LOCUS       NM_012704               1253 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus prostaglandin E receptor 3 (Ptger3), mRNA.
ACCESSION   NM_012704
VERSION     NM_012704.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1253)
  AUTHORS   Liu,Y., Liu,R., Huang,L., Zuo,G., Dai,J., Gao,L., Shi,H., Fang,Y.,
            Lu,Q., Okada,T., Wang,Z., Hu,X., Lenahan,C., Tang,J., Xiao,J. and
            Zhang,J.H.
  TITLE     Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative
            Stress and Neuronal Apoptosis Partially by Modulating
            p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in
            Rats
  JOURNAL   Oxid Med Cell Longev 2022, 7727616 (2022)
   PUBMED   36531208
  REMARK    GeneRIF: Inhibition of Prostaglandin E2 Receptor EP3 Attenuates
            Oxidative Stress and Neuronal Apoptosis Partially by Modulating
            p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in
            Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1253)
  AUTHORS   Sandhu,H.K., Neuman,J.C., Schaid,M.D., Davis,S.E., Connors,K.M.,
            Challa,R., Guthery,E., Fenske,R.J., Patibandla,C., Breyer,R.M. and
            Kimple,M.E.
  TITLE     Rat prostaglandin EP3 receptor is highly promiscuous and is the
            sole prostanoid receptor family member that regulates INS-1 (832/3)
            cell glucose-stimulated insulin secretion
  JOURNAL   Pharmacol Res Perspect 9 (2), e00736 (2021)
   PUBMED   33694300
  REMARK    GeneRIF: Rat prostaglandin EP3 receptor is highly promiscuous and
            is the sole prostanoid receptor family member that regulates INS-1
            (832/3) cell glucose-stimulated insulin secretion.
REFERENCE   3  (bases 1 to 1253)
  AUTHORS   Deng,C., Chen,S., Li,X., Luo,H., Zhang,Q., Hu,P., Wang,F.,
            Xiong,C., Sun,T. and Zhang,X.
  TITLE     Role of the PGE2 receptor in ischemia-reperfusion injury of the rat
            retina
  JOURNAL   Mol Vis 26, 36-47 (2020)
   PUBMED   32165825
  REMARK    GeneRIF: Role of the PGE2 receptor in ischemia-reperfusion injury
            of the rat retina.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1253)
  AUTHORS   Khazaeipool,Z., Wiederman,M. and Inoue,W.
  TITLE     Prostaglandin E2 depresses GABA release onto parvocellular
            neuroendocrine neurones in the paraventricular nucleus of the
            hypothalamus via presynaptic receptors
  JOURNAL   J Neuroendocrinol 30 (11), e12638 (2018)
   PUBMED   30084511
  REMARK    GeneRIF: Results show that prostaglandin E2, via actions of
            presynaptic EP3 receptors, potently depresses GABA release onto
            parvocellular neuroendocrine cells.
REFERENCE   5  (bases 1 to 1253)
  AUTHORS   Ni,H., Shen,J., Song,Y., Cao,M., Liu,X., Huang,J., Zhang,W.,
            Xie,L., Ning,X. and Ke,K.
  TITLE     EP3, Prostaglandin E2 Receptor Subtype 3, Associated with Neuronal
            Apoptosis Following Intracerebral Hemorrhage
  JOURNAL   Cell Mol Neurobiol 36 (6), 971-980 (2016)
   PUBMED   26718710
  REMARK    GeneRIF: that EP3 might exert its pro-apoptotic function on
            neuronal apoptosis
REFERENCE   6  (bases 1 to 1253)
  AUTHORS   Huang,C. and Tai,H.H.
  TITLE     Expression and site-directed mutagenesis of mouse prostaglandin E2
            receptor EP3 subtype in insect cells
  JOURNAL   Biochem J 307 (Pt 2) (Pt 2), 493-498 (1995)
   PUBMED   7733888
REFERENCE   7  (bases 1 to 1253)
  AUTHORS   Irie,A., Segi,E., Sugimoto,Y., Ichikawa,A. and Negishi,M.
  TITLE     Mouse prostaglandin E receptor EP3 subtype mediates calcium signals
            via Gi in cDNA-transfected Chinese hamster ovary cells
  JOURNAL   Biochem Biophys Res Commun 204 (1), 303-309 (1994)
   PUBMED   7945376
REFERENCE   8  (bases 1 to 1253)
  AUTHORS   Neuschafer-Rube,F., DeVries,C., Hanecke,K., Jungermann,K. and
            Puschel,G.P.
  TITLE     Molecular cloning and expression of a prostaglandin E2 receptor of
            the EP3 beta subtype from rat hepatocytes
  JOURNAL   FEBS Lett 351 (1), 119-122 (1994)
   PUBMED   8076679
REFERENCE   9  (bases 1 to 1253)
  AUTHORS   Irie,A., Sugimoto,Y., Namba,T., Asano,T., Ichikawa,A. and
            Negishi,M.
  TITLE     The C-terminus of the prostaglandin-E-receptor EP3 subtype is
            essential for activation of GTP-binding protein
  JOURNAL   Eur J Biochem 224 (1), 161-166 (1994)
   PUBMED   8076637
REFERENCE   10 (bases 1 to 1253)
  AUTHORS   Takeuchi,K., Takahashi,N., Abe,T. and Abe,K.
  TITLE     Two isoforms of the rat kidney EP3 receptor derived by alternative
            RNA splicing: intrarenal expression co-localization
  JOURNAL   Biochem Biophys Res Commun 199 (2), 834-840 (1994)
   PUBMED   8135830
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D29969.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D29969.1, X80133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132280, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1253
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..1253
                     /gene="Ptger3"
                     /gene_synonym="EP3; EP3R; Rep3; rEP3a; rEP3b"
                     /note="prostaglandin E receptor 3"
                     /db_xref="GeneID:24929"
                     /db_xref="RGD:3435"
     exon            1..913
                     /gene="Ptger3"
                     /gene_synonym="EP3; EP3R; Rep3; rEP3a; rEP3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1174
                     /gene="Ptger3"
                     /gene_synonym="EP3; EP3R; Rep3; rEP3a; rEP3b"
                     /function="coupled to adenylate cyclase"
                     /note="prostanoid EP3 receptor; PGE receptor, EP3 subtype;
                     PGE2 receptor EP3 subtype; prostaglandin E receptor 3
                     (subtype EP3)"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP3 subtype"
                     /protein_id="NP_036836.1"
                     /db_xref="GeneID:24929"
                     /db_xref="RGD:3435"
                     /translation="MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNA
                     LAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDP
                     SGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWL
                     SVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLA
                     LVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLL
                     IMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKF
                     CQMMNNLKRSFIAIPASLSMRISSPREG"
     exon            914..1093
                     /gene="Ptger3"
                     /gene_synonym="EP3; EP3R; Rep3; rEP3a; rEP3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1253
                     /gene="Ptger3"
                     /gene_synonym="EP3; EP3R; Rep3; rEP3a; rEP3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgtcctc cagcgcgctc cgctgcaacc ccgcagctga gcccagaggc tccggccctg
       61 tgcgccctac cgcggccccg ccactatggc cggcgtgtgg gcgccggagc actcggttga
      121 agcgcacagc aaccagtcaa gtgctgccga cggctgcggc tctgtgtccg tggccttccc
      181 catcaccatg atggtcactg gcttcgtggg caacgcgctg gccatgttgc ttgtgtcgcg
      241 cagctataga cgccgggaga gcaaacgcaa aaagtctttc ctgctgtgca ttggctggct
      301 ggcgctcacc gacttggtgg ggcagctcct gaccagtccg gtggtcatcc tcgtgtacct
      361 gtcgcagcga cgctgggagc aactcgaccc atcggggcgc ctgtgcacct tcttcgggct
      421 gaccatgaca gtgttcggac tgtcctcgct cttggtggcc agcgccatgg ccgtggagcg
      481 cgccctggct atccgtgcgc cgcactggta tgccagccac atgaagactc gcgccacgcg
      541 cgcggtactg ctgggtgtgt ggctgtctgt gctcgccttc gcgctgctgc ctgtgctggg
      601 cgtgggccgc tacagcgtgc agtggcccgg cacgtggtgc ttcatcagca ccgggccggc
      661 gggcaacgag acggactctg cgcgggagcc gggcagcgtg gcctttgcct ccgccttcgc
      721 ctgtctaggc ttgctggctc tggtggtgac ctttgcctgc aacctggcga ccatcaaagc
      781 cctggtgtcc cgctgccggg ccaaagccgc cgcctcgcag tccagcgccc agtggggccg
      841 gatcaccacg gagacggcta tccagcttat ggggatcatg tgtgtactgt ccgtctgctg
      901 gtcgccgcta ttgataatga tgctgaaaat gatcttcaat cagatgtcag tagagcaatg
      961 caagacgcag atgggaaagg agaaggagtg caattccttc ctaatcgccg ttcgcctggc
     1021 ttcgctgaac cagatcttgg atccctgggt ttatctgctg ctaagaaaga tccttcttcg
     1081 aaagttctgc cagatgatga acaacctgaa gcggagtttc attgcaatac ctgcttccct
     1141 gagtatgaga atttcttccc ccagggaagg ataactgaat cattttggat tgtatcttct
     1201 ttcggcctca tattttaagt tttccttgcc attaaacaca ccgagacaag ctt
//
