LOCUS       NM_017043               2811 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus prostaglandin-endoperoxide synthase 1 (Ptgs1),
            mRNA.
ACCESSION   NM_017043 XM_346652
VERSION     NM_017043.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2811)
  AUTHORS   Haidey,J.N., Peringod,G., Institoris,A., Gorzo,K.A., Nicola,W.,
            Vandal,M., Ito,K., Liu,S., Fielding,C., Visser,F., Nguyen,M.D. and
            Gordon,G.R.
  TITLE     Astrocytes regulate ultra-slow arteriole oscillations via
            stretch-mediated TRPV4-COX-1 feedback
  JOURNAL   Cell Rep 36 (5), 109405 (2021)
   PUBMED   34348138
  REMARK    GeneRIF: Astrocytes regulate ultra-slow arteriole oscillations via
            stretch-mediated TRPV4-COX-1 feedback.
REFERENCE   2  (bases 1 to 2811)
  AUTHORS   Suo,Z., Liu,Y., Li,Y., Xu,C., Liu,Y., Gao,M. and Dong,J.
  TITLE     Calcitriol inhibits COX-1 and COX-2 expressions of renal
            vasculature in hypertension: Reactive oxygen species involved?
  JOURNAL   Clin Exp Hypertens 43 (1), 91-100 (2021)
   PUBMED   32909857
  REMARK    GeneRIF: Calcitriol inhibits COX-1 and COX-2 expressions of renal
            vasculature in hypertension: Reactive oxygen species involved?
REFERENCE   3  (bases 1 to 2811)
  AUTHORS   Shojo,H., Borlongan,C.V. and Mabuchi,T.
  TITLE     Genetic and Histological Alterations Reveal Key Role of
            Prostaglandin Synthase and Cyclooxygenase 1 and 2 in Traumatic
            Brain Injury-Induced Neuroinflammation in the Cerebral Cortex of
            Rats Exposed to Moderate Fluid Percussion Injury
  JOURNAL   Cell Transplant 26 (7), 1301-1313 (2017)
   PUBMED   28933223
  REMARK    GeneRIF: COX1 and 2 gene expression and localization in the injured
            brain regulating prostaglandin synthase.
REFERENCE   4  (bases 1 to 2811)
  AUTHORS   Gariepy,H., Zhao,J. and Levy,D.
  TITLE     Differential contribution of COX-1 and COX-2 derived prostanoids to
            cortical spreading depression-Evoked cerebral oligemia
  JOURNAL   J Cereb Blood Flow Metab 37 (3), 1060-1068 (2017)
   PUBMED   27178425
  REMARK    GeneRIF: the long-lasting oligemia following cortical spreading
            depression consists of at least two distinct temporal phases,
            mediated by preferential actions of COX-1- and COX-2-derived
            prostanoids: an initial phase mediated by COX-1 that involves TXA2
            followed by a later phase, mediated by COX-2 and PGF2alpha.
REFERENCE   5  (bases 1 to 2811)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   6  (bases 1 to 2811)
  AUTHORS   Deininger,M.H. and Schluesener,H.J.
  TITLE     Cyclooxygenases-1 and -2 are differentially localized to microglia
            and endothelium in rat EAE and glioma
  JOURNAL   J Neuroimmunol 95 (1-2), 202-208 (1999)
   PUBMED   10229132
REFERENCE   7  (bases 1 to 2811)
  AUTHORS   Hwang,D., Scollard,D., Byrne,J. and Levine,E.
  TITLE     Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast
            cancer
  JOURNAL   J Natl Cancer Inst 90 (6), 455-460 (1998)
   PUBMED   9521170
REFERENCE   8  (bases 1 to 2811)
  AUTHORS   Kitzler,J., Hill,E., Hardman,R., Reddy,N., Philpot,R. and
            Eling,T.E.
  TITLE     Analysis and quantitation of splicing variants of the TPA-inducible
            PGHS-1 mRNA in rat tracheal epithelial cells
  JOURNAL   Arch Biochem Biophys 316 (2), 856-863 (1995)
   PUBMED   7864644
REFERENCE   9  (bases 1 to 2811)
  AUTHORS   Feng,L., Sun,W., Xia,Y., Tang,W.W., Chanmugam,P., Soyoola,E.,
            Wilson,C.B. and Hwang,D.
  TITLE     Cloning two isoforms of rat cyclooxygenase: differential regulation
            of their expression
  JOURNAL   Arch Biochem Biophys 307 (2), 361-368 (1993)
   PUBMED   8274023
REFERENCE   10 (bases 1 to 2811)
  AUTHORS   Hla,T. and Neilson,K.
  TITLE     Human cyclooxygenase-2 cDNA
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7384-7388 (1992)
   PUBMED   1380156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081816.1.
            
            On Feb 1, 2014 this sequence version replaced NM_017043.3.
            
            Summary: This is one of two genes encoding similar enzymes that
            catalyze the conversion of arachinodate to prostaglandin. The
            encoded protein regulates angiogenesis in endothelial cells, and is
            inhibited by nonsteroidal anti-inflammatory drugs such as aspirin.
            Based on its ability to function as both a cyclooxygenase and as a
            peroxidase, the encoded protein has been identified as a
            moonlighting protein. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081816.1, S67721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: inferred from conservation
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2811              BC081816.1         1-2811
FEATURES             Location/Qualifiers
     source          1..2811
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2811
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /note="prostaglandin-endoperoxide synthase 1"
                     /db_xref="GeneID:24693"
                     /db_xref="RGD:3439"
     exon            1..66
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1868
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /EC_number="1.14.99.1"
                     /note="cyclooxygenase 3; prostaglandin G/H synthase 1;
                     prostaglandin G/H synthase and cyclooxygenase; PHS 1; PGH
                     synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1"
                     /codon_start=1
                     /product="prostaglandin G/H synthase 1 precursor"
                     /protein_id="NP_058739.4"
                     /db_xref="GeneID:24693"
                     /db_xref="RGD:3439"
                     /translation="MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQ
                     NQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIW
                     EFVNATFIREVLMRLVLTVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKD
                     CPTPMGTKGKKQLPDIHLLAQRLLLRREFIPAPQGTNVLFAFFAQHFTHQFFKTSGKM
                     GPGFTKALGHGVDLGHIYGDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMR
                     YPPGVPPEKQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTT
                     RLILIGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIALEFNHLYHWHPL
                     MPDSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVA
                     EDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGEKEMAAELEELYGDIDALEFYPG
                     LMLEKCQPNSLFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNIVNTASL
                     KKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPSTEL"
     exon            67..162
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..279
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..420
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..564
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..746
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..830
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1077
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1364
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1512
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..2787
                     /gene="Ptgs1"
                     /gene_synonym="Cox-1; Cox-3; Cox1; Cox3; Pghs-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagtaac accagaagag ccagccgttg gcgttgcaca tccatctact cccagagtca
       61 tgagtcgaag gagtctctcg ctccagtttc ccctgctgct gctcctgctg ctgctcccac
      121 cacccccggt actgctcaca gatgctgggg taccctcacc agtcaatccc tgttgttact
      181 atccatgcca gaaccagggt gtctgtgtcc gcttcggcct cgaccactac caatgtgact
      241 gtactcgcac gggctactcg ggccccaact gtactatccc tgagatctgg acctggcttc
      301 ggagttccct gcggcccagc ccctcattca cccatttcct gctgacacac gggtactgga
      361 tctgggagtt tgtgaatgcc accttcatcc gagaagtact catgcgcctg gtactcacgg
      421 tgcggtccaa ccttatcccc agccctccaa cctacaacac agcacatgac tacatcagct
      481 gggagtcctt ctccaacgtg agctactata ctcgcattct gccctctgta cccaaagact
      541 gtcccacacc catgggaacc aaagggaaga agcagttacc agatattcat cttctggccc
      601 aacgattgct gctgagaagg gagttcattc ccgccccgca ggggaccaac gtcttgtttg
      661 ctttctttgc acaacacttc acccaccagt tcttcaagac ctctggaaag atgggtcctg
      721 gctttaccaa ggccttaggc catggggtag accttggcca catttatgga gatagtctgg
      781 aacgacagta ccacctgcgg ctcttcaagg atgggaaact taagtaccag gtgctggatg
      841 gagaggtgta cccaccttcc gtagaacagg cgtccgtgtt gatgcgctac ccaccaggtg
      901 tcccgcccga aaagcagatg gctgtgggcc aggaggtgtt tgggttgctc ccgggtctga
      961 tgctcttctc cacgatctgg ctgcgcgagc ataaccgtgt gtgtgacttg ctgaaggagg
     1021 agcatcctac atgggatgac gagcagctct tccagaccac tcgcctcatc cttatagggg
     1081 aaaccatcaa gattatcatc gaggagtacg tacagcactt gagtggctat ttcctgcagc
     1141 tcaagtttga cccggagctg ctgttccgag cccagttcca gtatcgcaac cgcatcgcct
     1201 tggaattcaa ccacctctat cactggcatc cgctcatgcc tgattccttc caagtgggct
     1261 cacaagagta cagctatgag cagtttttat ttaacacatc tatgctggtg gactacggtg
     1321 tcgaggcact ggtggatgcc ttctctcgcc agagggctgg ccggattggt gggggtagga
     1381 actttgacta ccatgttctg catgtggccg aggatgtcat caaggagtcc cgagaaatgc
     1441 gcctgcagtc cttcaatgaa taccgaaaga ggtttggcct gaagccttac acttctttcc
     1501 aggagttcac aggagagaag gagatggccg ctgagttgga ggagctatat ggtgacatcg
     1561 atgctttaga gttctacccg gggctgatgc tggagaagtg ccagcccaac tccctctttg
     1621 gggagagcat gatagagatg ggggctcctt tctccctcaa gggcctccta gggaatccca
     1681 tctgttcccc agagtactgg aaacccagca cattcggtgg tgatgtgggt ttcaacatcg
     1741 ttaacacagc ctcactgaag aaactggtct gcctcaacac caagacctgc ccctatgtct
     1801 ccttccgtgt gccagattac cctggagatg acgggtctgt cttcgtgaga ccttccactg
     1861 agctctgagg gggctcttct ggagggagga gttttgttcc tgaagaagac agtccttgat
     1921 gtgggtttcc tggctgggca ttgtgagagc tgacattgac atttggaact tggggtctca
     1981 cccttgccta gaatattgtg attttatttt attttttttt gccattttag gatgctgaat
     2041 cctttgctaa ctaagaaagt taggagtggt tttgtctggc gtcttagaac ttggctcctt
     2101 gttggcaaca cagaaagtta gatttctggt tgatttggaa tacaggctta gaactttata
     2161 tcacagggca gggtgtggtt ccaggcacct taatcccagc acttggaagg cagaggcagt
     2221 tgaatctctg tgagtttgag gccagtctgc tttatgcagt gagttctagg ccagccatgg
     2281 ctgcatagtt agactttttc tcaaaacaaa caaacaaaca atcaaacaca caactttaga
     2341 atgtagaact ccttaaaaaa ttcccttgaa agttaaaggg gttcttaatt ttcttcttag
     2401 aatctggagg ccccttagaa tgttgactat ctgacgggtg actcagaagg tcctgttcca
     2461 agtcaatgat ctataacatg ggccaaaaca ttcccaactt gaatgtctag aatgtggaat
     2521 tggttcattt tcctgttcag tgaaatggac acagaacaaa agaacccaat gtccagcaag
     2581 ggttgctttg cccaagtctg tgtctatacc agagggcaag gcagtaaggt gttcttgggt
     2641 gtcatgctta gactctttcc acagatgtgg agggaacagg tggactcatc tacgattttg
     2701 gttggaagcc accacagtcc tatccccaag caggtctttg ctcgtggcag ctctttctcg
     2761 tggagctaat aaaattctct tcccaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
