LOCUS       NM_031557               1777 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus prostaglandin I2 synthase (Ptgis), mRNA.
ACCESSION   NM_031557 XM_342583
VERSION     NM_031557.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Ozen,G., Amgoud,Y., Abdelazeem,H., Mani,S., Benyahia,C.,
            Bouhadoun,A., Tran-Dinh,A., Castier,Y., Guyard,A., Longrois,D.,
            Silverstein,A.M. and Norel,X.
  TITLE     Downregulation of PGI2 pathway in Pulmonary Hypertension Group-III
            patients
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 160, 102158 (2020)
   PUBMED   32673988
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   Wang,X.J., Xu,X.Q., Sun,K., Liu,K.Q., Li,S.Q., Jiang,X., Zhao,Q.H.,
            Wang,L., Peng,F.H., Ye,J., Wu,Y., Jiang,R., Zhang,J., Huang,W.,
            Wei,W.B., Yan,Y., Li,J.H., Liu,Q.Q., Li,S., Wang,Y., Zhang,S.Y.,
            Zhang,X. and Jing,Z.C.
  TITLE     Association of Rare PTGIS Variants With Susceptibility and
            Pulmonary Vascular Response in Patients With Idiopathic Pulmonary
            Arterial Hypertension
  JOURNAL   JAMA Cardiol 5 (6), 677-684 (2020)
   PUBMED   32236489
REFERENCE   3  (bases 1 to 1777)
  AUTHORS   Cao,Y., Guan,Y., Xu,Y.Y. and Hao,C.M.
  TITLE     Endothelial prostacyclin protects the kidney from
            ischemia-reperfusion injury
  JOURNAL   Pflugers Arch 471 (4), 543-555 (2019)
   PUBMED   30413885
REFERENCE   4  (bases 1 to 1777)
  AUTHORS   Ebmeyer,J., Behrend,J., Lorenz,M., Gunther,G., Reif,R.,
            Hengstler,J.G., Braeuning,A., Lampen,A. and Hessel-Pras,S.
  TITLE     Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis
            in human endothelial cells
  JOURNAL   Chem Biol Interact 298, 104-111 (2019)
   PUBMED   30465738
REFERENCE   5  (bases 1 to 1777)
  AUTHORS   Russo,A., Biselli-Chicote,P.M., Kawasaki-Oyama,R.S.,
            Castanhole-Nunes,M.M.U., Maniglia,J.V., de Santi Neto,D.,
            Pavarino,E.C. and Goloni-Bertollo,E.M.
  TITLE     Differential Expression of Prostaglandin I2 Synthase Associated
            with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma
  JOURNAL   J Oncol 2018, 6301980 (2018)
   PUBMED   30532780
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1777)
  AUTHORS   Numaguchi,Y., Naruse,K., Harada,M., Osanai,H., Mokuno,S.,
            Murase,K., Matsui,H., Toki,Y., Ito,T., Okumura,K. and Hayakawa,T.
  TITLE     Prostacyclin synthase gene transfer accelerates
            reendothelialization and inhibits neointimal formation in rat
            carotid arteries after balloon injury
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (3), 727-733 (1999)
   PUBMED   10073980
REFERENCE   7  (bases 1 to 1777)
  AUTHORS   Todaka,T., Yokoyama,C., Yanamoto,H., Hashimoto,N., Nagata,I.,
            Tsukahara,T., Hara,S., Hatae,T., Morishita,R., Aoki,M., Ogihara,T.,
            Kaneda,Y. and Tanabe,T.
  TITLE     Gene transfer of human prostacyclin synthase prevents neointimal
            formation after carotid balloon injury in rats
  JOURNAL   Stroke 30 (2), 419-426 (1999)
   PUBMED   9933282
REFERENCE   8  (bases 1 to 1777)
  AUTHORS   Myers,S.I., Turnage,R.H., Bartula,L., Kalley,B. and Meng,Y.
  TITLE     Estrogen increases male rat aortic endothelial cell (RAEC) PGI2
            release
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 54 (6), 403-409 (1996)
   PUBMED   8888351
REFERENCE   9  (bases 1 to 1777)
  AUTHORS   Miyata,A., Hara,S., Yokoyama,C., Inoue,H., Ullrich,V. and Tanabe,T.
  TITLE     Molecular cloning and expression of human prostacyclin synthase
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1728-1734 (1994)
   PUBMED   8185632
REFERENCE   10 (bases 1 to 1777)
  AUTHORS   Skidgel,R.A. and Printz,M.P.
  TITLE     PGI2 production by rat blood vessels: diminished prostacyclin
            formation in veins compared to arteries
  JOURNAL   Prostaglandins 16 (1), 1-16 (1978)
   PUBMED   360298
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061814.1.
            
            On Feb 9, 2004 this sequence version replaced NM_031557.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061814.1, U53855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1777
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /note="prostaglandin I2 synthase"
                     /db_xref="GeneID:25527"
                     /db_xref="RGD:3438"
     exon            1..152
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1581
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /EC_number="5.3.99.4"
                     /EC_number="4.2.1.152"
                     /note="prostaglandin I2 (prostacyclin) synthase;
                     hydroperoxy icosatetraenoate dehydratase"
                     /codon_start=1
                     /product="prostacyclin synthase"
                     /protein_id="NP_113745.1"
                     /db_xref="GeneID:25527"
                     /db_xref="RGD:3438"
                     /translation="MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLGHA
                     LEFGKDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWDLRTRLDFHPYAI
                     FLMERIFDLQLPNFNPSEEKARMKPTLMHKDLQALTEAMYTNLRTVLLGDSTEGGSGW
                     QEKGLLEFSYSSLLSAGYLTLYGVEASPRTHESQALDRDHSADVFRTFRQLDLMLPKL
                     ARGSLSVGDKDHACSVKSRLWKLLSPAGLASRADRSSWLESYLRHLEEMGVSEDMQAR
                     ALVLQLWATQGNMGPTAFWLLLFLLKNPEALDAVHAELKRIVWQAEKPVLQMTALPQK
                     ILDSMPVLDSVLNETLRLTAAPFITREVMADLALPMADRREFSLRRGDRLLLFPFLSP
                     QKDPEIYTEPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNQCLGKSYAIN
                     SIKQFVVLLLTHFDLELVSEDTEVPEFDLSRYGFGLMQPEEDVPIRYRTRL"
     exon            153..276
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            277..455
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            456..599
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            600..751
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            752..933
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1102
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1284
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1436
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1718
                     /gene="Ptgis"
                     /gene_synonym="PGIS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagctgag gatcctgcgg ttcggtgttg gtggcggtga cctgttgcca cccggcagcc
       61 gcacaccctc gagccatgtc ctgggccgct ctgctcggcc ttctggccgt gttattactg
      121 ttgctgctgc tgctgagccg ccggcgcgcg cggcgacccg gtgagcctcc gttggacctg
      181 ggcagcatcc cctggctggg ccatgccttg gagtttggga aggatgccgc cagcttcctt
      241 accaggatga aggagaagca cggtgacata tttactgtgc tggtgggggg caggtatgtc
      301 actgtcctcc tggacccaca ctcttacgac acagtggtgt gggatctgcg tacacggctg
      361 gacttccacc cctacgccat cttcctcatg gagaggattt ttgatctgca gcttccaaat
      421 ttcaacccca gcgaggagaa ggccaggatg aagccgacgc tcatgcacaa agacctgcag
      481 gcgctcacgg aagccatgta taccaacctg cgcaccgtcc tgctgggtga ctccacagaa
      541 ggaggcagtg gctggcagga gaaaggtctg cttgagttct cctacagctc cctgctcagc
      601 gctggctacc tgaccctgta tggagtggag gcctcaccac gcacccacga gagtcaggcc
      661 ctcgaccgtg accactcagc cgacgttttc cgcaccttcc gccagctgga tctgatgctc
      721 cccaaactgg ctcgaggctc cttgtcagtg ggggataaag accatgcatg cagtgtcaaa
      781 agccgcctgt ggaagctgct gtctccagcc ggactggcct ccagggctga ccggagcagc
      841 tggttggaga gttacctgag acatcttgag gagatggggg tatcagagga catgcaggcc
      901 cgggcactgg tgctgcagct ctgggccaca caagggaata tgggacccac ggctttctgg
      961 ctcctcctct tcctcctcaa gaacccggaa gccctcgatg ctgtccatgc agagctgaaa
     1021 cgcatcgtct ggcaagcaga gaagcctgtt ttacagatga ccgcactccc gcagaagatt
     1081 ctagacagca tgcctgtgct agacagtgtg ctcaatgaga ccctccggct cacggccgcc
     1141 cccttcatca cccgtgaggt catggcagac ctggccttgc ctatggcaga caggagggaa
     1201 ttctctcttc gacgcggtga ccgccttctc ctctttcctt tcctgagtcc ccagaaggac
     1261 ccagaaatct acacagaacc tgaagtcttt aaatacaacc ggttcttgaa cccagatggg
     1321 tcagaaaaga aagattttta caaagatggg aaacggctaa agaattacaa catgccttgg
     1381 ggcgcagggc acaaccagtg cctggggaag agctatgcca tcaacagcat caaacagttt
     1441 gtggtcctgc tgctgactca tttcgacctg gagctggtca gtgaggacac agaggtcccg
     1501 gagtttgacc ttagcagata tggctttggc ctgatgcagc cggaggaaga tgtgcccatc
     1561 cggtaccgta ccaggctgtg acctgtggag cagacactac actcatctgg ggcctcctga
     1621 cttcctgttg ttcctccaga atgctgtgtc cagaggaggg gacagtgaga acaccgagag
     1681 caggaaaagc taataaaagc tctgtgtctc gctgtgaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
