LOCUS       NM_001399426            3052 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus prostaglandin reductase 2 (Ptgr2), transcript
            variant 1, mRNA.
ACCESSION   NM_001399426 XM_006240326
VERSION     NM_001399426.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3052)
  AUTHORS   Wu,Y.H., Ko,T.P., Guo,R.T., Hu,S.M., Chuang,L.M. and Wang,A.H.
  TITLE     Structural basis for catalytic and inhibitory mechanisms of human
            prostaglandin reductase PTGR2
  JOURNAL   Structure 16 (11), 1714-1723 (2008)
   PUBMED   19000823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 7, 2022 this sequence version replaced XM_006240326.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1693453.1,
                                           SRR26360172.1394693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               JAXUCZ010000006.1  109662498-109662659
            163-247             JAXUCZ010000006.1  109671899-109671983
            248-366             JAXUCZ010000006.1  109674048-109674166
            367-558             JAXUCZ010000006.1  109676664-109676855
            559-729             JAXUCZ010000006.1  109680878-109681048
            730-939             JAXUCZ010000006.1  109684416-109684625
            940-1061            JAXUCZ010000006.1  109686395-109686516
            1062-1149           JAXUCZ010000006.1  109687017-109687104
            1150-1189           JAXUCZ010000006.1  109689400-109689439
            1190-3052           JAXUCZ010000006.1  109692370-109694232
FEATURES             Location/Qualifiers
     source          1..3052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3052
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /note="prostaglandin reductase 2"
                     /db_xref="GeneID:299194"
                     /db_xref="RGD:1310518"
     exon            1..162
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..247
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1266
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /EC_number="1.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     zinc-binding alcohol dehydrogenase domain-containing
                     protein 1; 15-oxoprostaglandin 13-reductase; zinc binding
                     alcohol dehydrogenase, domain containing 1; PRG-2"
                     /codon_start=1
                     /product="prostaglandin reductase 2 isoform 1"
                     /protein_id="NP_001386355.1"
                     /db_xref="GeneID:299194"
                     /db_xref="RGD:1310518"
                     /translation="MIIQRVVLDSRPGKNGNPVAENFRVEEVSLPDTINEGQVRVRTL
                     YLSVDPYMRCKMNEETGADYLAPWQLAQVADGGGLGVIEESKHQKLAKGDFVTSFYWP
                     WQTKAILDGNGLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGVQEKGHVSAGSNQTMVV
                     SGAAGACGSLAGQIGHLLGCSRVVGICGTHEKCLFLTSELGFDAAVNYKTGNVAEQLR
                     EACPDGVDVYFDNVGGDISNAVISQMNQNSHIILCGQISQYNKDVPYPPPLPPAVEAI
                     QKERNITRERFMVLNYKDRFEPGILQLSQWFKEGKLKIKETVANGLENMGVAFQSMMT
                     GGNIGKQIVRISEDSSP"
     exon            248..366
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..558
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..729
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..939
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1061
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1149
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1189
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..3052
                     /gene="Ptgr2"
                     /gene_synonym="Zadh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccacgca gggggccact gtatccgggc accggaagct ggatgaagcc ggcaaaaaag
       61 gaggaagttt caagccaggg tgacctgtgg gcgtcctcgt cgagctcccg gcgacaccgg
      121 cggtatagct tgggacgtag actaggggtt gcccagtaac aggaattatt ttatatagaa
      181 gtcttgtgaa accattgcac aaatcaagtg atgatcatac aaagagtggt attggattcc
      241 cgacctggga aaaatggaaa tcccgttgca gagaatttca gggtggaaga agtcagttta
      301 ccggatacta tcaacgaagg acaagttcga gtaagaactc tctatctctc cgtggatcct
      361 tacatgcgct gtaagatgaa cgaagagact ggtgctgact atttggcccc gtggcagctg
      421 gcacaggtgg ctgacggtgg aggacttgga gttatagaag agagcaagca ccagaagttg
      481 gccaaaggcg attttgtgac ttctttttac tggccctggc aaactaaggc aattctagac
      541 gggaatggcc ttgagaaggt agacccacaa cttgtggatg gacacctttc gtatttcctt
      601 ggagctatag gtatgcccgg cttgacttcc ttgattgggg tacaggaaaa aggtcatgta
      661 tctgctggat ctaatcagac catggttgtc agcggggcgg caggcgcctg tggatctttg
      721 gctgggcaga ttggccacct gcttggttgt tccagagtgg tgggaatttg tggaacgcat
      781 gagaaatgtc tctttttgac ctcagagctg gggtttgatg ctgcagtcaa ttacaaaaca
      841 gggaatgttg cagaacagct tcgagaagcg tgcccggacg gagtggatgt ttactttgac
      901 aatgttggag gtgacatcag caatgcggtg ataagtcaga tgaatcagaa cagccacatc
      961 attctgtgtg gtcagatttc tcagtacaat aaagacgtgc cctatcctcc tccgctgccc
     1021 cctgctgtag aagcaatcca gaaggaaaga aacatcacaa gagagagatt tatggtatta
     1081 aattataaag atagatttga gcctggaatt ctacagctga gtcagtggtt taaagaagga
     1141 aagctaaaga tcaaggagac tgtggcaaac ggcttggaaa acatgggagt tgcattccaa
     1201 tccatgatga caggaggcaa catagggaag cagatcgtcc gcatttcaga agattcttct
     1261 ccgtagtctt ggtgtgtctc catccaggag accctctatt ctccacttcc cacaaagatt
     1321 gttaagacat gtttaaaaat aatcttatag tacagttagt tctcattcct gtgtgatatt
     1381 ttctttgttg tataaccact ttatcttcaa tatcacattc attatacatt taatatgtga
     1441 ttgttaacca taatcagggg ttctgtgggt catgacccct ctggaggggt cacatatcag
     1501 atctcctgca caacagatat ttacgttaat attcataaca gcaaaattac agttataagg
     1561 aagcaaccaa ataattttat gattgtgggt caccacaaca ggagaaattg tattagaggg
     1621 ttgcagtatt agaaatattg atgccacaat agattgaaat tatctcctca ggtctcccac
     1681 tgccgagact gctaggatgc cagactggtg tcacttgtca cttggataac tttgcttgta
     1741 aaaactaata ttacatatat ttgtatcaag taattaaaag tccctgggtg atttttaaac
     1801 cccaggtttt ctaacccaac tgttaatgga atatatattt ttaaattact tttagaagtg
     1861 agtaaaattc tactctaatt ctaaggtgag aagtggttaa catttgttga actgggaaca
     1921 ttttttaaca ttttttacca ttcttcagac acaccggaag agggcatcag accccattac
     1981 agatggttgt gagccaccac gtggttgctg ggaattgaac tcaggacctc tggaagagca
     2041 gtcagtgctc ctaactactg agccatctcc agcccccatt tttaccattc ttaaactgag
     2101 ggtattagaa ttgagatagc ctttccctat ttttaatgag actttagaac tctctatttt
     2161 acacacccga atgtctgtgc accacgtgca tgcctggtgc ctgcatgggg ctctagtgcc
     2221 tgcagtgggg ctttgggtcc cccggagctg gagagttgag ccactctgtg ggtgcagggc
     2281 tctagaacgc agggcctcag gtagagcagc ctgcccaaag agaggcttca atggcctaag
     2341 tgtatgggtt tcgggcagca ctggggtatt tacagattgt gggacagttg gtggagggca
     2401 gacgttttgg attaggactg gtatgagaag ataagtgagt tgatgggagg ctccaggagc
     2461 caggtttaca ttgagaagtt gatctatgcg tgttctgcca aacaattgac tgtagcaagc
     2521 ctaacagctt actacatctc ataaaagctt gtgtgtattt taggaaaaac agtttttaga
     2581 cagaatctgt taggttggtt tctatgtgat ccacgctggc ctggaactca gttatccacc
     2641 tgcctgcctg cctccagagt gccaatgtta aaggcctgta ttaccatgct ggtacctcgg
     2701 agagctaata gacataacct tcactaagga atcaatcact ggttaaagtg agttgaggat
     2761 aggtcagggc acactgacct ctaggagcct tgaggctaat ccctaactgc acctcccccc
     2821 aacaagcacc aagtaaacaa gcttcagaaa atggtaggac taagtaaatt aactaatggt
     2881 catagacgtg actattccag atatattgat gtatcgcatt cgttttatta attgtaactc
     2941 aacctttaga aaaataaaac tggagctgtt ttctgagtat gacttatggc cactttttta
     3001 cagtcaatgt attttagagg caaaacttgt aataaatgta ttcaaattgt aa
//
