LOCUS       NM_020073               1836 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus parathyroid hormone 1 receptor (Pth1r), mRNA.
ACCESSION   NM_020073
VERSION     NM_020073.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Chen,H.M., Dai,J.J., Zhu,R., Peng,F.F., Wu,S.Z., Yu,H.,
            Krepinsky,J.C. and Zhang,B.F.
  TITLE     Parathyroid hormone-related protein induces fibronectin
            up-regulation in rat mesangial cells through reactive oxygen
            species/Src/EGFR signaling
  JOURNAL   Biosci Rep 39 (4) (2019)
   PUBMED   30926678
  REMARK    GeneRIF: Our study thus demonstrates the new role of PTHrP in
            fibronectin up-regulation for the first time in glomerular
            mesangial cells. These data also provided new insights to guide
            development of therapy for glomerular sclerosis
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Liu,C., Shao,G., Lu,Y., Xue,M., Liang,F., Zhang,Z. and Bai,L.
  TITLE     Parathyroid Hormone-Related Protein (1-40) Enhances Calcium Uptake
            in Rat Enterocytes Through PTHR1 Receptor and Protein Kinase
            Calpha/beta Signaling
  JOURNAL   Cell Physiol Biochem 51 (4), 1695-1709 (2018)
   PUBMED   30504697
  REMARK    GeneRIF: PTHrP (1-40) stimulates calcium uptake via PTHR1 receptor
            and PKC alpha/beta signaling pathway in rat enterocytes, and
            calcium transporters TRPV6 and CaBP-D9k are necessary for this
            stimulatory effect.
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Shimomura-Kuroki,J., Farooq,M., Sekimoto,T., Amizuka,N. and
            Shimomura,Y.
  TITLE     Characterization of a PTH1R missense mutation responsible for
            Jansen type metaphyseal chondrodysplasia
  JOURNAL   Odontology 105 (2), 150-154 (2017)
   PUBMED   27160269
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Filipovic,N., Vrdoljak,M., Vuica,A., Jeric,M., Jelicic Kadic,A.,
            Utrobicic,T., Masek,T. and Grkovic,I.
  TITLE     Expression of PTHrP and PTH/PTHrP receptor 1 in the superior
            cervical ganglia of rats
  JOURNAL   Neuropeptides 48 (6), 353-359 (2014)
   PUBMED   25278090
  REMARK    GeneRIF: Results show the expression of PTHrP and its receptor,
            PTHR1, in the majority of neurons and glial cells in the SCG of
            rats. Expression of PTHrP, but not PTHR1 in the cytoplasm of SCG
            neurons is influenced by ovarian activity.
REFERENCE   6  (bases 1 to 1836)
  AUTHORS   Lanske,B., Karaplis,A.C., Lee,K., Luz,A., Vortkamp,A., Pirro,A.,
            Karperien,M., Defize,L.H., Ho,C., Mulligan,R.C., Abou-Samra,A.B.,
            Juppner,H., Segre,G.V. and Kronenberg,H.M.
  TITLE     PTH/PTHrP receptor in early development and Indian
            hedgehog-regulated bone growth
  JOURNAL   Science 273 (5275), 663-666 (1996)
   PUBMED   8662561
REFERENCE   7  (bases 1 to 1836)
  AUTHORS   Kong,X.F., Schipani,E., Lanske,B., Joun,H., Karperien,M.,
            Defize,L.H., Juppner,H., Potts,J.T. Jr., Segre,G.V.,
            Kronenberg,H.M. et al.
  TITLE     The rat, mouse and human genes encoding the receptor for
            parathyroid hormone and parathyroid hormone-related peptide are
            highly homologous
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1290-1299 (1994)
   PUBMED   8185578
  REMARK    Erratum:[Biochem Biophys Res Commun. 1994 Jun 15;201(2):1058. doi:
            10.1006/bbrc.1994.1811.. PMID: 8002976]
REFERENCE   8  (bases 1 to 1836)
  AUTHORS   Pausova,Z., Bourdon,J., Clayton,D., Mattei,M.G., Seldin,M.F.,
            Janicic,N., Riviere,M., Szpirer,J., Levan,G., Szpirer,C. et al.
  TITLE     Cloning of a parathyroid hormone/parathyroid hormone-related
            peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell
            line: chromosomal assignment of the gene in the human, mouse, and
            rat genomes
  JOURNAL   Genomics 20 (1), 20-26 (1994)
   PUBMED   8020952
REFERENCE   9  (bases 1 to 1836)
  AUTHORS   Schneider,H., Feyen,J.H., Seuwen,K. and Movva,N.R.
  TITLE     Cloning and functional expression of a human parathyroid hormone
            receptor
  JOURNAL   Eur J Pharmacol 246 (2), 149-155 (1993)
   PUBMED   8397094
REFERENCE   10 (bases 1 to 1836)
  AUTHORS   Abou-Samra,A.B., Juppner,H., Force,T., Freeman,M.W., Kong,X.F.,
            Schipani,E., Urena,P., Richards,J., Bonventre,J.V., Potts,J.T. Jr.
            et al.
  TITLE     Expression cloning of a common receptor for parathyroid hormone and
            parathyroid hormone-related peptide from rat osteoblast-like cells:
            a single receptor stimulates intracellular accumulation of both
            cAMP and inositol trisphosphates and increases intracellular free
            calcium
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2732-2736 (1992)
   PUBMED   1313566
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L19475.1.
            
            On Jun 10, 2007 this sequence version replaced NM_020073.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L19475.1, M77184.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1836
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /note="parathyroid hormone 1 receptor"
                     /db_xref="GeneID:56813"
                     /db_xref="RGD:3442"
     exon            1..120
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1821
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /note="parathyroid hormone receptor 1; parathyroid
                     hormone/parathyroid hormone-related peptide receptor; PTH1
                     receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor"
                     /codon_start=1
                     /product="parathyroid hormone/parathyroid hormone-related
                     peptide receptor precursor"
                     /protein_id="NP_064458.1"
                     /db_xref="GeneID:56813"
                     /db_xref="RGD:3442"
                     /translation="MGAARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRA
                     QAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSR
                     RRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGH
                     NRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCT
                     RNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAV
                     GYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAV
                     FVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRET
                     NAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSF
                     QGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNV
                     GPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSC
                     SGLDEEASGSARPPPLLQEEWETVM"
     exon            121..223
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            224..358
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            359..469
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            470..588
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            589..683
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            684..879
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1033
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1094
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1161
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1256
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1398
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1440
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1836
                     /gene="Pth1r"
                     /gene_synonym="Pthr; Pthr1; PTHrel"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccggcggc ggctgccccg agggacgcgg ccctaggcgg tggcgatggg ggccgcccgg
       61 atcgcaccca gcctggcgct cctactctgc tgcccagtgc tcagctccgc atatgcgctg
      121 gtggatgcgg acgatgtctt taccaaagag gaacagattt tcctgctgca ccgtgcccag
      181 gcgcaatgtg acaagctgct caaggaagtt ctgcacacag cagccaacat aatggagtca
      241 gacaagggct ggacaccagc atctacgtca gggaagccca ggaaagagaa ggcatcggga
      301 aagttctacc ctgagtctaa agagaacaag gacgtgccca ccggcagcag gcgcagaggg
      361 cgtccctgtc tgcccgagtg ggacaacatc gtttgctggc cattaggggc accaggtgaa
      421 gtggtggcag taccttgtcc cgattacatt tatgacttca atcacaaagg ccatgcctac
      481 agacgctgtg accgcaatgg cagctgggag gtggttccag ggcacaaccg gacgtgggcc
      541 aactacagcg agtgcctcaa gttcatgacc aatgagacgc gggaacggga ggtatttgac
      601 cgcctaggca tgatctacac cgtgggatac tccatgtctc tcgcctccct cacggtggct
      661 gtgctcatcc tggcctattt taggcggctg cactgcacgc gcaactacat ccacatgcac
      721 atgttcctgt cgtttatgct gcgcgccgcg agcatcttcg tgaaggacgc tgtgctctac
      781 tctggcttca cgctggatga ggccgagcgc ctcacagagg aagagttgca catcatcgcg
      841 caggtgccac ctccgccggc cgctgccgcc gtaggctacg ctggctgccg cgtggcggtg
      901 accttcttcc tctacttcct ggctaccaac tactactgga ttctggtgga ggggctgtac
      961 ttgcacagcc tcatcttcat ggcctttttc tcagagaaga agtacctgtg gggcttcacc
     1021 atctttggct ggggtctacc ggctgtcttc gtggctgtgt gggtcggtgt cagagcaacc
     1081 ttggccaaca ctgggtgctg ggatctgagc tccgggcaca agaagtggat catccaggtg
     1141 cccatcctgg catctgttgt gctcaacttc atccttttta tcaacatcat ccgggtgctt
     1201 gccactaagc ttcgggagac caatgcgggc cggtgtgaca ccaggcagca gtaccggaag
     1261 ctgctcaggt ccacgttggt gctcgtgccg ctctttggtg tccactacac cgtcttcatg
     1321 gccttgccgt acaccgaggt ctcagggaca ttgtggcaga tccagatgca ttatgagatg
     1381 ctcttcaact ccttccaggg attttttgtt gccatcatat actgtttctg caatggtgag
     1441 gtgcaggcag agattaggaa gtcatggagc cgctggacac tggcgttgga cttcaagcgc
     1501 aaagcacgaa gtgggagtag cagctacagc tatggcccaa tggtgtctca cacgagtgtg
     1561 accaatgtgg gcccccgtgc aggactcagc ctccccctca gcccccgcct gcctcctgcc
     1621 actaccaatg gccactccca gctgcctggc catgccaagc caggggctcc agccactgag
     1681 actgaaaccc taccagtcac tatggcggtt cccaaggacg atggattcct taacggctcc
     1741 tgctcaggcc tggatgagga ggcctccggg tctgcgcggc cgcctccatt gttgcaggaa
     1801 gaatgggaaa cagtcatgtg actgggcact aggggg
//
