LOCUS       NM_031088               1353 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus prostaglandin E receptor 2 (Ptger2), mRNA.
ACCESSION   NM_031088
VERSION     NM_031088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   Li,X., Zhu,Y., Zhao,T., Zhang,X., Qian,H., Wang,J., Miao,X.,
            Zhou,L., Li,N. and Ye,L.
  TITLE     Role of COX-2/PGE2 signaling pathway in the apoptosis of rat
            ovarian granulosa cells induced by MEHP
  JOURNAL   Ecotoxicol Environ Saf 254, 114717 (2023)
   PUBMED   36889213
  REMARK    GeneRIF: Role of COX-2/PGE2 signaling pathway in the apoptosis of
            rat ovarian granulosa cells induced by MEHP.
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Deng,C., Chen,S., Li,X., Luo,H., Zhang,Q., Hu,P., Wang,F.,
            Xiong,C., Sun,T. and Zhang,X.
  TITLE     Role of the PGE2 receptor in ischemia-reperfusion injury of the rat
            retina
  JOURNAL   Mol Vis 26, 36-47 (2020)
   PUBMED   32165825
  REMARK    GeneRIF: Role of the PGE2 receptor in ischemia-reperfusion injury
            of the rat retina.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1353)
  AUTHORS   Parga,J.A., Garcia-Garrote,M., Martinez,S., Raya,A.,
            Labandeira-Garcia,J.L. and Rodriguez-Pallares,J.
  TITLE     Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal
            Cell-Neuroprotective Effects on Dopaminergic Neurons
  JOURNAL   Mol Neurobiol 55 (6), 4763-4776 (2018)
   PUBMED   28717970
  REMARK    GeneRIF: the involvement of prostaglandin signaling from
            mesenchymal stem cells in dopaminergic neuron survival through EP2
            receptors, is reported.
REFERENCE   4  (bases 1 to 1353)
  AUTHORS   Ota,H., Katanosaka,K., Murase,S., Furuyashiki,T., Narumiya,S. and
            Mizumura,K.
  TITLE     EP2 receptor plays pivotal roles in generating mechanical
            hyperalgesia after lengthening contractions
  JOURNAL   Scand J Med Sci Sports 28 (3), 826-833 (2018)
   PUBMED   28759126
  REMARK    GeneRIF: EP2 contributes to generating mechanical hyperalgesia
            through positive feedback upregulation of COX-2 expression in
            muscle after lengthening contractions
REFERENCE   5  (bases 1 to 1353)
  AUTHORS   Fu,Y., Yang,M.S., Jiang,J., Ganesh,T., Joe,E. and Dingledine,R.
  TITLE     EP2 Receptor Signaling Regulates Microglia Death
  JOURNAL   Mol Pharmacol 88 (1), 161-170 (2015)
   PUBMED   25715797
  REMARK    GeneRIF: These results indicate that EP2 activation, which
            initially promotes microglial activation, later causes delayed
            death of activated microglia, potentially contributing to the
            resolution phase of neuroinflammation.
REFERENCE   6  (bases 1 to 1353)
  AUTHORS   Sonoshita,M., Takaku,K., Sasaki,N., Sugimoto,Y., Ushikubi,F.,
            Narumiya,S., Oshima,M. and Taketo,M.M.
  TITLE     Acceleration of intestinal polyposis through prostaglandin receptor
            EP2 in Apc(Delta 716) knockout mice
  JOURNAL   Nat Med 7 (9), 1048-1051 (2001)
   PUBMED   11533709
REFERENCE   7  (bases 1 to 1353)
  AUTHORS   Araki,H., Ukawa,H., Sugawa,Y., Yagi,K., Suzuki,K. and Takeuchi,K.
  TITLE     The roles of prostaglandin E receptor subtypes in the
            cytoprotective action of prostaglandin E2 in rat stomach
  JOURNAL   Aliment Pharmacol Ther 14 Suppl 1, 116-124 (2000)
   PUBMED   10807413
REFERENCE   8  (bases 1 to 1353)
  AUTHORS   Dong,Y.L. and Yallampalli,C.
  TITLE     Pregnancy and exogenous steroid treatments modulate the expression
            of relaxant EP(2) and contractile FP receptors in the rat uterus
  JOURNAL   Biol Reprod 62 (3), 533-539 (2000)
   PUBMED   10684792
REFERENCE   9  (bases 1 to 1353)
  AUTHORS   Boie,Y., Stocco,R., Sawyer,N., Slipetz,D.M., Ungrin,M.D.,
            Neuschafer-Rube,F., Puschel,G.P., Metters,K.M. and Abramovitz,M.
  TITLE     Molecular cloning and characterization of the four rat
            prostaglandin E2 prostanoid receptor subtypes
  JOURNAL   Eur J Pharmacol 340 (2-3), 227-241 (1997)
   PUBMED   9537820
REFERENCE   10 (bases 1 to 1353)
  AUTHORS   Nemoto,K., Pilbeam,C.C., Bilak,S.R. and Raisz,L.G.
  TITLE     Molecular cloning and expression of a rat prostaglandin E2 receptor
            of the EP2 subtype
  JOURNAL   Prostaglandins 54 (4), 713-725 (1997)
   PUBMED   9440134
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031088.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U94708.1, U48858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-885               JAXUCZ010000015.1  20697046-20697930
            886-1353            JAXUCZ010000015.1  20708008-20708475
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1353
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptger-ep2"
                     /note="prostaglandin E receptor 2"
                     /db_xref="GeneID:81752"
                     /db_xref="RGD:620020"
     exon            1..885
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptger-ep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1116
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptger-ep2"
                     /note="prostaglandin E2 receptor type 2; prostanoid EP2
                     receptor; PGE receptor, EP2 subtype; PGE2 receptor EP2
                     subtype; prostaglandin E receptor EP2 subtype;
                     prostaglandin E receptor 2 (subtype EP2); prostaglandin E2
                     receptor EP2 subtype-like"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP2 subtype"
                     /protein_id="NP_112350.1"
                     /db_xref="GeneID:81752"
                     /db_xref="RGD:620020"
                     /translation="MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIAL
                     ALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVA
                     LAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPA
                     IYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNIS
                     VILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVC
                     SLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRT
                     SLRAPEAPGASCSTQQTDLCGQL"
     exon            886..1353
                     /gene="Ptger2"
                     /gene_synonym="EP2; Ptger-ep2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcctgga ggagagacca tctctcctca acgccctcca ccatggacaa ttctttcaat
       61 gactccaggc gagtggagaa ctgcgagagt cgtcagtatc tcctttcgga cgaaagccca
      121 gccatcagct cggtgatgtt cacggccggg gttctgggaa acctcatcgc gctggcactg
      181 ttggcgcgcc gctggcgtgg ggacacgggg tgtagcgccg gcagcaggac ctctatctcc
      241 ttgttccacg tgctggtaac ggaactggtg ctcaccgacc tgctggggac ctgcctcata
      301 agcccggtgg tgctggcttc ttattcgaga aaccagaccc tagtggccct ggctcccgaa
      361 agccgcgcgt gtacctattt cgctttcact atgaccttct ttagtctggc cacgatgctc
      421 atgctcttcg ccatggccct ggaacgctac ctcgccatcg gacaccctta cttctacagg
      481 cgccgcgtct ctcgccgcgg gggtttggcg gtgctgcctg ccatctatgg ggtctccttg
      541 ctcttctgtt ctctgccgct gctcaactac ggggagtacg tccagtactg tcctgggacg
      601 tggtgcttta tccagcacgg gaggaccgca taccttcagc tgtacgccac ggtgctcctg
      661 ctgctcatcg tggctgtgct cggctgcaac atcagcgtga tcctcaacct tattcgcatg
      721 cagcttcgga gcaaaagaag ccgctgcgga ttgtctggca gtagcctgag aggccccggg
      781 tctcgccgga gaggagaaag gacttctatg gcggaggaga cggaccacct cattctcctg
      841 gccattatga ccatcacctt cgctgtatgc tccctgcctt tcacaatctt tgcttatatg
      901 gatgaaacct cttcccgaaa ggaaaagtgg gacctccgag ctcttagatt tttatcagtg
      961 aactccataa ttgatccttg ggtttttgtc atccttagac caccagtcct gagactaatg
     1021 cgctcagtcc tctgttgtcg gacttcactg agagcaccgg aagctccagg agcttcctgt
     1081 tcgacccagc agacggacct ctgcggacag ttgtgagcat gcgctgcttg agggaacctg
     1141 ggccaaagcc tttaaatggc ctcgttggag gaacgtaaag ggccggaatg taaacaaatg
     1201 gccttgctct gagaaagcag atgcagaaga ctttaacgag gtggttgggg ctgcacacgt
     1261 gatgacgggg gccctttgtg gaaagtgtca gaggatgcat aaagttcaca tcgggtggcc
     1321 tttgagggac aaccagctgc atctaagacc cag
//
