LOCUS       NM_017318               3848 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Rattus norvegicus protein tyrosine kinase 2 beta (Ptk2b), mRNA.
ACCESSION   NM_017318
VERSION     NM_017318.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3848)
  AUTHORS   Rowe,C.J., Nwaolu,U., Salinas,D., Hong,J., Nunez,J., Lansford,J.L.,
            McCarthy,C.F., Potter,B.K., Levi,B.H. and Davis,T.A.
  TITLE     Inhibition of focal adhesion kinase 2 results in a macrophage
            polarization shift to M2 which attenuates local and systemic
            inflammation and reduces heterotopic ossification after polysystem
            extremity trauma
  JOURNAL   Front Immunol 14, 1280884 (2023)
   PUBMED   38116014
  REMARK    GeneRIF: Inhibition of focal adhesion kinase 2 results in a
            macrophage polarization shift to M2 which attenuates local and
            systemic inflammation and reduces heterotopic ossification after
            polysystem extremity trauma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3848)
  AUTHORS   Zheng,L., Spagnol,G., Gandhi,D.R., Sharma,K., Kumar,V., Patel,K.P.
            and Sorgen,P.L.
  TITLE     Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization,
            Infarct Size, and Cardiac Function in Rats With Heart Failure
  JOURNAL   Circ Heart Fail 16 (8), e010294 (2023)
   PUBMED   37465947
  REMARK    GeneRIF: Inhibition of Pyk2 Improves Cx43 Intercalated Disc
            Localization, Infarct Size, and Cardiac Function in Rats With Heart
            Failure.
REFERENCE   3  (bases 1 to 3848)
  AUTHORS   Luo,Q.Q., Wang,B., Chen,X., Qiu,H.Y., Li,W.T., Yan,X.J. and
            Chen,S.L.
  TITLE     Acute stress induces visceral hypersensitivity via glucocorticoid
            receptor-mediated membrane insertion of TRPM8: Involvement of a
            non-receptor tyrosine kinase Pyk2
  JOURNAL   Neurogastroenterol Motil 32 (10), 1514-1528 (2020)
   PUBMED   32391653
  REMARK    GeneRIF: Acute stress induces visceral hypersensitivity via
            glucocorticoid receptor-mediated membrane insertion of TRPM8:
            Involvement of a non-receptor tyrosine kinase Pyk2.
REFERENCE   4  (bases 1 to 3848)
  AUTHORS   Liu,Z., Hao,K.M., Wang,H.Y. and Qi,W.X.
  TITLE     Histone deacetylase-6 modulates amyloid beta-induced cognitive
            dysfunction rats by regulating PTK2B
  JOURNAL   Neuroreport 31 (10), 754-761 (2020)
   PUBMED   32453021
  REMARK    GeneRIF: Histone deacetylase-6 modulates amyloid beta-induced
            cognitive dysfunction rats by regulating PTK2B.
REFERENCE   5  (bases 1 to 3848)
  AUTHORS   Afonso,P., De Luca,P., Carvalho,R.S., Cortes,L., Pinheiro,P.,
            Oliveiros,B., Almeida,R.D., Mele,M. and Duarte,C.B.
  TITLE     BDNF increases synaptic NMDA receptor abundance by enhancing the
            local translation of Pyk2 in cultured hippocampal neurons
  JOURNAL   Sci Signal 12 (586) (2019)
   PUBMED   31213568
  REMARK    GeneRIF: these findings indicate that hnRNP K mediates the synaptic
            distribution of Pyk2 synthesis, and hence the synaptic
            incorporation of GluN2B-containing NMDARs, induced by BDNF, which
            may affect LTP and synaptic plasticity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3848)
  AUTHORS   Siciliano,J.C., Toutant,M., Derkinderen,P., Sasaki,T. and
            Girault,J.A.
  TITLE     Differential regulation of proline-rich tyrosine kinase 2/cell
            adhesion kinase beta (PYK2/CAKbeta) and pp125(FAK) by glutamate and
            depolarization in rat hippocampus
  JOURNAL   J Biol Chem 271 (46), 28942-28946 (1996)
   PUBMED   8910543
REFERENCE   7  (bases 1 to 3848)
  AUTHORS   Dikic,I., Tokiwa,G., Lev,S., Courtneidge,S.A. and Schlessinger,J.
  TITLE     A role for Pyk2 and Src in linking G-protein-coupled receptors with
            MAP kinase activation
  JOURNAL   Nature 383 (6600), 547-550 (1996)
   PUBMED   8849729
REFERENCE   8  (bases 1 to 3848)
  AUTHORS   Tokiwa,G., Dikic,I., Lev,S. and Schlessinger,J.
  TITLE     Activation of Pyk2 by stress signals and coupling with JNK
            signaling pathway
  JOURNAL   Science 273 (5276), 792-794 (1996)
   PUBMED   8670418
REFERENCE   9  (bases 1 to 3848)
  AUTHORS   Sasaki,H., Nagura,K., Ishino,M., Tobioka,H., Kotani,K. and
            Sasaki,T.
  TITLE     Cloning and characterization of cell adhesion kinase beta, a novel
            protein-tyrosine kinase of the focal adhesion kinase subfamily
  JOURNAL   J Biol Chem 270 (36), 21206-21219 (1995)
   PUBMED   7673154
REFERENCE   10 (bases 1 to 3848)
  AUTHORS   Lev,S., Moreno,H., Martinez,R., Canoll,P., Peles,E.,
            Musacchio,J.M., Plowman,G.D., Rudy,B. and Schlessinger,J.
  TITLE     Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation
            of ion channel and MAP kinase functions
  JOURNAL   Nature 376 (6543), 737-745 (1995)
   PUBMED   7544443
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017318.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101921.1, D45854.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000015.1  44656583-44656628   c
            47-287              JAXUCZ010000015.1  44590151-44590391   c
            288-466             JAXUCZ010000015.1  44571742-44571920   c
            467-554             JAXUCZ010000015.1  44571264-44571351   c
            555-634             JAXUCZ010000015.1  44569241-44569320   c
            635-697             JAXUCZ010000015.1  44560576-44560638   c
            698-752             JAXUCZ010000015.1  44560339-44560393   c
            753-893             JAXUCZ010000015.1  44559788-44559928   c
            894-968             JAXUCZ010000015.1  44559468-44559542   c
            969-1070            JAXUCZ010000015.1  44558835-44558936   c
            1071-1188           JAXUCZ010000015.1  44557791-44557908   c
            1189-1228           JAXUCZ010000015.1  44557339-44557378   c
            1229-1275           JAXUCZ010000015.1  44556917-44556963   c
            1276-1326           JAXUCZ010000015.1  44556068-44556118   c
            1327-1424           JAXUCZ010000015.1  44555554-44555651   c
            1425-1509           JAXUCZ010000015.1  44554706-44554790   c
            1510-1610           JAXUCZ010000015.1  44554298-44554398   c
            1611-1726           JAXUCZ010000015.1  44553917-44554032   c
            1727-1827           JAXUCZ010000015.1  44552731-44552831   c
            1828-1917           JAXUCZ010000015.1  44552477-44552566   c
            1918-2122           JAXUCZ010000015.1  44551550-44551754   c
            2123-2231           JAXUCZ010000015.1  44549671-44549779   c
            2232-2297           JAXUCZ010000015.1  44548226-44548291   c
            2298-2423           JAXUCZ010000015.1  44546008-44546133   c
            2424-2570           JAXUCZ010000015.1  44541408-44541554   c
            2571-2606           JAXUCZ010000015.1  44541271-44541306   c
            2607-2631           JAXUCZ010000015.1  44540939-44540963   c
            2632-2678           JAXUCZ010000015.1  44539955-44540001   c
            2679-2816           JAXUCZ010000015.1  44539219-44539356   c
            2817-2897           JAXUCZ010000015.1  44538897-44538977   c
            2898-3848           JAXUCZ010000015.1  44536275-44537225   c
FEATURES             Location/Qualifiers
     source          1..3848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..3848
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /note="protein tyrosine kinase 2 beta"
                     /db_xref="GeneID:50646"
                     /db_xref="RGD:628758"
     exon            1..46
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            47..287
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..3113
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /EC_number="2.7.10.2"
                     /note="CADTK; FADK 2; focal adhesion kinase 2;
                     proline-rich tyrosine kinase 2; calcium-dependent tyrosine
                     kinase; CAK-beta; cell adhesion kinase beta; PTK2B protein
                     tyrosine kinase 2 beta; PTK2 protein tyrosine kinase 2
                     beta; calcium-regulated non-receptor proline-rich tyrosine
                     kinase"
                     /codon_start=1
                     /product="protein-tyrosine kinase 2-beta"
                     /protein_id="NP_059014.2"
                     /db_xref="GeneID:50646"
                     /db_xref="RGD:628758"
                     /translation="MSGVSEPLSRVKVGTLRPPEGPPEPMVVVPVDVEKEDVRILKVC
                     FYSNSFNPGKNFKLVKCTVQTEIQEIITSILLSGRIGPNIQLAECYGLRLKHMKSDEI
                     HWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRN
                     DYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQM
                     QENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNIT
                     VDLVIGPKGIRQLTSQDTKPTCLAEFKQIRSIRCLPLEETQAVLQLGIEGAPQSLSIK
                     TSSLAEAENMADLIDGYCRLQGEHKGSLIIHAKKDGEKRNSLPQIPTLNLESRRSHLS
                     ESCSIESDIYAEIPDETLRRPGGPQYGVAREDVVLNRILGEGFFGEVYEGVYTNHKGE
                     KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIVMELYPYG
                     ELGHYLERNKNSLKVPTLVLYALQICKAMAYLESINCVHRDIAVRNILVASPECVKLG
                     DFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQ
                     PFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDI
                     YQMERDIAIEQERNARYRPPKILEPTAFQEPPPKPSRPKYKHPPQTNLLAPKLQFQVP
                     EGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIRPSSREEAQQLWE
                     AEKIKMRQVLDRQQKQMVEDSQWLRREERCLDPMVYMNDKSPLTPEKEAGYTEFTGPP
                     QKPPRLGAQSIQPTANLDRTDDLVYHNVMTLVEAVLELKNKLSQLPPEEYVVVVKNVG
                     LNLRKLIGSVDDLLPSLPASSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEDC
                     KRQMLTASHTLAVDAKNLLDAVDQAKVVANLAHPPAE"
     exon            288..466
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..554
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..634
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..697
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..752
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..893
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..968
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1070
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1188
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1228
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1275
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1326
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1424
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1509
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1610
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1726
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1827
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1917
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2122
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2231
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2297
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2423
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2570
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2606
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2631
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2678
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2816
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2897
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3848
                     /gene="Ptk2b"
                     /gene_synonym="CAK beta; CAKB; CAKbeta; Pyk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcccagc ccggagccct ggcccgagtc cgcgcctcgc ccgagggact gcaatgtgct
       61 ggtcctagct gcagtctgag aggatgtccg gggtgtctga gcccctgagc cgtgtaaaag
      121 tgggcacttt gcgcccgccc gagggccccc cagagcccat ggtagtggta ccagtagacg
      181 tggagaagga agacgtgcgt atcctcaagg tctgcttcta cagcaacagc ttcaacccag
      241 ggaagaactt caagcttgtc aaatgcacag tgcagacaga gatccaggag atcatcacct
      301 ccatcctcct gagtgggcga atagggccca acatccagct ggctgaatgc tatgggctga
      361 ggctgaagca catgaagtca gatgagatcc actggctgca cccacagatg actgtgggcg
      421 aagtgcagga caagtatgaa tgtctacacg tggaggctga gtggaggtat gaccttcaaa
      481 tccgctattt gccagaagac ttcatggaga gcctgaaaga agacaggact acactgctgt
      541 acttttatca acagctccgg aatgactaca tgcaacgcta tgccagcaag gtcagtgaag
      601 gcatggctct gcagctgggc tgtctggagc tcaggagatt cttcaaggac atgccccaca
      661 atgcacttga caaaaagtcc aactttgaac tcctggaaaa agaagtcggt ctggacctgt
      721 ttttcccaaa gcaaatgcag gaaaacttaa agcccaagca gttccggaag atgatccagc
      781 agaccttcca gcagtatgca tcactccggg aggaagagtg tgtcatgaaa ttcttcaata
      841 ctctggcagg ctttgccaac atcgaccagg agacctatcg ctgtgaactc attcaagggt
      901 ggaacattac tgtggacctg gtcattggcc ctaaaggcat ccgtcagctg acaagtcaag
      961 acacaaagcc cacctgcctc gccgagttca agcagatcag atccatcagg tgcctcccct
     1021 tggaagagac ccaggcagta ctgcagctgg gcatcgaggg tgccccccag tccttgtcca
     1081 tcaaaacctc gtccctggca gaggctgaga acatggctga cctcatagat ggctactgca
     1141 ggcttcaagg agagcataaa ggctctctca tcattcatgc caagaaagat ggtgagaaga
     1201 ggaacagcct gcctcagatc cccacactaa acctggagtc tcggcggtcc cacctctcag
     1261 aaagctgtag catagagtca gacatctatg cagagattcc tgatgagacc ctgcgaaggc
     1321 caggaggccc acagtatggt gttgcccgtg aagatgtagt tcttaaccgc attctgggtg
     1381 aaggcttctt cggggaggtc tacgaaggtg tctacacgaa ccataaaggg gaaaaaatta
     1441 atgtggccgt caagacctgt aagaaagatt gtaccctgga caacaaggag aagttcatga
     1501 gtgaggcagt gatcatgaag aatcttgacc accctcacat cgtcaagctg attggcatca
     1561 ttgaagagga acccacatgg atcgtcatgg aactgtatcc ttatggggag ctgggacact
     1621 acctggagcg aaataaaaat tccctgaagg tacccactct ggtcctgtac gctctgcaga
     1681 tatgcaaagc catggcctat ctggagagca tcaactgtgt ccacagggat attgctgtcc
     1741 ggaacatcct ggtggcctct cctgagtgtg tgaagctcgg ggactttggg ctctcccggt
     1801 acattgagga tgaggactat tacaaagctt ccgtgacccg tctccccatc aaatggatgt
     1861 cccccgagtc catcaacttt cgccgcttta caaccgccag tgacgtctgg atgtttgctg
     1921 tatgcatgtg ggagatcctc agctttggga agcagccttt cttctggctt gaaaacaagg
     1981 atgtcatcgg ggtgctggag aaaggggaca ggctgcctaa gcccgaactc tgcccgcctg
     2041 tcctttacac actcatgacc cgctgctggg actatgaccc cagcgaccgg ccccgcttta
     2101 cggagcttgt gtgcagtctc agtgacattt atcagatgga gagggacatt gcaatagaac
     2161 aagaaaggaa cgctcgttac cgacccccca aaatattgga gcccactgct tttcaggaac
     2221 ccccacccaa gcccagccgg cccaagtaca aacaccctcc acagaccaat ctgctggctc
     2281 ctaagctgca gttccaggtc cctgagggtc tgtgtgccag ctctcctaca cttacgagcc
     2341 ctatggagta tccatctcca gttaactcgc tgcacacccc gcctctgcac cgacacaatg
     2401 tcttcaagcg ccacagcatg cgggaggagg acttcatccg gcccagtagt cgagaagagg
     2461 cccagcagct ctgggaggca gagaagatca agatgaggca ggtcctagac agacagcaga
     2521 agcaaatggt ggaagattcc cagtggctga ggcgggagga aagatgcttg gacccgatgg
     2581 tttatatgaa tgacaagtcc ccactgaccc cagagaagga ggccggctac acggagttca
     2641 cagggccccc ccagaagcca ccacggctcg gtgcacagtc catccagcct acagccaact
     2701 tggacaggac tgatgacctc gtgtaccaca atgtcatgac cctggtggag gccgtgctgg
     2761 aactcaagaa caagctcagc cagctgcctc ctgaggagta tgtggtggtg gtgaagaatg
     2821 tggggctgaa cctgcggaag ctcatcggta gcgtggacga tctcctaccc tccttgccag
     2881 catcttctag aacagagatt gaagggaccc agaaactgct caacaaagac ctggcagagc
     2941 tcatcaacaa gatgaggttg gctcagcaga acgctgtgac atccctaagt gaggactgca
     3001 agcggcagat gctcacagca tcccataccc tggctgtgga tgccaagaac ctcctggatg
     3061 ctgtagacca agccaaggtt gtggctaatc tggcccaccc gcctgcagag tgatcaaggg
     3121 agggaccacc tgcctgcatc ttctgcccca acctttcctg ccttgccttt ggttattggt
     3181 cttctaggga aagctgagaa gagtcctccc cttaccactt tgcacgaccc ccctttcccc
     3241 aacccacccc agactgtgct acttgggcta catctggaca gaaaggactc tgggcacaga
     3301 cacggggtgg ggtgacatag ttcatagggg tacttctgcc agccattccc tcctacccca
     3361 gcctgggttg ctggagcatc attggggtca taactgtacc cctaccagcc aagatggctt
     3421 tctgcatgga catttgagag ccagtatttc tgtcctcttt agccctcagg gacccctgat
     3481 acagagggga cagagagggg ttttatttgt agagaagctg gtgagatgag agctgggcat
     3541 ggctctcttg tacagtgtac attggaattt atttaatgtg agtttggcct ggacagacag
     3601 ccatgggcca cagtccagga acaagctaat ccagccacag ggaagaagca gagtcagggg
     3661 tcagaatggg acttcatgtc ctccctgcgt ttctcttctc cctctttcct cctcccctct
     3721 tttcttagtc ctcctttttc tcttccccct tttcacatct gttcctttcc tctctcacat
     3781 ttgtggagaa catccattta ccttttctct ttttgatctg tggttgaatt aaaatcatta
     3841 gcattcgc
//
