LOCUS       NM_001105726            1629 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase, mitochondrial 1
            (Ptpmt1), mRNA.
ACCESSION   NM_001105726 XM_001077901 XM_342460
VERSION     NM_001105726.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1629)
  AUTHORS   Yi,J., Yue,L., Zhang,Y., Tao,N., Duan,H., Lv,L., Tan,Y. and Wang,H.
  TITLE     PTPMT1 protects cardiomyocytes from necroptosis induced by
            gamma-ray irradiation through alleviating mitochondria injury
  JOURNAL   Am J Physiol Cell Physiol 324 (6), C1320-C1331 (2023)
   PUBMED   37154493
  REMARK    GeneRIF: PTPMT1 protects cardiomyocytes from necroptosis induced by
            gamma-ray irradiation through alleviating mitochondria injury.
REFERENCE   2  (bases 1 to 1629)
  AUTHORS   Ren,M., Phoon,C.K. and Schlame,M.
  TITLE     Metabolism and function of mitochondrial cardiolipin
  JOURNAL   Prog Lipid Res 55, 1-16 (2014)
   PUBMED   24769127
  REMARK    Review article
REFERENCE   3  (bases 1 to 1629)
  AUTHORS   Niemi,N.M., Sacoman,J.L., Westrate,L.M., Gaither,L.A.,
            Lanning,N.J., Martin,K.R. and MacKeigan,J.P.
  TITLE     The pseudophosphatase MK-STYX physically and genetically interacts
            with the mitochondrial phosphatase PTPMT1
  JOURNAL   PLoS One 9 (4), e93896 (2014)
   PUBMED   24709986
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1629)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1629)
  AUTHORS   Zhang,J., Guan,Z., Murphy,A.N., Wiley,S.E., Perkins,G.A.,
            Worby,C.A., Engel,J.L., Heacock,P., Nguyen,O.K., Wang,J.H.,
            Raetz,C.R., Dowhan,W. and Dixon,J.E.
  TITLE     Mitochondrial phosphatase PTPMT1 is essential for cardiolipin
            biosynthesis
  JOURNAL   Cell Metab 13 (6), 690-700 (2011)
   PUBMED   21641550
REFERENCE   6  (bases 1 to 1629)
  AUTHORS   Doughty-Shenton,D., Joseph,J.D., Zhang,J., Pagliarini,D.J., Kim,Y.,
            Lu,D., Dixon,J.E. and Casey,P.J.
  TITLE     Pharmacological targeting of the mitochondrial phosphatase PTPMT1
  JOURNAL   J Pharmacol Exp Ther 333 (2), 584-592 (2010)
   PUBMED   20167843
REFERENCE   7  (bases 1 to 1629)
  AUTHORS   Rardin,M.J., Wiley,S.E., Murphy,A.N., Pagliarini,D.J. and
            Dixon,J.E.
  TITLE     Dual specificity phosphatases 18 and 21 target to opposing sides of
            the mitochondrial inner membrane
  JOURNAL   J Biol Chem 283 (22), 15440-15450 (2008)
   PUBMED   18385140
REFERENCE   8  (bases 1 to 1629)
  AUTHORS   Pagliarini,D.J., Wiley,S.E., Kimple,M.E., Dixon,J.R., Kelly,P.,
            Worby,C.A., Casey,P.J. and Dixon,J.E.
  TITLE     Involvement of a mitochondrial phosphatase in the regulation of ATP
            production and insulin secretion in pancreatic beta cells
  JOURNAL   Mol Cell 19 (2), 197-207 (2005)
   PUBMED   16039589
REFERENCE   9  (bases 1 to 1629)
  AUTHORS   Pagliarini,D.J., Worby,C.A. and Dixon,J.E.
  TITLE     A PTEN-like phosphatase with a novel substrate specificity
  JOURNAL   J Biol Chem 279 (37), 38590-38596 (2004)
   PUBMED   15247229
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_342460.3, XM_001077901.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219112.1, SRR8487227.306115.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1629
                     /gene="Ptpmt1"
                     /gene_synonym="Plip"
                     /note="protein tyrosine phosphatase, mitochondrial 1"
                     /db_xref="GeneID:29390"
                     /db_xref="RGD:1589783"
     exon            1..770
                     /gene="Ptpmt1"
                     /gene_synonym="Plip"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1178
                     /gene="Ptpmt1"
                     /gene_synonym="Plip"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /EC_number="3.1.3.27"
                     /note="PTEN-like phosphatase"
                     /codon_start=1
                     /product="phosphatidylglycerophosphatase and
                     protein-tyrosine phosphatase 1"
                     /protein_id="NP_001099196.1"
                     /db_xref="GeneID:29390"
                     /db_xref="RGD:1589783"
                     /translation="MVPVPGSPGPASDGGDSASESREASGGPQLSSSASFSRWLTASS
                     EAGGWPLRLAGWGGMAASAWLEAGLARVLFYPTLLYTVFRGRVGGPAHRDWYHRIDHT
                     VLLGALPLRSMTRRLVLDENVRGVITMNEEYETRFLCNTSKEWKNVGVEQLRLSTVDM
                     TGVPTLANLHRGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHNWSPEEAIE
                     AIAKIRSHISIRPSQLEILKEFHKEIAARAAKN"
     exon            771..851
                     /gene="Ptpmt1"
                     /gene_synonym="Plip"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1043
                     /gene="Ptpmt1"
                     /gene_synonym="Plip"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1629
                     /gene="Ptpmt1"
                     /gene_synonym="Plip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttgagaca gggtttcttt gtgtgccttg gctgttctgg aactagctac atagccagta
       61 gaaggtagtt tgggctacat agtgtgatct ggtctcaaaa aaagttaaga gagagacaga
      121 gagacagaca gacagtagac taccacttat gttcaggttc cctgcacccc caagagcagc
      181 agctccggtc aactacgctc ctcttacgcc cagatgaggg tcctccggtt cctcccctgt
      241 ttagaggagc ctcactgctc agcctcctcc ttggtaatgg gtgcactcgg gggccacggc
      301 ccctccctga ggtcaggggt tggagagcag gccctgctcc ttaggcaggg tcacagtttc
      361 accctatcgt tgccgttcta ctctccctac cccacccctc gcggcgcctc tcctttggag
      421 ccatggttcc tgtcccggga tcccccgggc ctgcctctga cggcggggac tcagcttcgg
      481 agagtcggga ggcatcaggt ggcccgcagc tctcgtcctc tgcgtccttc tcgcggtggc
      541 tgaccgcgag ctccgaagcg ggtggctggc cgctgcgctt ggcggggtgg ggcgggatgg
      601 cggcgtccgc gtggctggag gccggcctgg cccgggtgct cttctacccg acgctgctct
      661 acacagtgtt ccgggggagg gtgggcggcc cggcgcaccg cgattggtac caccgcatcg
      721 accacacagt gctgctgggc gcgctgccgc tgaggagcat gacgcgccgg ctggtactgg
      781 acgagaacgt gcgcggagtg atcactatga acgaggagta cgagaccaga ttcctgtgca
      841 acacctcgaa ggaatggaag aatgtgggag ttgagcagct acggctcagc acagtcgaca
      901 tgactggagt ccccaccttg gccaacctcc acagaggagt ccagtttgct ctcaagtacc
      961 agtccctggg ccagtgtgtc tacgtgcatt gtaaggctgg tcgatccaga agtgccacaa
     1021 tggtggcagc ctatctgatt caggtacaca actggagccc agaggaggct atagaagcta
     1081 tcgccaaaat ccggtcacac atctccatca ggcccagcca gttggaaatt ctcaaagagt
     1141 tccacaagga gattgctgca agggcagcaa agaactaact actggtctct tgtgctgaca
     1201 tgagtatgaa gtctgtggat gacaaagaac ttggctctcc gagatacagt aacatgttaa
     1261 aggacaaagc gcttaagcca ccaccactgc aaatgtgctg agtataatgt ccctcctttg
     1321 ccttccttcc tgaaataaca cttggatggc cacagagaac aagattgtct ggcgaaatct
     1381 tattttcttt gacagagata aggaatacta actttaacag aaatctattg tgtttctggt
     1441 atatgtgatg taaagcaaag catttaatgc tagaaaaggg aagaagagca tagatctgtt
     1501 ctttgttact gtcagatcca aattttaatt gtatgacttg gcaaaatgct tgcccagcat
     1561 gtataaggtc tcgaatttgg tccctagcag ttccaaaaat aaaaataaaa ataatcttac
     1621 ttccctggt
//
