LOCUS       NM_001108577            2479 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus protein phosphatase 2 phosphatase activator
            (Ptpa), mRNA.
ACCESSION   NM_001108577 XM_001077588 XM_342405
VERSION     NM_001108577.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2479)
  AUTHORS   Chen LJ, Wang YJ and Tseng GF.
  TITLE     Compression alters kinase and phosphatase activity and tau and MAP2
            phosphorylation transiently while inducing the fast adaptive
            dendritic remodeling of underlying cortical neurons
  JOURNAL   J Neurotrauma 27 (9), 1657-1669 (2010)
   PUBMED   20568963
  REMARK    GeneRIF: Protein phosphatase 2A, but not 2B, activity is
            downregulated following compressive injury of the cerebral cortex.
REFERENCE   2  (bases 1 to 2479)
  AUTHORS   Azam S, Drobetsky E and Ramotar D.
  TITLE     Overexpression of the cis/trans isomerase PTPA triggers caspase
            3-dependent apoptosis
  JOURNAL   Apoptosis 12 (7), 1243-1255 (2007)
   PUBMED   17333320
REFERENCE   3  (bases 1 to 2479)
  AUTHORS   Chao Y, Xing Y, Chen Y, Xu Y, Lin Z, Li Z, Jeffrey PD, Stock JB and
            Shi Y.
  TITLE     Structure and mechanism of the phosphotyrosyl phosphatase activator
  JOURNAL   Mol Cell 23 (4), 535-546 (2006)
   PUBMED   16916641
REFERENCE   4  (bases 1 to 2479)
  AUTHORS   Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit
            N and Marks AR.
  TITLE     PKA phosphorylation dissociates FKBP12.6 from the calcium release
            channel (ryanodine receptor): defective regulation in failing
            hearts
  JOURNAL   Cell 101 (4), 365-376 (2000)
   PUBMED   10830164
REFERENCE   5  (bases 1 to 2479)
  AUTHORS   Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS and Pallas DC.
  TITLE     A protein phosphatase methylesterase (PME-1) is one of several
            novel proteins stably associating with two inactive mutants of
            protein phosphatase 2A
  JOURNAL   J Biol Chem 274 (20), 14382-14391 (1999)
   PUBMED   10318862
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166861.1.
            
            On May 11, 2008 this sequence version replaced NM_001108577.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166861.1, SRR8487226.184199.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..2479
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /note="protein phosphatase 2 phosphatase activator"
                     /db_xref="GeneID:362102"
                     /db_xref="RGD:1308354"
     exon            1..213
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1154
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /note="protein phosphatase 2A, regulatory subunit B (PR
                     53); protein phosphatase 2 regulatory subunit 4; protein
                     phosphatase 2A regulatory subunit 4; protein phosphatase
                     2A activator, regulatory subunit 4"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 2A
                     activator"
                     /protein_id="NP_001102047.1"
                     /db_xref="GeneID:362102"
                     /db_xref="RGD:1308354"
                     /translation="MAEGERQPPPDSSEETPSATPTFIIPKKEIHTVPDMGKWKRSQA
                     YADYIGFILTLNEGVKGKKLTFDYKVSEAIEKLVALLDTLDRWIDETPPVDQPSRFGN
                     KAYRTWYAKLDQEAENLVATVIPTNLAAAVPEVAVYLKEAVGNSTRIDYGTGHEAAFA
                     AFLCCLCKIGVLRVDDQVAIVFKVFDRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFL
                     PFIWGSSQLIDHPHLEPRHFVDEKAVSENHKDYMFLQCILFITEMKTGPFAEHSNQLW
                     NISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPVTSG"
     exon            214..311
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     exon            312..398
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     exon            399..524
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     exon            525..642
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     exon            643..742
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     exon            743..867
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     exon            868..968
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1076
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..2451
                     /gene="Ptpa"
                     /gene_synonym="Ppp2r4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctgagt gcctcgctcc ggcatggctg ccgctttcac aggagtgtct gtaattctcg
       61 gcttccggtc gtagcgggcc agcgctcatt tccctgctgg aagctgggta gagccgggga
      121 gaggtgtggg gtgaactgtg agagagaacc gcgagcatcc gctccggctc ctgaaggaga
      181 agatggccga gggcgagcgg cagccgccgc cagattcttc agaagagacc ccttcagcta
      241 ctccgacctt catcattcca aaaaaggaga tccacacagt cccagatatg ggcaaatgga
      301 agcgctctca ggcatatgct gactacatcg gctttatcct aaccctgaat gaaggtgtga
      361 aagggaagaa gctaaccttc gactacaaag tctctgaggc cattgagaag ctggtggcac
      421 ttcttgatac gctggatagg tggattgatg aaaccccgcc agtggaccag ccttcccgat
      481 ttgggaacaa agcctacagg acctggtatg ccaaactcga tcaggaagca gaaaacttgg
      541 tggctacagt gatccccacc aacctggctg ctgctgtgcc tgaagtggca gtttacctga
      601 aggaggctgt ggggaactcc acacgcattg actatggcac agggcatgag gctgcctttg
      661 ctgctttcct ctgttgtctc tgcaagattg gtgtactccg ggtggacgac caggtggcta
      721 ttgtcttcaa ggtgtttgat aggtatcttg aggttatgcg gaagttgcag aagacataca
      781 ggatggagcc tgcgggcagc cagggcgtgt ggggtctgga tgacttccag ttcctgccct
      841 tcatctgggg cagctcccag ctcatagacc acccccacct ggagcccaga cattttgtgg
      901 acgagaaggc ggtgagcgaa aaccacaagg actacatgtt cctccagtgc atcctgttca
      961 tcaccgagat gaagaccggc ccctttgcag agcactccaa ccagctgtgg aacatcagtg
     1021 ctgtcccgtc ctggtctaaa gtgaaccagg gcctcattcg catgtataag gcggagtgcc
     1081 tggagaagtt ccctgtgatc cagcacttca agttcgggag cctgctgccc atccatccgg
     1141 tcacatcagg ctaggacagg ctgaaccacc agagccaccc tggccaggtt cctgtgccct
     1201 ctctgaccca gcacccctcc cacccacctt ctgttctttc tgtttgatga gatgggtgct
     1261 aagcagggtc tgagttgggg gaattaacca gagtatggcc agtttttgac tgtccatctg
     1321 gtggacaagc aagaagagag ggacttggac atggtcccag gccctgccgt ccctgtgttc
     1381 ctgcttcctt tccctcctgc ccaggcctat ttggaggaga caaggacatc ctgctcttcc
     1441 cactgcttcc ccctccccct cccatgatat gacgtctccc tcactaagag cggggtgggg
     1501 gtggggggct cacctctgga gaccggctgg tgggtttccc actagccatg ttccactagg
     1561 tgtctgcttt gaggctggag ggtgaggctg gggtggggag atgattgtgt agtgaccatg
     1621 gatgataagg cttcccaagg tcccatccta ggccctgggg agctgattgt atcctcatgc
     1681 tggcttggtt ggttccctgg cccttggctt tgctaggttc ctgactgcta ataccctttc
     1741 ctgggggtag cctagctgtg ggcgctgccc tggctcctgg gagagcccac tacttggtga
     1801 gatctgactt gccagagcca tcaagcaggg agaggtggag actcagggag gcagtaggac
     1861 ggctgtgtgt ggagagccca ctttcctcca gtcttggacc tcctgagtct gctgcctccc
     1921 acctacctgc tttgagtggt cttaaagttc ccctgaggcc cttggcttgc tgctctgctt
     1981 cctcaggtcc gtttgtggct tatgtgggag ggcaaagaag gcagcagccc tctgtcctgc
     2041 ttccctttgt gagatgagat aagtgctggc ataaactcag aatgggtaga ctgctaaggg
     2101 ggctgccaca gtcgccagtt ctctcccggc gagtggctga gctgggacct gcaggcttcc
     2161 ctgttccact tgggcctgcc ctgctgcact gcccatcctg cctgtgccca cctagctttt
     2221 gaggagtgga cactgagaag cacaacccag gggcttggcc agggattaac tatgatctgg
     2281 gcagagcagg gactgaagtt atcagagtca tgacagttta ccaaaaaagg accagggcca
     2341 gccttccttc cagggccagg ccactgcctt cctggctccc ttccctgttc ctgcatcccc
     2401 agccctgcgc cttccttgct gtttggatta aagcctctgt tttacacctg taaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaa
//
