LOCUS       NM_017066               1312 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus pleiotrophin (Ptn), mRNA.
ACCESSION   NM_017066
VERSION     NM_017066.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1312)
  AUTHORS   Tanga,N., Kuboyama,K., Kishimoto,A., Kiyonari,H., Shiraishi,A.,
            Suzuki,R., Watanabe,T., Fujikawa,A. and Noda,M.
  TITLE     The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT
            pathway for oligodendrocyte differentiation: Targeted inactivation
            of PTPRZ activity in mice
  JOURNAL   Glia 67 (5), 967-984 (2019)
   PUBMED   30667096
REFERENCE   2  (bases 1 to 1312)
  AUTHORS   Tang,C., Wang,M., Wang,P., Wang,L., Wu,Q. and Guo,W.
  TITLE     Neural Stem Cells Behave as a Functional Niche for the Maturation
            of Newborn Neurons through the Secretion of PTN
  JOURNAL   Neuron 101 (1), 32-44 (2019)
   PUBMED   30497772
REFERENCE   3  (bases 1 to 1312)
  AUTHORS   Yu,H.F., Tao,R., Yang,Z.Q., Wang,K., Yue,Z.P. and Guo,B.
  TITLE     Ptn functions downstream of C/EBPbeta to mediate the effects of
            cAMP on uterine stromal cell differentiation through targeting
            Hand2 in response to progesterone
  JOURNAL   J Cell Physiol 233 (2), 1612-1626 (2018)
   PUBMED   28657144
REFERENCE   4  (bases 1 to 1312)
  AUTHORS   Paveliev,M., Fenrich,K.K., Kislin,M., Kuja-Panula,J., Kulesskiy,E.,
            Varjosalo,M., Kajander,T., Mugantseva,E., Ahonen-Bishopp,A.,
            Khiroug,L., Kulesskaya,N., Rougon,G. and Rauvala,H.
  TITLE     HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by
            the CNS extracellular matrix
  JOURNAL   Sci Rep 6, 33916 (2016)
   PUBMED   27671118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1312)
  AUTHORS   Kuboyama,K., Fujikawa,A., Suzuki,R., Tanga,N. and Noda,M.
  TITLE     Role of Chondroitin Sulfate (CS) Modification in the Regulation of
            Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity:
            PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE
            DIFFERENTIATION
  JOURNAL   J Biol Chem 291 (35), 18117-18128 (2016)
   PUBMED   27445335
REFERENCE   6  (bases 1 to 1312)
  AUTHORS   Fang,W., Hartmann,N., Chow,D.T., Riegel,A.T. and Wellstein,A.
  TITLE     Pleiotrophin stimulates fibroblasts and endothelial and epithelial
            cells and is expressed in human cancer
  JOURNAL   J Biol Chem 267 (36), 25889-25897 (1992)
   PUBMED   1464602
REFERENCE   7  (bases 1 to 1312)
  AUTHORS   Wellstein,A., Fang,W.J., Khatri,A., Lu,Y., Swain,S.S.,
            Dickson,R.B., Sasse,J., Riegel,A.T. and Lippman,M.E.
  TITLE     A heparin-binding growth factor secreted from breast cancer cells
            homologous to a developmentally regulated cytokine
  JOURNAL   J Biol Chem 267 (4), 2582-2587 (1992)
   PUBMED   1733956
REFERENCE   8  (bases 1 to 1312)
  AUTHORS   Li,Y.S., Milner,P.G., Chauhan,A.K., Watson,M.A., Hoffman,R.M.,
            Kodner,C.M., Milbrandt,J. and Deuel,T.F.
  TITLE     Cloning and expression of a developmentally regulated protein that
            induces mitogenic and neurite outgrowth activity
  JOURNAL   Science 250 (4988), 1690-1694 (1990)
   PUBMED   2270483
REFERENCE   9  (bases 1 to 1312)
  AUTHORS   Kovesdi,I., Fairhurst,J.L., Kretschmer,P.J. and Bohlen,P.
  TITLE     Heparin-binding neurotrophic factor (HBNF) and MK, members of a new
            family of homologous, developmentally regulated proteins
  JOURNAL   Biochem Biophys Res Commun 172 (2), 850-854 (1990)
   PUBMED   1700712
REFERENCE   10 (bases 1 to 1312)
  AUTHORS   Merenmies,J. and Rauvala,H.
  TITLE     Molecular cloning of the 18-kDa growth-associated protein of
            developing brain
  JOURNAL   J Biol Chem 265 (28), 16721-16724 (1990)
   PUBMED   2170351
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017066.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062013.1, FQ223195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000004.1  66342268-66342332   c
            66-182              JAXUCZ010000004.1  66282084-66282200   c
            183-356             JAXUCZ010000004.1  66280909-66281082   c
            357-518             JAXUCZ010000004.1  66277800-66277961   c
            519-1312            JAXUCZ010000004.1  66260764-66261557   c
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1312
                     /gene="Ptn"
                     /gene_synonym="HARP; Hbnf"
                     /note="pleiotrophin"
                     /db_xref="GeneID:24924"
                     /db_xref="RGD:3444"
     exon            1..65
                     /gene="Ptn"
                     /gene_synonym="HARP; Hbnf"
                     /inference="alignment:Splign:2.1.0"
     exon            66..182
                     /gene="Ptn"
                     /gene_synonym="HARP; Hbnf"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..574
                     /gene="Ptn"
                     /gene_synonym="HARP; Hbnf"
                     /note="HBBM; OSF-1; HB-GAM; HBGF-8; osteoblast-specific
                     factor 1; heparin-binding brain mitogen; heparin-binding
                     growth factor 8; heparin-binding neutrophic factor;
                     heparin-binding growth-associated molecule; Pleiotrophin
                     (Heparine binding factor, Hbnf, in the mouse); heparin
                     affine regulatory peptide; heparin binding factor;
                     heparin-binding neurotrophic factor"
                     /codon_start=1
                     /product="pleiotrophin precursor"
                     /protein_id="NP_058762.1"
                     /db_xref="GeneID:24924"
                     /db_xref="RGD:3444"
                     /translation="MSSQQYQQQRRKFAAAFLALIFILAAVDTAEAGKKEKPEKKVKK
                     SDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQ
                     FQAWGECDLNTALKTRTGSLKRALHNADCQKTVTISKPCGKLTKPKPQAESKKKKKEG
                     KKQEKMLD"
     exon            183..356
                     /gene="Ptn"
                     /gene_synonym="HARP; Hbnf"
                     /inference="alignment:Splign:2.1.0"
     exon            357..518
                     /gene="Ptn"
                     /gene_synonym="HARP; Hbnf"
                     /inference="alignment:Splign:2.1.0"
     exon            519..1312
                     /gene="Ptn"
                     /gene_synonym="HARP; Hbnf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacctcgcc ctgcactttg caacaaaggc agcctgctag tcagcaagga catctgcaag
       61 ccaaaaaatg tcgtcccagc aataccagca gcaacgtcga aaatttgcag ctgccttcct
      121 ggccttgatt ttcatcctgg cagccgtgga cactgctgag gccgggaaaa aagagaaacc
      181 agaaaaaaag gtgaaaaaat ctgactgtgg agaatggcaa tggagtgtgt gcgtgcccac
      241 cagcggggac tgtggtctag gcacccggga gggcactcgc actggtgccg agtgcaaaca
      301 aaccatgaag actcagagat gtaagatccc ttgcaactgg aagaagcagt ttggagctga
      361 gtgcaaatac cagttccagg cttggggaga atgtgacctc aataccgcct tgaagaccag
      421 aactggcagt ctgaagagag ctctgcacaa tgccgactgt cagaaaactg tcaccatctc
      481 caagccctgt ggcaaactca ccaagcccaa gcctcaagcg gaatcaaaga agaagaaaaa
      541 ggaaggcaag aaacaggaga agatgctgga ttaaaagagg ccaccttttg tggacaagga
      601 aaaggacatc agcaagcagg atcagttaac tattacattt atacctactg taggcttttt
      661 attcaacagt tatctgtagc ttaagtacat gataggcaaa aacaaagaga aaagaaatgt
      721 ttttgtagta gcattttttt aatgtatacc atagtaccag taggggttta taataaagga
      781 ctgtaatact atttaggaag ttgagttgta gtacatgata gatggtagga ttgaggtaag
      841 tttttttttt tgtttttgtt ttgttttggt tttggtttgt tttgcttttc aaagttatgt
      901 gatatttcac atttaaatct ttttttttta catttccaaa ccttgtgcat caatttaaat
      961 gttacaacca tgtaaactac ttcccttatt agatagattt tcacctagac ttttttttcc
     1021 caattcagaa gaaaatatac actaaataaa gcagcaataa gatataatca ttctattgga
     1081 gagatatgca ttgctctctg ccagtggatg ctttctttga aagttagaaa accaggagaa
     1141 gaagagaggc agagcaacgg tgtagtgaaa tgttgatttt ttgttttttt aagaaaagga
     1201 ttaaaacatg aaatcctttc acttcggcag aaaaaaccat ttgttttctt gacaaaatta
     1261 tttttacatc cgaggaaaaa aatctaggaa aataaatcaa agtgatgctg aa
//
