LOCUS       NM_012637               1744 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, non-receptor type 1
            (Ptpn1), mRNA.
ACCESSION   NM_012637
VERSION     NM_012637.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1744)
  AUTHORS   Jiao,B., Zhang,W., Zhang,C., Zhang,K., Cao,X., Yu,S. and Zhang,X.
  TITLE     Protein tyrosine phosphatase 1B contributes to neuropathic pain by
            aggravating NF-kappaB and glial cells activation-mediated
            neuroinflammation via promoting endoplasmic reticulum stress
  JOURNAL   CNS Neurosci Ther 30 (2), e14609 (2024)
   PUBMED   38334011
  REMARK    GeneRIF: Protein tyrosine phosphatase 1B contributes to neuropathic
            pain by aggravating NF-kappaB and glial cells activation-mediated
            neuroinflammation via promoting endoplasmic reticulum stress.
REFERENCE   2  (bases 1 to 1744)
  AUTHORS   Song,Q., Ma,H., Zhu,L., Qi,Z., Lan,Z., Liu,K., Zhang,H., Wang,K.
            and Wang,N.
  TITLE     Upregulation of PTPN1 aggravates endotoxemia-induced cardiac
            dysfunction through inhibiting mitophagy
  JOURNAL   Int Immunopharmacol 126, 111315 (2024)
   PUBMED   38043267
  REMARK    GeneRIF: Upregulation of PTPN1 aggravates endotoxemia-induced
            cardiac dysfunction through inhibiting mitophagy.
REFERENCE   3  (bases 1 to 1744)
  AUTHORS   Liu,F., Chen,J., Hu,W., Gao,C., Zeng,Z., Cheng,S., Yu,K., Qian,Y.,
            Xu,D., Zhu,G., Zhao,J., Liu,X. and Wang,J.
  TITLE     PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate
            Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis
  JOURNAL   JACC Basic Transl Sci 7 (7), 697-712 (2022)
   PUBMED   35958694
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1744)
  AUTHORS   Zhang,Y., Guan,Q. and Wang,Z.
  TITLE     PTP1B inhibition ameliorates inflammatory injury and dysfunction in
            ox-LDL-induced HUVECs by activating the AMPK/SIRT1 signaling
            pathway via negative regulation of KLF2
  JOURNAL   Exp Ther Med 24 (1), 467 (2022)
   PUBMED   35747159
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1744)
  AUTHORS   Ghosh,S., Liu,H., Yazdankhah,M., Stepicheva,N., Shang,P.,
            Vaidya,T., Hose,S., Gupta,U., Calderon,M.J., Hu,M.W., Nair,A.P.,
            Weiss,J., Fitting,C.S., Bhutto,I.A., Gadde,S.G.K., Naik,N.K.,
            Jaydev,C., Lutty,G.A., Handa,J.T., Jayagopal,A., Qian,J.,
            Sahel,J.A., Rajasundaram,D., Sergeev,Y., Zigler,J.S. Jr., Sethu,S.,
            Watkins,S., Ghosh,A. and Sinha,D.
  TITLE     betaA1-crystallin regulates glucose metabolism and mitochondrial
            function in mouse retinal astrocytes by modulating PTP1B activity
  JOURNAL   Commun Biol 4 (1), 248 (2021)
   PUBMED   33627831
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1744)
  AUTHORS   Milarski,K.L., Zhu,G., Pearl,C.G., McNamara,D.J., Dobrusin,E.M.,
            MacLean,D., Thieme-Sefler,A., Zhang,Z.Y., Sawyer,T., Decker,S.J. et
            al.
  TITLE     Sequence specificity in recognition of the epidermal growth factor
            receptor by protein tyrosine phosphatase 1B
  JOURNAL   J Biol Chem 268 (31), 23634-23639 (1993)
   PUBMED   7693694
REFERENCE   7  (bases 1 to 1744)
  AUTHORS   Zhang,Z.Y., Thieme-Sefler,A.M., Maclean,D., McNamara,D.J.,
            Dobrusin,E.M., Sawyer,T.K. and Dixon,J.E.
  TITLE     Substrate specificity of the protein tyrosine phosphatases
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4446-4450 (1993)
   PUBMED   7685104
REFERENCE   8  (bases 1 to 1744)
  AUTHORS   Hashimoto,N., Zhang,W.R. and Goldstein,B.J.
  TITLE     Insulin receptor and epidermal growth factor receptor
            dephosphorylation by three major rat liver protein-tyrosine
            phosphatases expressed in a recombinant bacterial system
  JOURNAL   Biochem J 284 (Pt 2) (Pt 2), 569-576 (1992)
   PUBMED   1599438
REFERENCE   9  (bases 1 to 1744)
  AUTHORS   Frangioni,J.V., Beahm,P.H., Shifrin,V., Jost,C.A. and Neel,B.G.
  TITLE     The nontransmembrane tyrosine phosphatase PTP-1B localizes to the
            endoplasmic reticulum via its 35 amino acid C-terminal sequence
  JOURNAL   Cell 68 (3), 545-560 (1992)
   PUBMED   1739967
REFERENCE   10 (bases 1 to 1744)
  AUTHORS   Guan,K.L., Haun,R.S., Watson,S.J., Geahlen,R.L. and Dixon,J.E.
  TITLE     Cloning and expression of a protein-tyrosine-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1501-1505 (1990)
   PUBMED   2154749
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081829.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012637.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081829.1, M33962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1744
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /note="protein tyrosine phosphatase, non-receptor type 1"
                     /db_xref="GeneID:24697"
                     /db_xref="RGD:61965"
     exon            1..140
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1376
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /EC_number="3.1.3.48"
                     /note="PTP-1B; protein-tyrosine phosphatase 1B"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     1"
                     /protein_id="NP_036769.1"
                     /db_xref="GeneID:24697"
                     /db_xref="RGD:61965"
                     /translation="MEMEKEFEQIDKAGNWAAIYQDIRHEASDFPCRIAKLPKNKNRN
                     RYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQ
                     KSRGVVMLNRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLEL
                     ENLATQEAREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAG
                     IGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIE
                     GAKFIMGDSSVQDQWKELSHEDLEPPPEHVPPPPRPPKRTLEPHNGKCKELFSNHQWV
                     SEESCEDEDILAREESRAPSIAVHSMSSMSQDTEVRKRMVGGGLQSAQASVPTEEELS
                     PTEEEQKAHRPVHWKPFLVNVCMATALATGAYLCYRVCFH"
     exon            141..231
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            232..332
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            333..431
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            432..569
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            570..779
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            780..941
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1162
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1716
                     /gene="Ptpn1"
                     /gene_synonym="Ptp; Ptp1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcctcga gacgcggagc gacgcggcct agcgcggcgg acggccgagg gaactcgggc
       61 agtcgtcccg tcccgccatg gaaatggaga aggaattcga gcagatcgat aaggctggga
      121 actgggcggc tatttaccag gatattcgac atgaagccag tgacttccca tgcagaatag
      181 cgaaacttcc taagaacaaa aaccggaaca ggtaccgaga tgtcagccct tttgaccaca
      241 gtcggattaa attgcatcag gaagataatg actatatcaa tgccagcttg ataaaaatgg
      301 aggaagccca gaggagctat atcctcaccc agggcccttt accaaacacg tgcgggcact
      361 tctgggagat ggtgtgggag cagaagagca ggggcgtggt catgctcaac cgcatcatgg
      421 agaaaggctc gttaaaatgt gcccagtatt ggccacagaa agaagaaaaa gagatggtct
      481 tcgatgacac caatttgaag ctgacactga tctctgaaga tgtcaagtca tattacacag
      541 tacggcagtt ggagttggag aacctggcta cccaggaggc tcgagagatc ctgcatttcc
      601 actacaccac ctggcctgac tttggagtcc ctgagtcacc tgcctctttc ctcaatttcc
      661 tattcaaagt ccgagagtca ggctcactca gcccagagca cggccccatt gtggtccact
      721 gcagtgctgg cattggcagg tcagggacct tctgcctggc tgacacctgc ctcttactga
      781 tggacaagag gaaagacccg tcctctgtgg acatcaagaa agtgctgttg gagatgcgca
      841 ggttccgcat ggggctcatc cagacggccg accaactgcg cttctcctac ctggctgtga
      901 tcgagggtgc aaagttcatc atgggcgact cgtcagtgca ggatcagtgg aaggagcttt
      961 cccatgaaga cctggagcct ccccctgagc acgtgccccc acctccccgg ccacccaaac
     1021 gcacattgga gcctcacaat ggcaagtgca aggagctctt ctccaaccac cagtgggtga
     1081 gcgaggagag ctgtgaggat gaggacatcc tggccagaga ggaaagcaga gccccctcaa
     1141 ttgctgtgca cagcatgagc agtatgagtc aagacactga agttaggaaa cggatggtgg
     1201 gtggaggtct tcaaagtgct caggcatctg tccccactga ggaagagctg tccccaaccg
     1261 aggaggaaca aaaggcacac aggccagttc actggaagcc cttcctggtc aacgtgtgca
     1321 tggccacggc cctggcgact ggcgcgtacc tctgttaccg ggtatgtttt cactgacaga
     1381 ctgctgtgag gcatgagcgt ggtgggcgct gccactgccc aggttaggat ttggtctgcg
     1441 gcgtctaacc tggtgtagaa gaaacaacag cttacaagcc tgtggtggaa ctggaagggc
     1501 cagccccagg aggggcatct gtgcactggg ctttgaagga gcccctggtc ccaagaacag
     1561 agtctaatct cagggcctta acctgttcag gagaagtaga ggaaatgcca aatactcttc
     1621 ttgctctcac ctcactcctc ccctttctct ggttcgtttg tttttggaaa aaaaaaaaaa
     1681 gaattacaac acattgttgt ttttaacatt tataaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaa
//
