LOCUS       NM_001077644            1360 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus prostaglandin I2 receptor (Ptgir), mRNA.
ACCESSION   NM_001077644 XM_001064016 XM_218457
VERSION     NM_001077644.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1360)
  AUTHORS   Ng,K.Y., Wong,Y.H. and Wise,H.
  TITLE     Glial cells isolated from dorsal root ganglia express prostaglandin
            E(2) (EP(4)) and prostacyclin (IP) receptors
  JOURNAL   Eur J Pharmacol 661 (1-3), 42-48 (2011)
   PUBMED   21549696
  REMARK    GeneRIF: the expression of prostaglandin E(2) (EP(4)) and
            prostacyclin (IP) receptors in cultures of mixed dorsal root
            ganglia cells and in purified dorsal root ganglia glia
REFERENCE   2  (bases 1 to 1360)
  AUTHORS   Myren,M., Olesen,J. and Gupta,S.
  TITLE     Pharmacological and expression profile of the prostaglandin I(2)
            receptor in the rat craniovascular system
  JOURNAL   Vascul Pharmacol 55 (1-3), 50-58 (2011)
   PUBMED   21749934
  REMARK    GeneRIF: The prostaglandin I(2) receptor receptor mRNA transcripts
            and protein were present in meningeal as well as in cerebral rat
            vasculature.
REFERENCE   3  (bases 1 to 1360)
  AUTHORS   Falcetti,E., Hall,S.M., Phillips,P.G., Patel,J., Morrell,N.W.,
            Haworth,S.G. and Clapp,L.H.
  TITLE     Smooth muscle proliferation and role of the prostacyclin (IP)
            receptor in idiopathic pulmonary arterial hypertension
  JOURNAL   Am J Respir Crit Care Med 182 (9), 1161-1170 (2010)
   PUBMED   20622039
REFERENCE   4  (bases 1 to 1360)
  AUTHORS   Duong Van Huyen,J.P., Vessieres,E., Perret,C., Troise,A.,
            Prince,S., Guihot,A.L., Barbry,P., Henrion,D., Bruneval,P.,
            Laurent,S., Lelievre-Pegorier,M. and Fassot,C.
  TITLE     In utero exposure to maternal diabetes impairs vascular expression
            of prostacyclin receptor in rat offspring
  JOURNAL   Diabetes 59 (10), 2597-2602 (2010)
   PUBMED   20622163
  REMARK    GeneRIF: Fetal programming of prostacyclin receptor in rats exposed
            in utero to maternal hyperglycemia results in impaired
            vasodilatation.
REFERENCE   5  (bases 1 to 1360)
  AUTHORS   Graham,D.A. and Rush,J.W.
  TITLE     Cyclooxygenase and thromboxane/prostaglandin receptor contribute to
            aortic endothelium-dependent dysfunction in aging female
            spontaneously hypertensive rats
  JOURNAL   J Appl Physiol (1985) 107 (4), 1059-1067 (2009)
   PUBMED   19696359
  REMARK    GeneRIF: Cyclooxygenase and thromboxane/prostaglandin receptor
            contribute to aortic endothelium-dependent dysfunction in aging
            female spontaneously hypertensive rats.
REFERENCE   6  (bases 1 to 1360)
  AUTHORS   Takayama,K., Yuhki,K., Ono,K., Fujino,T., Hara,A., Yamada,T.,
            Kuriyama,S., Karibe,H., Okada,Y., Takahata,O., Taniguchi,T.,
            Iijima,T., Iwasaki,H., Narumiya,S. and Ushikubi,F.
  TITLE     Thromboxane A2 and prostaglandin F2alpha mediate inflammatory
            tachycardia
  JOURNAL   Nat Med 11 (5), 562-566 (2005)
   PUBMED   15834430
REFERENCE   7  (bases 1 to 1360)
  AUTHORS   Sasaki,Y., Usui,T., Tanaka,I., Nakagawa,O., Sando,T., Takahashi,T.,
            Namba,T., Narumiya,S. and Nakao,K.
  TITLE     Cloning and expression of a cDNA for rat prostacyclin receptor
  JOURNAL   Biochim Biophys Acta 1224 (3), 601-605 (1994)
   PUBMED   7803522
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D28966.1.
            
            On or before Nov 10, 2006 this sequence version replaced
            XM_218457.3, XM_001064016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132305, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1360
                     /gene="Ptgir"
                     /note="prostaglandin I2 receptor"
                     /db_xref="GeneID:292661"
                     /db_xref="RGD:1310890"
     exon            1..937
                     /gene="Ptgir"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1333
                     /gene="Ptgir"
                     /note="PGI receptor; prostanoid IP receptor; PGI2
                     receptor; prostaglandin I2 (prostacyclin) receptor (IP);
                     prostaglandin I receptor (IP)"
                     /codon_start=1
                     /product="prostacyclin receptor"
                     /protein_id="NP_001071112.1"
                     /db_xref="GeneID:292661"
                     /db_xref="RGD:1310890"
                     /translation="MVASGGRPDGPPSITPESPLIVGGREWQGMAGSCWNITYVQDSV
                     GPATSTLMFVAGVVGNGLALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFV
                     AYARNSSLLGLAHGGTMLCDTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLD
                     GPRCARLALPAIYAFCCLFCSLPLLGLGEHQQYCPGSWCFIRMRSPQPGGCAFSLAYA
                     SLMALLVTSIFFCNGSVTLSLCHMYRQQRRHHGSFVPTSRAREDEVYHLILLALMTGI
                     MAVCSLPLTIRGFTQAIAPDSREMGDLHAFRFNAFNPILDPWVFILFRKAVFQRLKFW
                     LCCLCARSVHGDLQTPLSRPVSGRRDTLAPDSLQAKEGNWVPLSTWGTGQVAPLTAVP
                     LSGGDGCSVGMPSKTEAVVACSLC"
     exon            938..1360
                     /gene="Ptgir"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagaaga cggaaacaaa agacagaaac acacgcacac ggggaactgg gagttgactg
       61 gcagatccca gctgccctga ggatggtggc cagcggtgga cgtcctgatg gtcccccttc
      121 tatcaccccc gagagccctc tcattgtagg tggcagagag tggcagggta tggcaggttc
      181 ttgctggaac atcacctacg ttcaagactc ggtaggacct gccaccagca ccctgatgtt
      241 tgtggctggt gtggtgggca acgggctagc actgggcatc ctgggtgccc gacggaggtc
      301 acacccatcg gcgtttgcag tgttggtcac tgggctggca gtgacggatc tgctgggcac
      361 gtgcttcttg agccccgcgg tgtttgtggc ctatgctcga aacagctctt tgctgggcct
      421 ggcccacggt gggacgatgc tgtgtgacac tttcgccttc gctatgactt tcttcggcct
      481 ggcctccacg ctcatcctct tcgccatggc tgtggagcgg tgcctggctc tcagtcatcc
      541 ctacctgtac gcccagctgg acgggccccg ctgtgcccgc ttggctttgc ctgccatcta
      601 cgctttctgt tgtctcttct gctcactgcc cctgctgggc ctgggcgagc accagcagta
      661 ttgtcccggg agctggtgct tcatccgcat gcgttccccc cagcctggtg gctgtgcctt
      721 ctccctggcc tatgccagtc tcatggccct gctggtgacc tccatcttct tctgcaacgg
      781 ctccgtcact ctcagcctct gtcacatgta ccgccaacag agacggcacc atggctcgtt
      841 tgtgccgacc tctcgggcac gagaggatga agtttaccac ctgattctgc tggccctcat
      901 gacaggcatc atggccgtat gctccctgcc tctcacgatc agaggattca cgcaggccat
      961 cgccccagac agcagagaga tgggggacct ccacgccttc cgttttaatg ccttcaaccc
     1021 catcctggac ccctgggtct tcatcctttt ccgaaaggct gtcttccaac gcctcaagtt
     1081 ctggttgtgt tgtctgtgtg cccgttctgt ccatggggat ctgcagacgc ccctctcccg
     1141 gcccgtgtcg gggagaagag acacactggc tcccgattct ctccaggcta aggaagggaa
     1201 ctgggtgccc ctgtcaacct ggggtacggg gcaggtggca ccattgactg ctgtgcctct
     1261 gtctggtggt gatggctgtt ctgtgggaat gccatccaaa acagaggctg tggttgcctg
     1321 ctccctctgc tgatacctaa gctggtcctg cttgccatcc
//
