LOCUS       XM_039078472            5864 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus protein tyrosine kinase 2 (Ptk2),
            transcript variant X2, mRNA.
ACCESSION   XM_039078472
VERSION     XM_039078472.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051342.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5864
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5864
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /note="protein tyrosine kinase 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 46 ESTs, 5 long SRA reads, 16 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 10 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:25614"
                     /db_xref="RGD:3443"
     CDS             1500..4922
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /codon_start=1
                     /product="focal adhesion kinase 1 isoform X1"
                     /protein_id="XP_038934400.1"
                     /db_xref="GeneID:25614"
                     /db_xref="RGD:3443"
                     /translation="MLLERAGQEALRSTGAVYMEKSGCSPFPVCWAKEYDRYLASSKR
                     MAAAYLDPNLNHTPSSSTKTHLGTGTERSPGAMERVLKVFHYFESSNEPTTWASIIRH
                     GDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHP
                     PEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQDIALKLGCL
                     EIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFA
                     NLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNP
                     THLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYC
                     RLVNGATQSFIIRPQKEGERALPSIPKLANNEKQGMRTHAVSVSGINHCQHKVKKARR
                     FLPLVFCSLEPPPTDEISGDETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIE
                     LGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHP
                     HIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLES
                     KRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFR
                     RFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLM
                     TKCWAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPP
                     KPSRPGYPSPRSSEGFYPSPQHMVQTNHYQISGYPGSHGIPAMAGSIYPGQASLLDQT
                     ELWNHRPQEMSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKE
                     ERFLKPDVRLSRGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSN
                     LSSISSPAESYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKI
                     QPAPPEEYVPMVKEVGLALRTLLATVDETIPILPASTHREIEMAQKLLNSDLGELISK
                     MKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH"
ORIGIN      
        1 ggcgcggcgg ggacccggag gcccaaaagc cgaaaaacaa aagaggtggc aggcggagtg
       61 ccgagcagcc gcggggtggc cggcgcgggg cttccagtgc gagcgcacga acccgggagt
      121 cattgtgctg tccaagttcc ctccgccccg acccagcccc gccacggcgc gctgcctgtc
      181 cccgccggtc ctcgccggct gcttttgtgg caccgctctg aggagtgagg gtgtctgtgt
      241 gcgcacttgt gtcggttaat tgtaaggttt ttgcggagaa attcactgag gagaaagttg
      301 ctctttttga aagctatttc aacagtgtct cattcttgca tagttagact gcagctgggt
      361 gtttggcagt gggaccaaga taatagcaat actgtaatga ttatgggaac tggttgaaat
      421 aggttggagc tgaaggcaca gcaagagttt gcgggttcgt tttaaatcct gaccagtgct
      481 ggcatttcta tttaggatga aagctttatc gtggttgtgg ttataggtta ttactacttg
      541 tagtgaaata ccagcgcctc acagtctctg tctatctgtg tgtgtgtgtg tgtgtgtgtc
      601 agtgtgggtg tatatttata aaaggaggaa tgaaaagtct cctttgaaag acaggtctct
      661 ctgagcagtg acctgggaca gaagtattgt gaatgcagac gttaaacgag gtagttcata
      721 tagcattagc attctacgta tttttgtgga ggtacactat agataatatt tccattcagt
      781 gatactgttg agtttcatgt agtatttaag tatttaaaca tgaacttttt tttcctgggg
      841 atgaaaccca cggcttccca cgtggttagt gctgggccac aaagccacgc ccccagtctt
      901 aacaggaaac tttaagggac gtggacatga ttcccaatat cattatcaat ttagttgttt
      961 tatatttgtg gctgtcgtag gcgggctgat ccctggcctc ctttctagac acttgagctt
     1021 attaaaaggc tataggagta cattttcctg gaaagaattt tattaggaac attgacgtat
     1081 aatctaactt attcgtgatt tacagacaaa ggtggtctct gtttgggggg cgcccacaag
     1141 tcacagcttt taggattgtg tggattatac agagatgatg cgtggacagg tctctgggct
     1201 acaatgaaaa gaggaaacag atactaggat attttttaag acagctgttt gatttcttct
     1261 caaaatcact gctgccttct gagctatttc ggaagcagaa gattcagtaa ctgagaggcc
     1321 accgtggagc tgctggaaac tgttacagaa ggagcacctc tcaaaccgtg cttcaggctc
     1381 tgaaaaaaag gagcacaggg gaagcttagt cttgctttgg atccaagcaa atgctgtcgg
     1441 agcgatgaac tgggactttg tgtgcggact cctggcttga tcttgatagg attgggtgta
     1501 tgttgttgga acgggcaggc caagaggccc tgagatctac aggtgccgtc tatatggaga
     1561 aaagcggctg tagtccattt ccagtgtgtt gggctaaaga atatgacaga tacctagcat
     1621 ctagcaaaag aatggcagct gcttatcttg acccaaactt gaatcacaca ccaagttcga
     1681 gtactaagac tcacctgggt actggcacgg aacggtcccc tggtgcaatg gaacgagtat
     1741 taaaggtctt tcattatttt gaaagcagta atgagccaac cacctgggcc agtattatca
     1801 ggcatggaga cgctactgac gtcaggggaa tcattcagaa gatagtggac agtcacaaag
     1861 taaagcacgt ggcctgctat ggatttcgcc tcagtcacct gcgatcggag gaggtgcact
     1921 ggctgcatgt ggacatgggt gtctccagtg tgagggagaa atacgaactc gcccacccac
     1981 cagaggagtg gaaatatgag ttgagaattc gttatttgcc aaaaggattt ctaaaccagt
     2041 ttactgaaga taagccaaca ttgaatttct tctatcaaca ggtgaagagt gactacatgc
     2101 tagaaatagc tgatcaagta gaccaagaca tagctttgaa gttgggttgt ttggaaatta
     2161 ggcgatccta ctgggagatg aggggcaacg ccctagagaa gaagtccaac tatgaagtgt
     2221 tagagaaaga tgttggttta aagcgatttt ttcccaagag tttactggat tccgtcaagg
     2281 ccaaaacact aagaaagctg atccagcaaa cattcaggca gtttgccaac cttaatagag
     2341 aagaaagcat cctgaaattc tttgagattc tctctccagt gtacagattt gacaaagagt
     2401 gcttcaagtg tgcccttggg tcaagttgga ttatttctgt ggaactggcg atcggcccag
     2461 aagaagggat cagttacctg acagacaagg gctgcaatcc cacacaccta gcggacttca
     2521 accaagtgca gactatccag tactcaaaca gtgaagacaa agacaggaaa ggaatgctac
     2581 aactcaaaat cgctggtgct cctgagcctc tgacagtgac ggccccatcc ctaaccattg
     2641 cagagaacat ggctgacctg atcgatggat actgccggct ggtgaacgga gccacgcagt
     2701 ccttcatcat cagaccccag aaagaaggtg aacgggcatt gccatcaata ccaaagttgg
     2761 ccaacaatga aaagcaaggc atgcggacac atgcagtctc tgtgtcaggg atcaatcact
     2821 gccaacataa agttaagaaa gctaggcgct ttctcccttt ggtcttctgt tctcttgaac
     2881 ctcctccaac ggatgaaatt agtggggacg agacagatga ctatgccgag atcatcgatg
     2941 aggaagacac atacaccatg ccctcaaaaa gctatggaat agatgaagcc agggattatg
     3001 agattcagag agaaagaata gaacttggac gctgtattgg agaaggccag tttggagatg
     3061 tacatcaagg cgtgtacctg agcccagaga atccagcttt ggctgttgca atcaaaacat
     3121 gtaaaaactg tacttcggac agcgtgagag agaagttcct tcaagaagcc ttaacaatgc
     3181 gccagtttga ccatcctcac atcgtgaagc tgattggagt cattacagag aacccagttt
     3241 ggataatcat ggagttgtgc acacttggag agctgaggtc atttttgcaa gtaaggaaat
     3301 acagcttgga tctagcatct ttgatcttat atgcctatca gcttagtaca gcactcgcgt
     3361 atctggagag caaaagattt gttcacaggg acattgctgc acggaatgtt ctggtgtctt
     3421 caaatgattg tgtaaaatta ggagactttg gattatctcg atatatggaa gacagtactt
     3481 actataaagc ttccaaagga aaattaccta ttaaatggat ggctccagag tcaatcaatt
     3541 ttcgacgttt tacctcagct agtgacgtgt ggatgtttgg tgtgtgtatg tgggagatac
     3601 tgatgcatgg cgtgaagcct tttcaaggag tgaagaacaa tgatgtgatc ggtcgaattg
     3661 aaaatgggga aagattacca atgcctccaa attgtcctcc caccctctac agccttatga
     3721 cgaaatgttg ggcctatgac cccagcagac ggcccaggtt tactgaacta aaagctcagc
     3781 tcagcacaat cctggaggaa gagaaggtgc agcaagaaga acggatgagg atggaatcca
     3841 gaagacaggc aacagtgtcc tgggactctg gagggtctga tgaagcacca cccaagccca
     3901 gcagacctgg ttatcctagc ccgaggtcca gtgaaggatt ttatcccagc ccacagcaca
     3961 tggtccagac caatcactat cagatctctg gctacccagg ttcccatgga atcccagcca
     4021 tggctggcag catttaccca ggtcaggcat ctcttctgga ccagacagaa ttgtggaatc
     4081 acagacctca ggagatgtcc atgtggcagc ccagtgtgga ggactcagca gctttagatc
     4141 ttcgagggat gggacaggtg cttcctcctc acctgatgga agagcggcta atccgacagc
     4201 agcaggaaat ggaggaagac cagcgctggc tggaaaagga agagcgattc ctgaaacctg
     4261 atgtgaggct ctctcgaggc agcatcgaca gggaggacgg gagttttcag ggtccgactg
     4321 gaaaccaaca catctatcag cctgtgggaa aaccagatcc tgcagctcca ccaaagaaac
     4381 cacctcgccc tggagcacct ggccacctaa gcaacttgtc cagcatcagc agccctgcag
     4441 aaagctacaa tgagggtgtc aagccgtgga ggcttcagcc ccaggaaatc agcccccctc
     4501 ccactgccaa ccttgaccga tccaatgaca aggtatatga aaatgtgacg ggcctagtga
     4561 aggctgtcat tgagatgtcc agcaaaatcc aaccagctcc tccagaagag tacgtcccta
     4621 tggtgaagga agttggcctg gccctgcgga ccttactggc cactgtggat gagaccattc
     4681 ccatccttcc agccagcacc catcgagaga tcgagatggc acagaagctg ctgaactccg
     4741 acttgggtga gctcatcagc aagatgaagc tggcgcagca gtatgtcatg accagccttc
     4801 agcaggagta caagaagcag atgctgacag ctgctcacgc cctggctgtg gatgccaaga
     4861 atctacttga tgttattgat caagcgagac tgaaaatgct agggcagaca cggccacact
     4921 gagccactgg ccattgaaca tggctttctg ccctttggga gatcttctct agcattccac
     4981 cagcagcgag gaagtaacct tgtcctcggt cgcccgcact cacagctcca actgatgaca
     5041 gctagctgaa agtctctctt gtataagttt aactacttat acatggtttt gattctgtta
     5101 tttttctaaa tagtgttcag aaaactctgg atccaaaatg tggcattttt ctgagaatga
     5161 agattgtaca ttaagaagct tttaaaatat acttggtgtt caaattggga tgtatgttcc
     5221 tagaagtggt aattcatact gaccatgact tcgaattgga agagaagtgt ctgaggaggg
     5281 agggctccca agacactgag actggctatc cttcctgcca gaattcctgt ccagactgaa
     5341 ttgcaatatg ctaatctcat ttatagagaa agtgcataaa agctatattt tgaagaatga
     5401 gtggtttcaa aagaaaactt ctgccctccc tgtcttcacc ttctttcctg tggatcctga
     5461 agcattgggt tgcaaactat ctctagaact gacaaaaact tgtctttcct cctcagaatt
     5521 ctgtgccagt tttgtaccag agcactccca actgcatcaa gaagttccag gaccatccct
     5581 gttctccatt tttatataat ttataagaat gattaaagcc atgttgactc ttacagccac
     5641 tggagctaac tgatcttcat tgcgtctgtc ttcccaggga ggatcccgca ggacaaacag
     5701 ggatgtggtt ttctttagat gtccagttgt tacaccatgc attctgttag gtggttttga
     5761 gagcatacct tccctttagt ttgttgggga tataaattat tctcaggaag aatataataa
     5821 attgtacagt tactctgacc tattaaaaag gtggcgccag gaaa
//
