cttagctgag gtgtgtcatg ttgtccagtg ccctgcatcg taggctgccg attcagtgtg
     5221 gacctagaat gttcgaccta ggactagctt ccaatactgt cctgccatca ctctgatttg
     5281 actttgtggt gagcgtcacc acatgacagg ggtgtgccag cccatcgaag caggacagac
     5341 acaggtggat tgtgccccag ggtgggattt gtgtgctcta tgctccatgt caagccatgt
     5401 gaaggtcagg acccttctga agcttttctt ccaatggtac gttgtttgaa gatgctttcc
     5461 tgtcacacct aaacatttgg aaatatccca ctgacaagaa cacattgtaa aacaaaactt
     5521 taattaaaga gtaatatatg gca
//
