LOCUS       NM_001108968            2142 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus protein tyrosine kinase 6 (Ptk6), mRNA.
ACCESSION   NM_001108968 XM_001057955 XM_345485
VERSION     NM_001108968.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang
            S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Hu Z, Zhou Y,
            Marks JR, Liang H, Hung MC, Lin C and Yang L.
  TITLE     The LINK-A lncRNA activates normoxic HIF1alpha signalling in
            triple-negative breast cancer
  JOURNAL   Nat Cell Biol 18 (2), 213-224 (2016)
   PUBMED   26751287
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Patel P, Asbach B, Shteyn E, Gomez C, Coltoff A, Bhuyan S, Tyner
            AL, Wagner R and Blain SW.
  TITLE     Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating
            the activity of cyclin D-cyclin-dependent kinase 4
  JOURNAL   Mol Cell Biol 35 (9), 1506-1522 (2015)
   PUBMED   25733683
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Zheng Y, Asara JM and Tyner AL.
  TITLE     Protein-tyrosine kinase 6 promotes peripheral adhesion complex
            formation and cell migration by phosphorylating p130 CRK-associated
            substrate
  JOURNAL   J Biol Chem 287 (1), 148-158 (2012)
   PUBMED   22084245
REFERENCE   4  (bases 1 to 2142)
  AUTHORS   Zheng Y, Peng M, Wang Z, Asara JM and Tyner AL.
  TITLE     Protein tyrosine kinase 6 directly phosphorylates AKT and promotes
            AKT activation in response to epidermal growth factor
  JOURNAL   Mol Cell Biol 30 (17), 4280-4292 (2010)
   PUBMED   20606012
REFERENCE   5  (bases 1 to 2142)
  AUTHORS   Kang SA, Lee ES, Yoon HY, Randazzo PA and Lee ST.
  TITLE     PTK6 inhibits down-regulation of EGF receptor through
            phosphorylation of ARAP1
  JOURNAL   J Biol Chem 285 (34), 26013-26021 (2010)
   PUBMED   20554524
REFERENCE   6  (bases 1 to 2142)
  AUTHORS   Hong E, Shin J, Kim HI, Lee ST and Lee W.
  TITLE     Solution structure and backbone dynamics of the non-receptor
            protein-tyrosine kinase-6 Src homology 2 domain
  JOURNAL   J Biol Chem 279 (28), 29700-29708 (2004)
   PUBMED   15056653
REFERENCE   7  (bases 1 to 2142)
  AUTHORS   Derry JJ, Prins GS, Ray V and Tyner AL.
  TITLE     Altered localization and activity of the intracellular tyrosine
            kinase BRK/Sik in prostate tumor cells
  JOURNAL   Oncogene 22 (27), 4212-4220 (2003)
   PUBMED   12833144
REFERENCE   8  (bases 1 to 2142)
  AUTHORS   Takemori H, Katoh Y, Horike N, Doi J and Okamoto M.
  TITLE     ACTH-induced nucleocytoplasmic translocation of salt-inducible
            kinase. Implication in the protein kinase A-activated gene
            transcription in mouse adrenocortical tumor cells
  JOURNAL   J Biol Chem 277 (44), 42334-42343 (2002)
   PUBMED   12200423
REFERENCE   9  (bases 1 to 2142)
  AUTHORS   Qiu H and Miller WT.
  TITLE     Regulation of the nonreceptor tyrosine kinase Brk by
            autophosphorylation and by autoinhibition
  JOURNAL   J Biol Chem 277 (37), 34634-34641 (2002)
   PUBMED   12121988
REFERENCE   10 (bases 1 to 2142)
  AUTHORS   Derry JJ, Richard S, Valderrama Carvajal H, Ye X, Vasioukhin V,
            Cochrane AW, Chen T and Tyner AL.
  TITLE     Sik (BRK) phosphorylates Sam68 in the nucleus and negatively
            regulates its RNA binding ability
  JOURNAL   Mol Cell Biol 20 (16), 6114-6126 (2000)
   PUBMED   10913193
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474066.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057955.1, XM_345485.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132270, SAMD00132273
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..2142
                     /gene="Ptk6"
                     /note="protein tyrosine kinase 6"
                     /db_xref="GeneID:366275"
                     /db_xref="RGD:1309098"
     exon            1..521
                     /gene="Ptk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1647
                     /gene="Ptk6"
                     /EC_number="2.7.10.1"
                     /note="PTK6 protein tyrosine kinase 6"
                     /codon_start=1
                     /product="protein-tyrosine kinase 6"
                     /protein_id="NP_001102438.1"
                     /db_xref="GeneID:366275"
                     /db_xref="RGD:1309098"
                     /translation="MVSLDKAHLGPKYVGLWDFKARTDEELSFQAGDLLHVTRKEEQW
                     WWATLLDAEGKALAEGYVPHNYLAEKETVESEPWFFGCISRSEAMHRLQSEDYPKGTF
                     LIRVSQKPGADYVLSVWDAEAVRHYRIWRNSAGRLHLNEVVSFSSLSELVNYHKTHNL
                     SPGLQLSMACWKLKTEPLPHWDDWERPREEFTLCKKLGSGYFGEVFEGLWKGLVRVAV
                     KVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGSLLQLL
                     RDSDEKDLPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLA
                     RLVKEDIYLSRDHNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMS
                     NHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKLSGITRYENL
                     V"
     exon            522..643
                     /gene="Ptk6"
                     /inference="alignment:Splign:2.1.0"
     exon            644..807
                     /gene="Ptk6"
                     /inference="alignment:Splign:2.1.0"
     exon            808..961
                     /gene="Ptk6"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1123
                     /gene="Ptk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1305
                     /gene="Ptk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1459
                     /gene="Ptk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..2142
                     /gene="Ptk6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgtgtaac tgtggctagg tcttgtcaag gggttgttta gctgacaggc tttcaccgag
       61 tgtgaacaca tagcatggtc ttatcctgta gataaaagaa caaacagggg ctagaagggc
      121 cttcagggtg gagctaggtt agtccatctc caatcagtgc cgggtgtggc tgctctcctg
      181 cccatcataa ggaagtaggt gtgactggct ttctgggaaa agttcctcct acctctccca
      241 gcagtaagtg tctacaagta ggccacagtt ggctctgcca ctaagcctgc catggtgtct
      301 ttggacaagg ctcacctggg tcctaagtat gtgggcctct gggacttcaa agcacgaacg
      361 gacgaggagc tgagctttca ggcaggagac ctcctccatg ttaccaggaa ggaggaacag
      421 tggtggtggg ccaccctgct ggatgcggaa ggcaaggcct tggctgaggg ctacgtgccc
      481 cacaactacc tggctgagaa ggaaactgtg gagtctgaac cgtggttctt tggttgcatc
      541 tcccgctcag aggccatgca caggctgcag tctgaggact acccgaaggg taccttcctg
      601 atcagagtca gccagaagcc aggagcagac tatgtcctct ccgtgtggga tgctgaggct
      661 gttcgacatt acaggatctg gaggaacagt gcgggcaggc tgcacctgaa tgaggtggta
      721 tccttctcca gtctgtctga gcttgtgaac taccacaaga cccacaacct gtcccctggc
      781 ctacagctct ccatggcctg ctggaagctc aaaactgagc ccttgcccca ctgggatgac
      841 tgggagaggc cgagggagga gttcacgctc tgtaagaagc tggggtctgg ctactttggg
      901 gaggtctttg aagggctctg gaaaggcctg gtccgtgtgg ctgtgaaggt gatctctaga
      961 gacaatctcc tgcaccagca caccttccag gctgagattc aagccatgaa gaagctgcga
     1021 cacaagcaca tcctgtcgct gtacgctgtg gcaactgcag gggacccagt ctatatcatc
     1081 acggagctca tgcccaaggg gagcctgctg cagctattgc gggactcgga tgagaaagac
     1141 ctgcctattt tggaactggt ggactttgca tcacaggttg ccgagggcat gtgctacctg
     1201 gaatctcaga attacattca ccgtgacctg gctgcaagga acgttctcgt tactgagaac
     1261 aatctctgca aagtggggga ctttgggctg gccaggctcg tcaaggagga catctacctt
     1321 tcccgtgacc acaacgtccc ctacaaatgg acagcacctg aggcactttc ccgagggcat
     1381 tactccatca aatcggatgt ctggtctttt ggtgttctcc ttcatgaaat tttcagcagg
     1441 gggcagatgc cctacccagg catgtccaat cacgaaacct tcctgagggt ggatgccggc
     1501 taccgcatgc cctgcccctt ggagtgccca cccaacatac acaagctgat gcttagctgt
     1561 tggagcagag accctaagca gagaccctgc ttcaaagacc tgtgtgagaa actctcaggt
     1621 atcactaggt atgagaacct ggtctgagct cctcggctgt ggccaggacc cacagaagag
     1681 ggcctcgtgg ttatcctgga tttctaccga aggcatgcac cacccttcag tttactgaga
     1741 agaaggggta gggaacacac caaacatatc ttaaacactg agtgtggtca aggaaagaaa
     1801 gaggcagcag ccatgttcct ttcccattta tcctcctcca ggaggcagta cacaaaatcc
     1861 aggaagtcac tctctggctt cctcatccct tctcgcaaga cttcatgtga cggagaagcc
     1921 aagaagagtc taggcaatag tctttgtgga attcttgcca tatcactttt agagcttgac
     1981 tgcccacaaa cacatagccc acccattagt gccttaattc tgcaggatct tatgccacgt
     2041 aaaactcaga agaagtttgc atgattttct ctttataacc ttggcttcgc tggaggagtc
     2101 tcgcctagga agctcaagac agataaaatg atatgaaatt tc
//
