LOCUS       NM_001414231            1569 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type 2
            (Ptpn2), transcript variant 2, mRNA.
ACCESSION   NM_001414231 XM_006254855
VERSION     NM_001414231.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Gao,J., Hu,J., Li,P., Che,K., Wang,F. and Yan,S.
  TITLE     Human umbilical cord mesenchymal stem cells alleviate the imbalance
            of CD4+ T cells via protein tyrosine phosphatase non-receptor type
            2/signal transducer and activator of transcription 3 signaling in
            ameliorating experimental autoimmune thyroiditis in rats
  JOURNAL   Endocr J 69 (6), 613-625 (2022)
   PUBMED   35153255
  REMARK    GeneRIF: Human umbilical cord mesenchymal stem cells alleviate the
            imbalance of CD4(+) T cells via protein tyrosine phosphatase
            non-receptor type 2/signal transducer and activator of
            transcription 3 signaling in ameliorating experimental autoimmune
            thyroiditis in rats.
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Zhu,Y., Yao,J., Duan,Y., Xu,H., Cheng,Q., Gao,X., Li,S., Yang,F.,
            Liu,H. and Yuan,J.
  TITLE     Protein Expression Profile in Rat Silicosis Model Reveals
            Upregulation of PTPN2 and Its Inhibitory Effect on
            Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3
  JOURNAL   Int J Mol Sci 21 (4), 1189 (2020)
   PUBMED   32054021
  REMARK    GeneRIF: Protein Expression Profile in Rat Silicosis Model Reveals
            Upregulation of PTPN2 and Its Inhibitory Effect on
            Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Adel,S., Mansour,A., Louka,M., Matboli,M., Elmekkawi,S.F. and
            Swelam,N.
  TITLE     Evaluation of MicroRNA-210 and Protein tyrosine phosphatase,
            non-receptor type 2 in Pre-eclampsia
  JOURNAL   Gene 596, 105-109 (2017)
   PUBMED   27746364
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Ren,F., Geng,Y., Minami,T., Qiu,Y., Feng,Y., Liu,C., Zhao,J.,
            Wang,Y., Fan,X., Wang,Y., Li,M., Li,J. and Chang,Z.
  TITLE     Nuclear termination of STAT3 signaling through SIPAR
            (STAT3-Interacting Protein As a Repressor)-dependent recruitment of
            T cell tyrosine phosphatase TC-PTP
  JOURNAL   FEBS Lett 589 (15), 1890-1896 (2015)
   PUBMED   26026268
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   Li,H., Spagnol,G., Naslavsky,N., Caplan,S. and Sorgen,P.L.
  TITLE     TC-PTP directly interacts with connexin43 to regulate gap junction
            intercellular communication
  JOURNAL   J Cell Sci 127 (Pt 15), 3269-3279 (2014)
   PUBMED   24849651
  REMARK    GeneRIF: interacts with connexin43 modulating gap junctions
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   You-Ten,K.E., Muise,E.S., Itie,A., Michaliszyn,E., Wagner,J.,
            Jothy,S., Lapp,W.S. and Tremblay,M.L.
  TITLE     Impaired bone marrow microenvironment and immune function in T cell
            protein tyrosine phosphatase-deficient mice
  JOURNAL   J Exp Med 186 (5), 683-693 (1997)
   PUBMED   9271584
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   Reddy,R.S. and Swarup,G.
  TITLE     Alternative splicing generates four different forms of a
            non-transmembrane protein tyrosine phosphatase mRNA
  JOURNAL   DNA Cell Biol 14 (12), 1007-1015 (1995)
   PUBMED   8534367
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Lorenzen,J.A., Dadabay,C.Y. and Fischer,E.H.
  TITLE     COOH-terminal sequence motifs target the T cell protein tyrosine
            phosphatase to the ER and nucleus
  JOURNAL   J Cell Biol 131 (3), 631-643 (1995)
   PUBMED   7593185
REFERENCE   9  (bases 1 to 1569)
  AUTHORS   Radha,V., Kamatkar,S. and Swarup,G.
  TITLE     Binding of a protein-tyrosine phosphatase to DNA through its
            carboxy-terminal noncatalytic domain
  JOURNAL   Biochemistry 32 (9), 2194-2201 (1993)
   PUBMED   8443161
REFERENCE   10 (bases 1 to 1569)
  AUTHORS   Swarup,G., Kamatkar,S., Radha,V. and Rema,V.
  TITLE     Molecular cloning and expression of a protein-tyrosine phosphatase
            showing homology with transcription factors Fos and Jun
  JOURNAL   FEBS Lett 280 (1), 65-69 (1991)
   PUBMED   1849097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 16, 2022 this sequence version replaced XM_006254855.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.41726.1,
                                           SRR22582416.641817.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000018.1  63564335-63564481   c
            148-238             JAXUCZ010000018.1  63548299-63548389   c
            239-339             JAXUCZ010000018.1  63530672-63530772   c
            340-438             JAXUCZ010000018.1  63523654-63523752   c
            439-573             JAXUCZ010000018.1  63517823-63517957   c
            574-783             JAXUCZ010000018.1  63515565-63515774   c
            784-936             JAXUCZ010000018.1  63510943-63511095   c
            937-1103            JAXUCZ010000018.1  63509482-63509648   c
            1104-1205           JAXUCZ010000018.1  63505925-63506026   c
            1206-1569           JAXUCZ010000018.1  63498890-63499253   c
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1569
                     /gene="Ptpn2"
                     /note="protein tyrosine phosphatase, non-receptor type 2"
                     /db_xref="GeneID:117063"
                     /db_xref="RGD:620710"
     exon            1..147
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1227
                     /gene="Ptpn2"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tyrosine-protein phosphatase non-receptor type 2;
                     protein-tyrosine phosphatase PTP-S"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 2
                     isoform 2"
                     /protein_id="NP_001401160.1"
                     /db_xref="GeneID:117063"
                     /db_xref="RGD:620710"
                     /translation="MSATIEREFEELDAQCRWQPLYLEIRNESHDYPHRVAKFPENRN
                     RNRYRDVSPYDHSRVKLQSAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVW
                     QQKTRAVVMLNRTVEKESVKCAQYWPTDDREMVFKETGFSVKLLSEDVKSYYTVHLLQ
                     LENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSA
                     GIGRSGTFSLVDTCLVLMEKGEDVNVKQILLSMRKYRMGLIQTPDQLRFSYMAIIEGA
                     KYTKGDSNIQKRWKELSKEDLSPVCDHSQNRTMTEKYNGKRIGSEDEKLTGLSSKVPD
                     TVEESSESILRKRIREDRKATTAQKVQQMRQRLNETERKRKRPRLTDT"
     exon            148..238
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            239..339
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..438
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..573
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            574..783
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..936
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1103
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1205
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1569
                     /gene="Ptpn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgccagcg ctctccccgg atagagcggg gcccgagcct gtccgctgtg gtggttccgc
       61 tcgcgctccc ccgccgccat gtcggctacc atcgagcggg agttcgagga actggatgct
      121 cagtgtcgct ggcagccgtt atacttggaa attcgaaatg aatcccatga ctatcctcat
      181 agagtggcca agtttccaga aaacagaaat cgaaacagat acagagatgt aagcccatat
      241 gatcacagtc gtgttaaact gcagagtgct gaaaatgatt atattaatgc cagcttagtt
      301 gacatagaag aggcacaaag aagttacatc ttaacacagg gcccacttcc taacacgtgc
      361 tgccatttct ggctcatggt gtggcagcaa aagaccagag cagttgtcat gctaaaccga
      421 actgtagaga aagaatcggt taaatgtgca cagtactggc caacggatga ccgagagatg
      481 gtgtttaagg aaacaggatt cagcgtgaag ctcttatctg aagatgtgaa atcatattat
      541 acagtacatc tactacagtt agaaaatatc aatagtggtg aaaccagaac catatctcac
      601 tttcattata ccacctggcc agattttggc gttccagagt caccagcttc attcctaaat
      661 ttcttgttta aagttagaga atctggttct ttgaaccctg accatgggcc tgcagtgatc
      721 cattgcagtg caggcatcgg gcgctctggc accttctctc ttgtagatac ctgtctcgtt
      781 ctgatggaga aaggagagga tgttaatgtg aaacaaatat tactgagtat gagaaagtat
      841 cgaatgggac tcattcagac gccggaccag ctcagattct cctacatggc cataatagaa
      901 ggagcaaagt atacaaaagg agattcaaat atacagaaac ggtggaaaga actttctaaa
      961 gaagatttat ctcctgtttg tgatcactca cagaacagaa cgatgactga gaagtacaac
     1021 gggaagagaa tagggtcaga agatgaaaag ttaacaggac tttcttctaa ggttccagat
     1081 actgtggaag agagcagtga gagtattctc cggaaacgca ttcgagagga tagaaaggct
     1141 acaaccgctc agaaggtgca gcagatgaga cagaggctaa atgaaactga acggaaaagg
     1201 aaaaggccaa gattgacaga cacctaaatg ttcatgactt gagactattc tgcagctata
     1261 aattttgaac ctttgatgtg caaagcaaga cctgaagccc actccggaaa ctaaagtgag
     1321 gcttgctaac cctgtagatt gcctcacaag ttgtctgttt acaaagtaag ctttacatcc
     1381 aggggatgaa gaacgccacc agcagaagac ttgcaaaccc tttaatttga tgtattgttt
     1441 tttaacatgt gtatgaattg tagaaagatg taaagaaaat aaattaggag agactacttt
     1501 gtattgtact gccattccta atgtattttt atactttttg gcagcattaa atatttttat
     1561 taaatagac
//
