LOCUS       NM_021583               1254 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus prostaglandin E synthase (Ptges), mRNA.
ACCESSION   NM_021583
VERSION     NM_021583.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   Lin,M.H., Lee,Y.C., Liao,J.B., Chou,C.Y. and Yang,Y.F.
  TITLE     PTGES is involved in myofibroblast differentiation via
            HIF-1alpha-dependent glycolysis pathway
  JOURNAL   J Cell Mol Med 28 (20), e70157 (2024)
   PUBMED   39417702
  REMARK    GeneRIF: PTGES is involved in myofibroblast differentiation via
            HIF-1alpha-dependent glycolysis pathway.
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   Lin,Y.M., Fu,Y., Hegde,S., Tang,Y., Radhakrishnan,R. and Shi,X.Z.
  TITLE     Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in
            Long-term Motility Dysfunction after Bowel Obstruction
  JOURNAL   Sci Rep 8 (1), 8831 (2018)
   PUBMED   29891860
  REMARK    GeneRIF: In conclusion, microsomal PGES-1 plays a critical role in
            the continuous suppression of motor function in the post-bowel
            obstruction state.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Gao,C., Fu,Y., Li,Y., Zhang,X., Zhang,L., Yu,F., Xu,S.S., Xu,Q.,
            Zhu,Y., Guan,Y., Wang,X. and Kong,W.
  TITLE     Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits
            Vascular Smooth Muscle Cell Calcification
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (1), 108-121 (2016)
   PUBMED   26543101
  REMARK    GeneRIF: Suggest pivotal role of COX-2-mPGES-1-PGE2 axis in
            vascular calcification. Inhibition of COX-2 or mPGES-1 may increase
            the risk of calcification and subsequent adverse cardiovascular
            events during chronic renal failure.
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Waclawik,A., Rivero-Muller,A., Rahman,N.A. and Ziecik,A.J.
  TITLE     Functional consequences of knocking down porcine prostaglandin
            synthases in SK-6 swine kidney cell line
  JOURNAL   Reprod Biol 15 (1), 42-47 (2015)
   PUBMED   25726376
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   Bylund,J., Annas,A., Hellgren,D., Bjurstrom,S., Andersson,H. and
            Svanhagen,A.
  TITLE     Amide hydrolysis of a novel chemical series of microsomal
            prostaglandin E synthase-1 inhibitors induces kidney toxicity in
            the rat
  JOURNAL   Drug Metab Dispos 41 (3), 634-641 (2013)
   PUBMED   23284082
  REMARK    GeneRIF: Using metabolic profiling and exploratory rat toxicity
            studies, a new and active mPGES-1 inhibitor with improved margins
            to chemically induced kidney toxicity in rats has been identified.
REFERENCE   6  (bases 1 to 1254)
  AUTHORS   Lazarus,M., Kubata,B.K., Eguchi,N., Fujitani,Y., Urade,Y. and
            Hayaishi,O.
  TITLE     Biochemical characterization of mouse microsomal prostaglandin E
            synthase-1 and its colocalization with cyclooxygenase-2 in
            peritoneal macrophages
  JOURNAL   Arch Biochem Biophys 397 (2), 336-341 (2002)
   PUBMED   11795891
REFERENCE   7  (bases 1 to 1254)
  AUTHORS   Jabbour,H.N., Milne,S.A., Williams,A.R., Anderson,R.A. and
            Boddy,S.C.
  TITLE     Expression of COX-2 and PGE synthase and synthesis of PGE(2)in
            endometrial adenocarcinoma: a possible autocrine/paracrine
            regulation of neoplastic cell function via EP2/EP4 receptors
  JOURNAL   Br J Cancer 85 (7), 1023-1031 (2001)
   PUBMED   11592775
REFERENCE   8  (bases 1 to 1254)
  AUTHORS   Mancini,J.A., Blood,K., Guay,J., Gordon,R., Claveau,D., Chan,C.C.
            and Riendeau,D.
  TITLE     Cloning, expression, and up-regulation of inducible rat
            prostaglandin e synthase during lipopolysaccharide-induced pyresis
            and adjuvant-induced arthritis
  JOURNAL   J Biol Chem 276 (6), 4469-4475 (2001)
   PUBMED   11067848
REFERENCE   9  (bases 1 to 1254)
  AUTHORS   Murakami,M., Naraba,H., Tanioka,T., Semmyo,N., Nakatani,Y.,
            Kojima,F., Ikeda,T., Fueki,M., Ueno,A., Oh,S. and Kudo,I.
  TITLE     Regulation of prostaglandin E2 biosynthesis by inducible
            membrane-associated prostaglandin E2 synthase that acts in concert
            with cyclooxygenase-2
  JOURNAL   J Biol Chem 275 (42), 32783-32792 (2000)
   PUBMED   10869354
REFERENCE   10 (bases 1 to 1254)
  AUTHORS   Satoh,K., Nagano,Y., Shimomura,C., Suzuki,N., Saeki,Y. and
            Yokota,H.
  TITLE     Expression of prostaglandin E synthase mRNA is induced in
            beta-amyloid treated rat astrocytes
  JOURNAL   Neurosci Lett 283 (3), 221-223 (2000)
   PUBMED   10754227
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB048730.1.
            
            On Aug 30, 2012 this sequence version replaced NM_021583.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB048730.1, BC105858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1254              AB048730.1         3-1256
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1254
                     /gene="Ptges"
                     /gene_synonym="mPGES-1; Pges"
                     /note="prostaglandin E synthase"
                     /db_xref="GeneID:59103"
                     /db_xref="RGD:62076"
     exon            1..169
                     /gene="Ptges"
                     /gene_synonym="mPGES-1; Pges"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..502
                     /gene="Ptges"
                     /gene_synonym="mPGES-1; Pges"
                     /EC_number="2.5.1.18"
                     /EC_number="5.3.99.3"
                     /note="glutathione peroxidase PTGES; glutathione
                     transferase PTGES; inducible prostaglandin E synthase;
                     microsomal prostaglandin E synthase 1"
                     /codon_start=1
                     /product="prostaglandin E synthase"
                     /protein_id="NP_067594.1"
                     /db_xref="GeneID:59103"
                     /db_xref="RGD:62076"
                     /translation="MTSLGLVMENSQVLPAFLLCSTLLVIKMYAVAVITGQVRLRKKA
                     FANPEDALKRGGLQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWI
                     HFLVVLTGRVVHTVAYLGKMNPRIRSGAYVLAQFACFSMALQILWEVAHHL"
     exon            170..252
                     /gene="Ptges"
                     /gene_synonym="mPGES-1; Pges"
                     /inference="alignment:Splign:2.1.0"
     exon            253..1254
                     /gene="Ptges"
                     /gene_synonym="mPGES-1; Pges"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagtcccg gtgtcccgga gtccaggctg gctagctgag atgacttccc tgggtttggt
       61 gatggagaac agccaggtgc tccccgcctt tctgctctgc agcacactgc tggtcatcaa
      121 gatgtacgcg gtggctgtca tcacaggcca agtcaggctg cggaagaagg cttttgccaa
      181 ccccgaggac gcgttgaaac gtggaggtct ccagtactgc aggagtgacc cagatgtgga
      241 gcgctgcctc agagcccacc gcaacgacat ggagacgatc taccccttcc tcttccttgg
      301 tttcgtctac tcattcctgg gacccaaccc tctcatcgcc tggatacatt tcctcgtggt
      361 cctcacaggc cgtgtggtac acaccgtggc ctacctgggc aaaatgaacc cacgcattcg
      421 ctccggggcc tatgttctgg cccagttcgc ctgtttctcc atggccctac agatcctctg
      481 ggaagtggcc caccatctgt gaccagcagc tgaagcctcc tcagatacca caatgggaga
      541 cggagccatg aaggctgaac cagaggactt ggtgcccctt ctagaacagg gatgggctca
      601 ggtccagggt tcctggctaa gctaggtgtg tggatctctg agcctaatgt gcaaatgtgt
      661 gtcttagcct tttgggaccc tgggtgatgt gtccgattag aaccgcttac agattgacag
      721 aacatccttc acctcacaaa tgccttaaac ttcctcttac ccataaagca aaggacagaa
      781 gattgtccaa cagagccatc atgccatata gggctaagga tgagggcttc tcagacctac
      841 ctgtaattct ggcacagcca gaggagagac acgtgactgg tgtgtgtctc agggcgtcct
      901 cacaagaggc ccagcagtgg ccggctccca gtggaagtag ggtgccatgt tttcagagga
      961 gggcaggtca gagcttccct gtcccctgtt gatacctctc tgtcctgcct tagctagcac
     1021 aggctcaggg tgaagcaaat gttcccagct cagcctgctc ctgcgcggcc ttggctcctc
     1081 caaagactga aagtcaagga tgggctttga ccaaccgcta aaaaccgcac ctgtgaggtt
     1141 tgaagatgcc aaacatctac tcctgtgaaa aatctcacct atgtgtgtgc agtgtccctc
     1201 cagagtcctc ctgagaccgg ttcaggctta gccattaaac agcagagtgt gacc
//
