LOCUS       NM_013015                759 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus prostaglandin D2 synthase (Ptgds), mRNA.
ACCESSION   NM_013015
VERSION     NM_013015.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Liu,Y.R., Tang,Z.S., Duan,J.A., Chen,L., Sun,J., Zhou,R.,
            Song,Z.X., Shi,X.B. and Zhu,H.Y.
  TITLE     ER-depletion lowering the 'hypothalamus-uterus-kidney' axis
            functions by perturbing the renal ERbeta/Ptgds signalling pathway
  JOURNAL   Aging (Albany NY) 11 (21), 9500-9529 (2019)
   PUBMED   31708494
  REMARK    GeneRIF: ER-depletion lowering the 'hypothalamus-uterus-kidney'
            axis functions by perturbing the renal ERbeta/Ptgds signalling
            pathway.
REFERENCE   2  (bases 1 to 759)
  AUTHORS   Li,X., Zhang,Y., Zhang,B., Liu,X., Hong,L., Liu,L.P., Wu,C.Z. and
            Cui,X.
  TITLE     HIF-1alpha-l-PGDS-PPARgamma regulates hypoxia-induced ANP secretion
            in beating rat atria
  JOURNAL   Prostaglandins Other Lipid Mediat 134, 38-46 (2018)
   PUBMED   29287795
  REMARK    GeneRIF: HIF-1alpha-l-PGDS-PPARgamma regulates hypoxia-induced ANP
            secretion in beating rat atria
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Shan,L.N., Chai,W.S., Lu,S.J., Song,Y.G., Su,D., Yang,S., Shi,X.B.
            and Wang,W.
  TITLE     The significant effect of chronic intermittent hypoxia on
            prostaglandin D2 biosynthesis in rat brain
  JOURNAL   Biochem Biophys Res Commun 483 (1), 283-287 (2017)
   PUBMED   28025147
  REMARK    GeneRIF: Lipocalin-type prostaglandin synthase (L-PGDS) may have a
            role in sleep and chronic intermittent hypoxia
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Moniot,B., Ujjan,S., Champagne,J., Hirai,H., Aritake,K., Nagata,K.,
            Dubois,E., Nidelet,S., Nakamura,M., Urade,Y., Poulat,F. and
            Boizet-Bonhoure,B.
  TITLE     Prostaglandin D2 acts through the Dp2 receptor to influence male
            germ cell differentiation in the foetal mouse testis
  JOURNAL   Development 141 (18), 3561-3571 (2014)
   PUBMED   25142465
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Takiguchi,Y., Sun,G.W., Ogawa,K. and Matsunaga,T.
  TITLE     Long-lasting changes in the cochlear K+ recycling structures after
            acute energy failure
  JOURNAL   Neurosci Res 77 (1-2), 33-41 (2013)
   PUBMED   23827367
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Igarashi,M., Nagata,A., Toh,H., Urade,Y. and Hayaishi,O.
  TITLE     Structural organization of the gene for prostaglandin D synthase in
            the rat brain
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5376-5380 (1992)
   PUBMED   1608945
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Peitsch,M.C. and Boguski,M.S.
  TITLE     The first lipocalin with enzymatic activity
  JOURNAL   Trends Biochem Sci 16 (10), 363 (1991)
   PUBMED   1723819
REFERENCE   8  (bases 1 to 759)
  AUTHORS   Nagata,A., Suzuki,Y., Igarashi,M., Eguchi,N., Toh,H., Urade,Y. and
            Hayaishi,O.
  TITLE     Human brain prostaglandin D synthase has been evolutionarily
            differentiated from lipophilic-ligand carrier proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 4020-4024 (1991)
   PUBMED   1902577
REFERENCE   9  (bases 1 to 759)
  AUTHORS   Urade,Y., Nagata,A., Suzuki,Y., Fujii,Y. and Hayaishi,O.
  TITLE     Primary structure of rat brain prostaglandin D synthetase deduced
            from cDNA sequence
  JOURNAL   J Biol Chem 264 (2), 1041-1045 (1989)
   PUBMED   2642896
REFERENCE   10 (bases 1 to 759)
  AUTHORS   Gerritsen,M.E. and Printz,M.P.
  TITLE     Prostaglandin D synthase in microvessels from the rat cerebral
            cortex
  JOURNAL   Prostaglandins 22 (4), 553-566 (1981)
   PUBMED   6119739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J04488.1.
            
            On Jun 9, 2003 this sequence version replaced NM_013015.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04488.1, FQ101581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..759
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /note="prostaglandin D2 synthase"
                     /db_xref="GeneID:25526"
                     /db_xref="RGD:3433"
     exon            1..148
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..604
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /EC_number="5.3.99.2"
                     /note="prostaglandin-H2 D-isomerase; PGDS; PGDS2; PGD2
                     synthase; glutathione-independent PGD synthetase;
                     lipocalin-type prostaglandin-D synthase;
                     glutathione-independent PGD synthase; Prostaglandin D
                     synthase; prostaglandin D2 synthase (brain)"
                     /codon_start=1
                     /product="prostaglandin-H2 D-isomerase precursor"
                     /protein_id="NP_037147.1"
                     /db_xref="GeneID:25526"
                     /db_xref="RGD:3433"
                     /translation="MAALPMLWTGLVLLGLLGFPQTPAQGHDTVQPNFQQDKFLGRWY
                     SAGLASNSSWFREKKELLFMCQTVVAPSTEGGLNLTSTFLRKNQCETKVMVLQPAGVP
                     GQYTYNSPHWGSFHSLSVVETDYDEYAFLFSKGTKGPGQDFRMATLYSRAQLLKEELK
                     EKFITFSKDQGLTEEDIVFLPQPDKCIQE"
     exon            149..288
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /inference="alignment:Splign:2.1.0"
     exon            289..365
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /inference="alignment:Splign:2.1.0"
     exon            366..482
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /inference="alignment:Splign:2.1.0"
     exon            483..584
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /inference="alignment:Splign:2.1.0"
     exon            585..640
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /inference="alignment:Splign:2.1.0"
     exon            641..759
                     /gene="Ptgds"
                     /gene_synonym="PH2DISO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcaggctc agacacctgc tctactccaa gcaaatggct gctcttccaa tgctgtggac
       61 cgggctggtc ctcttgggtc tcttgggatt tccacagacc ccagcccagg gccatgacac
      121 agtgcagccc aactttcaac aagacaagtt cctggggcgc tggtacagcg cgggcctcgc
      181 ctccaattca agctggttcc gggagaagaa agagctactg tttatgtgcc agacagtggt
      241 agctccctcc acagaaggcg gcctcaacct cacctctacc ttcctaagga aaaaccagtg
      301 tgagaccaag gtgatggtac tgcagccggc aggggttccc ggacagtaca cctacaacag
      361 cccccactgg ggcagcttcc actccctctc agtggtagaa accgactacg atgagtacgc
      421 gttcctgttc agcaagggca ccaagggccc aggccaggac ttccgcatgg ccaccctcta
      481 cagcagagcc cagcttctga aggaggaact gaaggagaaa ttcatcacct ttagcaagga
      541 ccagggcctc acagaggagg acattgtttt cctgccccaa ccggataagt gcattcaaga
      601 gtaaacacag gtgagagaag tcagtcacag gtaacacatg gtgatgtggc ctcaggactc
      661 ccgtgctctg tcactcttga gacccaagcc ctggctcccc aaagaccttc tccgccctcc
      721 agctttgcct tggtggagaa ataaaatcca aagcaagtc
//
