LOCUS       NM_031579               2822 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein tyrosine phosphatase 4A1 (Ptp4a1), mRNA.
ACCESSION   NM_031579 XM_003750673
VERSION     NM_031579.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2822)
  AUTHORS   Park,H., Seok,J., You,J.H., Kim,J.Y., Lim,J.Y. and Kim,G.J.
  TITLE     Increased phosphatase regenerating liver-1 trigger vascular
            remodeling in injured ovary via platelet-derived growth factor
            signaling pathway
  JOURNAL   Stem Cell Res Ther 13 (1), 95 (2022)
   PUBMED   35255961
  REMARK    GeneRIF: Increased phosphatase regenerating liver-1 trigger
            vascular remodeling in injured ovary via platelet-derived growth
            factor signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2822)
  AUTHORS   Kim,S.H., Kim,J.Y., Park,S.Y., Jeong,W.T., Kim,J.M., Bae,S.H. and
            Kim,G.J.
  TITLE     Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing
            placenta-derived mesenchymal stem cells ameliorates liver cirrhosis
            via ER stress-dependent calcium
  JOURNAL   Stem Cell Res Ther 12 (1), 551 (2021)
   PUBMED   34689832
  REMARK    GeneRIF: Activation of the EGFR-PI3K-CaM pathway by
            PRL-1-overexpressing placenta-derived mesenchymal stem cells
            ameliorates liver cirrhosis via ER stress-dependent calcium.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2822)
  AUTHORS   Schmidt,J., de Avila,J. and McLean,D.
  TITLE     Regulation of protein tyrosine phosphatase 4a1, B-cell
            translocation gene 2, nuclear receptor subfamily 4a1 and
            diacylglycerol O-acyltransferase 1 by follicle stimulating hormone
            in the rat ovary
  JOURNAL   Reprod Fertil Dev 18 (7), 757-765 (2006)
   PUBMED   17032584
  REMARK    GeneRIF: genes induced by FSH in rat Sertoli cells would also show
            hormonal regulation during rat folliculogenesis
REFERENCE   4  (bases 1 to 2822)
  AUTHORS   Sun,J.P., Wang,W.Q., Yang,H., Liu,S., Liang,F., Fedorov,A.A.,
            Almo,S.C. and Zhang,Z.Y.
  TITLE     Structure and biochemical properties of PRL-1, a phosphatase
            implicated in cell growth, differentiation, and tumor invasion
  JOURNAL   Biochemistry 44 (36), 12009-12021 (2005)
   PUBMED   16142898
REFERENCE   5  (bases 1 to 2822)
  AUTHORS   Wang,S.F., Liang,Q., Li,G.W. and Gao,K.
  TITLE     Gene expression profile in rat small intestinal allografts after
            cold preservation/reperfusion
  JOURNAL   World J Gastroenterol 11 (6), 885-889 (2005)
   PUBMED   15682487
REFERENCE   6  (bases 1 to 2822)
  AUTHORS   Zeng,Q., Dong,J.M., Guo,K., Li,J., Tan,H.X., Koh,V., Pallen,C.J.,
            Manser,E. and Hong,W.
  TITLE     PRL-3 and PRL-1 promote cell migration, invasion, and metastasis
  JOURNAL   Cancer Res 63 (11), 2716-2722 (2003)
   PUBMED   12782572
REFERENCE   7  (bases 1 to 2822)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   8  (bases 1 to 2822)
  AUTHORS   Scarlato,M., Beesley,J. and Pleasure,D.
  TITLE     Analysis of oligodendroglial differentiation using cDNA arrays
  JOURNAL   J Neurosci Res 59 (3), 430-435 (2000)
   PUBMED   10679780
REFERENCE   9  (bases 1 to 2822)
  AUTHORS   Takano,S., Fukuyama,H., Fukumoto,M., Kimura,J., Xue,J.H., Ohashi,H.
            and Fujita,J.
  TITLE     PRL-1, a protein tyrosine phosphatase, is expressed in neurons and
            oligodendrocytes in the brain and induced in the cerebral cortex
            following transient forebrain ischemia
  JOURNAL   Brain Res Mol Brain Res 40 (1), 105-115 (1996)
   PUBMED   8840018
REFERENCE   10 (bases 1 to 2822)
  AUTHORS   Diamond,R.H., Cressman,D.E., Laz,T.M., Abrams,C.S. and Taub,R.
  TITLE     PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell
            growth
  JOURNAL   Mol Cell Biol 14 (6), 3752-3762 (1994)
   PUBMED   8196618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC097307.1 and JAXUCZ010000009.1.
            
            On Jun 6, 2015 this sequence version replaced NM_031579.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097307.1, L27843.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2457              BC097307.1         1-2457
            2458-2822           JAXUCZ010000009.1  40710250-40710614   c
FEATURES             Location/Qualifiers
     source          1..2822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..2822
                     /gene="Ptp4a1"
                     /gene_synonym="PRL-1"
                     /note="protein tyrosine phosphatase 4A1"
                     /db_xref="GeneID:29463"
                     /db_xref="RGD:61970"
     exon            1..200
                     /gene="Ptp4a1"
                     /gene_synonym="PRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            201..822
                     /gene="Ptp4a1"
                     /gene_synonym="PRL-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             718..1239
                     /gene="Ptp4a1"
                     /gene_synonym="PRL-1"
                     /EC_number="3.1.3.48"
                     /note="protein-tyrosine phosphatase of regenerating liver
                     1; protein tyrosine phosphatase 4a1-like; protein tyrosine
                     phosphatase type IVA, member 1"
                     /codon_start=1
                     /product="protein tyrosine phosphatase type IVA 1"
                     /protein_id="NP_113767.1"
                     /db_xref="GeneID:29463"
                     /db_xref="RGD:61970"
                     /translation="MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTT
                     IVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAV
                     HCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF
                     KDSNGHRNNCCIQ"
     exon            823..915
                     /gene="Ptp4a1"
                     /gene_synonym="PRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1046
                     /gene="Ptp4a1"
                     /gene_synonym="PRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1121
                     /gene="Ptp4a1"
                     /gene_synonym="PRL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..2822
                     /gene="Ptp4a1"
                     /gene_synonym="PRL-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcattgg ctctgggctg cggccggctc ggcgacgctc ctcgggcagc tcactgcatg
       61 gtcgtctggt gcccccgccg cctgcatcgc cgccgccgcc ccgcgacgcc caccgccgcc
      121 tgccctgccg ccgccgcctg cgccgcctcg ggatcggctg tatgattagg ccacaatctt
      181 caatgagtag acatattcct cagttctgtg gtgttctcgg tcacacattt atggagtttc
      241 tgaagggcag tggagactac tgccaggcac agcacgacct ctatgcagac aagtgaactg
      301 tagaaattca ttactactcc accaagaagc ccccataaga gtggatagcc tggacacagt
      361 cgtgttgaat tgaaatctgc agagcatttt ccaagagctc agacctggat ggggtaaacc
      421 tcagtgcact tcctttgtat cgcctcagta ttcctggatt gaagagtcac tgcttcttgt
      481 gaggaggttc atttcattgc ccgtttctcc cgactcatac tcaaagcact gagaatttca
      541 agtggagtat attgaatatt gaagtagact tcaggttgtt ttttggtttt gttttggttt
      601 tttgttttgt tttgttttgt tttgttttgg ttttcagttt ttgtttggaa tcatttctgt
      661 attcaatttt ttaattcttt cataacccta ttgggtgttt ttttaaacta aattaacatg
      721 gctcgaatga accgccctgc tcctgtggaa gtcacataca agaacatgag atttcttatt
      781 acacacaatc caaccaatgc gaccttaaac aaatttatag aggaacttaa gaagtatgga
      841 gttaccacaa tagtaagagt atgcgaagca acttacgaca ctactcttgt ggagaaagaa
      901 ggcattcatg ttcttgactg gccttttgat gatggtgcac caccatccaa ccagattgtt
      961 gatgactggt taagtcttgt gaagattaag tttcgtgaag aacctggttg ctgtattgct
     1021 gtccattgtg tcgcaggcct tggcagagct ccggtgcttg ttgccctagc attaattgaa
     1081 ggtggaatga aatatgaaga tgcagtacaa ttcataagac aaaagcggcg cggagctttt
     1141 aacagcaagc aacttctgta cctggagaag taccgtccta aaatgcggct ccgcttcaag
     1201 gattccaacg gtcatagaaa caactgttgt attcaataaa actggggtgc ctgatgccat
     1261 tgccttggaa gaggaacttc agatgggacc tgatttgtta tttacccaat gtgtccactt
     1321 acctgtggaa gctccagggg aatattgaaa aagttttacc aggccacaag cttgacagaa
     1381 ttgcaacctc tataattggg ctatgatcaa cacgtttgga cacttagcaa aagatttttg
     1441 ctggtcagca tttaaaatgt gcttattatt tgtaccaatt gacctttcct aaaataaggt
     1501 attgagtaat gtcattaaat gtactcctgt gccagaatat tattagtcta taaggaattt
     1561 agaaggatta ggtgccaaaa tacccagcac aatacttgta tatttttagc atcatacaga
     1621 accaaaattc caagaactaa gaactctcca gaccttccat ggtgtattcc ttcagtcatt
     1681 tcaaacaccg cagggcttct cttgttatct gcctgctcac tctatgttta catctcccac
     1741 acttacacca gaacacatca ggtttgctta gctatctttt aagtcttgca atgattattt
     1801 aatgtctctg tcttattttg tgctgttttg ggaaacctcc atttgaaaat caactttgtt
     1861 acagaagcac atatcttcaa taatgtctcc agacaaaaag ccttatagtt aatttaatgt
     1921 ttgcactcgg gtgcaacctg acagggaggg cctgaacaag aaaggagagg aggctattaa
     1981 atatttttag taatatgttg cctttgtctt gtgcagaaca tgtagagtat gctctttaat
     2041 ttagtaaata tttttaagac gtagagatac attgttgtag ctaaccactt aatcaaaatt
     2101 tctgaaattc ttgtgttttc catacctatc tgaggttttc caacttgttt gaattatggt
     2161 tttccccttc tcttcccaat ctcttgcaaa aaagtaaaag tgggatctgc tagtgaactg
     2221 agcagaaata ttttatacgc cttttgagct atgtaactta ataattggat acttgatcat
     2281 ttgttttatt atgtaatcga taaaatggtg atgtgtatta atgttagttc aaccatatat
     2341 ttatactgtc tgggaatgtg tggttatagt tctgtgggag aaatagtttg tcagtgttca
     2401 ccagcttgta aaaacttagt gcgagagctt caacatctaa ataaatgatg aaacgcattc
     2461 gtcactgagg tcactttgct taaaattaac ttaatttgta gaaaacagtg gattcaatta
     2521 ttatcatttc agtttatgga caaatttgtt agggttacca agtgcgttta aaaattgctc
     2581 tttaaaggtc tagataattg tgaatcaatt gaatgttggg taccaaggga aaacggtttg
     2641 taatagttga tgaccttgat ttttaattca attccaccag tcacttgtag ctttatgcag
     2701 tttccaatcc acttttctca tttttaagtt tattacttac ctgtatatat tttgaaatta
     2761 atttgaacct gagtatttgg cacatgatgg cttaataaat tttaactttc aataatctga
     2821 aa
//
