LOCUS       NM_013115               3001 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus prostaglandin F receptor (Ptgfr), mRNA.
ACCESSION   NM_013115 XM_579372
VERSION     NM_013115.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Fukuda,M., Aoki,T., Manabe,T., Maekawa,A., Shirakawa,T.,
            Kataoka,H., Takagi,Y., Miyamoto,S. and Narumiya,S.
  TITLE     Exacerbation of intracranial aneurysm and aortic dissection in
            hypertensive rat treated with the prostaglandin F-receptor
            antagonist AS604872
  JOURNAL   J Pharmacol Sci 126 (3), 230-242 (2014)
   PUBMED   25341845
  REMARK    GeneRIF: Prostaglandin F-receptor antagonist AS604872 exacerbates
            vascular inflammation in hypertensive animals, facilitating
            intracranial aneurysm formation and aortic dissection.
REFERENCE   2  (bases 1 to 3001)
  AUTHORS   Anadol,E., Kanca,H., Yar,A.S., Helvacioglu,F., Menevse,S.,
            Calguner,E. and Erdogan,D.
  TITLE     Prostaglandin F receptor expression in intrauterine tissues of
            pregnant rats
  JOURNAL   J Vet Sci 15 (1), 125-131 (2014)
   PUBMED   24136214
  REMARK    GeneRIF: There was an increase rat prostaglandin F receptor
            expression in rat uterus with advancing gestation, a marked
            elevation of expression at term, and a concominant decrease during
            the postpartum period.
REFERENCE   3  (bases 1 to 3001)
  AUTHORS   Ueno,T. and Fujimori,K.
  TITLE     Novel suppression mechanism operating in early phase of
            adipogenesis by positive feedback loop for enhancement of
            cyclooxygenase-2 expression through prostaglandin F2alpha receptor
            mediated activation of MEK/ERK-CREB cascade
  JOURNAL   FEBS J 278 (16), 2901-2912 (2011)
   PUBMED   21668646
REFERENCE   4  (bases 1 to 3001)
  AUTHORS   Suzuki-Yamamoto,T., Toida,K., Sugimoto,Y. and Ishimura,K.
  TITLE     Colocalization of prostaglandin F(2alpha) receptor FP and
            prostaglandin F synthase-I in the spinal cord
  JOURNAL   J Lipid Res 50 (10), 1996-2003 (2009)
   PUBMED   19429887
  REMARK    GeneRIF: Data found that FP localizes in neuronal somata and
            dendrites but not in ependymal cells, tanycytes, or endothelial
            cells. Immunohistochemical analysis of serial sections showed the
            colocalization of FP and PGFS I.
REFERENCE   5  (bases 1 to 3001)
  AUTHORS   Almirza,W.H., Dernison,M.M., Peters,P.H., van Zoelen,E.J. and
            Theuvenet,A.P.
  TITLE     Role of the prostanoid FP receptor in action potential generation
            and phenotypic transformation of NRK fibroblasts
  JOURNAL   Cell Signal 20 (11), 2022-2029 (2008)
   PUBMED   18703136
  REMARK    GeneRIF: Activity of PGF(2alpha) by putative pacemaker cells
            underlies the generation of calcium action potentials in normal rat
            kidney monolayers.
REFERENCE   6  (bases 1 to 3001)
  AUTHORS   Yonekura,H., Sakurai,S., Liu,X., Migita,H., Wang,H., Yamagishi,S.,
            Nomura,M., Abedin,M.J., Unoki,H., Yamamoto,Y. and Yamamoto,H.
  TITLE     Placenta growth factor and vascular endothelial growth factor B and
            C expression in microvascular endothelial cells and pericytes.
            Implication in autocrine and paracrine regulation of angiogenesis
  JOURNAL   J Biol Chem 274 (49), 35172-35178 (1999)
   PUBMED   10575000
REFERENCE   7  (bases 1 to 3001)
  AUTHORS   Olofsson,J.I., Leung,C.H., Bjurulf,E., Ohno,T., Selstam,G., Peng,C.
            and Leung,P.C.
  TITLE     Characterization and regulation of a mRNA encoding the
            prostaglandin F2alpha receptor in the rat ovary
  JOURNAL   Mol Cell Endocrinol 123 (1), 45-52 (1996)
   PUBMED   8912810
REFERENCE   8  (bases 1 to 3001)
  AUTHORS   Orlicky,D.J.
  TITLE     Negative regulatory activity of a prostaglandin F2 alpha receptor
            associated protein (FPRP)
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 54 (4), 247-259 (1996)
   PUBMED   8804121
REFERENCE   9  (bases 1 to 3001)
  AUTHORS   Lake,S., Gullberg,H., Wahlqvist,J., Sjogren,A.M., Kinhult,A.,
            Lind,P., Hellstrom-Lindahl,E. and Stjernschantz,J.
  TITLE     Cloning of the rat and human prostaglandin F2 alpha receptors and
            the expression of the rat prostaglandin F2 alpha receptor
  JOURNAL   FEBS Lett 355 (3), 317-325 (1994)
   PUBMED   7988697
REFERENCE   10 (bases 1 to 3001)
  AUTHORS   Kitanaka,J., Hasimoto,H., Sugimoto,Y., Negishi,M., Aino,H.,
            Gotoh,M., Ichikawa,A. and Baba,A.
  TITLE     Cloning and expression of a cDNA for rat prostaglandin F2 alpha
            receptor
  JOURNAL   Prostaglandins 48 (1), 31-41 (1994)
   PUBMED   7972878
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013115.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN16093047
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000002.1  243425564-243425623 c
            61-931              JAXUCZ010000002.1  243423769-243424639 c
            932-3001            JAXUCZ010000002.1  243393350-243395419 c
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..3001
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="prostaglandin F receptor"
                     /db_xref="GeneID:25652"
                     /db_xref="RGD:3436"
     exon            1..60
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
     exon            61..931
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1234
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /note="PGF receptor; prostanoid FP receptor; PGF2-alpha
                     receptor"
                     /codon_start=1
                     /product="prostaglandin F2-alpha receptor"
                     /protein_id="NP_037247.1"
                     /db_xref="GeneID:25652"
                     /db_xref="RGD:3436"
                     /translation="MSINSSKQPASSAAGLIANTTCQTENRLSVFFSIIFMTVGIVSN
                     SLAIAILMKAYQRFRRKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFD
                     QSNILCSVFGISMVFSGLCPLFLGSTMAIERCIGVTNPLFHSTKITSKHVKMILSGVC
                     MFAVFVALLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSSLGLLALGISFS
                     CNAVTGVTLLRVKFRSQQHRQGRSHHLEMVIQLLAIMCVSCVCWSPFLVTMANIAING
                     NNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWE
                     LSSIKNSLKVAAISESPAAEKENQQASSEAGL"
     exon            932..3001
                     /gene="Ptgfr"
                     /gene_synonym="PF2AR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaatgttg caagctgagg ccccttgggg gtgtgggctc tgtaactggc aaagtcaact
       61 atgtctgcac ttcgaggctg cacagtcgtg acagagagat gacttgaggg ggacggcgtt
      121 tatctccaca acgatgtcca taaacagttc caagcagccg gcgtcctctg cagctggact
      181 catcgccaac acgacttgcc agacggagaa ccggctttca gtgttctttt caataatctt
      241 catgacggtg gggattgtat ctaacagcct ggccattgcc atcctcatga aggcatatca
      301 gagatttaga cggaagtcga aggcttcttt cctgctcttg gctagtggcc tggtgatcac
      361 agacttcttc ggccacctca tcaacggagg gatagctgtc ttcgtatacg cttctgataa
      421 agactggatc cgcttcgatc aatcgaacat cctgtgcagt gtttttggga tctccatggt
      481 gttctctggc ttgtgcccac ttttcctggg cagtacgatg gccattgaga ggtgcatcgg
      541 ggtcaccaac cctctattcc actctacaaa gatcacgtct aagcatgtga aaatgatact
      601 gagcggtgtg tgcatgtttg ctgtcttcgt ggccctgttg cccatccttg gacaccgaga
      661 ttatcaaatc caagcatcca gaacttggtg cttctacaac acagagcaca tcgaagactg
      721 ggaagacagg ttctatctct tgttcttttc ttccctggga ctcttagctc tcggcatctc
      781 attctcgtgc aacgccgtca cgggagtcac acttttgaga gtgaagttta gaagtcagca
      841 gcacaggcaa ggcaggtctc accacctgga gatggtcatt cagctcctgg ccataatgtg
      901 tgtctcctgc gtctgctgga gtccctttct ggtgacgatg gccaacattg caatcaatgg
      961 aaataattcc ccagtgacct gtgagacgac gctctttgct ctccgaatgg caacctggaa
     1021 ccagatatta gacccctggg tctacattct gctacggaag gctgtcctta ggaacctgta
     1081 caagcttgcc agtcgctgct gtggagtgaa catcatcagc ttgcacatct gggaactcag
     1141 ctccatcaag aattccttaa aggttgctgc tatctctgag tcaccggctg cagagaagga
     1201 gaatcagcaa gcatctagtg aggctggact gtaagtcaat gcacagctag aagaaagtta
     1261 tgggaacttc cgaaacatct tacctgacca gactcagagc ataactggaa cacttggacc
     1321 tctgtgtgta gttcaggagt acactggtca gacaaagctt ctgacttttg ttatgctggc
     1381 tgctgcatgg ttgtgcattt tcatttgttg gtgtcaacag gagattcaac atggtggagt
     1441 taagtagagt acacatttta tctgcgtgac ttatgttttt ggaataaatg aatctgttga
     1501 ggccctgtgc ctttatttga cctatttttc caagcacctt aatgctacct gcaccgtgac
     1561 atggccattt gaggagcact gacttgcaga caaagcttaa agtaacacaa gactttttgt
     1621 gtttgtgtgt gcagctctgc tctgtttacc aacccacgtg tcctcaatgt ctgcatgacc
     1681 atgacatctg agtctcgtgg tgactttgat ggccactatg taggcagctc agcttgacat
     1741 tgtggggctg atgaggataa tcattcttgt cacaactcac atgtgtggtt gcttgcattt
     1801 gttgttgtga aggtcaatta ttttttccac attggctgtc ctcctataaa gtcataggtt
     1861 ttcagtgtct aagtaatccc cctttcctct gaaaattgta gaggaataca ggctttatct
     1921 tagcacagat tcagctcatg atagcatatc ataagcccta ttgtggatga tgcaaacatt
     1981 gaaatcccac ttacacatgc caagaacatg gcagacattg ctttacctga gctatcattt
     2041 ctgtgtcaga gaataaaaaa cgatcaagac acattcgaag tctcttggag ctattgtgtt
     2101 tctgccttac acacacaggc ataagggagt tctgttaaca gtaatttcac taaataagtt
     2161 gaaccacact tccaaaagcc tgtgttatca gtgaggagtg gaaagatctg aaattagcca
     2221 ggagttggga tccactgttg tggttaaccc gaggctaagg gacaagattc tgtcgccaag
     2281 tttcccaatc ttaattcaca cttctccttt gtataattta acacaaagat actcaatttc
     2341 agtaatcact ctaaacatta gttccatcag tgactacggt tagtggttat attttataaa
     2401 gaaatgtatt ttcatattta aaaaattcct ttcttttatc gtttgtcttt atttaaaaat
     2461 ttctattttt ttctttgcta tgtgtatgag tgtttcaccc gaatgtattt ccgagcatta
     2521 cgtaccttcc tagaacttac ttaaaccaga aaaggacatc gggtccttac agatggttat
     2581 aagctaccat gtggatacta ggaattgagc ccaggttctc tggaagagca gctgtagaga
     2641 gaattttaat ccagcaattt gtgaattcaa tagacttaaa atagtacctc caacatggtt
     2701 tctctggcaa aagatcacat ccgaagagct tctaggttta tatgatctgg cttgaatgca
     2761 gacattctct ggattatagt acaatctggc tgtaacacag acacaccctt agtacacacc
     2821 tttaatccct aacagtgaag gaaagttagt ttgtagaagg aagtagtcac ttttgaaatc
     2881 gatgtccagt tgagggtcag acagagtgac gaatcagaga aagttttgac agaatgagtt
     2941 agagaaagga tgtgctcaat tcacgtgaga acagtacgga aagagaggat gccgaaaagg
     3001 g
//
