LOCUS       NM_017044                704 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus parathyroid hormone (Pth), mRNA.
ACCESSION   NM_017044
VERSION     NM_017044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 704)
  AUTHORS   Wang,L., Tang,R., Zhang,Y., Chen,S., Guo,Y., Wang,X., Liu,Z.,
            Liu,H., Zhang,X. and Liu,B.C.
  TITLE     PTH-induced EndMT via miR-29a-5p/GSAP/Notch1 pathway contributed to
            valvular calcification in rats with CKD
  JOURNAL   Cell Prolif 54 (6), e13018 (2021)
   PUBMED   33945189
  REMARK    GeneRIF: PTH-induced EndMT via miR-29a-5p/GSAP/Notch1 pathway
            contributed to valvular calcification in rats with CKD.
REFERENCE   2  (bases 1 to 704)
  AUTHORS   Chen,X.J., Chen,X., Wu,W.J., Zhou,Q., Gong,X.H. and Shi,B.M.
  TITLE     Effects of FGF-23-mediated ERK/MAPK signaling pathway on
            parathyroid hormone secretion of parathyroid cells in rats with
            secondary hyperparathyroidism
  JOURNAL   J Cell Physiol 233 (9), 7092-7102 (2018)
   PUBMED   29633272
  REMARK    GeneRIF: FGF-23 could inhibit signaling transduction of ERK/MAPK
            pathway and accelerate the secretion of PTH in rats with secondary
            hyperparathyroidism.
REFERENCE   3  (bases 1 to 704)
  AUTHORS   Znorko,B., Pawlak,D., Oksztulska-Kolanek,E., Domaniewski,T.,
            Pryczynicz,A., Roszczenko,A., Rogalska,J., Lipowicz,P.,
            Doroszko,M., Brzoska,M.M. and Pawlak,K.
  TITLE     RANKL/OPG system regulation by endogenous PTH and PTH1R/ATF4 axis
            in bone: Implications for bone accrual and strength in growing rats
            with mild uremia
  JOURNAL   Cytokine 106, 19-28 (2018)
   PUBMED   29529595
  REMARK    GeneRIF: A decrease in the RANKL/OPG ratio, associated with
            PTH-dependent activation of the anabolic PTH1R/ATF4 pathway, seems
            to be responsible for the unexpected, beneficial effect of PTH on
            cortical bone accrual and strength.
REFERENCE   4  (bases 1 to 704)
  AUTHORS   Sawada,K., Wu-Wong,J.R., Chen,Y.W., Wessale,J.L., Kanai,G.,
            Kakuta,T. and Fukagawa,M.
  TITLE     Vitamin D receptor agonist VS-105 directly modulates parathyroid
            hormone expression in human parathyroid cells and in 5/6
            nephrectomized rats
  JOURNAL   J Steroid Biochem Mol Biol 167, 48-54 (2017)
   PUBMED   27989797
  REMARK    GeneRIF: VS-105 exerts a rapid effect on suppressing serum PTH,
            directly down-regulates the PTH gene, and modulates PTH, VDR and
            CaSR gene expression more effectively than paricalcitol
REFERENCE   5  (bases 1 to 704)
  AUTHORS   Kir,S., Komaba,H., Garcia,A.P., Economopoulos,K.P., Liu,W.,
            Lanske,B., Hodin,R.A. and Spiegelman,B.M.
  TITLE     PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure
            and Cancer
  JOURNAL   Cell Metab 23 (2), 315-323 (2016)
   PUBMED   26669699
  REMARK    GeneRIF: PTHrP and PTH mediate wasting through a common mechanism
            involving PTHR.
REFERENCE   6  (bases 1 to 704)
  AUTHORS   Parkinson,D.B. and Thakker,R.V.
  TITLE     A donor splice site mutation in the parathyroid hormone gene is
            associated with autosomal recessive hypoparathyroidism
  JOURNAL   Nat Genet 1 (2), 149-152 (1992)
   PUBMED   1302009
REFERENCE   7  (bases 1 to 704)
  AUTHORS   Arnold,A., Horst,S.A., Gardella,T.J., Baba,H., Levine,M.A. and
            Kronenberg,H.M.
  TITLE     Mutation of the signal peptide-encoding region of the
            preproparathyroid hormone gene in familial isolated
            hypoparathyroidism
  JOURNAL   J Clin Invest 86 (4), 1084-1087 (1990)
   PUBMED   2212001
REFERENCE   8  (bases 1 to 704)
  AUTHORS   Schmelzer,H.J., Gross,G., Widera,G. and Mayer,H.
  TITLE     Nucleotide sequence of a full-length cDNA clone encoding
            preproparathyroid hormone from pig and rat
  JOURNAL   Nucleic Acids Res 15 (16), 6740 (1987)
   PUBMED   3628009
REFERENCE   9  (bases 1 to 704)
  AUTHORS   Heinrich,G., Kronenberg,H.M., Potts,J.T. Jr. and Habener,J.F.
  TITLE     Gene encoding parathyroid hormone. Nucleotide sequence of the rat
            gene and deduced amino acid sequence of rat preproparathyroid
            hormone
  JOURNAL   J Biol Chem 259 (5), 3320-3329 (1984)
   PUBMED   6321505
REFERENCE   10 (bases 1 to 704)
  AUTHORS   Chou,C.H., Fritz,R.B., Chou,F.C. and Kibler,R.F.
  TITLE     The immune response of Lewis rats to peptide 68-88 of guinea pig
            myelin basic protein. I. T cell determinants
  JOURNAL   J Immunol 123 (4), 1540-1543 (1979)
   PUBMED   90087
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X05721.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X05721.1, S80127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680444
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..704
                     /gene="Pth"
                     /gene_synonym="PTH-(1-84); Pth1; Pthr1"
                     /note="parathyroid hormone"
                     /db_xref="GeneID:24694"
                     /db_xref="RGD:3440"
     exon            1..113
                     /gene="Pth"
                     /gene_synonym="PTH-(1-84); Pth1; Pthr1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..204
                     /gene="Pth"
                     /gene_synonym="PTH-(1-84); Pth1; Pthr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..466
                     /gene="Pth"
                     /gene_synonym="PTH-(1-84); Pth1; Pthr1"
                     /note="hypothalamic parathyroid hormone; parathyrin"
                     /codon_start=1
                     /product="parathyroid hormone precursor"
                     /protein_id="NP_058740.1"
                     /db_xref="GeneID:24694"
                     /db_xref="RGD:3440"
                     /translation="MMSASTMAKVMILMLAVCLLTQADGKPVKKRAVSEIQLMHNLGK
                     HLASVERMQWLRKKLQDVHNFVSLGVQMAAREGSYQRPTKKEENVLVDGNSKSLGEGD
                     KADVDVLVKAKSQ"
     exon            205..704
                     /gene="Pth"
                     /gene_synonym="PTH-(1-84); Pth1; Pthr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcatatga aactcaggct tgaagaactg cagtccagtt catcagctgt ctggcttact
       61 ccagcttaat acagggtcac tcctgaagga tcctctctga gagtcattgt atgtgaagat
      121 gatgtctgca agcaccatgg ctaaggtgat gatcctcatg ctggcagttt gtctccttac
      181 ccaggcagat gggaaacccg ttaagaagag agctgtcagt gaaatacagc ttatgcacaa
      241 cctgggcaaa cacctggcct ctgtggagag gatgcaatgg ctgagaaaaa agctgcaaga
      301 tgtacacaat tttgttagtc ttggagtcca aatggctgcc agagaaggca gttaccagag
      361 gcccaccaag aaggaggaaa atgtccttgt tgatggcaat tcaaaaagtc ttggcgaggg
      421 ggacaaagct gatgtggatg tattagttaa ggctaaatct cagtaaatgc tgacgtattc
      481 tagaccgtgc tgagcaataa catatgctgc tatcctttca agctccacga agatcaccaa
      541 gtgctaattc ttctactgta ataaaagttt gaaatttgat tccacttttg ctcatttaag
      601 gtctcttcca atgattccat ttcaatatat tcttcttttt aaagtattac acatttccac
      661 ttctctcctt aaatataaat aaagtttaat gatcatgaac caaa
//
