LOCUS       NM_001130989            1659 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus prostaglandin E synthase 3 (Ptges3), mRNA.
ACCESSION   NM_001130989
VERSION     NM_001130989.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1659)
  AUTHORS   Woodford,M.R., Sager,R.A., Marris,E., Dunn,D.M., Blanden,A.R.,
            Murphy,R.L., Rensing,N., Shapiro,O., Panaretou,B., Prodromou,C.,
            Loh,S.N., Gutmann,D.H., Bourboulia,D., Bratslavsky,G., Wong,M. and
            Mollapour,M.
  TITLE     Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates
            folding of kinase and non-kinase clients
  JOURNAL   EMBO J 36 (24), 3650-3665 (2017)
   PUBMED   29127155
REFERENCE   2  (bases 1 to 1659)
  AUTHORS   Nakatani,Y., Miyazaki,Y. and Hara,S.
  TITLE     Cytosolic Prostaglandin E Synthase Is Involved in c-Fos Expression
            in Rat Fibroblastic 3Y1 Cells
  JOURNAL   Biol Pharm Bull 40 (11), 1963-1967 (2017)
   PUBMED   29093345
  REMARK    GeneRIF: Study in cultured rat fibroblasts suggests that cPGES/p23
            is involved in the activation of ERK to promote c-Fos expression.
REFERENCE   3  (bases 1 to 1659)
  AUTHORS   Majed,B.H. and Khalil,R.A.
  TITLE     Molecular mechanisms regulating the vascular prostacyclin pathways
            and their adaptation during pregnancy and in the newborn
  JOURNAL   Pharmacol Rev 64 (3), 540-582 (2012)
   PUBMED   22679221
  REMARK    Review article
REFERENCE   4  (bases 1 to 1659)
  AUTHORS   Yang,J. and Fuller,P.J.
  TITLE     Interactions of the mineralocorticoid receptor--within and without
  JOURNAL   Mol Cell Endocrinol 350 (2), 196-205 (2012)
   PUBMED   21784126
  REMARK    Review article
REFERENCE   5  (bases 1 to 1659)
  AUTHORS   Hirata,T. and Narumiya,S.
  TITLE     Prostanoids as regulators of innate and adaptive immunity
  JOURNAL   Adv Immunol 116, 143-174 (2012)
   PUBMED   23063076
  REMARK    Review article
REFERENCE   6  (bases 1 to 1659)
  AUTHORS   Weaver,A.J., Sullivan,W.P., Felts,S.J., Owen,B.A. and Toft,D.O.
  TITLE     Crystal structure and activity of human p23, a heat shock protein
            90 co-chaperone
  JOURNAL   J Biol Chem 275 (30), 23045-23052 (2000)
   PUBMED   10811660
REFERENCE   7  (bases 1 to 1659)
  AUTHORS   Weikl,T., Abelmann,K. and Buchner,J.
  TITLE     An unstructured C-terminal region of the Hsp90 co-chaperone p23 is
            important for its chaperone function
  JOURNAL   J Mol Biol 293 (3), 685-691 (1999)
   PUBMED   10543959
REFERENCE   8  (bases 1 to 1659)
  AUTHORS   Holt,S.E., Aisner,D.L., Baur,J., Tesmer,V.M., Dy,M., Ouellette,M.,
            Trager,J.B., Morin,G.B., Toft,D.O., Shay,J.W., Wright,W.E. and
            White,M.A.
  TITLE     Functional requirement of p23 and Hsp90 in telomerase complexes
  JOURNAL   Genes Dev 13 (7), 817-826 (1999)
   PUBMED   10197982
REFERENCE   9  (bases 1 to 1659)
  AUTHORS   Whitesell,L., Sutphin,P.D., Pulcini,E.J., Martinez,J.D. and
            Cook,P.H.
  TITLE     The physical association of multiple molecular chaperone proteins
            with mutant p53 is altered by geldanamycin, an hsp90-binding agent
  JOURNAL   Mol Cell Biol 18 (3), 1517-1524 (1998)
   PUBMED   9488468
REFERENCE   10 (bases 1 to 1659)
  AUTHORS   Czar,M.J., Welsh,M.J. and Pratt,W.B.
  TITLE     Immunofluorescence localization of the 90-kDa heat-shock protein to
            cytoskeleton
  JOURNAL   Eur J Cell Biol 70 (4), 322-330 (1996)
   PUBMED   8864660
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001130989.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166579.1, DY308945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               JAXUCZ010000007.1  1075309-1075602
            295-408             JAXUCZ010000007.1  1085057-1085170
            409-478             JAXUCZ010000007.1  1085603-1085672
            479-577             JAXUCZ010000007.1  1086586-1086684
            578-667             JAXUCZ010000007.1  1087930-1088019
            668-730             JAXUCZ010000007.1  1090067-1090129
            731-755             JAXUCZ010000007.1  1090811-1090835
            756-1659            JAXUCZ010000007.1  1091460-1092363
FEATURES             Location/Qualifiers
     source          1..1659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1659
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /note="prostaglandin E synthase 3"
                     /db_xref="GeneID:362809"
                     /db_xref="RGD:1561913"
     exon            1..294
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..775
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /EC_number="5.3.99.3"
                     /note="cPGES; hsp90 co-chaperone; telomerase-binding
                     protein p23; progesterone receptor complex p23; cytosolic
                     prostaglandin E2 synthase; prostaglandin E synthase 3
                     (cytosolic)"
                     /codon_start=1
                     /product="prostaglandin E synthase 3"
                     /protein_id="NP_001124461.1"
                     /db_xref="GeneID:362809"
                     /db_xref="RGD:1561913"
                     /translation="MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGS
                     DNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVD
                     FNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
                     "
     exon            295..408
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /inference="alignment:Splign:2.1.0"
     exon            409..478
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /inference="alignment:Splign:2.1.0"
     exon            479..577
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /inference="alignment:Splign:2.1.0"
     exon            578..667
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /inference="alignment:Splign:2.1.0"
     exon            668..730
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /inference="alignment:Splign:2.1.0"
     exon            731..755
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1659
                     /gene="Ptges3"
                     /gene_synonym="RGD1561913"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccgccgc ccggcctcac cacccctcgc gcgcacgcac gctccttctc cgtcctcgcg
       61 ccccttttcc tacactttcc tcctctcccg ggctgaggga gccgctctcc gcgcgttgca
      121 ttctgggcat cgaggccgag cccgccgctg ccgccgccgt cgcctaaggg gaacgaggag
      181 aggccgcgac cgggtagaga ccgccggagt cgctgccgga gaggagtcga ctcgccagcc
      241 gccgccagcg aggcccgccc acccgttcgc ctggccctct gccccgttca ccatgcagcc
      301 tgcttctgca aagtggtacg accgaaggga ctatgtattc attgaatttt gtgttgaaga
      361 cagtaaagat gttaatgtaa actttgaaaa atccaaactt actttcagtt gtcttggagg
      421 aagtgataat tttaagcatt taaatgaaat tgatcttttt cattgtattg atccaaatga
      481 ttccaagcat aaaagaacgg acagatcgat tttatgttgt ttgcgaaaag gagaatccgg
      541 ccaatcctgg cctaggttaa caaaggaaag ggcaaagctt aattggctta gtgtggactt
      601 caataattgg aaagattggg aggatgactc agatgaagac atgtctaatt ttgaccgttt
      661 ctctgagatg atggatcaca tgggtggtga tgaggatgta gatttaccag aagtagacgg
      721 agcagatgat gattcacaag acagtgatga tgaaaaaatg ccagatctgg agtaaagagt
      781 ggtatcatcg cctggatatt gaggggaaaa aaaaaataac ttctgcaaga tttcataatt
      841 gagaaaatcc ctgagttgat agctctaaag gcagatatgc tgtacttggc tcctttaacc
      901 catttttcaa cttttttttt tttaaggctt cactaagggt tgattatgta ccattgtatg
      961 gggcaattta agtcagctaa ggcaatatcc gtatgcatga acatttccca gaattccatg
     1021 aagcagttga ggtcctaggc aactgctaca gcagctctga tgaataactg catctcatct
     1081 aagtcttctt ttgtcataat acacttaact tctccattaa gaaagttctc agcttaggga
     1141 aagataaagg ttttagatcc tagataatgg gcttgaagga ggtggaaaca aattggctaa
     1201 tatcttaagc tgatgccccg ccattcttcc aggatacctt tcagaattat tccactaaag
     1261 tttatttttc aaaaaaatgt actttacatc attgtttgtg atcacttgtc agtgttcagg
     1321 tgtattttag ctaagactag tggatgccct aacttagatg gtttttgaag cctatacctt
     1381 tggtattgtt tggcccttaa gcttttacat ctcttagcat ggaggacaaa gaaagctgta
     1441 cattgttgct tgagaatatg tacattttag accagatttg tacttgcact gtcagtatgg
     1501 caaatgagtg gaaaatgtta atacactatt ggatttttta tttcctgttt tgatttcagc
     1561 ttatgccctg gctggaaaac ctcaatttat gttcatgaca gtggggattt ttttaaatgt
     1621 ctacattctt tctaataaac tgttggaaga tttcttggc
//
