LOCUS       NM_057115               3167 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type
            12 (Ptpn12), mRNA.
ACCESSION   NM_057115 XM_346684
VERSION     NM_057115.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3167)
  AUTHORS   Gorostizaga AB, Mori Sequeiros Garcia MM, Acquier AB, Lopez-Costa
            JJ, Mendez CF, Maloberti PM and Paz C.
  TITLE     ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With
            Paxillin
  JOURNAL   J Cell Biochem 117 (9), 2170-2181 (2016)
   PUBMED   27061092
  REMARK    GeneRIF: data demonstrate PTP-PEST expression in adrenal ZF and its
            regulation by ACTH/PKA and also suggest an ACTH-induced
            PTP-PEST-paxillin interaction
REFERENCE   2  (bases 1 to 3167)
  AUTHORS   Li H, Yang F, Liu C, Xiao P, Xu Y, Liang Z, Liu C, Wang H, Wang W,
            Zheng W, Zhang W, Ma X, He D, Song X, Cui F, Xu Z, Yi F, Sun JP and
            Yu X.
  TITLE     Crystal Structure and Substrate Specificity of PTPN12
  JOURNAL   Cell Rep 15 (6), 1345-1358 (2016)
   PUBMED   27134172
REFERENCE   3  (bases 1 to 3167)
  AUTHORS   Motohashi S, Koizumi K, Honda R, Maruyama A, Palmer HE and Mashima
            K.
  TITLE     Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast
            cell-activating signals in PTP activity-dependent and -independent
            manners
  JOURNAL   Cell Immunol 289 (1-2), 128-134 (2014)
   PUBMED   24791697
  REMARK    GeneRIF: PTP-PEST is involved in the regulation of
            FcepsilonRI-mediated mast cell activation through at least two
            different processes represented by PTP activity-dependent and
            -independent pathways.
REFERENCE   4  (bases 1 to 3167)
  AUTHORS   Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I,
            Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E,
            Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck
            SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R,
            Bentires-Alj M, Elledge SJ and Westbrook TF.
  TITLE     Activation of multiple proto-oncogenic tyrosine kinases in breast
            cancer via loss of the PTPN12 phosphatase
  JOURNAL   Cell 144 (5), 703-718 (2011)
   PUBMED   21376233
REFERENCE   5  (bases 1 to 3167)
  AUTHORS   Ceacareanu AC, Ceacareanu B, Zhuang D, Chang Y, Ray RM, Desai L,
            Chapman KE, Waters CM and Hassid A.
  TITLE     Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell
            motility by decreasing Rac1 activity: essential role of PTP-PEST
            and p130cas
  JOURNAL   Am J Physiol Cell Physiol 290 (4), C1263-C1270 (2006)
   PUBMED   16354758
  REMARK    GeneRIF: Data suggest that IGF-I induces smooth muscle cell
            motility by increasing phosphotyrosine levels of p130(cas) and
            activating Rac1, and that nitric oxide decreases motility by
            activating PTP-PEST
REFERENCE   6  (bases 1 to 3167)
  AUTHORS   Gupta A, Lee BS, Khadeer MA, Tang Z, Chellaiah M, Abu-Amer Y,
            Goldknopf J and Hruska KA.
  TITLE     Leupaxin is a critical adaptor protein in the adhesion zone of the
            osteoclast
  JOURNAL   J Bone Miner Res 18 (4), 669-685 (2003)
   PUBMED   12674328
REFERENCE   7  (bases 1 to 3167)
  AUTHORS   Garton AJ, Burnham MR, Bouton AH and Tonks NK.
  TITLE     Association of PTP-PEST with the SH3 domain of p130cas; a novel
            mechanism of protein tyrosine phosphatase substrate recognition
  JOURNAL   Oncogene 15 (8), 877-885 (1997)
   PUBMED   9285683
REFERENCE   8  (bases 1 to 3167)
  AUTHORS   Kitamura T, Nakamura K, Mizuno Y and Kikuchi K.
  TITLE     Gene expressions of protein tyrosine phosphatases in regenerating
            rat liver and rat ascites hepatoma cells
  JOURNAL   Jpn J Cancer Res 86 (9), 811-818 (1995)
   PUBMED   7591957
REFERENCE   9  (bases 1 to 3167)
  AUTHORS   Charest A, Wagner J, Shen SH and Tremblay ML.
  TITLE     Murine protein tyrosine phosphatase-PEST, a stable cytosolic
            protein tyrosine phosphatase
  JOURNAL   Biochem J 308 (Pt 2) (Pt 2), 425-432 (1995)
   PUBMED   7772023
REFERENCE   10 (bases 1 to 3167)
  AUTHORS   Moriyama T, Kawanishi S, Inoue T, Imai E, Kaneko T, Xia C, Takenaka
            M, Noguchi T, Kamada T and Ueda N.
  TITLE     cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP)
            from rat kidney
  JOURNAL   FEBS Lett 353 (3), 305-308 (1994)
   PUBMED   7957881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D38072.1, CK367675.1, DY560717.1, CV102923.1, BP489229.1 and
            CX570435.1.
            
            On Jan 3, 2008 this sequence version replaced NM_057115.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1193              D38072.1           66-1258
            1194-1722           CK367675.1         154-682
            1723-1887           DY560717.1         454-618
            1888-2506           CV102923.1         1-619
            2507-2871           BP489229.1         79-443
            2872-3167           CX570435.1         280-575
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3167
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /note="protein tyrosine phosphatase, non-receptor type 12"
                     /db_xref="GeneID:117255"
                     /db_xref="RGD:620894"
     exon            1..168
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2370
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     12"
                     /protein_id="NP_476456.2"
                     /db_xref="GeneID:117255"
                     /db_xref="RGD:620894"
                     /translation="MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRT
                     EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPRA
                     YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPF
                     KISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
                     YQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSA
                     VQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDGNEISTGNMVSSIDSEKQDSPPP
                     KPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVL
                     HMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKSFD
                     GNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPE
                     SSEESQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNS
                     TAEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASAT
                     VSPASSTESACTRRVLPMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLA
                     DMPIRSDWHELPSQECSEHRESEGLITSGNDKHDAGVSHTAACSPTFSDKKEEITESL
                     TEVTDIGFGNRCGKPKGPRDPPSEWT"
     exon            169..277
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            278..354
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            355..450
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            451..489
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            490..561
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            562..621
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            622..764
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            765..831
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            832..909
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1005
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1091
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..2047
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2116
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2184
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2215
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2308
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..3167
                     /gene="Ptpn12"
                     /gene_synonym="Ptpg1; RKPTP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagcgagc tggggaagac ggagcgggcg ctgcggcgcg cgggcgggcg gcggggggga
       61 cgcgggagga tggagcaagt ggagattctg aggaggttca tccagagggt ccaggccatg
      121 aaaagtccgg accacaatgg ggaggacaac ttcgcccggg acttcatgcg attgagaaga
      181 ttgtctacca aatatagaac agaaaagatt tatcccacag ccactggaga aaaagaagaa
      241 aatgttaaaa agaacagata taaggacata ctgccatttg atcacagccg agttaagttg
      301 actttgaaga caccatccca agattcagat tatatcaatg caaattttat taagggtgta
      361 tatgggccga gagcatacgt ggcaacccaa gggcctttgg cgaatacagt catagacttc
      421 tggaggatga tatgggagta caatgtggtg atcattgtaa tggcctgtcg tgaatttgag
      481 atgggaagga aaaagtgtga gcgctattgg cctttgtatg gagaagatcc tataacattt
      541 gcaccattta aaatttcttg tgaaaatgaa caagcaagaa cagactactt cattcgaaca
      601 cttttacttg aatttcaaaa tgaatcccgt cgactctatc agtttcatta cgtgaactgg
      661 ccagaccatg atgtcccttc gtcattcgat tctatcctgg acatgataag tctaatgagg
      721 aagtaccaag agcacgaaga tgtgcctatt tgtatccatt gcagtgcagg ctgtggacgg
      781 acaggtgcta tttgtgccat cgactacacg tggaacttac tgaaagcagg gaaaattcca
      841 gaggaattta atgtatttaa tttaatacaa gaaatgagaa cacaaaggca ctctgcagta
      901 caaacgaagg agcagtatga actcgtccat agagctattg cccaactgtt tgaaaaacag
      961 ctacaactgt atgaaatcca cggagcccag aaaatcactg atggtaatga aattagcact
     1021 ggaaacatgg tcagttccat tgatagtgaa aaacaagatt ctcctcctcc aaagccacca
     1081 cggactcgaa gttgtcttgt agagggggat gccaaggaag aaatcctcca gccaccagag
     1141 cctcacccgg tgccgcccat cctgacaccg tcgcctcctt cagcattccc aaccgttacc
     1201 actgtgtggc aagacagtga caggtaccac ccaaagccag tgctgcacat ggcttcccca
     1261 gagcagcccc caacggacct caacagaaac tatgataagt cagcggacct aatggggaga
     1321 agcgaatctg ctgttgagca cacagataaa aagttagaac aaaatttaag ttttgagatt
     1381 aagaaagtcc ctctccaaga agggcccaaa agttttgatg ggaacacact cttgaatagg
     1441 ggacatgcga ttaaaattaa gtctgcttca tcttctgtag ttgacaaaag ctctaagcca
     1501 caggagttaa gttcaggtga tctaaaggtt cacgatgtgt ctcagaattc ctgtgcggac
     1561 tgcagtgcct cacacttaga caacgctcct gagtcttcag aagagtccca gaactcacac
     1621 acacctccac ggccagactg cttgcccctt gataagaaag gacatgtgac atggtcactt
     1681 catggacctg aaaatgccac acctgtatct gactcaccag ataatcattc tcaaactcta
     1741 aaaactgtga gttccacacc aaactcgaca gcagaagagg aatcccacga tctcacagag
     1801 caccataaca gctcccctct gccgagagct cctctcagct ttaccaaccc tcttcactct
     1861 gacgactccg actcagacga agggaactcc gatggtgctg tgaccaagaa caaaactagc
     1921 atttcaacag caagtgccac cgtgtctcct gccagtagta ccgagagtgc ttgcactagg
     1981 agagtactgc ccatgtccat tgccaggcag gaaatggcag gaaggcggca ttcaggtgct
     2041 gagaaagatg ctgacgttag tgaagagtcg cctcctccct tacctgaaag aactcccgag
     2101 tcttttgtat tagcagatat gcccataaga tctgattggc atgaacttcc aagtcaggag
     2161 tgctcggagc acagggaatc tgaaggcttg ataacctctg gaaatgacaa acacgatgca
     2221 ggggtttccc acacagcggc ttgttcaccc actttcagtg acaagaaaga ggaaataaca
     2281 gaaagtctaa cagaagtcac agacattggt tttggtaatc gctgtggaaa acctaaagga
     2341 ccaagagatc caccttcaga atggacatga ttcagggagt taaaagacac tttaaattat
     2401 actggaaaat tcaagtgcca ctgaaagcca gatttatagt attccatctt taaaatgtgg
     2461 gactgatagc agtgtagatt gttaccttaa tattttttgc tgggaccatc tacctgcctt
     2521 atactacact taggagaaag tattacatat tgtttatttt gtaacttcaa gtattattgc
     2581 cttaatgtct cttaaccctg ttacaagctg cttgtagacc tgttaatata gtaatacttt
     2641 tatgataaac tgagttaaag gactactctt ttgctgtttt atcatgtatg cattattttg
     2701 tatatgtaca gggcaagtag gtatataatt tgataaagtt gaagtcctaa aatattatta
     2761 acagaagatg taagaatttc tgcatggttt aagtctttgt gtatcttact tgtaaattat
     2821 ttgccctgaa attttagaaa actgtttctg aattttaaac ttgctggatt cgtgtagcca
     2881 gcattgcagg ttatcagaga tcaaagagtg taataataat accttttgta aattgtaagc
     2941 aaaaagttat ttttatatta tatactgtct aattgttcac cctaatggtt cttgttttcg
     3001 tctagtcatg gagattcagt aagtgccttg gaacaacatt gacttccctt agctcgagtg
     3061 tgttactttc aagtttgaat tcaactgggg ttagaagact atcagaatct atgtatgttt
     3121 caggatattt gttgacctgc cattaaaaaa acaaacagtt ttacact
//
