LOCUS       NM_031089               2542 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus parathyroid hormone 2 receptor (Pth2r), mRNA.
ACCESSION   NM_031089
VERSION     NM_031089.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Dimitrov,E.L., Kim,Y.Y. and Usdin,T.B.
  TITLE     Regulation of hypothalamic signaling by tuberoinfundibular peptide
            of 39 residues is critical for the response to cold: a novel
            peptidergic mechanism of thermoregulation
  JOURNAL   J Neurosci 31 (49), 18166-18179 (2011)
   PUBMED   22159128
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Ross,G., Engel,P., Abdallah,Y., Kummer,W. and Schluter,K.D.
  TITLE     Tuberoinfundibular peptide of 39 residues: a new mediator of
            cardiac function via nitric oxide production in the rat heart
  JOURNAL   Endocrinology 146 (5), 2221-2228 (2005)
   PUBMED   15677763
  REMARK    GeneRIF: results suggest that an inhibition of endogenous nitric
            oxide production unmasks a profound negative inotropic effect of
            tuberoinfundibular peptide (TIP39) that is mediated by an
            activation of the parathyroid hormone receptor 2
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Bisello,A., Manen,D., Pierroz,D.D., Usdin,T.B., Rizzoli,R. and
            Ferrari,S.L.
  TITLE     Agonist-specific regulation of parathyroid hormone (PTH) receptor
            type 2 activity: structural and functional analysis of PTH- and
            tuberoinfundibular peptide (TIP) 39-stimulated desensitization and
            internalization
  JOURNAL   Mol Endocrinol 18 (6), 1486-1498 (2004)
   PUBMED   14988434
  REMARK    GeneRIF: specific interactions within the ligand-receptor
            bimolecular complex mediate distinct postactivation responses of
            class II G protein- coupled receptors and provide novel insights
            into the physiological regulation of PTH2R activity
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Eichinger,A., Fiaschi-Taesch,N., Massfelder,T., Fritsch,S.,
            Barthelmebs,M. and Helwig,J.J.
  TITLE     Transcript expression of the tuberoinfundibular peptide
            (TIP)39/PTH2 receptor system and non-PTH1 receptor-mediated tonic
            effects of TIP39 and other PTH2 receptor ligands in renal vessels
  JOURNAL   Endocrinology 143 (8), 3036-3043 (2002)
   PUBMED   12130570
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Goold,C.P., Usdin,T.B. and Hoare,S.R.
  TITLE     Regions in rat and human parathyroid hormone (PTH) 2 receptors
            controlling receptor interaction with PTH and with antagonist
            ligands
  JOURNAL   J Pharmacol Exp Ther 299 (2), 678-690 (2001)
   PUBMED   11602681
REFERENCE   6  (bases 1 to 2542)
  AUTHORS   Usdin,T.B., Bonner,T.I., Harta,G. and Mezey,E.
  TITLE     Distribution of parathyroid hormone-2 receptor messenger
            ribonucleic acid in rat
  JOURNAL   Endocrinology 137 (10), 4285-4297 (1996)
   PUBMED   8828488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000009.1.
            
            On Jun 2, 2021 this sequence version replaced NM_031089.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U55836.1, SRR26360194.1404278.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984027, SAMN16418971
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000009.1  74199785-74200076
            293-395             JAXUCZ010000009.1  74210489-74210591
            396-506             JAXUCZ010000009.1  74227482-74227592
            507-622             JAXUCZ010000009.1  74227707-74227822
            623-720             JAXUCZ010000009.1  74242358-74242455
            721-910             JAXUCZ010000009.1  74248058-74248247
            911-1064            JAXUCZ010000009.1  74249397-74249550
            1065-1125           JAXUCZ010000009.1  74253310-74253370
            1126-1189           JAXUCZ010000009.1  74258419-74258482
            1190-1284           JAXUCZ010000009.1  74270369-74270463
            1285-1423           JAXUCZ010000009.1  74299188-74299326
            1424-1465           JAXUCZ010000009.1  74301168-74301209
            1466-2542           JAXUCZ010000009.1  74303250-74304326
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..2542
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /note="parathyroid hormone 2 receptor"
                     /db_xref="GeneID:81753"
                     /db_xref="RGD:620612"
     exon            1..292
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1858
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /note="PTH2 receptor; parathyroid hormone receptor 2"
                     /codon_start=1
                     /product="parathyroid hormone 2 receptor precursor"
                     /protein_id="NP_112351.2"
                     /db_xref="GeneID:81753"
                     /db_xref="RGD:620612"
                     /translation="MPWLEALPYICGWLILRSCLLVGAQLDSDGTITIEEQIVLVMKA
                     KMQCELNITAQFQEGEGNCFPEWDGLICWPRGTAGKTSAMPCPSYVYDFNHKGVAFRH
                     CTPNGTWDFIHGSNKTWANYSDCFLQPDINIGKQEFFENLYILYTVGYSISFGSLAVA
                     ILIIGYFRRLHCTRNYIHLHLFVSFMLRAMSIFVKDRVAQAHLGVEALQSLVMQGDLQ
                     NFIGGPSVDKSQYVGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVSFFSDTKYLWG
                     FILIGWGFPAVFVVAWAVARATLADTRCWELSAGDRWIYQAPILAAIGLNFILFLNTV
                     RVLATKIWETNAVGHDMRKQYRKLAKSTLVLVLVFGVHYIVFICQPHSFSGLWWEIRM
                     HCELFFNSFQGFFVSIVYCYCNGEVQAEVKKTWTRWNLSIDWKKAPPCGGHRYGSVLT
                     TVTHSTSSQSQMGPSTRLVLISSKPAKTACRQIDSHVTLPGYVWSSSEQDCQPQSTPE
                     ETKKGHGRQEDDSPVGESSRPVAFTIDTEGCKGESHPI"
     exon            293..395
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            396..506
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..622
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..720
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..910
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1064
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1125
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1189
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1284
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1423
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1465
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..2542
                     /gene="Pth2r"
                     /gene_synonym="Pthr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccctcccg cagctgtcct ctgtagaagg cgggaccacc cagagccctc aggaccggga
       61 ttcccagact ccgggcgcag gcagccagac ccccgagagt cctggttgtg cctccagctg
      121 cccagcggcg cctcgctccc catcacaagt ttggtccata ctggataagt aagctagtct
      181 gggataccga ctgcttgtgc cttaggaggg tttggacatg ccctggctgg aagctttacc
      241 ctacatctgt ggatggctga ttctccgtag ctgtctcctg gttggagcgc agctggattc
      301 tgatggcacc atcactatag aggagcagat tgttcttgtt atgaaggcta aaatgcaatg
      361 tgaactcaac atcacagctc agttccaaga aggagagggc aattgcttcc cagaatggga
      421 tggactcatt tgttggccta gaggaacggc ggggaaaacg tcagctatgc cctgtccttc
      481 atatgtttat gatttcaatc acaaaggagt tgctttccgg cactgcactc ccaatggaac
      541 gtgggatttt attcatggct caaataaaac ctgggctaac tattcagact gctttctgca
      601 gcctgatatc aacataggaa agcaagagtt ctttgaaaac ctctacatcc tgtacactgt
      661 cggctattcc atctcttttg gctccttggc agtagccatt ctcatcattg gctatttcag
      721 gcggttgcat tgcactagga actatatcca cttgcatttg tttgtgtcct tcatgctgag
      781 agccatgagc atctttgtca aggacagagt agcccaggct cacctgggag tagaggcact
      841 gcagtctctg gtgatgcagg gtgaccttca gaacttcatt ggaggaccat ctgtggacaa
      901 atctcagtat gtggggtgca agatcgctgt cgtgatgttt atttatttct tggctacaaa
      961 ctattattgg atcctggtgg aagggctcta cctgcataac ttaatctttg tgtctttctt
     1021 ttctgacacc aaatacctgt ggggcttcat cttgataggc tggggatttc cagcggtatt
     1081 tgttgtggcc tgggcagtag cacgagccac tctggcggat accaggtgtt gggaacttag
     1141 tgctggagac aggtggattt accaggctcc aatcttggcg gctattgggc tgaattttat
     1201 tctgttcctg aatacagtta gagttcttgc tactaaaatt tgggagacca atgctgttgg
     1261 gcatgacatg agaaagcagt acaggaaact ggctaagtca acgctggtcc tggtgctggt
     1321 gtttggtgtg cattacatcg tgttcatctg ccagccgcac tccttctcgg ggctctggtg
     1381 ggagatccgt atgcactgcg agctcttctt caactccttc cagggattct tcgtgtctat
     1441 tgtctattgc tactgcaacg gagaggtaca ggctgaggtg aagaagacct ggactcgttg
     1501 gaatctgtcc atcgactgga aaaaggcgcc gccttgtggc ggccacaggt acggctcggt
     1561 gctcaccact gtcacacaca gcaccagcag ccagtcacag atgggaccaa gcacacgcct
     1621 ggtgctcatc tctagcaaac ccgccaagac tgcctgcaga cagatcgaca gtcatgtgac
     1681 tctacctggc tacgtctgga gtagttctga gcaggactgt caaccacaat ctaccccgga
     1741 ggagactaaa aaaggtcatg ggcgacagga agatgatagt ccagtggggg agtcttccag
     1801 gccagtagca ttcaccatag acacggaagg atgcaaggga gaatcccacc ctatctgaat
     1861 caccatttgc agctcttgtg gattggcgga tctggctgtg tgggaggacc taagttggaa
     1921 gactggaatt ctgaaataag gcgtcgctta aacatttcca gtttctatga gtgggttttt
     1981 tttataatac tttctctgtg gttattatta ttttgctttt attggataag aaaggtttca
     2041 aacgcctggc tctacctttt tttcccctca ttaatgtcac cccgaatatg atgaggatat
     2101 ttagtttgca tcattttcct ttcaagaaat cactaacctt tatgtttcgc attttaatga
     2161 ccttctgctg tcacattcat tttgtctatg tactggaaca atctaagaaa gtacattgga
     2221 aaactaaaat tctaagacca actacattgg aaaatcaatt ggacattaat aaagcaatgc
     2281 atttctgaca gttatgattg attctaggag caaagaaaac catcccattc tgcttttgaa
     2341 tgtttccttg tgtgacgagt caaacatgct ctttgctctt tcttgtaaac catgacaagt
     2401 caagagtttt cccagtatta gaaagctgat gctgtatggc ctcatttctg ctagcccaca
     2461 gggcaacttg tctttttctt tgtttttctc ttgtttgctg tgttacagat ggtgtgcggg
     2521 ttacattaaa agttagtttt aa
//
