LOCUS       NM_032076               1473 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus prostaglandin E receptor 4 (Ptger4), mRNA.
ACCESSION   NM_032076
VERSION     NM_032076.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1473)
  AUTHORS   Li,X., Zhu,Y., Zhao,T., Zhang,X., Qian,H., Wang,J., Miao,X.,
            Zhou,L., Li,N. and Ye,L.
  TITLE     Role of COX-2/PGE2 signaling pathway in the apoptosis of rat
            ovarian granulosa cells induced by MEHP
  JOURNAL   Ecotoxicol Environ Saf 254, 114717 (2023)
   PUBMED   36889213
  REMARK    GeneRIF: Role of COX-2/PGE2 signaling pathway in the apoptosis of
            rat ovarian granulosa cells induced by MEHP.
REFERENCE   2  (bases 1 to 1473)
  AUTHORS   Shirakami,Y., Nakanishi,T., Ozawa,N., Ideta,T., Kochi,T.,
            Kubota,M., Sakai,H., Ibuka,T., Tanaka,T. and Shimizu,M.
  TITLE     Inhibitory effects of a selective prostaglandin E2 receptor
            antagonist RQ-15986 on inflammation-related colon tumorigenesis in
            APC-mutant rats
  JOURNAL   PLoS One 16 (5), e0251942 (2021)
   PUBMED   34003864
  REMARK    GeneRIF: Inhibitory effects of a selective prostaglandin E2
            receptor antagonist RQ-15986 on inflammation-related colon
            tumorigenesis in APC-mutant rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1473)
  AUTHORS   Deng,C., Chen,S., Li,X., Luo,H., Zhang,Q., Hu,P., Wang,F.,
            Xiong,C., Sun,T. and Zhang,X.
  TITLE     Role of the PGE2 receptor in ischemia-reperfusion injury of the rat
            retina
  JOURNAL   Mol Vis 26, 36-47 (2020)
   PUBMED   32165825
  REMARK    GeneRIF: Role of the PGE2 receptor in ischemia-reperfusion injury
            of the rat retina.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1473)
  AUTHORS   Viana,M.N., Leiguez,E., Gutierrez,J.M., Rucavado,A., Markus,R.P.,
            Marcola,M., Teixeira,C. and Fernandes,C.M.
  TITLE     A representative metalloprotease induces PGE2 synthesis in
            fibroblast-like synoviocytes via the NF-kappaB/COX-2 pathway with
            amplification by IL-1beta and the EP4 receptor
  JOURNAL   Sci Rep 10 (1), 3269 (2020)
   PUBMED   32094439
  REMARK    GeneRIF: A representative metalloprotease induces PGE2 synthesis in
            fibroblast-like synoviocytes via the NF-kappaB/COX-2 pathway with
            amplification by IL-1beta and the EP4 receptor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1473)
  AUTHORS   Holt,M.C., Ho,C.S., Morano,M.I., Barrett,S.D. and Stein,A.J.
  TITLE     Improved homology modeling of the human & rat EP4 prostanoid
            receptors
  JOURNAL   BMC Mol Cell Biol 20 (1), 37 (2019)
   PUBMED   31455205
  REMARK    GeneRIF: This work has generated a set of novel homology models of
            the rEP4 and hEP4 receptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1473)
  AUTHORS   Boie,Y., Stocco,R., Sawyer,N., Slipetz,D.M., Ungrin,M.D.,
            Neuschafer-Rube,F., Puschel,G.P., Metters,K.M. and Abramovitz,M.
  TITLE     Molecular cloning and characterization of the four rat
            prostaglandin E2 prostanoid receptor subtypes
  JOURNAL   Eur J Pharmacol 340 (2-3), 227-241 (1997)
   PUBMED   9537820
REFERENCE   7  (bases 1 to 1473)
  AUTHORS   Zeng,L., An,S. and Goetzl,E.J.
  TITLE     Selective regulation of RNK-16 cell matrix metalloproteinases by
            the EP4 subtype of prostaglandin E2 receptor
  JOURNAL   Biochemistry 35 (22), 7159-7164 (1996)
   PUBMED   8679543
REFERENCE   8  (bases 1 to 1473)
  AUTHORS   Mori,K., Tanaka,I., Kotani,M., Miyaoka,F., Sando,T., Muro,S.,
            Sasaki,Y., Nakagawa,O., Ogawa,Y., Usui,T., Ozaki,S., Ichikawa,A.,
            Narumiya,S. and Nakao,K.
  TITLE     Gene expression of the human prostaglandin E receptor EP4 subtype:
            differential regulation in monocytoid and lymphoid lineage cells by
            phorbol ester
  JOURNAL   J Mol Med (Berl) 74 (6), 333-336 (1996)
   PUBMED   8862514
REFERENCE   9  (bases 1 to 1473)
  AUTHORS   Sando,T., Usui,T., Tanaka,I., Mori,K., Sasaki,Y., Fukuda,Y.,
            Namba,T., Sugimoto,Y., Ichikawa,A., Narumiya,S. et al.
  TITLE     Molecular cloning and expression of rat prostaglandin E receptor
            EP2 subtype
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1329-1333 (1994)
   PUBMED   8185583
REFERENCE   10 (bases 1 to 1473)
  AUTHORS   Bastien,L., Sawyer,N., Grygorczyk,R., Metters,K.M. and Adam,M.
  TITLE     Cloning, functional expression, and characterization of the human
            prostaglandin E2 receptor EP2 subtype
  JOURNAL   J Biol Chem 269 (16), 11873-11877 (1994)
   PUBMED   8163486
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U94709.1.
            
            On Jun 10, 2007 this sequence version replaced NM_032076.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U94709.1, D28860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155306, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1473
                     /gene="Ptger4"
                     /gene_synonym="EP4; Ptger; Ptgerep4"
                     /note="prostaglandin E receptor 4"
                     /db_xref="GeneID:84023"
                     /db_xref="RGD:628641"
     CDS             1..1467
                     /gene="Ptger4"
                     /gene_synonym="EP4; Ptger; Ptgerep4"
                     /note="prostaglandin E2 receptor type 4; prostanoid EP4
                     receptor; PGE receptor, EP4 subtype; PGE2 receptor EP4
                     subtype; prostaglandin E receptor 4 (subtype EP4)"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP4 subtype"
                     /protein_id="NP_114465.3"
                     /db_xref="GeneID:84023"
                     /db_xref="RGD:628641"
                     /translation="MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCK
                     SRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFF
                     GLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGR
                     SERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFM
                     RRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVIL
                     LIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYIL
                     LRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREIS
                     STSQTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSES
                     VLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI"
     exon            1..876
                     /gene="Ptger4"
                     /gene_synonym="EP4; Ptger; Ptgerep4"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1473
                     /gene="Ptger4"
                     /gene_synonym="EP4; Ptger; Ptgerep4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtccatcc ccggagtcaa cgcgtccttc tcctccactc cggagaggtt gaacagccca
       61 gtgaccattc ccgcagtgat gtttatcttc ggggtggtgg gcaacctggt ggccatcgta
      121 gtattgtgca agtcgcgcaa ggagcagaag gagactacct tttacactct ggtatgtggg
      181 ctggctgtca ctgacctact gggcacattg ttggtaagcc cagtgaccat cgccacatac
      241 atgaagggcc agtggcccgg agaccaggca ttgtgtgact acagcacctt catcctactt
      301 ttcttcggcc tgtcgggtct cagcatcatc tgtgccatga gcattgagcg ctacctggcc
      361 atcaaccacg cctacttcta cagccactac gtggacaagc ggctggccgg tctcacgctc
      421 ttcgccgtct atgcatctaa cgtgctcttc tgcgcactgc ccaacatggg cctgggtagg
      481 tccgagcggc agtacccggg gacctggtgc ttcatcgact ggaccaccaa cgtaacggcc
      541 tacgccgcct tctcttacat gtacgcgggc ttcagttcct tcctcatcct cgccaccgtg
      601 ctctgcaatg tgctggtgtg cggcgcgctg ctccgcatgc accgccagtt catgcgccgc
      661 acctcgctgg gcacggagca gcaccacgcg gccgctgcag cagcggtggc ttcggtggcc
      721 tgtcggggtc acgcggccgc ctccccagcc ctgcagcgcc tcagtgactt tcgccgccgc
      781 aggagcttcc ggcgcatcgc gggtgcagag atccagatgg tcatcttact catcgccacc
      841 tctctggtgg tgctcatctg ctccattccg ctcgtggtgc gagtgttcat caaccagtta
      901 tatcagccaa gtgtggtgaa agacatcagc agaaacccgg atttgcaggc catcagaatt
      961 gcttctgtga accccatcct ggacccttgg atctacatcc ttcttcggaa gactgtgctc
     1021 agtaaagcca tagaaaagat caagtgcctc ttctgccgca ttggtggttc tggcagagac
     1081 ggttcagcac agcactgctc agagagtcgg aggacatctt ctgccatgtc tggccactcc
     1141 cgctccttcc tctcgcggga gttgagggag atcagcagca cctctcagac cctcctatac
     1201 ctgccagacc taactgaaag cagcctcgga ggcaagaatt tgcttccagg tacgcatggc
     1261 atgggcctga cccaagcaga caccacctcg ctgagaactt tgcgaatttc agagacctca
     1321 gactcctccc agggccagga ctctgagagt gtcttgttgg tggatgaggt tagtgggagc
     1381 cagagagagg agcctgcctc taaggggaac tctctgcaag tcacgttccc cagtgaaacg
     1441 ctgaaattat ctgaaaaatg tatatagtag ctt
//
