LOCUS       NM_013088               5526 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type
            11 (Ptpn11), transcript variant 2, mRNA.
ACCESSION   NM_013088
VERSION     NM_013088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5526)
  AUTHORS   Wang,D. and Cao,Q.
  TITLE     Shp2 in Alveolar Macrophages Regulates Macrophage I Phenotype in
            Acute Lung Injury
  JOURNAL   Int J Toxicol 41 (5), 412-419 (2022)
   PUBMED   35652623
  REMARK    GeneRIF: Shp2 in Alveolar Macrophages Regulates Macrophage I
            Phenotype in Acute Lung Injury.
REFERENCE   2  (bases 1 to 5526)
  AUTHORS   Han,N., Su,Y., Guo,M. and Yu,L.
  TITLE     Retinal Src homology region 2-containing protein tyrosine
            phosphatase 2 silencing alleviates diabetic retinopathy via
            suppressing inflammatory response and oxidative stress by
            regulating Yes-associated protein 1 activity
  JOURNAL   Exp Anim 71 (3), 376-384 (2022)
   PUBMED   35400714
  REMARK    GeneRIF: Retinal Src homology region 2-containing protein tyrosine
            phosphatase 2 silencing alleviates diabetic retinopathy via
            suppressing inflammatory response and oxidative stress by
            regulating Yes-associated protein 1 activity.
REFERENCE   3  (bases 1 to 5526)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 5526)
  AUTHORS   Ouyang,W., Liu,C., Pan,Y., Han,Y., Yang,L., Xia,J. and Xu,F.
  TITLE     SHP2 deficiency promotes Staphylococcus aureus pneumonia following
            influenza infection
  JOURNAL   Cell Prolif 53 (1), e12721 (2020)
   PUBMED   31782850
REFERENCE   5  (bases 1 to 5526)
  AUTHORS   Lundby,A., Franciosa,G., Emdal,K.B., Refsgaard,J.C., Gnosa,S.P.,
            Bekker-Jensen,D.B., Secher,A., Maurya,S.R., Paul,I., Mendez,B.L.,
            Kelstrup,C.D., Francavilla,C., Kveiborg,M., Montoya,G., Jensen,L.J.
            and Olsen,J.V.
  TITLE     Oncogenic Mutations Rewire Signaling Pathways by Switching Protein
            Recruitment to Phosphotyrosine Sites
  JOURNAL   Cell 179 (2), 543-560 (2019)
   PUBMED   31585087
REFERENCE   6  (bases 1 to 5526)
  AUTHORS   Kharitonenkov,A., Schnekenburger,J., Chen,Z., Knyazev,P., Ali,S.,
            Zwick,E., White,M. and Ullrich,A.
  TITLE     Adapter function of protein-tyrosine phosphatase 1D in insulin
            receptor/insulin receptor substrate-1 interaction
  JOURNAL   J Biol Chem 270 (49), 29189-29193 (1995)
   PUBMED   7493946
REFERENCE   7  (bases 1 to 5526)
  AUTHORS   Klinghoffer,R.A. and Kazlauskas,A.
  TITLE     Identification of a putative Syp substrate, the PDGF beta receptor
  JOURNAL   J Biol Chem 270 (38), 22208-22217 (1995)
   PUBMED   7545675
REFERENCE   8  (bases 1 to 5526)
  AUTHORS   Ahmad,F. and Goldstein,B.J.
  TITLE     Purification, identification and subcellular distribution of three
            predominant protein-tyrosine phosphatase enzymes in skeletal muscle
            tissue
  JOURNAL   Biochim Biophys Acta 1248 (1), 57-69 (1995)
   PUBMED   7711057
REFERENCE   9  (bases 1 to 5526)
  AUTHORS   Mei,L., Doherty,C.A. and Huganir,R.L.
  TITLE     RNA splicing regulates the activity of a SH2 domain-containing
            protein tyrosine phosphatase
  JOURNAL   J Biol Chem 269 (16), 12254-12262 (1994)
   PUBMED   7512964
REFERENCE   10 (bases 1 to 5526)
  AUTHORS   Hiraga,A., Munakata,H., Hata,K., Suzuki,Y. and Tsuiki,S.
  TITLE     Purification and characterization of a rat liver protein-tyrosine
            phosphatase with sequence similarity to src-homology region 2
  JOURNAL   Eur J Biochem 209 (1), 195-206 (1992)
   PUBMED   1382983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 20, 2010 this sequence version replaced NM_013088.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The resulting isoform (2) lacks an internal 4-aa segment, compared
            to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1013137.1,
                                           SRR26360176.327991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               JAXUCZ010000012.1  41026079-41026268
            191-313             JAXUCZ010000012.1  41044762-41044884
            314-508             JAXUCZ010000012.1  41048060-41048254
            509-701             JAXUCZ010000012.1  41050918-41051110
            702-818             JAXUCZ010000012.1  41052488-41052604
            819-932             JAXUCZ010000012.1  41053022-41053135
            933-1029            JAXUCZ010000012.1  41059954-41060050
            1030-1109           JAXUCZ010000012.1  41062730-41062809
            1110-1268           JAXUCZ010000012.1  41062901-41063059
            1269-1400           JAXUCZ010000012.1  41066304-41066435
            1401-1555           JAXUCZ010000012.1  41070315-41070469
            1556-1623           JAXUCZ010000012.1  41071323-41071390
            1624-1775           JAXUCZ010000012.1  41071822-41071973
            1776-1888           JAXUCZ010000012.1  41078856-41078968
            1889-1979           JAXUCZ010000012.1  41081353-41081443
            1980-5526           JAXUCZ010000012.1  41082031-41085577
FEATURES             Location/Qualifiers
     source          1..5526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..5526
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /note="protein tyrosine phosphatase, non-receptor type 11"
                     /db_xref="GeneID:25622"
                     /db_xref="RGD:3447"
     exon            1..190
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1958
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tyrosine-protein phosphatase non-receptor type 11; encodes
                     catalytic domain; protein tyrosine phosphatase SH-PTP2;
                     SHP-2; PTP-1D; protein-tyrosine phosphatase SYP;
                     protein-tyrosine phosphatase 1D; SH-PTP2 protein tyrosine
                     phosphatase, non-receptor type 11"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     11 isoform 2"
                     /protein_id="NP_037220.2"
                     /db_xref="GeneID:25622"
                     /db_xref="RGD:3447"
                     /translation="MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLS
                     VRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
                     NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGES
                     NDSKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNT
                     TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNK
                     NRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCL
                     QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDECALKEYGVMRVRNVRESA
                     AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIV
                     DAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE
                     AQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLVDQTSGDQSPLPPCTPT
                     PPCAEMREDSARVYENVGLMQQQRSFR"
     exon            191..313
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..508
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..701
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..818
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..932
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1029
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1109
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1268
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1400
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1555
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1623
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1775
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1888
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1979
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..5526
                     /gene="Ptpn11"
                     /gene_synonym="Shp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcgc agtgtccggg atccaggcct gccaggggtt gtgcgcgcgg ccggccggct
       61 ctgcccgctc ccgtgtcggc tcccgagcgg ggcctcactc ggccccctcc atgtgacggc
      121 gcctcgtgga gcctgagtga gcagcgggtc cgtgcggagc cggaggcggg aggaacatga
      181 catcccggag atggtttcac cccaatatca ctggtgtgga ggcagagaat ctcctgctga
      241 cccgaggagt cgatggcagt ttcttagcga ggcccagcaa gagtaaccct ggagacttca
      301 ctctgtctgt tagaagaaat ggagccgtta cccacatcaa gattcagaac actggggact
      361 actatgacct ctatggcggg gaaaagtttg ccaccttggc tgaactggtc cagtattaca
      421 tggagcatca cgggcagctg aaagagaaga atggagatgt tattgagctc aagtacccac
      481 tgaactgtgc agaccctacc tctgaaaggt ggttccacgg tcacttgtct ggaaaagaag
      541 cagagaagct gctgacagag aaggggaagc atggcagttt cctcgtccgg gagagccaga
      601 gccaccctgg ggacttcgtc ctctccgtcc gcactggtga tgacaaaggg gagagcaatg
      661 acagcaagtc caaagtgacc catgtcatga tccgctgtca ggagctgaaa tatgatgttg
      721 gtggaggaga gcgctttgac tctttgacag acctggtgga gcattacaag aagaacccca
      781 tggtggagac actgggcaca gtcctgcagc tcaaacagcc cctcaacaca actcgtatta
      841 atgccgctga aatcgaaagc cgggttcggg agttaagcaa gctagccgag accacagata
      901 aagtcaaaca gggcttttgg gaagaatttg agactctaca gcaacaggaa tgcaaacttc
      961 tctacagccg aaaagaagga cagagacaag aaaataaaaa caaaaataga tacaaaaaca
     1021 tcctgccctt tgatcatacc agggttgtcc tgcacgatgg ggatcccaac gagccagttt
     1081 ctgattacat caatgccaac atcatcatgc ctgaatttga aaccaagtgc aacaattcaa
     1141 aacccaaaaa gagttacatt gccactcaag gctgcctgca gaacacggtg aatgacttct
     1201 ggcggatggt gttccaggag aactctcgag tcattgtcat gaccacaaag gaagtggaga
     1261 gagggaagag caagtgtgtc aagtactggc ctgatgagtg tgcactcaaa gagtatggcg
     1321 tcatgcgtgt gaggaacgtc agagaaagtg ctgcgcatga ctacacctta cgagaactca
     1381 aactctctaa ggtcggacaa ggaaacacag agagaaccgt ctggcagtac cactttcgga
     1441 cctggccaga ccacggtgtg cctagtgacc ctggaggtgt gctggacttc ctggaggagg
     1501 tccaccacaa gcaggagagc atcgtggatg caggccctgt cgtggttcac tgcagtgctg
     1561 ggattggccg gacaggaacg ttcattgtga ttgatatcct tattgacatc atccgagaga
     1621 aaggtgtgga ctgtgacatc gacgttccta aaaccattca gatggtacgg tcccagaggt
     1681 cagggatggt ccagacagaa gcacagtacc ggttcatcta catggccgtc cagcactaca
     1741 tagagacgct gcaacgcagg atcgaggagg agcagaaaag caaaaggaaa ggacatgaat
     1801 ataccaatat taagtattcc ctggtggacc agacaagtgg cgatcagagt cccctgccac
     1861 cttgcacccc aacgccaccc tgtgcggaaa tgcgggagga cagcgctcga gtctatgaga
     1921 acgtgggcct catgcagcag cagaggagtt tcagatgagc ttcgggtggc agcgcgcaga
     1981 tgtgaacttt caccccttcc ctaaaatgtc aagaatagac gagaaagttt ccaggacccg
     2041 tgttcagaag ctcgccgggg ttgactgact gccttttgag aagcgaagtt tggaaccatt
     2101 tgaaagagca cgtgcctaat tggcacctcc tttcctcagc taaggagaaa ctgctctgcg
     2161 ttgtcgacag tgctattgtc atggaattgg ttttgaattg tgaagcagct aaattgtgct
     2221 ctgtattttc tacattgtgg gactcaaatt ctagtcacgg gcaggatttt gtttgtttct
     2281 ttttatgacc ttaacagacc tgttaagacc tgattttttt tttttttctt cctttctctt
     2341 tgaggagtta tgggctcctt gtaagaagaa aggatttagg gaacttcagg cacagcctcc
     2401 cccaaaatca ttgttcatct tgctgccctt catggggctc ccagtgccct ggctggtggc
     2461 tgcttagggt ccctcatcat cacagagact cactgtttag ttccagggac cccagggact
     2521 gggagggttg catctggcga gggcctctga ctgtgccaca ctggatgggg gacatgaagg
     2581 tggcctctcg tttatggcct gagcccacca caccttgagc agccccttag catctctctg
     2641 tcaacaccat ggcactgggg atcctgtgct tcctgcagat acgtgttggg gcacattcaa
     2701 cacagactga cctggtcaag gacagttcac gtttggtggc ttcttttctt tagtgaaatg
     2761 accgttcagt cattgtatta gagggtcaag ggatagggat aggaagtcat ggttcaaagg
     2821 ccctgggaac tggcgtgtga gaagtctttc ctctgaagat ggctccttgg cttcaggtgt
     2881 ggacagtgaa gctgttctgg gaaaagccac catgttgtct gtgtactgga gtattggtaa
     2941 gatccctggg tgagcagtat ttggtcctca cttgcccccc acccccattc ttcagtacag
     3001 caagtctgac ctgggtttca tgagcccctc tgtcctgtga gggtcacttg ggaagttggc
     3061 aacatggtca agacactggg cttctgtttt aatgtggtgt tttccacgtc tcttctcctg
     3121 ggtgtctgtg tagacagatg gctgggtcct taatgtgtcc cccaagttgc aaaggcagaa
     3181 gtggccaggc cttcttcaga ctcaggcctg gagcgagcat gactttttcc gtggctgcta
     3241 tgagagaatc aggctcagcc caaggtgtgg agtggtggtc ccatgctctg gggccaccag
     3301 tctgtcagat agccccagcc cgtgccatag aagcaagtgg ctgtagttag caagagccca
     3361 ggctgcttat agtagctggt gtaaactgtg tgtcagatga gaaatgtaca gcaggccttc
     3421 tagaagcttc tgagtcagct tttctgtcac cacatgtgtg ctgtaccatg cccctgaaga
     3481 cttggtgagt gagtagatgg gagctcattc tccggcgcct tggctgaggg tgaagtgggg
     3541 cagtcttggc caggcctcct gtcagttcca gtcagatgct tttgccctag ccaaacagca
     3601 ggatctgcta atgttctgcc gtaagtgcct tctccagagc tgtccctctg cccgagtgtt
     3661 gatcctcgag agcacgtctc gacgagagct tccagattcg atgctcatga ccaagcactg
     3721 gcacaggctc cacctgcact cttcttgctt cagttcctga aaggaaggac tggacctgcc
     3781 ctgcagctgc cctttctggg gcctcctact ccctggtagc ctgaggtagt tggggagcac
     3841 aggggccacc atttccttag agcatgtgca tccatccttg tccttctccg ctgaattcag
     3901 ttgcttcaga gcacaccgtg gcctggccgg aatgtggaga ctgctgtctt ctcggcgagc
     3961 ccgcaatgaa atcagtcagt gttcacagcc gggtcccaga tcccattctt tatagcacat
     4021 tgtcacagtg aactatgttg ggttgttgct aatatcaaga ctctggactt ggagggcaga
     4081 gtttatcacc agcacacaga ggttagctga gcagctgttc tactgagcta acatttctac
     4141 ctgcagcttg agatcctgga gcagagagac ctgtggttgg cccgtgttca gcacagcaag
     4201 tggtttcctt cggattccct cctagaatcc agtcagtggc catcctcccg ggtctgtcag
     4261 tgtgatggaa ggtggtcgca gggtctcagg agggcgctct gtgtgttggt gtgttgtgga
     4321 gtctggaaag aggaggtgtg gatttgaaac agtggggtga aagttgcaca ggtggttcat
     4381 gagcaagtca tggcacaggg ccagcactga gcagacgaca tgtgacacac atggtcccct
     4441 cactgctgag ccttttaaat tagaagcata ggattttgta cttggggagg ggtggggtgg
     4501 ggagattgtc tagcacatgg ccttggtttc tagaaagctt cacttgagag tattaatgct
     4561 tgtcacacgg tgtgcggcct tcctgatgcc ccaggctgcc tctgccattg cagttggtgc
     4621 ctttctaatg ggaaactggg gctgggaaac agtaccgcca gcagctcaga ggtgctcagc
     4681 attgtttcca ggggtttgct gggggttcaa gagagcatga gtcctgtttt cctgcaacag
     4741 gaccgaggta ggtgcactcg ggagggaaac acacaggtag aagtgtgggc tctgctcctg
     4801 ttgattgtct ggggacattt tacatcgttt cagatgcctg tcatagggtc tgcgctagcc
     4861 taccgttttg ttgaatctct tccccttctt ggaaagaaac tcccgagtag agtttactgc
     4921 atctcccatc gctagcagct ctgctcttgc agagttttcg ggacacagca aagcagagag
     4981 cagctcctgt cggtgctgta gaacctggct gtgcatcaaa gtagtttgac aacttcccct
     5041 cctaaacttc aatcatggga ttaataatat acctgtttat ttatgaccta attgtgactc
     5101 ttattactaa aagctagtgg gaaaggccca tccaagaagc tagtgactag actcacgctt
     5161 agctttccca cagcatagga agcatcaggc agagtattaa agaaatataa tattttactg
     5221 ataaacctgt cctttaaaag gaacgtgttt tgggtgtcat cattttggtg tgaatcatgt
     5281 aagtgttggc tgtttgctgt gtattacact ttagtgtcag gagacgcact cagcgggctt
     5341 ctgcccacgc atatcgtgta gtctgcggat ttttaagcga cattaacaga atagtttgtg
     5401 tagagaaacc tcaagctgtt gcctccccac ctgcgtcatg agtgtatgtg catccgggta
     5461 tcatcagagg cagtgtattt gtgagctgtc tggaactaaa agtgagaata aaaccatttt
     5521 cttgta
//
