LOCUS       NM_001100789            8258 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type
            13 (Ptpn13), mRNA.
ACCESSION   NM_001100789
VERSION     NM_001100789.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8258)
  AUTHORS   Zhu N, Zhang XJ, Zou H, Zhang YY, Xia JW, Zhang P, Zhang YZ, Li J,
            Dong L, Wumaier G and Li SQ.
  TITLE     PTPL1 suppresses lung cancer cell migration via inhibiting
            TGF-beta1-induced activation of p38 MAPK and Smad 2/3 pathways and
            EMT
  JOURNAL   Acta Pharmacol Sin 42 (8), 1280-1287 (2021)
   PUBMED   33536603
REFERENCE   2  (bases 1 to 8258)
  AUTHORS   Chen J, Zhao X, Yuan Y and Jing JJ.
  TITLE     The expression patterns and the diagnostic/prognostic roles of PTPN
            family members in digestive tract cancers
  JOURNAL   Cancer Cell Int 20, 238 (2020)
   PUBMED   32536826
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8258)
  AUTHORS   Huang W, Bei L and Eklund EA.
  TITLE     Inhibition of Fas associated phosphatase 1 (Fap1) facilitates
            apoptosis of colon cancer stem cells and enhances the effects of
            oxaliplatin
  JOURNAL   Oncotarget 9 (40), 25891-25902 (2018)
   PUBMED   29899829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8258)
  AUTHORS   Kilvaer TK, Rakaee M, Hellevik T, Ostman A, Strell C, Bremnes RM,
            Busund LT, Donnem T and Martinez-Zubiaurre I.
  TITLE     Tissue analyses reveal a potential immune-adjuvant function of
            FAP-1 positive fibroblasts in non-small cell lung cancer
  JOURNAL   PLoS One 13 (2), e0192157 (2018)
   PUBMED   29415055
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8258)
  AUTHORS   Kilvaer TK, Khanehkenari MR, Hellevik T, Al-Saad S, Paulsen EE,
            Bremnes RM, Busund LT, Donnem T and Martinez IZ.
  TITLE     Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic
            Impact and Their Correlations with Tumor Molecular Markers
  JOURNAL   PLoS One 10 (8), e0134965 (2015)
   PUBMED   26252379
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8258)
  AUTHORS   Gross C, Heumann R and Erdmann KS.
  TITLE     The protein kinase C-related kinase PRK2 interacts with the protein
            tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif
  JOURNAL   FEBS Lett 496 (2-3), 101-104 (2001)
   PUBMED   11356191
REFERENCE   7  (bases 1 to 8258)
  AUTHORS   Cuppen E, van Ham M, Wansink DG, de Leeuw A, Wieringa B and
            Hendriks W.
  TITLE     The zyxin-related protein TRIP6 interacts with PDZ motifs in the
            adaptor protein RIL and the protein tyrosine phosphatase PTP-BL
  JOURNAL   Eur J Cell Biol 79 (4), 283-293 (2000)
   PUBMED   10826496
REFERENCE   8  (bases 1 to 8258)
  AUTHORS   Lee SH, Shin MS, Park WS, Kim SY, Kim HS, Lee JH, Han SY, Lee HK,
            Park JY, Oh RR, Jang JJ, Lee JY and Yoo NJ.
  TITLE     Immunohistochemical localization of FAP-1, an inhibitor of
            Fas-mediated apoptosis, in normal and neoplastic human tissues
  JOURNAL   APMIS 107 (12), 1101-1108 (1999)
   PUBMED   10660140
REFERENCE   9  (bases 1 to 8258)
  AUTHORS   Cuppen E, van Ham M, Pepers B, Wieringa B and Hendriks W.
  TITLE     Identification and molecular characterization of BP75, a novel
            bromodomain-containing protein
  JOURNAL   FEBS Lett 459 (3), 291-298 (1999)
   PUBMED   10526152
REFERENCE   10 (bases 1 to 8258)
  AUTHORS   Boekelheide K, Lee J, Shipp EB, Richburg JH and Li G.
  TITLE     Expression of Fas system-related genes in the testis during
            development and after toxicant exposure
  JOURNAL   Toxicol Lett 102-103, 503-508 (1998)
   PUBMED   10022303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474022.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..8258
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /note="protein tyrosine phosphatase, non-receptor type 13"
                     /db_xref="GeneID:498331"
                     /db_xref="RGD:1563360"
     exon            1..312
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            313..432
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..7685
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /EC_number="3.1.3.48"
                     /note="gene_id=rCG37921.0 transcript_id=rCT37921.0
                     protein_id=rCP41782.0 isoform=CRA_b; protein Tyr
                     phosphatase; tyrosine-protein phosphatase non-receptor
                     type 13-like"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     13"
                     /protein_id="NP_001094259.1"
                     /db_xref="GeneID:498331"
                     /db_xref="RGD:1563360"
                     /translation="MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQEVFRRVSIADP
                     AALGFIISPWSLLLLPSGSVSFTDENVCSQDLRAFTAPEVLQSHSLTSLSDVEKVHIY
                     SLGMTLYWGADHEVPQSQPIKLGDHLNSILLGMCEDVLYARVSVRTVLDACSAHIRNS
                     NCAPSFSYVKQLVKLVLGNISGTDPLSHSSEEKPDRSQAIRDRLRGKGLPIGRSSTSD
                     ALDTHKAPLSQQTFLNKGLSKSMGFLSVRDTQEEEDYSKEIPSDNNSRHEDSEPFSSP
                     YQFKTSSPHIDVLSKKKTWASSMDLLCAADRDLSGEIGRYQHCDPETGTGRTSITSRK
                     KEGRYSDGSIALDVFGPQKAEPVIHSRELPASSAVSSALDRIRERQKKLQVLREAMNV
                     EEPVRRYKTYHSDLFSTSSESPSIISSDSDFRQVRKSEASKRFESSSGLPGVDDTVQS
                     RPSRQYETSLEGSLINQEMMLRRQEEEMMQLQARMALRQSRLSLYPGDTIKTSMLDIS
                     RDPLREMALETAMTQRKLRNFFGPEFVKTTVEPFASLDLPRSILLQTKKGKSEEQRKK
                     VNIMLLSGQRLELTCDTKTVCRDVFDMVVAHIGLVEHHLFALATLKENEYFFVDPDLK
                     LTKVAPEGWKEEPKRKGKAAVDFTLFFRIKFFMDDVSLIQHSLTCHQYYLQLRKDLLE
                     ERIHCDDEASLLLASLALQAEYGDYQPEVHGLSYFRLEHYLPARVMEKLDMSYIKEEL
                     PKLHNTYAGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF
                     EVHNGVRALVLRFPWRETKKISFSKKKITLQNTSDGIKHAFQTDSSKACQYLLQLCSS
                     QHKFQLQMRARQSNQDAQDLERASFRSLNLQAESVRGFNVGRAISTGSLASSTFNKLA
                     VRPLSVQAEILKRLSCSEWSLYQPLQNSSKEKNDKASWEEKPRGMSKSYHDLSQASLC
                     PHRKQVINMESLPQAFAELVGKPLYPMARSDTESLAGLPQLNNSKSVASLNRSPERRS
                     HESDSSVEDPGQAYVVGMSLPSSGKSSSQVPFKDNDSLHKRWSTVSSPEREITLVNLK
                     KDLKHGLGFQIVGGGKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLISVNSVSLEGV
                     SHHAAVDILQNAPEDVTLVISQPKEKPTKVPSTPVHFANGMKNYTKKPSSMQDSAMDP
                     SEDQPWPRGPLRHVPESPFGLSSGLREGSLSSQDSRTESASLSQSHVNGFFTSHLGDR
                     GWQEPQHSSPSPPVTSKITEKTFSDSYRSPARRQGTCDVTELPGCADSDIDDPTYSSS
                     QDRQAPKQEPSSPLKASDKMSFAAFPGPSPEPGDAFEVELAKTDGSLGISVTGGVNTS
                     VRHGGIYVKAVIPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHL
                     LLEKGQSPTSRERDPASPRCPTPDQDAQSQAPEKMEKQTAHVKDYSFVTEDNTFEVKL
                     FKNSSGLGFSFSREDNLTPELINGSIVRVKKLFPGQPAAESGKINVGDVILKVNGAPL
                     KGLSQQDVISALRGTAPEVSLLLCRPAPGVLPEVNTALLTPLHSPAHAFLNSRKEHSQ
                     PSPLSVEQCASSDENGLSGQSKRQCKPPSRRESYSDHSDSGEEESVRAAAKMPNVIPL
                     SAFAPEALRSQGEPASTMFYLPRKIPGKPESESSRLPHPLDVSPGQIRQPPAECAPSD
                     SPGKHLTHLASQLHKEENMTALKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKG
                     SQSIGCYVHDVIQDPAKGDGRLRPGDRLVKVNDADVTNMTHTDAVNLLRAAPKTVRLV
                     IGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGRGSPHGVVYISDINPRSAAAVD
                     CSLQLLDIIHYVNGVSTHGMTLEEANRALDLSLPSVVLKVTRDGCPVVPCSTRSAISA
                     LRPLEANGLSSMEPYGQPALTPKKSFSKVNGDGASGAMCPGGKGLSSPRKKSADLMEA
                     RESDSRDDDVYDDPQEAEVIQSLLDVVDEEAQNLLNQTKASRRACSPDPLRTNGEASE
                     DGEDTDCDGSPLPEDVPESVNGGGGKACFASLIQASQEEKPVKEEATQESRESTTETT
                     DREDSSKDPLFLTNEELAALPVVRVPPSGKYTGTQLQATIRTLQGLLDQGIPSKELEN
                     LQELKPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGDEGGYINASFIRIPVGTQEF
                     VYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANE
                     RLRLALLRMQQLKGFVVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSHPEDLLTFIS
                     YMRHIRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMV
                     QTEGQYVFCYQVVLYVLTHLQAEEQKAQPGLPQ"
     exon            433..611
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            612..677
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            678..863
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            864..951
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1497
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1593
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1675
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1898
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1973
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2154
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2308
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2447
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2600
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2783
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2946
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3361
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3456
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3513
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3603
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..3711
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3843
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..4301
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            4302..4433
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            4434..4527
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4613
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..4776
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            4777..4991
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            4992..5090
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            5091..5422
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            5423..5600
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            5601..5759
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            5760..5931
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            5932..6142
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6143..6213
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6214..6275
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6276..6369
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6370..6507
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6508..6593
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6594..6631
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6632..6735
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6736..6884
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6885..6975
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            6976..7313
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            7314..7529
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            7530..7592
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
     exon            7593..8258
                     /gene="Ptpn13"
                     /gene_synonym="ptp; Ptp-bl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcgcggcg agggtgacac accatggtca cagttctcgg aggtctccgc gccgctgccg
       61 agcagcgctc cccggctctc ccgtccgcct cagccgcctg gacagcaccg cgcaccggcg
      121 gccgtcgttg agacgctgcg gagtcgcggc gggccggcgg gagctcggcg ggggtcgccg
      181 cccggcgatg ctacttctgt cgctgccgac cctctccgcg cacgcccgaa gcagctcggg
      241 gaagaagaag cggcggctct cggcgcccgc gcgctgcgct ccggtcgccg taccgggact
      301 ccccacgagc cggtaatatg catgtgtcac tagcagaggc cctggaggtt cggggtggac
      361 ctctgcagga ggaggaaata tgggctgtat taaatcaaag tgctgagagc ctgcaagaag
      421 tattcagaag agtgagcatt gctgaccccg ctgctcttgg cttcatcatc tctccgtggt
      481 cactgctgtt gctgccgtct ggcagtgtgt ccttcacaga tgaaaatgtc tgcagtcagg
      541 accttcgagc attcaccgca cccgaggttc ttcagagcca ctcgctgacg tctctctcag
      601 atgtagaaaa ggtccatatt tattctctcg gaatgacatt gtattggggg gccgaccatg
      661 aagtacctca gagccagccc atcaagctgg gagaccatct caacagcatt ctgctgggca
      721 tgtgcgagga tgttctttat gctcgggtgt ccgtccggac cgtgctggac gcctgcagcg
      781 cccacatcag gaacagcaac tgtgcgccct ccttttccta tgtgaagcag ttggtaaagc
      841 tggttctggg aaatatttct gggacggatc cgctttccca tagcagtgaa gaaaagcctg
      901 accggagcca ggccatccga gaccgactga gaggaaaagg attacccata ggaagaagct
      961 ccacttctga cgcactagac acacacaagg ctccactctc tcagcagacc tttcttaaca
     1021 aagggcttag taaatctatg ggatttctgt ccgtcagaga cacacaagag gaggaagatt
     1081 attccaagga aattccctcc gataataatt ccaggcatga agactctgag cctttctcct
     1141 ccccttacca gttcaaaact agtagtccac acattgacgt actctctaag aagaagacct
     1201 gggcttcgtc catggacttg ctctgtgcgg ccgacagaga cctttctgga gagattggaa
     1261 ggtaccaaca ctgtgaccct gagacaggga cgggacggac gtcgatcact tctaggaaga
     1321 aagaaggacg gtactctgac ggaagcattg ccttggatgt cttcggccct cagaaagcag
     1381 agccagtgat ccacagccga gaactgccgg cttcctccgc tgtttcgagc gctttggacc
     1441 gaattcgaga gagacaaaag aaacttcagg ttctgagaga agccatgaat gtagaagagc
     1501 cagtccgaag atacaaaact taccacagcg atctgttcag cacttccagt gaaagcccgt
     1561 ctattatttc ctcggactca gacttcaggc aagtgagaaa aagcgaagct tccaagaggt
     1621 ttgaatccag cagtggtctt cccggagtag atgacactgt ccagtcacga cccagtagac
     1681 aatatgaaac atccctcgaa ggcagcttga tcaaccagga gatgatgcta aggcgacaag
     1741 aggaagaaat gatgcagctg caagccagga tggctctcag acagtcacgg ctgagcctgt
     1801 atcccgggga caccatcaaa acttccatgc ttgatatctc tagagatcca ctaagggaaa
     1861 tggccctgga gacagccatg acccagagaa agctaaggaa tttctttggc cccgagtttg
     1921 tgaagacgac agttgagcca tttgcgtctt tggatttgcc gcgctccatc ctcttgcaga
     1981 ccaagaaggg gaagagtgag gagcagagga agaaagtaaa cataatgctt ttgagtgggc
     2041 agaggctcga gctcacctgc gacaccaaga ccgtctgcag agacgtcttc gacatggtcg
     2101 tggctcacat cggcctggtg gagcatcact tgttcgctct cgccaccctc aaagagaatg
     2161 aatatttctt tgtcgatccc gacttaaaat taacaaaagt ggccccggag ggatggaaag
     2221 aagaaccgaa gagaaagggc aaagccgctg ttgattttac tttgtttttc cgaattaaat
     2281 ttttcatgga tgatgttagt ctgatacaac acagcctaac ctgccatcag tattaccttc
     2341 agctgaggaa agacctcctg gaggagagga tccactgcga cgatgaggca tccctgctcc
     2401 tcgcctcctt ggctctccag gccgagtatg gagattatca accagaggtt cacggcttgt
     2461 cctactttcg cctggagcat tatctgcccg ccagagtgat ggagaagctt gacatgtcct
     2521 acattaagga ggagctaccc aaactgcaca acacctatgc aggcgcctct gagaaggaga
     2581 cggagctcga gttcttaaag gtctgccaaa ggctgacaga gtacggagtt cattttcacc
     2641 gggtgcaccc tgaaaagaag tcacagacag gaatactgct gggagtctgt tccaaaggtg
     2701 tgcttgtgtt tgaggttcac aatggagttc gcgccttggt ccttcgcttc ccatggaggg
     2761 aaacaaaaaa gatttccttt tcaaaaaaga aaatcacgtt acaaaataca tcagacggaa
     2821 tcaagcacgc attccagaca gacagcagca aggcctgcca atacctgctg cagctgtgct
     2881 cctcccagca taaattccag ctacagatga gggcgagaca gagcaaccag gatgcccaag
     2941 acttagagag agcttcgttt aggagcctga acctgcaagc agaatctgtt agaggattta
     3001 atgtgggccg cgccatcagc actggcagtc tggccagcag caccttcaac aaacttgccg
     3061 tccgacccct gtcagtgcaa gccgagattc tgaagaggct gtcctgctca gagtggtcgc
     3121 tttaccagcc actgcaaaac agttcaaaag agaagaatga caaagcgtcc tgggaggaaa
     3181 agcctagagg gatgagcaaa tcgtatcacg atctcagtca ggcctctctc tgtcctcatc
     3241 ggaaacaggt cattaacatg gagtccctac cacaagcctt tgcggagctg gtgggaaaac
     3301 cattgtaccc gatggcaaga tctgacacag agtcactggc aggactcccc cagcttaata
     3361 attcaaagtc tgttgccagt ttaaatagaa gccccgaaag gaggagccat gaatcagact
     3421 cgtccgttga agaccctggc caagcatatg ttgtaggaat gagtttgcct agttctggaa
     3481 agtcttcatc ccaagtaccc tttaaagaca atgattcatt gcacaaaaga tggagcactg
     3541 tctcttcacc agaaagggag atcacactgg tgaacctgaa gaaagacttg aagcatggct
     3601 taggatttca gattgtcggt ggggggaaaa tgggaaggct ggatctagga gtgtttatca
     3661 gcgccgttac ccctggaggg cctgctgacc tggatggatg cctaaagcct ggagaccgtt
     3721 tgatatctgt gaacagtgtg agtttggaag gagtcagtca ccatgctgca gttgacattt
     3781 tgcagaatgc acctgaagat gtgacacttg tcatctccca gccaaaagaa aaaccaacca
     3841 aagtgccttc tactcctgtt cactttgcca atggaatgaa aaactacacc aagaaaccgt
     3901 cctccatgca ggacagtgct atggacccat cagaggacca gccctggcca cggggccctc
     3961 tgaggcacgt cccagagagt ccctttggtc tctcctcggg cctgcgggaa ggaagcctca
     4021 gttcccaaga ttccaggact gaaagtgcca gcttgtccca gagccacgtc aatggcttct
     4081 ttaccagcca cttaggtgac cgaggctggc aggagccaca gcacagcagc ccatcaccac
     4141 ctgtaacctc caagatcacc gagaagacct tctctgacag ttaccgtagc ccggccaggc
     4201 ggcaaggcac ctgtgatgtg actgagctcc ctggctgtgc cgactccgac atagacgatc
     4261 ccacttacag cagcagtcaa gaccgtcagg caccaaaaca ggaaccttcc tccccactga
     4321 aagcatccga caaaatgagc tttgcagcct tccctgggcc atcccctgag ccgggagacg
     4381 cgtttgaggt cgagctggct aaaaccgatg gcagcttggg gataagtgtc acgggaggtg
     4441 tgaataccag cgtccggcat ggtggtatct atgtgaaagc cgttattccc aacggagcgg
     4501 cagagacaga tggcagaatt cacaaaggtg atcgagtgct tgctgtgaac ggagtcagtc
     4561 tggaaggagc gacccacaag caggctgtgg aaacgttgag aaacacgggg caggtggtcc
     4621 atctgttgtt agaaaagggg cagtcgccaa catctagaga acgtgatcct gcaagcccac
     4681 ggtgtcccac tccagaccag gatgcccaaa gtcaagcccc agaaaagatg gagaagcaaa
     4741 cagcccatgt caaagactac agctttgtta ctgaagataa tacatttgag gtcaaactgt
     4801 ttaaaaatag ctcgggcctt gggttcagtt tctctcgaga agataatctt acaccagagc
     4861 taataaatgg cagcatagta agggttaaaa agcttttccc tggacagcca gctgcagaaa
     4921 gtgggaaaat caatgttgga gatgttatac tgaaagttaa cggagccccc ttgaagggac
     4981 tgtctcagca ggacgtcata tctgctctca ggggaacagc tccagaagtg tccttgctcc
     5041 tctgcagacc cgcacctggt gtgctgccag aagtcaatac tgcacttttg accccactgc
     5101 actccccagc acacgcattc ctaaacagca ggaaagagca ttcccagccg tcacccttgt
     5161 cggtggagca gtgcgccagc tcagacgaga acgggttgtc cggccaaagc aaaagacagt
     5221 gcaagcctcc gtcccggaga gagagttaca gcgaccacag cgacagtgga gaggaagagt
     5281 ccgtgagagc tgcagcgaaa atgccgaatg tgatcccact gtcagccttt gcacccgaag
     5341 cactgagaag ccagggagaa cccgcaagca ccatgtttta cctccctcgg aaaatccccg
     5401 gcaagccgga gtcagagagc agccgtcttc ctcatccact ggacgtgagc ccgggacaga
     5461 tccgccagcc cccggcagag tgtgctccct ctgactcccc tgggaaacac cttacacatc
     5521 tcgcttctca gctgcacaaa gaggaaaaca tgacagcttt gaagaatgac ttgggaaacc
     5581 accttgagga ttctgagctg gaagtagagc ttctcattac cctggttaaa tcggaaaaag
     5641 gaagtctggg tttcacagta accaaaggca gtcagagtat tggctgttat gtccatgatg
     5701 tcatacagga tccagccaaa ggtgatggaa ggctaaggcc tggagaccgg cttgtaaagg
     5761 ttaacgacgc agatgttaca aacatgaccc acaccgatgc ggtaaatctg ctgcgagctg
     5821 cgcccaaaac tgtccgacta gttatagggc ggattctaga gttacccagg atgcccgtgt
     5881 ttccccattt gctgcctgac atcacagtca cgtgccacgg agaggagttg ggattttctc
     5941 tctccggagg ccgtggcagt ccccacggag tggtgtatat cagtgatatc aacccgaggt
     6001 cagctgcagc tgtggactgc agtctccagc tgttagacat catccattat gtgaacggag
     6061 tcagcacaca tggaatgacc ttggaagaag caaacagggc cttggacctc tcccttcctt
     6121 cagtggtgct gaaagtaaca agagacggtt gtcccgtggt gccttgttca acgagatctg
     6181 ccatttctgc tctcaggccc ctcgaagcca acggtcttag cagcatggag ccttatggac
     6241 agcccgcact cacgcctaag aaatccttct ccaaggttaa cggggatgga gcgagtggag
     6301 ccatgtgtcc tggaggaaaa ggcttgtcct ctccgaggaa gaaatcagca gacctgatgg
     6361 aagccagaga atctgactcc cgggatgatg atgtctatga cgatcctcaa gaggctgaag
     6421 tcatccagtc cctgctggat gtcgtggatg aggaagccca gaacctccta aaccagacga
     6481 aggcctccag aagagcctgt tctccagatc cactgaggac aaatggggag gcatcagaag
     6541 acggagaaga tactgactgt gatgggtctc cgttacctga ggatgtccct gagtcagtga
     6601 acggcggggg aggaaaagca tgctttgcaa gcttaatcca ggcatcccaa gaagagaagc
     6661 ccgtcaaaga ggaagccacg caggaaagca gagagtcgac aacggagaca acagaccgtg
     6721 aggattccag caaagatccc ctctttttga cgaatgagga gctggcggcc ctgccagtgg
     6781 tcagagtccc tccctctggc aagtacacgg gcacacagtt gcaggccacc atccgcacgc
     6841 ttcaaggcct gcttgaccaa gggatcccct ctaaggagct cgagaacctt caagaattaa
     6901 agcctttgga tcagtgtctg attgggcaga ctaaggaaaa ccgcaggaag aacagataca
     6961 aaaatatcct tccctatgac accacaagag tgcctcttgg agatgaagga ggatacatca
     7021 acgccagttt catcaggatc ccggtgggga cgcaggaatt cgtgtacatt gcttgccagg
     7081 ggcctttgcc caccaccgtg ggggatttct ggcagatggt ttgggagcag aactccacgg
     7141 tgatagcgat gatgacgcag gaggtggaag gagaaaagat caaatgccag cggtactggc
     7201 caagcatcct cggcacaact accatggcca acgagaggct gcgcctggcc ctcctgagaa
     7261 tgcagcagct gaagggcttc gtggtgcggg tgatggccct ggaggatatt cagacagggg
     7321 aggtgcgaca tatttctcat ctgaatttca ctgcctggcc agaccacgat acgccgtcac
     7381 atccagagga cctcctcacg ttcatctcct acatgagaca tatccgtagg tcgggcccgg
     7441 tcatcacaca ctgtagtgct ggcattggac gatcaggaac cctcatttgc atagacgtgg
     7501 tcctagggct aatcagccaa gatctcgaat tcgacatctc tgacctggtg cgctgcatga
     7561 gactacagag gcacggcatg gtgcagaccg agggtcagta tgtcttttgc tatcaagtcg
     7621 tcctctacgt cctgactcac ctccaggcgg aagaacagaa ggcacagcca gggctcccac
     7681 agtgacgcag cccagcctct gaaggttcct cgcctccagc cgggacgcct ccagccgacg
     7741 cctgctctcc actccacgag agcagcaagg ccaagccgca ccgccatgtt tagtccctcg
     7801 cgcttgaagg acaagtgctc ccgtcagatg cgaacgtcaa gatgctgtgt ttttacagcc
     7861 gctttgacct ccaatggtta tgaaaactcc tttatcatgg accggacaaa gcaggtctta
     7921 gggctggaga cagcatttga tcatagtgga tgttgttaca aagacacact gagtctattt
     7981 ttaatgtacc aaatcctgtt tatagcaaaa tttttccagt attttaataa agtagattta
     8041 ttttataggg ggatacttga agccagtatt taagctttta atgacagtaa tattggcata
     8101 gaagagaaac tagcaatgtt tactgtatcc gtttctaatg tttactatat ataatttcct
     8161 gtaatatatt tatatacttt tcacgaacat ggagttatca gatactgttt gtacctgtgt
     8221 catctcactt tgtaaataaa actacacctt aaaacata
//
