LOCUS       NM_001395741            4233 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus protein tyrosine kinase 7 (Ptk7), mRNA.
ACCESSION   NM_001395741 XM_039083179
VERSION     NM_001395741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4233)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   2  (bases 1 to 4233)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 4233)
  AUTHORS   Puppo,F., Thome,V., Lhoumeau,A.C., Cibois,M., Gangar,A., Lembo,F.,
            Belotti,E., Marchetto,S., Lecine,P., Prebet,T., Sebbagh,M.,
            Shin,W.S., Lee,S.T., Kodjabachian,L. and Borg,J.P.
  TITLE     Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin
            canonical signalling
  JOURNAL   EMBO Rep 12 (1), 43-49 (2011)
   PUBMED   21132015
REFERENCE   4  (bases 1 to 4233)
  AUTHORS   Golubkov,V.S., Chekanov,A.V., Cieplak,P., Aleshin,A.E.,
            Chernov,A.V., Zhu,W., Radichev,I.A., Zhang,D., Dong,P.D. and
            Strongin,A.Y.
  TITLE     The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a
            highly efficient proteolytic target of membrane type-1 matrix
            metalloproteinase: implications in cancer and embryogenesis
  JOURNAL   J Biol Chem 285 (46), 35740-35749 (2010)
   PUBMED   20837484
REFERENCE   5  (bases 1 to 4233)
  AUTHORS   Paudyal,A., Damrau,C., Patterson,V.L., Ermakov,A., Formstone,C.,
            Lalanne,Z., Wells,S., Lu,X., Norris,D.P., Dean,C.H., Henderson,D.J.
            and Murdoch,J.N.
  TITLE     The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and
            exhibits defects in neural tube, heart and lung development and
            abnormal planar cell polarity in the ear
  JOURNAL   BMC Dev Biol 10, 87 (2010)
   PUBMED   20704721
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4233)
  AUTHORS   Yamada,S., Uchimura,E., Ueda,T., Nomura,T., Fujita,S.,
            Matsumoto,K., Funeriu,D.P., Miyake,M. and Miyake,J.
  TITLE     Identification of twinfilin-2 as a factor involved in neurite
            outgrowth by RNAi-based screen
  JOURNAL   Biochem Biophys Res Commun 363 (4), 926-930 (2007)
   PUBMED   17910947
REFERENCE   7  (bases 1 to 4233)
  AUTHORS   Jones,C. and Chen,P.
  TITLE     Planar cell polarity signaling in vertebrates
  JOURNAL   Bioessays 29 (2), 120-132 (2007)
   PUBMED   17226800
  REMARK    Review article
REFERENCE   8  (bases 1 to 4233)
  AUTHORS   Lange,S., Xiang,F., Yakovenko,A., Vihola,A., Hackman,P.,
            Rostkova,E., Kristensen,J., Brandmeier,B., Franzen,G., Hedberg,B.,
            Gunnarsson,L.G., Hughes,S.M., Marchand,S., Sejersen,T., Richard,I.,
            Edstrom,L., Ehler,E., Udd,B. and Gautel,M.
  TITLE     The kinase domain of titin controls muscle gene expression and
            protein turnover
  JOURNAL   Science 308 (5728), 1599-1603 (2005)
   PUBMED   15802564
REFERENCE   9  (bases 1 to 4233)
  AUTHORS   Lu,X., Borchers,A.G., Jolicoeur,C., Rayburn,H., Baker,J.C. and
            Tessier-Lavigne,M.
  TITLE     PTK7/CCK-4 is a novel regulator of planar cell polarity in
            vertebrates
  JOURNAL   Nature 430 (6995), 93-98 (2004)
   PUBMED   15229603
REFERENCE   10 (bases 1 to 4233)
  AUTHORS   Jung,J.W., Shin,W.S., Song,J. and Lee,S.T.
  TITLE     Cloning and characterization of the full-length mouse Ptk7 cDNA
            encoding a defective receptor protein tyrosine kinase
  JOURNAL   Gene 328, 75-84 (2004)
   PUBMED   15019986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Aug 3, 2021 this sequence version replaced XM_039083179.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1267421.1,
                                           SRR26360186.1243364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000009.1  21849756-21850017
            263-550             JAXUCZ010000009.1  21887982-21888269
            551-653             JAXUCZ010000009.1  21888707-21888809
            654-844             JAXUCZ010000009.1  21889122-21889312
            845-995             JAXUCZ010000009.1  21889406-21889556
            996-1144            JAXUCZ010000009.1  21892381-21892529
            1145-1411           JAXUCZ010000009.1  21892755-21893021
            1412-1545           JAXUCZ010000009.1  21899712-21899845
            1546-1681           JAXUCZ010000009.1  21899961-21900096
            1682-1801           JAXUCZ010000009.1  21900220-21900339
            1802-1951           JAXUCZ010000009.1  21902978-21903127
            1952-2102           JAXUCZ010000009.1  21903233-21903383
            2103-2230           JAXUCZ010000009.1  21903482-21903609
            2231-2434           JAXUCZ010000009.1  21905684-21905887
            2435-2590           JAXUCZ010000009.1  21906832-21906987
            2591-2823           JAXUCZ010000009.1  21907690-21907922
            2824-2904           JAXUCZ010000009.1  21908917-21908997
            2905-3056           JAXUCZ010000009.1  21912076-21912227
            3057-3235           JAXUCZ010000009.1  21914156-21914334
            3236-4233           JAXUCZ010000009.1  21915080-21916077
FEATURES             Location/Qualifiers
     source          1..4233
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..4233
                     /gene="Ptk7"
                     /note="protein tyrosine kinase 7"
                     /db_xref="GeneID:301242"
                     /db_xref="RGD:1310472"
     exon            1..262
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..3396
                     /gene="Ptk7"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase-like 7; PTK7 protein
                     tyrosine kinase 7; inactive tyrosine-protein kinase 7"
                     /codon_start=1
                     /product="inactive tyrosine-protein kinase 7 precursor"
                     /protein_id="NP_001382670.1"
                     /db_xref="GeneID:301242"
                     /db_xref="RGD:1310472"
                     /translation="MGARQLPLLRALLLPLLAGAHSAIVFIKEPSSQDALQGRRALLR
                     CEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDSGAFQCVARDNITGE
                     EARSANASFNIKWIEAGPVVLKHPASAAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTP
                     LSDDQSTHTVSSKERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSIADESFAR
                     VLLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRKAMVFANG
                     SLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPLEPRVFIAGGEERVA
                     CPAPQGLPTPSVWWEHAGVRLPAHGRVHQKGLELVFATIAESDAGVYTCHAANLAGQR
                     RQDVNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRF
                     EVSKNGTLRINSVEVYDGTVYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEF
                     DKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN
                     EPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRIL
                     DPTKLGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPLMEDS
                     EGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMEC
                     LNGGPLQNGQPSAEIQEEVALTSLGSGPTATNKRHSTGDKMHFPRASLQPITTLGKSE
                     FGEVFLAKAQGLDEGATETLVLVKSLQNKDEQQQLDFRREFEMFGKLNHANVVRLLGL
                     CREAEPHYMVLEYVDLGDLKQFLRISKNKDEKLKSQPLSTKQKVALCSQVALGMEHLS
                     NNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAVLE
                     GDFSTKSDVWAFGVLMWEVFTHGEMPHGGQGDDEVLADLQAGKARLPQPEGCPSKLYR
                     LMQRCWALNPKDRPSFSEIASTLGDGPADSKQ"
     exon            263..550
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            551..653
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            654..844
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            845..995
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1144
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1411
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1545
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1681
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1801
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1951
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2102
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2230
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2434
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2590
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2823
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2904
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3056
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3235
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..4233
                     /gene="Ptk7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgtgcag gcggagggga gggggcgtcg ggggcgtggc ttggcggcgg cggcgcgctc
       61 gagggcttgg atgtacgggg cgcgcgcggc tccagctccg gacgcctcgg gctcgggctg
      121 cagctgctgc ggcggccccc gcgctccggt ccgcgcgccc gctcgccgac tgccttgtac
      181 ttcgccgctc gtctgcagcc cgccaggatg ggagcccgcc agctgcctct gctcagagcc
      241 ctgcttctgc cgttgctggc cggtgcccat tctgccatcg tctttatcaa ggagccatcc
      301 tcccaggatg cacttcaagg gcgccgggcg ctgctccgct gtgaggtcga ggctccggac
      361 cccgtgcacg tgtactggtt gctcaatggc gtgcctgtcc aggacaccga gcgacgcttc
      421 gcccaaggta gcagcctgag ctttgcggct gtggaccggc ttcaagattc tggtgccttc
      481 cagtgtgtgg ctcgggacaa tatcactgga gaggaagccc gcagtgccaa tgcctccttc
      541 aacatcaaat ggatcgaggc gggtcctgtg gttctgaagc atccagcctc agcagctgag
      601 atccagccgc agacccaggt cacactccga tgtcacattg atgggcaccc tcggcctacc
      661 taccagtggt tccgagacgg gacccccctc tctgatgatc agagcaccca cacagtcagc
      721 agcaaggaga ggaacctgac cctacgacct gccagtcccg aacatagcgg cctctactcc
      781 tgctgtgccc acaatgcctt tggccaggcc tgcagcagcc agaacttcac cttgagtatt
      841 gcagatgaga gctttgccag ggtgctgctg gcacctcagg acgtcgttgt ggcaaggaat
      901 gaggaggcca tgttccattg ccagttttca gctcagccgc ccccgagcct gcagtgggtc
      961 tttgaggatg agactcccat cacgaaccga agccgtcccc ctcacctccg caaagccatg
     1021 gtgtttgcca atggctccct gctgctgacc caagtccggc cacggaacgc aggagtctac
     1081 cgttgcattg gtcagggaca gaggggtccc cccatcgtcc tagaagccac tcttcacctg
     1141 gcagagatcg aagacatgct gccgttggaa ccacgggtgt tcatagctgg tggtgaggaa
     1201 cgtgttgcct gcccagcccc ccagggtctg cctacgccca gtgtctggtg ggaacacgct
     1261 ggagtccgtc ttcctgctca tggaagggtc caccagaagg gcctcgagct cgtgtttgcc
     1321 actatcgctg agagtgacgc cggtgtctac acctgccacg cagccaacct ggctggtcag
     1381 cggcgacagg atgtgaacat cacagtggcc actgttccca cgtggttaag gaagccccaa
     1441 gacagccagc tggaagaggg caaacctggc tacctgcact gtctgacaca ggccacaccc
     1501 aagcccaccg tcatctggta caggaaccag atgcttatct cggaggactc acgcttcgaa
     1561 gtctcaaaga atgggacctt gcgcatcaac agtgtggagg tatatgacgg gacagtgtac
     1621 cgctgtgtga gcagcacccc agctggcagc atcgaggccc aggcccgtgt ccaggtgctg
     1681 gaaaaactca agttcacgcc accgccacag ccacagcaat gcatggagtt tgataaggag
     1741 gctacggtgc cctgctcagc cactggccga gagaaaccca cggttaagtg ggtacgggca
     1801 gatgggagca gcctccccga atgggtgaca gacaatgcgg ggaccctgca ctttgcccga
     1861 gtgacccgag atgacgctgg caactacacc tgcattgcgt ccaatgagcc acagggccag
     1921 atccgtgccc atgtccagct gacggtggca gttttcatca cgttcaaggt ggaaccggag
     1981 cgtacaacgg tgtaccaggg ccacacggcg ctgctgcggt gtgaggcgca gggggatccc
     2041 aagcctctta ttcagtggaa gggcaaagac cgaatcctgg accccaccaa gctgggaccc
     2101 aggatgcaca tcttccagaa cggctccctg gtgatccatg atgtggcccc tgaggactca
     2161 ggctcctaca cctgcatcgc tggcaacagc tgtaacatca ggcacacaga ggccccgctc
     2221 ttagtcgtgg acaagccgct gatggaggac tcagagggcc caggcagccc tcccccgtac
     2281 aagatgatcc agaccatcgg gctgtcagtg ggtgcagctg tagcctatat catagctgta
     2341 ctgggcctca tgttctactg caagaagagg tgtaaagcca agagactgca gaaacagcct
     2401 gaaggggagg agcctgagat ggagtgcctc aatggtgggc ctttgcagaa tggacagccg
     2461 tcagcagaga tccaggaaga agtggcgttg accagcttgg gctctggccc tacagccacc
     2521 aacaagcgcc acagcactgg cgataagatg catttccctc gggccagcct gcagcccatc
     2581 accactctgg ggaaaagcga gttcggggag gtgttcctcg caaaggctca gggcttagac
     2641 gaaggcgcga cagagaccct ggtgcttgtg aaaagcctgc agaacaagga cgagcagcag
     2701 cagctggact tccggaggga gtttgagatg tttgggaaac tgaaccatgc caacgtggtg
     2761 cggctcctgg ggctgtgccg ggaggctgag ccccattaca tggtgctgga gtatgtggac
     2821 ctgggagatc tcaaacagtt cctgaggatt tccaagaaca aggatgaaaa gttgaagtca
     2881 cagcccctca gcaccaaaca gaaggtggcc ctgtgttccc aggtggccct gggcatggaa
     2941 cacttgtcca acaaccgctt tgtgcacaag gacttagctg ctcgcaactg cctggtcagc
     3001 gcccagaggc aggtgaaggt gtccgcgctg ggcctcagca aggatgtata caacagtgaa
     3061 tactaccact tccgccaggc ctgggtacct ttgcgttgga tgtccccaga ggctgtcctg
     3121 gagggtgact tctccaccaa gtctgacgtc tgggcctttg gcgtgctcat gtgggaagtg
     3181 ttcactcatg gagagatgcc ccatggtgga cagggagatg atgaggtgct ggcggacttg
     3241 caggctggga aggctcggct cccgcagccc gaaggctgcc cgtctaagct ctaccggctg
     3301 atgcaacgct gctgggccct gaaccccaag gaccggccct ccttcagcga gatcgctagc
     3361 accctgggag atggccctgc agacagcaag cagtgaggga gcctcacagg ctgtccctca
     3421 ggacggcgcg ggcagggaag aacccctctt gaggggagcc tgcagcatga ggggcaagat
     3481 aaccctgttc ttggccttgg ggtccctgcc caagcacaac aggcattgct gagggctggc
     3541 agtgcctagg cgtttctctt tgcctcagcc actggggagg ctgattcaaa cccaggctgg
     3601 gtgacttaag accatgggct gggggcatct ttctttgcga ccccttccct tatcagggac
     3661 agtatgggta cctcaggtaa ccccaatttc tggcctgaga cttctggcca ggtccagctc
     3721 tgtcactaat ctgccaatgg ggagggctgg gctggggctg actaggtgtg ggggacttta
     3781 atacacaaat atactcaaag ttccaggata actctgggca cacaggacca acgggcctct
     3841 tggcccatgg gtcccacctg ggggcgccta gcaggtcatg aagggcacgg cagcagagtc
     3901 ctccccaccg tgggcttgtg cacactaagc cagacccctg gctcagtctc ctttcctcac
     3961 cctaagtgcc tggcagatga agtgttcggg agcttttgac acttatataa cccgcccctt
     4021 ttgtatgcac cttgggcggc ctttgtatgt aattgcagcg tggggtgggt gggcatgggg
     4081 aggtctgggt gggccctaga ggaagtaggg agggagggcc acccctgcct catactctta
     4141 cttactgttg ttgtttgttt gttctacggt tttgtttttg ttttgttttg ttttttacac
     4201 tcgctgctct caataaagaa gccttttttt aaa
//
