LOCUS       NM_013081               4559 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein tyrosine kinase 2 (Ptk2), mRNA.
ACCESSION   NM_013081
VERSION     NM_013081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4559)
  AUTHORS   de Oliveira Neves,V.G., Blascke de Mello,M.M., Rodrigues,D.,
            Pernomian,L., de Oliveira,I.S., Parente,J.M., Arantes,E.C.,
            Tostes,R.C. and Castro,M.M.
  TITLE     Type I collagen proteolysis by matrix metalloproteinase-2
            contributes to focal adhesion kinase activation and vascular smooth
            muscle cell proliferation in the aorta in early hypertension
  JOURNAL   Vascul Pharmacol 152, 107211 (2023)
   PUBMED   37607602
  REMARK    GeneRIF: Type I collagen proteolysis by matrix metalloproteinase-2
            contributes to focal adhesion kinase activation and vascular smooth
            muscle cell proliferation in the aorta in early hypertension.
REFERENCE   2  (bases 1 to 4559)
  AUTHORS   Chen,B., Wu,P., Liang,L., Zhao,C., Wang,Z., He,L., Zhang,R. and
            Xu,N.
  TITLE     Inhibited effect of an RGD peptide hydrogel on the expression of
            beta1-integrin, FAK, and Akt in Tenon's capsule fibroblasts
  JOURNAL   J Biomed Mater Res B Appl Biomater 109 (11), 1857-1865 (2021)
   PUBMED   33847460
  REMARK    GeneRIF: Inhibited effect of an RGD peptide hydrogel on the
            expression of beta1-integrin, FAK, and Akt in Tenon's capsule
            fibroblasts.
REFERENCE   3  (bases 1 to 4559)
  AUTHORS   Shangguan,Y., Wu,Z., Xie,X., Zhou,S., He,H., Xiao,H., Liu,L.,
            Zhu,J., Chen,H., Han,H., Wang,H. and Chen,L.
  TITLE     Low-activity programming of the PDGFRbeta/FAK pathway mediates
            H-type vessel dysplasia and high susceptibility to osteoporosis in
            female offspring rats after prenatal dexamethasone exposure
  JOURNAL   Biochem Pharmacol 185, 114414 (2021)
   PUBMED   33434537
  REMARK    GeneRIF: Low-activity programming of the PDGFRbeta/FAK pathway
            mediates H-type vessel dysplasia and high susceptibility to
            osteoporosis in female offspring rats after prenatal dexamethasone
            exposure.
REFERENCE   4  (bases 1 to 4559)
  AUTHORS   Garcia-Keller,C., Scofield,M.D., Neuhofer,D., Varanasi,S.,
            Reeves,M.T., Hughes,B., Anderson,E., Richie,C.T., Mejias-Aponte,C.,
            Pickel,J., Hope,B.T., Harvey,B.K., Cowan,C.W. and Kalivas,P.W.
  TITLE     Relapse-Associated Transient Synaptic Potentiation Requires
            Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin
            in D1-Expressing Neurons
  JOURNAL   J Neurosci 40 (44), 8463-8477 (2020)
   PUBMED   33051346
  REMARK    GeneRIF: Relapse-Associated Transient Synaptic Potentiation
            Requires Integrin-Mediated Activation of Focal Adhesion Kinase and
            Cofilin in D1-Expressing Neurons.
REFERENCE   5  (bases 1 to 4559)
  AUTHORS   Ramaniuk,O., Klimova,Z., Grousl,T. and Vomastek,T.
  TITLE     Quantitative Phase Imaging of Spreading Fibroblasts Identifies the
            Role of Focal Adhesion Kinase in the Stabilization of the Cell Rear
  JOURNAL   Biomolecules 10 (8), 1089 (2020)
   PUBMED   32707896
  REMARK    GeneRIF: Quantitative Phase Imaging of Spreading Fibroblasts
            Identifies the Role of Focal Adhesion Kinase in the Stabilization
            of the Cell Rear.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4559)
  AUTHORS   Judson,P.L., He,X., Cance,W.G. and Van Le,L.
  TITLE     Overexpression of focal adhesion kinase, a protein tyrosine kinase,
            in ovarian carcinoma
  JOURNAL   Cancer 86 (8), 1551-1556 (1999)
   PUBMED   10526262
REFERENCE   7  (bases 1 to 4559)
  AUTHORS   Derkinderen,P., Toutant,M., Burgaya,F., Le Bert,M., Siciliano,J.C.,
            de Franciscis,V., Gelman,M. and Girault,J.A.
  TITLE     Regulation of a neuronal form of focal adhesion kinase by
            anandamide
  JOURNAL   Science 273 (5282), 1719-1722 (1996)
   PUBMED   8781236
REFERENCE   8  (bases 1 to 4559)
  AUTHORS   Burgaya,F. and Girault,J.A.
  TITLE     Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals
            multiple transcripts with different patterns of expression
  JOURNAL   Brain Res Mol Brain Res 37 (1-2), 63-73 (1996)
   PUBMED   8738136
REFERENCE   9  (bases 1 to 4559)
  AUTHORS   Calalb,M.B., Polte,T.R. and Hanks,S.K.
  TITLE     Tyrosine phosphorylation of focal adhesion kinase at sites in the
            catalytic domain regulates kinase activity: a role for Src family
            kinases
  JOURNAL   Mol Cell Biol 15 (2), 954-963 (1995)
   PUBMED   7529876
REFERENCE   10 (bases 1 to 4559)
  AUTHORS   Russell,J.C., Koeslag,D.G., Manickavel,V., Amy,R.M. and
            Dolphin,P.J.
  TITLE     Effects of advancing age and severe food restriction on
            pathological processes in the insulin resistant JCR:LA-corpulent
            rat
  JOURNAL   Diabetes Res 15 (2), 53-62 (1990)
   PUBMED   2132399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1, AF020777.1, EV773243.1, U43942.1, CB713440.1,
            CA511845.1, CA508631.1 and AI717382.1.
            
            On Jul 31, 2012 this sequence version replaced NM_013081.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF020777.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               JAXUCZ010000007.1  107171761-107172091 c
            332-1076            AF020777.1         331-1075
            1077-1689           EV773243.1         172-784
            1690-2013           U43942.1           214-537
            2014-3338           AF020777.1         2013-3337
            3339-3785           CB713440.1         48-494
            3786-4164           CA511845.1         278-656
            4165-4542           CA508631.1         16-393              c
            4543-4559           AI717382.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..4559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4559
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /note="protein tyrosine kinase 2"
                     /db_xref="GeneID:25614"
                     /db_xref="RGD:3443"
     exon            1..400
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            401..627
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..3600
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /EC_number="2.7.10.2"
                     /note="FADK 1; pp125FAK; focal adhesion kinase-related
                     nonkinase; PTK2 protein tyrosine kinase 2"
                     /codon_start=1
                     /product="focal adhesion kinase 1"
                     /protein_id="NP_037213.1"
                     /db_xref="GeneID:25614"
                     /db_xref="RGD:3443"
                     /translation="MAAAYLDPNLNHTPSSSTKTHLGTGTERSPGAMERVLKVFHYFE
                     SSNEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDM
                     GVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIA
                     DQVDQDIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAK
                     TLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGP
                     EEGISYLTDKGCNPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSL
                     TIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANNEKQGMRTHAVSVS
                     ETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALA
                     VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELR
                     SFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFG
                     LSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQ
                     GVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEE
                     EKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTN
                     HYQISGYPGSHGIPAMAGSIYPGQASLLDQTELWNHRPQEMSMWQPSVEDSAALDLRG
                     MGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSFQGPTG
                     NQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPAESYNEGVKPWRLQPQEISP
                     PPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD
                     ETIPILPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAHAL
                     AVDAKNLLDVIDQARLKMLGQTRPH"
     exon            628..794
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            795..882
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            883..962
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1025
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1080
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1221
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1299
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1407
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1525
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1556
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1609
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1666
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1764
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1849
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1950
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2066
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2167
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2257
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2462
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2574
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2661
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2799
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2931
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..2994
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3034
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3141
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3150
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3306
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3387
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..4542
                     /gene="Ptk2"
                     /gene_synonym="FAK; FRNK; p125FAK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taggaaccca gatccatggg gtctcatgac tagctggttt tatcctgttc attggcttaa
       61 tctggccagg acggtctgtg tttcagattt cggaagcaga agattcagta actgagaggc
      121 caccgtggag ctgctggaaa ctgttacaga aggagcacct ctcaaaccgt gcttcaggct
      181 ctgaaaaaaa ggagcacagg ggaagcttag tcttgctttg gatccaagca aatgctgtcg
      241 gagcgatgaa ctgggacttt gtgtgcggac tcctggcttg atcttgatag gattgggtgt
      301 atgttgttgg aacgggcagg ccaagaggcc ctgagatcta caggtgccgt ctatatggag
      361 aaaagcggct gtagtccatt tccagtgtgt tgggctaaag aatatgacag atacctagca
      421 tctagcaaaa gaatggcagc tgcttatctt gacccaaact tgaatcacac accaagttcg
      481 agtactaaga ctcacctggg tactggcacg gaacggtccc ctggtgcaat ggaacgagta
      541 ttaaaggtct ttcattattt tgaaagcagt aatgagccaa ccacctgggc cagtattatc
      601 aggcatggag acgctactga cgtcagggga atcattcaga agatagtgga cagtcacaaa
      661 gtaaagcacg tggcctgcta tggatttcgc ctcagtcacc tgcgatcgga ggaggtgcac
      721 tggctgcatg tggacatggg tgtctccagt gtgagggaga aatacgaact cgcccaccca
      781 ccagaggagt ggaaatatga gttgagaatt cgttatttgc caaaaggatt tctaaaccag
      841 tttactgaag ataagccaac attgaatttc ttctatcaac aggtgaagag tgactacatg
      901 ctagaaatag ctgatcaagt agaccaagac atagctttga agttgggttg tttggaaatt
      961 aggcgatcct actgggagat gaggggcaac gccctagaga agaagtccaa ctatgaagtg
     1021 ttagagaaag atgttggttt aaagcgattt tttcccaaga gtttactgga ttccgtcaag
     1081 gccaaaacac taagaaagct gatccagcaa acattcaggc agtttgccaa ccttaataga
     1141 gaagaaagca tcctgaaatt ctttgagatt ctctctccag tgtacagatt tgacaaagag
     1201 tgcttcaagt gtgcccttgg gtcaagttgg attatttctg tggaactggc gatcggccca
     1261 gaagaaggga tcagttacct gacagacaag ggctgcaatc ccacacacct agcggacttc
     1321 aaccaagtgc agactatcca gtactcaaac agtgaagaca aagacaggaa aggaatgcta
     1381 caactcaaaa tcgctggtgc tcctgagcct ctgacagtga cggccccatc cctaaccatt
     1441 gcagagaaca tggctgacct gatcgatgga tactgccggc tggtgaacgg agccacgcag
     1501 tccttcatca tcagacccca gaaagaaggt gaacgggcat tgccatcaat accaaagttg
     1561 gccaacaatg aaaagcaagg catgcggaca catgcagtct ctgtgtcaga gacagatgac
     1621 tatgccgaga tcatcgatga ggaagacaca tacaccatgc cctcaaccag ggattatgag
     1681 attcagagag aaagaataga acttggacgc tgtattggag aaggccagtt tggagatgta
     1741 catcaaggcg tgtacctgag cccagagaat ccagctttgg ctgttgcaat caaaacatgt
     1801 aaaaactgta cttcggacag cgtgagagag aagttccttc aagaagcctt aacaatgcgc
     1861 cagtttgacc atcctcacat cgtgaagctg attggagtca ttacagagaa cccagtttgg
     1921 ataatcatgg agttgtgcac acttggagag ctgaggtcat ttttgcaagt aaggaaatac
     1981 agcttggatc tagcatcttt gatcttatat gcctatcagc ttagtacagc actcgcgtat
     2041 ctggagagca aaagatttgt tcacagggac attgctgcac ggaatgttct ggtgtcttca
     2101 aatgattgtg taaaattagg agactttgga ttatctcgat atatggaaga cagtacttac
     2161 tataaagctt ccaaaggaaa attacctatt aaatggatgg ctccagagtc aatcaatttt
     2221 cgacgtttta cctcagctag tgacgtgtgg atgtttggtg tgtgtatgtg ggagatactg
     2281 atgcatggcg tgaagccttt tcaaggagtg aagaacaatg atgtgatcgg tcgaattgaa
     2341 aatggggaaa gattaccaat gcctccaaat tgtcctccca ccctctacag ccttatgacg
     2401 aaatgttggg cctatgaccc cagcagacgg cccaggttta ctgaactaaa agctcagctc
     2461 agcacaatcc tggaggaaga gaaggtgcag caagaagaac ggatgaggat ggaatccaga
     2521 agacaggcaa cagtgtcctg ggactctgga gggtctgatg aagcaccacc caagcccagc
     2581 agacctggtt atcctagccc gaggtccagt gaaggatttt atcccagccc acagcacatg
     2641 gtccagacca atcactatca gatctctggc tacccaggtt cccatggaat cccagccatg
     2701 gctggcagca tttacccagg tcaggcatct cttctggacc agacagaatt gtggaatcac
     2761 agacctcagg agatgtccat gtggcagccc agtgtggagg actcagcagc tttagatctt
     2821 cgagggatgg gacaggtgct tcctcctcac ctgatggaag agcggctaat ccgacagcag
     2881 caggaaatgg aggaagacca gcgctggctg gaaaaggaag agcgattcct gaaacctgat
     2941 gtgaggctct ctcgaggcag catcgacagg gaggacggga gttttcaggg tccgactgga
     3001 aaccaacaca tctatcagcc tgtgggaaaa ccagatcctg cagctccacc aaagaaacca
     3061 cctcgccctg gagcacctgg ccacctaagc aacttgtcca gcatcagcag ccctgcagaa
     3121 agctacaatg agggtgtcaa gccgtggagg cttcagcccc aggaaatcag cccccctccc
     3181 actgccaacc ttgaccgatc caatgacaag gtatatgaaa atgtgacggg cctagtgaag
     3241 gctgtcattg agatgtccag caaaatccaa ccagctcctc cagaagagta cgtccctatg
     3301 gtgaaggaag ttggcctggc cctgcggacc ttactggcca ctgtggatga gaccattccc
     3361 atccttccag ccagcaccca tcgagagatc gagatggcac agaagctgct gaactccgac
     3421 ttgggtgagc tcatcagcaa gatgaagctg gcgcagcagt atgtcatgac cagccttcag
     3481 caggagtaca agaagcagat gctgacagct gctcacgccc tggctgtgga tgccaagaat
     3541 ctacttgatg ttattgatca agcgagactg aaaatgctag ggcagacacg gccacactga
     3601 gccactggcc attgaacatg gctttctgcc ctttgggaga tcttctctag cattccacca
     3661 gcagcgagga agtaaccttg tcctcggtcg cccgcactca cagctccaac tgatgacagc
     3721 tagctgaaag tctctcttgt ataagtttaa ctacttatac atggttttga ttctgttatt
     3781 tttctaaata gtgttcagaa aactctggat ccaaaatgtg gcatttttct gagaatgaag
     3841 attgtacatt aagaagcttt taaaatatac ttggtgttca aattgggatg tatgttccta
     3901 gaagtggtaa ttcatactga ccatgacttc gaattggaag agaagtgtct gaggagggag
     3961 ggctcccaag acactgagac tggctatcct tcctgccaga attcctgtcc agactgaatt
     4021 gcaatatgct aatctcattt atagagaaag tgcataaaag ctatattttg aagaatgagt
     4081 ggtttcaaaa gaaaacttct gccctccctg tcttcacctt ctttcctgtg gatcctgaag
     4141 cattgggttg caaactatct ctagaactga caaaaacttg tctttcctcc tcagaattct
     4201 gtgccagttt tgtaccagag cactcccaac tgcatcaaga agttccagga ccatccctgt
     4261 tctccatttt tatataattt ataagaatga ttaaagccat gttgactctt acagccactg
     4321 gagctaactg atcttcattg cgtctgtctt cccagggagg atcccgcagg acaaacaggg
     4381 atgtggtttt ctttagatgt ccagttgtta caccatgcat tctgttaggt ggttttgaga
     4441 gcataccttc cctttagttt gttggggata taaattattc tcaggaagaa tataataaat
     4501 tgtacagtta ctctgaccta ttaaaaaggt ggcgccagga aaaaaaaaaa aaaaaaaaa
//
