LOCUS       NM_138863               1162 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus prostaglandin reductase 1 (Ptgr1), mRNA.
ACCESSION   NM_138863
VERSION     NM_138863.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Sanchez-Rodriguez,R., Torres-Mena,J.E., Quintanar-Jurado,V.,
            Chagoya-Hazas,V., Rojas Del Castillo,E., Del Pozo Yauner,L.,
            Villa-Trevino,S. and Perez-Carreon,J.I.
  TITLE     Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis
            and promotes cell proliferation and resistance to oxidative stress
  JOURNAL   Free Radic Biol Med 102, 87-99 (2017)
   PUBMED   27867096
  REMARK    GeneRIF: Ptgr1 was overexpressed during the early phase in altered
            hepatocyte foci, and this high level of expression was maintained
            in persistent nodules until tumors developed. Ptgr1 expression was
            regulated by NRF2, which bound to an antioxidant response element
            at -653bp in the rat Ptgr1 gene.
REFERENCE   2  (bases 1 to 1162)
  AUTHORS   Cheng,Y., Zhao,J., Tse,H.F., Le,X.C. and Rong,J.
  TITLE     Plant Natural Products Calycosin and Gallic Acid Synergistically
            Attenuate Neutrophil Infiltration and Subsequent Injury in
            Isoproterenol-Induced Myocardial Infarction: A Possible Role for
            Leukotriene B4 12-Hydroxydehydrogenase?
  JOURNAL   Oxid Med Cell Longev 2015, 434052 (2015)
   PUBMED   26265982
REFERENCE   3  (bases 1 to 1162)
  AUTHORS   Sanchez-Rodriguez,R., Torres-Mena,J.E., De-la-Luz-Cruz,M.,
            Bernal-Ramos,G.A., Villa-Trevino,S., Chagoya-Hazas,V.,
            Landero-Lopez,L., Garcia-Roman,R., Rouimi,P., Del-Pozo-Yauner,L.,
            Melendez-Zajgla,J. and Perez-Carreon,J.I.
  TITLE     Increased expression of prostaglandin reductase 1 in hepatocellular
            carcinomas from clinical cases and experimental tumors in rats
  JOURNAL   Int J Biochem Cell Biol 53, 186-194 (2014)
   PUBMED   24853774
  REMARK    GeneRIF: The increased expression and activity of PTGR1 in liver
            carcinogenesis encourage further research aimed at understanding
            the metabolic role of PTGR1 in HCC and its potential application
            for human cancer diagnosis and treatment
REFERENCE   4  (bases 1 to 1162)
  AUTHORS   Vitturi,D.A., Chen,C.S., Woodcock,S.R., Salvatore,S.R., Bonacci,G.,
            Koenitzer,J.R., Stewart,N.A., Wakabayashi,N., Kensler,T.W.,
            Freeman,B.A. and Schopfer,F.J.
  TITLE     Modulation of nitro-fatty acid signaling: prostaglandin reductase-1
            is a nitroalkene reductase
  JOURNAL   J Biol Chem 288 (35), 25626-25637 (2013)
   PUBMED   23878198
  REMARK    GeneRIF: These results situate PtGR-1 as a critical modulator of
            both the steady state levels and signaling activities of fatty acid
            nitroalkenes in vivo.
REFERENCE   5  (bases 1 to 1162)
  AUTHORS   Waki,H., Hendy,E.B., Hindmarch,C.C., Gouraud,S., Toward,M.,
            Kasparov,S., Murphy,D. and Paton,J.F.
  TITLE     Excessive leukotriene B4 in nucleus tractus solitarii is
            prohypertensive in spontaneously hypertensive rats
  JOURNAL   Hypertension 61 (1), 194-201 (2013)
   PUBMED   23172924
REFERENCE   6  (bases 1 to 1162)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1162)
  AUTHORS   Bougioukou,D.J. and Stewart,J.D.
  TITLE     Opposite stereochemical courses for enzyme-mediated alkene
            reductions of an enantiomeric substrate pair
  JOURNAL   J Am Chem Soc 130 (24), 7655-7658 (2008)
   PUBMED   18500801
  REMARK    GeneRIF: These data showed unequivocally that Ltb4dh mediated net
            trans-addition of hydrogen to (R)-perillaldehyde but followed the
            opposite stereochemical course (net syn-addition) for
            (S)-perillaldehyde.
REFERENCE   8  (bases 1 to 1162)
  AUTHORS   Dick,R.A., Kwak,M.K., Sutter,T.R. and Kensler,T.W.
  TITLE     Antioxidative function and substrate specificity of
            NAD(P)H-dependent alkenal/one oxidoreductase. A new role for
            leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin
            13-reductase
  JOURNAL   J Biol Chem 276 (44), 40803-40810 (2001)
   PUBMED   11524419
REFERENCE   9  (bases 1 to 1162)
  AUTHORS   Primiano,T., Li,Y., Kensler,T.W., Trush,M.A. and Sutter,T.R.
  TITLE     Identification of dithiolethione-inducible gene-1 as a leukotriene
            B4 12-hydroxydehydrogenase: implications for chemoprevention
  JOURNAL   Carcinogenesis 19 (6), 999-1005 (1998)
   PUBMED   9667737
REFERENCE   10 (bases 1 to 1162)
  AUTHORS   Primiano,T., Gastel,J.A., Kensler,T.W. and Sutter,T.R.
  TITLE     Isolation of cDNAs representing dithiolethione-responsive genes
  JOURNAL   Carcinogenesis 17 (11), 2297-2303 (1996)
   PUBMED   8968041
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089775.1.
            
            On Feb 20, 2005 this sequence version replaced NM_138863.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089775.1, FQ229147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..1162
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /note="prostaglandin reductase 1"
                     /db_xref="GeneID:192227"
                     /db_xref="RGD:621195"
     exon            1..25
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     exon            26..141
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1025
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /EC_number="1.3.1.48"
                     /EC_number="1.3.1.74"
                     /note="DIG-1; PRG-1; D3T-inducible gene 1 protein;
                     15-oxoprostaglandin 13-reductase; dithiolethione-inducible
                     gene 1 protein; NADP-dependent leukotriene B4
                     12-hydroxydehydrogenase; dithiolethione-inducible gene-1;
                     NAD(P)H-dependent alkenal/one oxidoreductase"
                     /codon_start=1
                     /product="prostaglandin reductase 1"
                     /protein_id="NP_620218.1"
                     /db_xref="GeneID:192227"
                     /db_xref="RGD:621195"
                     /translation="MVQAKTWTLKKHFEGFPTDSNFELRTTELPPLNNGEVLLEALFL
                     SVDPYMRVAAKKLKEGDSMMGEQVARVVESKNSAFPTGTIVVALLGWTSHSISDGNGL
                     RKLPAEWPDKLPLSLALGTVGMPGLTAYFGLLDICGLKGGETVLVNAAAGAVGSVVGQ
                     IAKLKGCKVVGTAGSDEKVAYLKKLGFDVAFNYKTVKSLEEALRTASPDGYDCYFDNV
                     GGEFSNTVILQMKTFGRIAICGAISQYNRTGPCPPGPSPEVIIYQQLRMEGFIVTRWQ
                     GEVRQKALTDLMNWVSEGKIRYHEYITEGFEKMPAAFMGMLKGDNLGKTIVKA"
     exon            142..187
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     exon            188..244
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     exon            245..412
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     exon            413..530
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     exon            531..686
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     exon            687..795
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     exon            796..914
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1137
                     /gene="Ptgr1"
                     /gene_synonym="Dig1; Ltb4dh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaaggag tttctgtgag actgtgttca tcaggatggt acaagctaag acctggaccc
       61 taaagaagca ctttgaaggc ttccctacgg acagtaactt tgagttgagg acgactgagc
      121 tcccaccctt aaataatgga gaggtcctgc tggaagccct gttcctctcc gtggaccctt
      181 acatgagagt tgcagcaaaa aaactgaagg agggcgacag catgatgggt gaacaagtgg
      241 ccagagttgt ggaaagtaaa aactcagcct tcccaacggg aacgattgtt gtggctttat
      301 taggttggac atcacattcc atttctgatg ggaatggact gagaaagcta cctgcagagt
      361 ggcctgacaa gctaccactg tctttggctt tggggacagt tggcatgcca ggcctcactg
      421 cctactttgg cctgcttgac atctgtggct tgaagggtgg agaaacagtg ctggtcaatg
      481 cggcagccgg ggctgtgggc tctgttgtgg ggcagatagc taagctcaag ggctgcaaag
      541 ttgttggtac agccgggtct gatgaaaagg ttgcctatct taagaagctt ggattcgatg
      601 tggcctttaa ctacaagaca gtaaagtcat tggaagaagc tttgaggaca gcctctccag
      661 atggttatga ttgctacttt gataatgtcg gtggagagtt ttcaaacact gttatactgc
      721 agatgaagac gtttggaaga attgccatct gtggcgccat ctctcaatac aaccgcactg
      781 gcccatgtcc cccaggccca tctccagagg tcattatcta tcagcaactc cgcatggagg
      841 ggttcatcgt tactcggtgg caaggagaag tccgccagaa ggctctgaca gacttgatga
      901 attgggtttc agagggtaag atccggtatc atgaatacat cactgaagga tttgagaaga
      961 tgcccgcagc gttcatggga atgttgaaag gagacaatct ggggaagact atagtgaaag
     1021 cgtgaaaaaa aatggctcac gaatggctta accatttaat acaaatgcat atgtaaaacg
     1081 taactgcaag gagtttggcc tatctaataa aacatggtgg gttttttcca tctgtgaaaa
     1141 aaaaaaaaaa aaaaaaaaaa aa
//
