LOCUS       NM_001107832            2044 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus prostaglandin E synthase 2 (Ptges2), mRNA.
ACCESSION   NM_001107832 XM_001078154 XM_231144
VERSION     NM_001107832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2044)
  AUTHORS   Majed BH and Khalil RA.
  TITLE     Molecular mechanisms regulating the vascular prostacyclin pathways
            and their adaptation during pregnancy and in the newborn
  JOURNAL   Pharmacol Rev 64 (3), 540-582 (2012)
   PUBMED   22679221
  REMARK    Review article
REFERENCE   2  (bases 1 to 2044)
  AUTHORS   Hirata T and Narumiya S.
  TITLE     Prostanoids as regulators of innate and adaptive immunity
  JOURNAL   Adv Immunol 116, 143-174 (2012)
   PUBMED   23063076
  REMARK    Review article
REFERENCE   3  (bases 1 to 2044)
  AUTHORS   Zhao X, Leon IR, Bak S, Mogensen M, Wrzesinski K, Hojlund K and
            Jensen ON.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   4  (bases 1 to 2044)
  AUTHORS   Jiang H, Deng CS, Zhang M and Xia J.
  TITLE     Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic
            colitis by inhibiting expression of cyclooxygenase-2
  JOURNAL   World J Gastroenterol 12 (24), 3848-3853 (2006)
   PUBMED   16804969
  REMARK    GeneRIF: Curcumin has therapeutic effects on TNBS acid-induced
            colitis, the mechanisms seem to be related to COX-2 inhibition and
            PGE(2) improvement.
REFERENCE   5  (bases 1 to 2044)
  AUTHORS   Leppilampi M, Parkkila S, Karttunen T, Gut MO, Gros G and Sjoblom
            M.
  TITLE     Carbonic anhydrase isozyme-II-deficient mice lack the duodenal
            bicarbonate secretory response to prostaglandin E2
  JOURNAL   Proc Natl Acad Sci U S A 102 (42), 15247-15252 (2005)
   PUBMED   16217040
REFERENCE   6  (bases 1 to 2044)
  AUTHORS   Giannico G, Mendez M and LaPointe MC.
  TITLE     Regulation of the membrane-localized prostaglandin E synthases
            mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts
  JOURNAL   Am J Physiol Heart Circ Physiol 288 (1), H165-H174 (2005)
   PUBMED   15358613
  REMARK    GeneRIF: Prostaglandin E synthase(PGES)-1 and -2 are colocalized
            with COX-2 in cardiac myocytes and fibroblasts.
REFERENCE   7  (bases 1 to 2044)
  AUTHORS   Watanabe K, Ohkubo H, Niwa H, Tanikawa N, Koda N, Ito S and Ohmiya
            Y.
  TITLE     Essential 110Cys in active site of membrane-associated
            prostaglandin E synthase-2
  JOURNAL   Biochem Biophys Res Commun 306 (2), 577-581 (2003)
   PUBMED   12804604
REFERENCE   8  (bases 1 to 2044)
  AUTHORS   Hu J, Meng Q, Roy SK, Raha A, Hu J, Zhang J, Hashimoto K and
            Kalvakolanu DV.
  TITLE     A novel transactivating factor that regulates
            interferon-gamma-dependent gene expression
  JOURNAL   J Biol Chem 277 (33), 30253-30263 (2002)
   PUBMED   12050152
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001078154.1, XM_231144.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231959.1, SRR8487226.130213.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..2044
                     /gene="Ptges2"
                     /note="prostaglandin E synthase 2"
                     /db_xref="GeneID:311865"
                     /db_xref="RGD:1310836"
     exon            1..787
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..1666
                     /gene="Ptges2"
                     /EC_number="5.3.99.3"
                     /codon_start=1
                     /product="prostaglandin E synthase 2"
                     /protein_id="NP_001101302.1"
                     /db_xref="GeneID:311865"
                     /db_xref="RGD:1310836"
                     /translation="MAQAARVAWVLGSSRCALSEGLLTRPWTQLSAQSRAGFTRAAAG
                     NRGASIRKGSPRLLGVAALALGGALGLYHTVRWHLRSQDLHAERSAVQLSLSNRLQLT
                     LYQYKTCPFCSKVRAFLDFHSLPYQVVEVNPVRRTEIKFSSYRKVPILVAQEGDSLQQ
                     LNDSSVIISALKTYLVSGQPLEEIITYYPPMKAMNDQGKEVTEFGNKYWLMLDQKEAQ
                     QMYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPAEALASFDYIVREGKFGAVEATM
                     AKYVGAAAMYFISKRLKSRHHLQDDVRVDLYEAANKWVTAVGKDRPFMGGQKPNLADL
                     AVYGVLRVMEGLEAFDDLMRHSHIQPWYLRMERAIKEASSMHCMHPNCKD"
     exon            788..985
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1044
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1194
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1395
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1513
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2044
                     /gene="Ptges2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttgaggc ctttgggttg gcgatccggc ccccttagct tgaaccattt ccgaagcacg
       61 tggttttcaa ggcccccgct gggtttgaga aaagtttatg gttcgcgtca caacagcagc
      121 gtacagcatt gcgggagggc agaaggcgtc taagacgctg cggccgccta ttggagacag
      181 cgttggactt tttctgggta gtgcatgggt cggaagactg gcgttttccc tgacatcgta
      241 gattcacgat gtggaaacgc ccgaccacga gtcacaggtt accgttgcac ccctagaagg
      301 cagcgacatc aagccacttc caaagcccct ggggtgtagt tctgcctctc aggcagacaa
      361 gcgctcccgt tcccttcacg gcctctagtc ctacttggcg tcatcgttac cctaggcaac
      421 acacagacac agagtgctgt ccctttaagg aatcctagca ccttggccat tttagttttg
      481 cgcgcccgcc cgcagcaccg gcaaagcgaa catggcccag gcagcgcgcg ttgcgtgggt
      541 gcttggctct agccggtgcg ccctgtcaga ggggctgctc acacgaccct ggacacaact
      601 ctcggcacag agccgggcgg gcttcaccag ggcggcagcg ggaaaccggg gcgcctcgat
      661 ccgcaagggg agcccgcggt tgctgggggt ggcggcgctg gccctgggcg gcgctctggg
      721 gctgtaccac actgtgcggt ggcacctgcg ctcccaggac ctccacgccg agcgctcggc
      781 tgtgcagctg tccctgtcca accgcctgca gctgaccctg taccagtaca agacatgtcc
      841 cttctgcagc aaagtccgtg ccttcctcga cttccactcc ctgccctatc aggtggtaga
      901 ggtgaatccc gtgagaagga ccgagattaa attctcctcc tacaggaagg tacccatcct
      961 ggtggcccag gaaggagaca gcttgcaaca gctcaatgac tcctcagtca tcattagtgc
     1021 cctcaagacc tacctggttt cagggcagcc cctggaagag atcatcactt attacccacc
     1081 catgaaggcc atgaatgatc agggcaagga ggtaaccgag ttcggcaaca agtactggct
     1141 catgctggac cagaaggagg cccagcagat gtatggcgga aaggaagcca ggacggagga
     1201 gatgaagtgg cggcagtggg cggatgactg gctggtgcat ctcatctctc ccaacgtgta
     1261 ccgaacacct gccgaggccc tggcttcctt cgactatatt gtccgtgagg gcaagtttgg
     1321 ggctgtggag gccaccatgg ccaagtacgt gggcgcagct gccatgtact tcatcagcaa
     1381 gcgcctcaaa agcaggcacc acctgcagga tgatgtccgg gtagacctct atgaagcagc
     1441 caacaagtgg gtgacagccg tgggcaaaga ccggccattc atggggggtc agaagcctaa
     1501 ccttgctgac ctggcagtgt atggtgtgct gcgagtgatg gagggtctgg aagcctttga
     1561 cgacctgatg cgacactcac acatccagcc ttggtacctg cggatggagc gggccatcaa
     1621 agaagcctct tcaatgcact gtatgcaccc taattgcaaa gactagctgc tagaggcacg
     1681 agacctggac cagtccctgg ctgtgcttgt agggcagtca tttcatctct agcctccagt
     1741 tctctatttc taatactgga catttctagg gcccttgacg ctgaggacaa ggcccaaact
     1801 taatagctgt tctgaggata aagggtctgg gggtcacaaa ggactaccct ccaatcccag
     1861 ttccagagcc tgatctccca acggggactc ctttcaactc ctctagggct cagtcccttg
     1921 ttgactcgga tcaggcaatc tgttaacaaa agccctgtcc acgtgcctcg gagttccagc
     1981 tcttcccgtg cccctgggac tgttgtattt gtaataaagg agaggtctgc tgctcccctc
     2041 tggc
//
