LOCUS       NM_001080149            3040 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type
            20 (Ptpn20), mRNA.
ACCESSION   NM_001080149 XM_001060487 XM_224639
VERSION     NM_001080149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3040)
  AUTHORS   Xu,H., Miyajima,M., Nakajima,M., Ogino,I., Kawamura,K., Akiba,C.,
            Kamohara,C., Sakamoto,K., Karagiozov,K., Nakamura,E., Tada,N.,
            Arai,H. and Kondo,A.
  TITLE     Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1
            cotransporter in the choroid plexus: an evidence of genetic risk
            for hydrocephalus in an experimental study
  JOURNAL   Fluids Barriers CNS 19 (1), 39 (2022)
   PUBMED   35658898
  REMARK    GeneRIF: Ptpn20 deletion in H-Tx rats enhances phosphorylation of
            the NKCC1 cotransporter in the choroid plexus: an evidence of
            genetic risk for hydrocephalus in an experimental study.
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129117.1.
            
            On or before Jan 13, 2007 this sequence version replaced
            XM_224639.4, XM_001060487.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3040
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /note="protein tyrosine phosphatase, non-receptor type 20"
                     /db_xref="GeneID:306281"
                     /db_xref="RGD:1309812"
     exon            1..78
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            79..229
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1461
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /EC_number="3.1.3.48"
                     /note="protein tyrosine phosphatase, non-receptor type
                     20B"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     20"
                     /protein_id="NP_001073618.1"
                     /db_xref="GeneID:306281"
                     /db_xref="RGD:1309812"
                     /translation="MSSPGNVRQKHGRDNDEHEGDSDDLNLQKSLPSSSQQKTPTKPV
                     FGNKVNSESVKTSHHMSFSNKYDLVFPEPVESDNDETLWDVRDLSHRNRWSSVDPESA
                     GPSKTVSTVLSESSTDTAVSERELTQLAQIRPLIFNSSSRAALRDCLKALQKKEELDI
                     IREFLELEEMIPPDDFKSGYELQNRDKNRYRDILPYDSTRVPLGKNKDYINASYIRIV
                     NHEEEYFYIATQGPLPDTIEDFWQMVLENNCNVIAMITREIEGGVIKCCSYWPVSLKE
                     PLEFKHFHVLLENFQITQYFVIRIFQIVKKSTGKSHSVKHLQFIKWPDHGTPASADFF
                     IKYVRYVRKSHITGPLLVHCSAGVGRTGVFICVDVVFCTIEKNYSFNIMNIVTQMRKQ
                     RFGMIQTKEQYQFCYEIVLEVLQNLLALN"
     exon            230..324
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            325..422
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            423..541
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            542..690
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            691..781
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1116
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1332
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1395
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..3017
                     /gene="Ptpn20"
                     /gene_synonym="Ptpn20b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatctctgac tcactgcact ggagtttggc aaaagcatct cagaagtggg tgtgcttttt
       61 tgaatgaaat gatcaatgga gcgctccgat tgtatgctgg cccctggata ctaaatagac
      121 ctgcctgact ccaggaacta aggctccgta tctgcagaag ctttttgccc atctcattcc
      181 ggctatgggg acaacatgtc ttcacccggg aatgttagac aaaaacatgg aagagataat
      241 gatgaacatg agggtgactc agatgacctg aatctccaga agtctttgcc ttcatcaagt
      301 cagcaaaaga cacctacaaa accggttttt gggaataaag tgaattcaga gagtgtaaaa
      361 acctcccacc atatgtcatt ctcgaataag tatgaccttg tttttccaga gcctgtagaa
      421 agtgacaatg atgagacatt gtgggatgtc agagacctgt cccacagaaa caggtggagc
      481 agtgtggatc cggagtccgc agggccatca aagactgtct ccacagtgct ttctgaaagt
      541 agcactgaca cagctgtctc ggaaagggag ctgactcagt tagctcagat ccgaccgcta
      601 atattcaaca gttcctcaag agctgccctg agggactgtt tgaaagcgct ccagaaaaaa
      661 gaagagcttg atatcatccg tgagtttttg gaattagaag aaatgattcc gcctgatgac
      721 ttcaagtctg ggtatgagct acagaacaga gacaagaaca gataccgaga tattcttcca
      781 tatgattcaa cccgtgttcc tcttggaaaa aacaaggact acatcaacgc tagttacatt
      841 agaatagtaa atcatgaaga agagtatttt tatatcgcca ctcaaggacc actgccggac
      901 actatagaag acttttggca gatggttttg gaaaataatt gtaatgttat tgctatgata
      961 accagagaga tagaaggtgg agttatcaag tgttgcagtt actggcccgt ttctctgaag
     1021 gagcctttgg aattcaaaca ctttcatgtc cttctggaga actttcagat aactcagtat
     1081 tttgtcatcc gaatatttca aattgtgaag aagtccacag gaaagagtca ctctgtaaaa
     1141 cacttgcagt tcatcaaatg gccagaccat ggcactcctg cctcagcaga ttttttcatc
     1201 aaatatgtcc gttatgtgag gaagagccac attacaggac ccctccttgt ccactgcagt
     1261 gctggtgtag gccgaacagg ggtgttcata tgtgtggatg ttgtgttctg taccatcgag
     1321 aagaactact cattcaacat catgaacata gtgacccaga tgagaaagca gcgcttcggc
     1381 atgattcaaa ccaaggagca gtatcagttc tgttacgaga ttgtgcttga agttcttcag
     1441 aatcttctgg ctttgaatta aggaagactt ccacgcctgt cacttgagac tgccaagcag
     1501 cctggagctg ggctgtgtgg aattgtctgc tggccgagcg atttgctttc tggtttcttc
     1561 tgaaaatcct gagggcagca cctctgggct ccgagtgaac cctcttcagt tgatctttct
     1621 ggaatagcaa aataccctcc atgccttcca ctgaaactaa acttacgtga aacaacctca
     1681 gcttggctgt ttggtttgtg gtattacaga gtttaataaa agacttaaat gtgttcgtta
     1741 agattttatt tggaaaggtg gccaaaagcc tcagacaatt tccaaccctt tacaagcctg
     1801 actctgggag aacatggggg caataaactg caggctcaca gactgacctc ttgtgggcag
     1861 ttagcagaca tttttatctg tgtctatact cccagctggt gactgactca ctcaaaggga
     1921 ctctaattag gatggactga cttttgatat aaaatgggct ttgtgtctta tacttccaca
     1981 gtcccagagt gccctgggga tttcgaagga aggaaggaag agctgcattc ctggagcggc
     2041 agtcaggtcc ttgtctgctg ccctgggaag ccccttgtag gtgaatggtg tccctcctta
     2101 cctgaacaca ctggtgaaca tcccaaacta aaatccacat ccatccctaa agtcagtgga
     2161 aatgtttgcc agacccaact acacttcttt cctatcctgc cccgagtcaa tgtactctcc
     2221 catctgcttt atcagaagca agtatcatat gacacttccc tcctaatctg taactagccc
     2281 atacatttaa tttaatacaa tgatattgct ctgtaagttt gagtcattct tggtacctgt
     2341 tgtgtcaagt ttttttcttt ttaactaaga tctaaaaaaa aaaagctttt tttcccttct
     2401 ggaggaccat taagtcattt ctttcctcta taagaatatt tagatgctgg acattgaact
     2461 agattttgaa gtaccaaatt catagttgtg aaagtgaaaa cttccatatg cttgttaaga
     2521 aaattctgga cattgttgca tttatcatat caggattctg cctcagacaa ttgtagtgat
     2581 tctttggttg aaggttttca atgatcagac aatcctaatt ataagccaca aagaaattga
     2641 taagtgtatt tgtacagtga attcagtagc gatcagagct gtgaatcata ttgaaaattc
     2701 ctaaaattat aaatgctaaa cttttaagag gcttatattt ttggttaaat gaatacttga
     2761 attgcttaaa ttcaaattga taattctcac tttaaaaatg attatatgcc atatatttga
     2821 cattaactca agttgatggt tatagctatt tatactgttt atattcataa tagtctatgc
     2881 tgaacaataa tattctgatt attgatcact aacatttgta tctataactg tattttcatt
     2941 ctgttactat aaaacaataa gtataatata gaacaatggc ctgtgtgttg ttattaaata
     3001 aaaatatttc ctttgcaaaa aaaaaaaaaa aaaaaaaaaa
//
