LOCUS       NM_017232               4382 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus prostaglandin-endoperoxide synthase 2 (Ptgs2),
            mRNA.
ACCESSION   NM_017232
VERSION     NM_017232.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4382)
  AUTHORS   Toi,M., Toshiya,T., Noguchi,K., Yamanaka,H., Kobayashi,K.,
            Okubo,M., Kishima,K. and Dai,Y.
  TITLE     COX2 expression plays a role in spinal cord injury-induced
            neuropathic pain
  JOURNAL   Neurosci Lett 823, 137663 (2024)
   PUBMED   38286397
  REMARK    GeneRIF: COX2 expression plays a role in spinal cord injury-induced
            neuropathic pain.
REFERENCE   2  (bases 1 to 4382)
  AUTHORS   Zhang,X.H., Cui,H., Zheng,S.M., Lu,Y., Yuan,H.W., Zhang,L.,
            Wang,H.H. and Du,R.S.
  TITLE     Electroacupuncture regulates microglial polarization via inhibiting
            NF-kappaB/COX2 pathway following traumatic brain injury
  JOURNAL   Brain Res 1818, 148516 (2023)
   PUBMED   37562566
  REMARK    GeneRIF: Electroacupuncture regulates microglial polarization via
            inhibiting NF-kappaB/COX2 pathway following traumatic brain injury.
REFERENCE   3  (bases 1 to 4382)
  AUTHORS   Dourado,T.M.H., Assis,V.O., Awata,W.M.C., de Mello,M.M.B.,
            Carnio,E.C., Castro,M.M. and Tirapelli,C.R.
  TITLE     Mineralocorticoid receptors contribute to ethanol-induced vascular
            hypercontractility through reactive oxygen species generation and
            up-regulation of cyclooxygenase 2
  JOURNAL   Eur J Pharmacol 949, 175723 (2023)
   PUBMED   37059378
  REMARK    GeneRIF: Mineralocorticoid receptors contribute to ethanol-induced
            vascular hypercontractility through reactive oxygen species
            generation and up-regulation of cyclooxygenase 2.
REFERENCE   4  (bases 1 to 4382)
  AUTHORS   Abo-El Fetoh,M.E., Abdel-Fattah,M.M., Mohamed,W.R., Ramadan,L.A.A.
            and Afify,H.
  TITLE     Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated
            ADAM-17 signaling in testosterone-induced benign prostatic
            hyperplasia
  JOURNAL   Inflammopharmacology 31 (1), 499-516 (2023)
   PUBMED   36586043
  REMARK    GeneRIF: Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via
            PGE2-mediated ADAM-17 signaling in testosterone-induced benign
            prostatic hyperplasia.
REFERENCE   5  (bases 1 to 4382)
  AUTHORS   Xu,S., Yang,J., Wan,H., Yu,L. and He,Y.
  TITLE     Combination of Radix Astragali and Safflower Promotes Angiogenesis
            in Rats with Ischemic Stroke via Silencing PTGS2
  JOURNAL   Int J Mol Sci 24 (3), 2126 (2023)
   PUBMED   36768450
  REMARK    GeneRIF: Combination of Radix Astragali and Safflower Promotes
            Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4382)
  AUTHORS   Kulmacz,R.J. and Wang,L.H.
  TITLE     Comparison of hydroperoxide initiator requirements for the
            cyclooxygenase activities of prostaglandin H synthase-1 and -2
  JOURNAL   J Biol Chem 270 (41), 24019-24023 (1995)
   PUBMED   7592599
REFERENCE   7  (bases 1 to 4382)
  AUTHORS   Hla,T. and Neilson,K.
  TITLE     Human cyclooxygenase-2 cDNA
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7384-7388 (1992)
   PUBMED   1380156
REFERENCE   8  (bases 1 to 4382)
  AUTHORS   Ryseck,R.P., Raynoschek,C., Macdonald-Bravo,H., Dorfman,K.,
            Mattei,M.G. and Bravo,R.
  TITLE     Identification of an immediate early gene, pghs-B, whose protein
            product has prostaglandin synthase/cyclooxygenase activity
  JOURNAL   Cell Growth Differ 3 (7), 443-450 (1992)
   PUBMED   1419907
REFERENCE   9  (bases 1 to 4382)
  AUTHORS   Sirois,J. and Richards,J.S.
  TITLE     Purification and characterization of a novel, distinct isoform of
            prostaglandin endoperoxide synthase induced by human chorionic
            gonadotropin in granulosa cells of rat preovulatory follicles
  JOURNAL   J Biol Chem 267 (9), 6382-6388 (1992)
   PUBMED   1556140
REFERENCE   10 (bases 1 to 4382)
  AUTHORS   Hobel,W., Dudeck,J., Bockmann,R.D. and Weber,G.
  TITLE     Improvements of the algorithm for defining QRS onset and offset in
            the Pipberger program
  JOURNAL   Adv Cardiol 21, 181-184 (1978)
   PUBMED   619537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Oct 12, 2022 this sequence version replaced NM_017232.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF233596.1, S67722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000013.1  64714063-64714258
            197-313             JAXUCZ010000013.1  64714993-64715109
            314-457             JAXUCZ010000013.1  64715232-64715375
            458-601             JAXUCZ010000013.1  64715993-64716136
            602-783             JAXUCZ010000013.1  64716684-64716865
            784-867             JAXUCZ010000013.1  64717784-64717867
            868-1114            JAXUCZ010000013.1  64717993-64718239
            1115-1401           JAXUCZ010000013.1  64718409-64718695
            1402-1549           JAXUCZ010000013.1  64719084-64719231
            1550-4382           JAXUCZ010000013.1  64719488-64722320
FEATURES             Location/Qualifiers
     source          1..4382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..4382
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /note="prostaglandin-endoperoxide synthase 2"
                     /db_xref="GeneID:29527"
                     /db_xref="RGD:620349"
     exon            1..196
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1959
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /EC_number="1.14.99.1"
                     /note="prostaglandin G/H synthase 2; PGH synthase 2;
                     prostaglandin H2 synthase 2; cyclooxygenase-2"
                     /codon_start=1
                     /product="prostaglandin G/H synthase 2 precursor"
                     /protein_id="NP_058928.3"
                     /db_xref="GeneID:29527"
                     /db_xref="RGD:620349"
                     /translation="MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDC
                     TRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRNSIMRYV
                     LTSRSHLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDS
                     KEVLEKVLLRREFIPDPQGTNMMFAFFAQHFTHQFFKTDQKRGPGFTRGLGHGVDLNH
                     VYGETLDRQHKLRLFQDGKLKYQVIGGEVYPPTVKDTQVDMIYPPHVPEHLRFAVGQE
                     VFGLVPGLMMYATIWLREHNRVCDILKQEHPEWDDERLFQTSRLILIGETIKIVIEDY
                     VQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYTFKQ
                     FLYNNSILLEHGLAHFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLN
                     EYRKRFSLKPYTSFEELTGEKEMAAELKALYHDIDAMELYPALLVEKPRPDAIFGETM
                     VELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFRIINTASIQSLICNNVKGCPFASF
                     NVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL"
     exon            197..313
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            314..457
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            458..601
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            602..783
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            784..867
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1114
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1401
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1549
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..4382
                     /gene="Ptgs2"
                     /gene_synonym="COX-2; Cox2; PGHS-2; Pghs2; PHS II"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgtcaaa ctgagcggag agcttcagga gtacgaagac cctgcctacg aaggaactca
       61 gctctgtgtc ctgccagctc ccccgccagc ttcactgcca ccaacgctgc cacaactgct
      121 gccaccaccg ctgccacctc tgcgatgctc ttccgagctg tgctgctctg cgctgccctg
      181 gcgctcagcc atgcagcaaa tccttgctgt tccaacccat gtcaaaaccg tggtgaatgt
      241 atgagcatag gatttgacca atataaatgt gactgtaccc ggactggatt ctacggtgaa
      301 aactgtacta cgcctgagtt tctgacaaga atcaaattac tgctgaagcc caccccaaac
      361 acagtacact acatcctgac ccacttcaag ggagtctgga acattgtgaa caacattccc
      421 ttccttcgga attcaatcat gagatacgtg ttgacgtcca gatcacattt gattgacagc
      481 ccaccaactt acaatgtgca ctacggttac aaaagttggg aagctttctc caacctctcc
      541 tactacacca gggcccttcc tcctgtggct gatgactgcc caactcccat gggtgtgaaa
      601 ggaaataagg aacttcctga ttcaaaagaa gttctggaaa aggttcttct gaggagagag
      661 ttcatcccgg atccccaagg cacaaatatg atgttcgcat tctttgccca gcacttcact
      721 catcagtttt tcaagacaga tcagaagcga ggacctgggt tcacccgagg actgggccat
      781 ggagtggact taaatcatgt ttacggtgaa actctagaca gacaacataa acttcgactt
      841 ttccaggatg gaaaattgaa atatcaggtc atcggtggag aggtgtatcc tcccacagtc
      901 aaagacactc aggtagacat gatctaccct ccccacgtcc ctgagcacct gcggttcgct
      961 gtggggcagg aagtctttgg tctggtgccg ggtctgatga tgtatgctac catctggctt
     1021 cgggagcaca acagagtgtg tgatatactc aaacaggagc atcctgagtg ggatgacgag
     1081 cgactgttcc aaaccagcag gctcatactg ataggagaga cgatcaagat agtgatcgaa
     1141 gactacgtgc aacacctgag cggttaccac ttcaaactca agttcgaccc agagctgctt
     1201 ttcaaccagc agttccagta tcagaaccgc attgcctctg aattcaacac actctatcac
     1261 tggcatccgc tgctgccgga caccttcaac attgaagacc aggagtacac tttcaaacag
     1321 tttctctaca acaactccat cctccttgaa cacggacttg ctcactttgt tgagtcattc
     1381 accagacaga ttgctggccg ggttgctggg ggaaggaatg ttccaatcgc tgtacaagca
     1441 gtggcaaagg cctccattga ccagagcaga gagatgaaat accagtctct caatgagtac
     1501 cgcaaacgct tctccctgaa accttacaca tcgtttgaag aacttacagg agagaaagaa
     1561 atggctgcag agttgaaagc cctctaccat gacatcgatg ccatggaact gtatcccgcc
     1621 ctgctggtgg aaaagcctcg tccagatgct atctttgggg agaccatggt agaacttgga
     1681 gctccattct ccttgaaagg ccttatgggt aatcccatct gttctcctca atactggaaa
     1741 cctagcacct tcggaggaga agtgggtttt aggatcatca acactgcctc aattcagtct
     1801 ctcatctgca ataatgtgaa agggtgtccc tttgcctctt tcaatgtgca agacccgcag
     1861 cctaccaaga cagccaccat caacgcaagt gcctcccact ccagactaga tgacattaac
     1921 cctacagtac taatcaaaag gcgttcaact gagctgtaag agtctactga ccatatttat
     1981 ttatttatat gaacaattta atttaattat ttaatattta tacagaatgc tttttttcac
     2041 ttaacatctt ctataacaga aggcaatatt cttgaacaat gttccatttg tgaagattcc
     2101 tgtgtttgta ctttaaatat gtgttatccg aaaatgaaag ggaaaaaaag aacactttca
     2161 tttttcggca taagccagtg agaagggaaa tgaattttga tatctttata cttgaatgtc
     2221 agctcatgac tagcttaata agaacaaatg aaaggtgtat gaatatttaa atgctgttac
     2281 aaggagggaa atgtgaatat ttaaatgctg ttacaaggag ggaaatgctg cattgttggt
     2341 tatgactgtg tcatccttac tatgttagga gcaaccgatg tggaattgtt tttaaatctt
     2401 gcatatcttt atctcatcaa agcaaagggg tacaagtcca gttttaaatg agcatgaagg
     2461 cagataccgg caactgtctt tttatttttt aaaagcaatc ttttgaaaca aatgatttgc
     2521 aatgtctaaa tcaggagttg gaatcacttt cgaaagccct tactttcttg agctgtcaaa
     2581 tttgtaccca cacagattaa gcagctacca taaacacaaa tctctaaaac tggggaaaac
     2641 tattatgact gatggttaag ataccatgtc agggatcttt cttttctcag gagtagtgaa
     2701 aagctactat gacaatcaga ccttccttgt acgtcagatt gctggcgtag gaaggtggcg
     2761 gagcccgtga tgttctgtcc taaacgatgg aaaagcttta aagcttgtgt gtgagtggta
     2821 gccagcaaaa cctatcatag caacaaaaga gtccacaaac aaaataacca agaacaaaga
     2881 agggttccaa gctaaagacc gcatcgaggg ttaaactttt gaaggagact ttcagatcct
     2941 cctgtggtgc tggctgtgac ttgccaggct ggacttttaa agagtttttc tgttgcacag
     3001 tatgacacaa cagcccatct ctcaatgcaa aaggtatcag tgggcttctt caaaactttg
     3061 aaatgtcttc cagctcacgg taccagaagt gcagtaggcc ccatgcaatg tgtgagttca
     3121 gcctggatgc cagcatgatg ctctccttac tctgtttctt gtagtcattt tgctctgaga
     3181 aactgctgat tgatctgttt ttgtagctgt gttccaggct cttagtattc tttctttaac
     3241 ctccattaat attttctcta cttgaagttt tacattcagg aaaaacctca gctcaggact
     3301 actgtgtagc tccccttcgg aggaagaagt tactttagac aaaaggcaaa aaaattaaat
     3361 gtatttttca tttgtaatta tatggaaggg ccctaccaag atgctagaat tggagggggt
     3421 tcctgacaag aaagttacat tcttgtcctg aagaattgct ttcttattta aaaacagagt
     3481 cagttagtgg gtagttctgg gcaatagaaa taaatataaa acaataatga caatcattct
     3541 ctacatctca ttatcagctg aggtactgta tattactgaa tttactgaag atagttatgt
     3601 ctttcagaca ttgttgttat aaactatgtt taagcctact acaagtgttt cttttttgca
     3661 ttatgtcaga attgatgtac ctttttttta atgattacct ccctgtacta ctgtgcgaac
     3721 aatcaaacaa aatgatgaga ttaatggtca tggataaatt tcaagaaaac tagtgtattt
     3781 gattgaaaag tttaaagtta gaacttaggc cattggaatt tactcatata gcaaactgcg
     3841 tagagccaat attgactcac ctacacacgt tatacagatt gacattttag acattttgaa
     3901 ggccccgtag gtattttatt agttagaact taattttttg aaaaacatat ccaaagcaca
     3961 ataggcatta gaatttgtgc atcgagaact gattacaaat aatattgata tgtatgtaaa
     4021 taactgagaa gtatgtctta tgaagaaata tattttatta caaaaaatta taaaacattt
     4081 tcaagattat atgctttaaa agtttaagat cagaaaataa tcaactttag aaaaacacgt
     4141 ataaaaattg ttaacatcat tgattaaaaa aaaaaaaaaa aagccaacat gattgttgtg
     4201 aacatcaacc tgctgactga acctgggaat tcaggttaag tatgtgactg ctgccgtgcc
     4261 tcagagaaat ttgtatttaa attaacttat gtaaaaaaaa atcttagaac aaatgtttgt
     4321 ttatttttat acttatttaa gaaattgaaa acttctgaaa ataaagtttg attgtgtctt
     4381 ta
//
