LOCUS       NM_001109144             481 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Rattus norvegicus parathyroid hormone 2 (Pth2), mRNA.
ACCESSION   NM_001109144 XM_001079083 XM_574444
VERSION     NM_001109144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cservenak,M., Bodnar,I., Usdin,T.B., Palkovits,M., Nagy,G.M. and
            Dobolyi,A.
  TITLE     Tuberoinfundibular peptide of 39 residues is activated during
            lactation and participates in the suckling-induced prolactin
            release in rat
  JOURNAL   Endocrinology 151 (12), 5830-5840 (2010)
   PUBMED   20861230
  REMARK    GeneRIF: TIP39 neurons in the PIL may regulate suckling-induced
            prolactin release in rat dams.
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Palkovits,M., Helfferich,F., Dobolyi,A. and Usdin,T.B.
  TITLE     Acoustic stress activates tuberoinfundibular peptide of 39 residues
            neurons in the rat brain
  JOURNAL   Brain Struct Funct 214 (1), 15-23 (2009)
   PUBMED   19936783
  REMARK    GeneRIF: TIP39 neurons are sensitive to loud noise and they may
            participate in the central organization of responses to acoustic
            stress; non-TIP39-expressing neurons may play a prevalent role in
            the activity of the 'acoustic thalamus'
REFERENCE   3  (bases 1 to 481)
  AUTHORS   Brenner,D., Bago,A.G., Gallatz,K., Palkovits,M., Usdin,T.B. and
            Dobolyi,A.
  TITLE     Tuberoinfundibular peptide of 39 residues in the embryonic and
            early postnatal rat brain
  JOURNAL   J Chem Neuroanat 36 (1), 59-68 (2008)
   PUBMED   18495420
  REMARK    GeneRIF: The complex pattern of TIP39 expression during early brain
            development suggests the involvement of TIP39 in transient
            functions during ontogeny.
REFERENCE   4  (bases 1 to 481)
  AUTHORS   Wang,J., Palkovits,M., Usdin,T.B. and Dobolyi,A.
  TITLE     Forebrain projections of tuberoinfundibular peptide of 39 residues
            (TIP39)-containing subparafascicular neurons
  JOURNAL   Neuroscience 138 (4), 1245-1263 (2006)
   PUBMED   16458435
  REMARK    GeneRIF: Our data provide an anatomical basis for the potential
            involvement of rostral subparafascicular neurons in limbic and
            autonomic regulation, with TIP39 cells being major
            subparafascicular output neurons projecting to forebrain regions.
REFERENCE   5  (bases 1 to 481)
  AUTHORS   Ross,G., Engel,P., Abdallah,Y., Kummer,W. and Schluter,K.D.
  TITLE     Tuberoinfundibular peptide of 39 residues: a new mediator of
            cardiac function via nitric oxide production in the rat heart
  JOURNAL   Endocrinology 146 (5), 2221-2228 (2005)
   PUBMED   15677763
  REMARK    GeneRIF: results suggest that an inhibition of endogenous nitric
            oxide production unmasks a profound negative inotropic effect of
            tuberoinfundibular peptide (TIP39) that is mediated by an
            activation of the parathyroid hormone receptor 2 receptor
REFERENCE   6  (bases 1 to 481)
  AUTHORS   Dobolyi,A., Palkovits,M. and Usdin,T.B.
  TITLE     Expression and distribution of tuberoinfundibular peptide of 39
            residues in the rat central nervous system
  JOURNAL   J Comp Neurol 455 (4), 547-566 (2003)
   PUBMED   12508326
REFERENCE   7  (bases 1 to 481)
  AUTHORS   Della Penna,K., Kinose,F., Sun,H., Koblan,K.S. and Wang,H.
  TITLE     Tuberoinfundibular peptide of 39 residues (TIP39): molecular
            structure and activity for parathyroid hormone 2 receptor
  JOURNAL   Neuropharmacology 44 (1), 141-153 (2003)
   PUBMED   12559132
REFERENCE   8  (bases 1 to 481)
  AUTHORS   Dobolyi,A., Palkovits,M., Bodnar,I. and Usdin,T.B.
  TITLE     Neurons containing tuberoinfundibular peptide of 39 residues
            project to limbic, endocrine, auditory and spinal areas in rat
  JOURNAL   Neuroscience 122 (4), 1093-1105 (2003)
   PUBMED   14643775
  REMARK    GeneRIF: TIP39-containing neurons project to a number of limbic
            areas implicating them in limbic and endocrine functions; those
            that project to the medial paralemniscal nucleus may participate in
            auditory and nociceptive functions.
REFERENCE   9  (bases 1 to 481)
  AUTHORS   Dobolyi,A., Ueda,H., Uchida,H., Palkovits,M. and Usdin,T.B.
  TITLE     Anatomical and physiological evidence for involvement of
            tuberoinfundibular peptide of 39 residues in nociception
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1651-1656 (2002)
   PUBMED   11818570
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_574444.1, XM_001079083.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..481
                     /gene="Pth2"
                     /gene_synonym="RGD1559447; Tifp39; Tip39"
                     /note="parathyroid hormone 2"
                     /db_xref="GeneID:499149"
                     /db_xref="RGD:1559447"
     exon            1..240
                     /gene="Pth2"
                     /gene_synonym="RGD1559447; Tifp39; Tip39"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..415
                     /gene="Pth2"
                     /gene_synonym="RGD1559447; Tifp39; Tip39"
                     /note="tuberoinfundibular peptide of 39 residues (TIP39)
                     preprohormone; tuberoinfundibular peptide of 39 amino
                     acids"
                     /codon_start=1
                     /product="tuberoinfundibular peptide of 39 residues
                     precursor"
                     /protein_id="NP_001102614.1"
                     /db_xref="GeneID:499149"
                     /db_xref="RGD:1559447"
                     /translation="MVTLRFCSLCPQVMETCQMSRSPRERLLLLLLLLLLVPWGTGPA
                     SGVALPLAGVFSLRAPGRGWADLGTPLSRRSLALADDAAFRERARLLAALERRRWLDS
                     YMQKLLLLDAP"
     exon            241..481
                     /gene="Pth2"
                     /gene_synonym="RGD1559447; Tifp39; Tip39"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccactgcacg gtaggggggc ctgcgggaga ctggtggcgg ggttgggccg tgggctctag
       61 gcttctgggt gtgatggtga cattgagatt ctgttccctg tgtccacagg tgatggagac
      121 ctgccagatg tccaggagcc ctcgagagcg gctgctgctg cttttgctgc ttctactgct
      181 tgtgccctgg ggcactggcc ctgcctcagg tgttgctctg cccctcgctg gtgtgttcag
      241 cctgcgagcc ccgggccgtg gctgggcgga cttgggtacc cccctgtctc ggcgcagcct
      301 ggcgctagct gacgacgcgg cttttcggga gcgcgcgcgc ctgctggccg ccctggagcg
      361 ccgccgctgg ctggactctt acatgcagaa gctgttgcta ctggacgcgc cctgagccta
      421 ataaagagcc tgtcacactg cgactgcgcc tccttgctac gcctctctct tgtgggtgtg
      481 t
//
