LOCUS       NP_001401160             382 aa            linear   ROD 01-MAY-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 2 isoform 2 [Rattus
            norvegicus].
ACCESSION   NP_001401160 XP_006254917
VERSION     NP_001401160.1
DBSOURCE    REFSEQ: accession NM_001414231.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 382)
  AUTHORS   Gao,J., Hu,J., Li,P., Che,K., Wang,F. and Yan,S.
  TITLE     Human umbilical cord mesenchymal stem cells alleviate the imbalance
            of CD4+ T cells via protein tyrosine phosphatase non-receptor type
            2/signal transducer and activator of transcription 3 signaling in
            ameliorating experimental autoimmune thyroiditis in rats
  JOURNAL   Endocr J 69 (6), 613-625 (2022)
   PUBMED   35153255
  REMARK    GeneRIF: Human umbilical cord mesenchymal stem cells alleviate the
            imbalance of CD4(+) T cells via protein tyrosine phosphatase
            non-receptor type 2/signal transducer and activator of
            transcription 3 signaling in ameliorating experimental autoimmune
            thyroiditis in rats.
REFERENCE   2  (residues 1 to 382)
  AUTHORS   Zhu,Y., Yao,J., Duan,Y., Xu,H., Cheng,Q., Gao,X., Li,S., Yang,F.,
            Liu,H. and Yuan,J.
  TITLE     Protein Expression Profile in Rat Silicosis Model Reveals
            Upregulation of PTPN2 and Its Inhibitory Effect on
            Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3
  JOURNAL   Int J Mol Sci 21 (4), 1189 (2020)
   PUBMED   32054021
  REMARK    GeneRIF: Protein Expression Profile in Rat Silicosis Model Reveals
            Upregulation of PTPN2 and Its Inhibitory Effect on
            Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 382)
  AUTHORS   Adel,S., Mansour,A., Louka,M., Matboli,M., Elmekkawi,S.F. and
            Swelam,N.
  TITLE     Evaluation of MicroRNA-210 and Protein tyrosine phosphatase,
            non-receptor type 2 in Pre-eclampsia
  JOURNAL   Gene 596, 105-109 (2017)
   PUBMED   27746364
REFERENCE   4  (residues 1 to 382)
  AUTHORS   Ren,F., Geng,Y., Minami,T., Qiu,Y., Feng,Y., Liu,C., Zhao,J.,
            Wang,Y., Fan,X., Wang,Y., Li,M., Li,J. and Chang,Z.
  TITLE     Nuclear termination of STAT3 signaling through SIPAR
            (STAT3-Interacting Protein As a Repressor)-dependent recruitment of
            T cell tyrosine phosphatase TC-PTP
  JOURNAL   FEBS Lett 589 (15), 1890-1896 (2015)
   PUBMED   26026268
REFERENCE   5  (residues 1 to 382)
  AUTHORS   Li,H., Spagnol,G., Naslavsky,N., Caplan,S. and Sorgen,P.L.
  TITLE     TC-PTP directly interacts with connexin43 to regulate gap junction
            intercellular communication
  JOURNAL   J Cell Sci 127 (Pt 15), 3269-3279 (2014)
   PUBMED   24849651
  REMARK    GeneRIF: interacts with connexin43 modulating gap junctions
REFERENCE   6  (residues 1 to 382)
  AUTHORS   You-Ten,K.E., Muise,E.S., Itie,A., Michaliszyn,E., Wagner,J.,
            Jothy,S., Lapp,W.S. and Tremblay,M.L.
  TITLE     Impaired bone marrow microenvironment and immune function in T cell
            protein tyrosine phosphatase-deficient mice
  JOURNAL   J Exp Med 186 (5), 683-693 (1997)
   PUBMED   9271584
REFERENCE   7  (residues 1 to 382)
  AUTHORS   Reddy,R.S. and Swarup,G.
  TITLE     Alternative splicing generates four different forms of a
            non-transmembrane protein tyrosine phosphatase mRNA
  JOURNAL   DNA Cell Biol 14 (12), 1007-1015 (1995)
   PUBMED   8534367
REFERENCE   8  (residues 1 to 382)
  AUTHORS   Lorenzen,J.A., Dadabay,C.Y. and Fischer,E.H.
  TITLE     COOH-terminal sequence motifs target the T cell protein tyrosine
            phosphatase to the ER and nucleus
  JOURNAL   J Cell Biol 131 (3), 631-643 (1995)
   PUBMED   7593185
REFERENCE   9  (residues 1 to 382)
  AUTHORS   Radha,V., Kamatkar,S. and Swarup,G.
  TITLE     Binding of a protein-tyrosine phosphatase to DNA through its
            carboxy-terminal noncatalytic domain
  JOURNAL   Biochemistry 32 (9), 2194-2201 (1993)
   PUBMED   8443161
REFERENCE   10 (residues 1 to 382)
  AUTHORS   Swarup,G., Kamatkar,S., Radha,V. and Rema,V.
  TITLE     Molecular cloning and expression of a protein-tyrosine phosphatase
            showing homology with transcription factors Fos and Jun
  JOURNAL   FEBS Lett 280 (1), 65-69 (1991)
   PUBMED   1849097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 16, 2022 this sequence version replaced XP_006254917.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.41726.1,
                                           SRR22582416.641817.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     Protein         1..382
                     /product="tyrosine-protein phosphatase non-receptor type 2
                     isoform 2"
                     /EC_number="3.1.3.48"
                     /note="tyrosine-protein phosphatase non-receptor type 2;
                     protein-tyrosine phosphatase PTP-S"
                     /calculated_mol_wt=44372
     Region          19..272
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P18031; propagated from
                     UniProtKB/Swiss-Prot (P35233.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P18031; propagated from
                     UniProtKB/Swiss-Prot (P35233.2)"
     Site            68
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P18031; propagated from
                     UniProtKB/Swiss-Prot (P35233.2)"
     Site            293
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17706; propagated from
                     UniProtKB/Swiss-Prot (P35233.2)"
     Site            298
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17706; propagated from
                     UniProtKB/Swiss-Prot (P35233.2)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17706; propagated from
                     UniProtKB/Swiss-Prot (P35233.2)"
     Site            320
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06180; propagated from
                     UniProtKB/Swiss-Prot (P35233.2)"
     Site            339
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P18031; propagated from
                     UniProtKB/Swiss-Prot (P35233.2)"
     CDS             1..382
                     /gene="Ptpn2"
                     /coded_by="NM_001414231.1:79..1227"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:117063"
                     /db_xref="RGD:620710"
ORIGIN      
        1 msatierefe eldaqcrwqp lyleirnesh dyphrvakfp enrnrnryrd vspydhsrvk
       61 lqsaendyin aslvdieeaq rsyiltqgpl pntcchfwlm vwqqktravv mlnrtvekes
      121 vkcaqywptd dremvfketg fsvkllsedv ksyytvhllq leninsgetr tishfhyttw
      181 pdfgvpespa sflnflfkvr esgslnpdhg pavihcsagi grsgtfslvd tclvlmekge
      241 dvnvkqills mrkyrmgliq tpdqlrfsym aiiegakytk gdsniqkrwk elskedlspv
      301 cdhsqnrtmt ekyngkrigs edekltglss kvpdtveess esilrkrire drkattaqkv
      361 qqmrqrlnet erkrkrprlt dt
//
