LOCUS       NM_001012070            1297 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus prostaglandin D2 receptor 2 (Ptgdr2), mRNA.
ACCESSION   NM_001012070 XM_219584
VERSION     NM_001012070.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1297)
  AUTHORS   Calbet,M., Andres,M., Armengol,C., Bravo,M., Eichhorn,P., Lopez,R.,
            Garcia-Gonzalez,V., Roberts,R. and Miralpeix,M.
  TITLE     Pharmacological characterization of CRTh2 antagonist LAS191859:
            Long receptor residence time translates into long-lasting in vivo
            efficacy
  JOURNAL   Pharmacol Res 111, 208-216 (2016)
   PUBMED   27317944
  REMARK    GeneRIF: CRTh2 mediates most prostaglandin D2 pro-inflammatory
            effects and long receptor residence time of antagonist LAS191859
            translates into long-lasting in vivo efficacy.
REFERENCE   2  (bases 1 to 1297)
  AUTHORS   Moniot,B., Ujjan,S., Champagne,J., Hirai,H., Aritake,K., Nagata,K.,
            Dubois,E., Nidelet,S., Nakamura,M., Urade,Y., Poulat,F. and
            Boizet-Bonhoure,B.
  TITLE     Prostaglandin D2 acts through the Dp2 receptor to influence male
            germ cell differentiation in the foetal mouse testis
  JOURNAL   Development 141 (18), 3561-3571 (2014)
   PUBMED   25142465
REFERENCE   3  (bases 1 to 1297)
  AUTHORS   Liu,H., Zheng,M., Qiao,J., Dang,Y., Zhang,P. and Jin,X.
  TITLE     Role of prostaglandin D2 /CRTH2 pathway on asthma exacerbation
            induced by Aspergillus fumigatus
  JOURNAL   Immunology 142 (1), 78-88 (2014)
   PUBMED   24329550
  REMARK    GeneRIF: Production of prostaglandin D2 followed by eosinophil
            recruitment into the airways via a CRTH2 receptor are the major
            pathogenic factors responsible for the A. fumigatus-induced
            enhancement of airway inflammation and responsiveness.
REFERENCE   4  (bases 1 to 1297)
  AUTHORS   Kanda,H., Kobayashi,K., Yamanaka,H. and Noguchi,K.
  TITLE     COX-1-dependent prostaglandin D2 in microglia contributes to
            neuropathic pain via DP2 receptor in spinal neurons
  JOURNAL   Glia 61 (6), 943-956 (2013)
   PUBMED   23505121
  REMARK    GeneRIF: We believe that PGD2 signaling via DP2 signaling pathway
            from microglia to neurons is one of the triggering factors for
            mechanical allodynia in this neuropathic pain model.
REFERENCE   5  (bases 1 to 1297)
  AUTHORS   Kagawa,S., Fukunaga,K., Oguma,T., Suzuki,Y., Shiomi,T., Sayama,K.,
            Kimura,T., Hirai,H., Nagata,K., Nakamura,M. and Asano,K.
  TITLE     Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil
            accumulation in the airways of mice with chronic asthma
  JOURNAL   Int Arch Allergy Immunol 155 Suppl 1, 6-11 (2011)
   PUBMED   21646789
REFERENCE   6  (bases 1 to 1297)
  AUTHORS   Shirasaki,H., Kikuchi,M., Kanaizumi,E. and Himi,T.
  TITLE     Accumulation of CRTH2-positive leukocytes in human allergic nasal
            mucosa
  JOURNAL   Ann Allergy Asthma Immunol 102 (2), 110-115 (2009)
   PUBMED   19230460
REFERENCE   7  (bases 1 to 1297)
  AUTHORS   Lukacs,N.W., Berlin,A.A., Franz-Bacon,K., Sasik,R., Sprague,L.J.,
            Ly,T.W., Hardiman,G., Boehme,S.A. and Bacon,K.B.
  TITLE     CRTH2 antagonism significantly ameliorates airway hyperreactivity
            and downregulates inflammation-induced genes in a mouse model of
            airway inflammation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 295 (5), L767-L779 (2008)
   PUBMED   18757520
REFERENCE   8  (bases 1 to 1297)
  AUTHORS   Tirouvanziam,R., Gernez,Y., Conrad,C.K., Moss,R.B., Schrijver,I.,
            Dunn,C.E., Davies,Z.A., Herzenberg,L.A. and Herzenberg,L.A.
  TITLE     Profound functional and signaling changes in viable inflammatory
            neutrophils homing to cystic fibrosis airways
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4335-4339 (2008)
   PUBMED   18334635
REFERENCE   9  (bases 1 to 1297)
  AUTHORS   Hirai,H., Abe,H., Tanaka,K., Takatsu,K., Sugamura,K., Nakamura,M.
            and Nagata,K.
  TITLE     Gene structure and functional properties of mouse CRTH2, a
            prostaglandin D2 receptor
  JOURNAL   Biochem Biophys Res Commun 307 (4), 797-802 (2003)
   PUBMED   12878180
REFERENCE   10 (bases 1 to 1297)
  AUTHORS   Hirai,H., Tanaka,K., Yoshie,O., Ogawa,K., Kenmotsu,K., Takamori,Y.,
            Ichimasa,M., Sugamura,K., Nakamura,M., Takano,S. and Nagata,K.
  TITLE     Prostaglandin D2 selectively induces chemotaxis in T helper type 2
            cells, eosinophils, and basophils via seven-transmembrane receptor
            CRTH2
  JOURNAL   J Exp Med 193 (2), 255-261 (2001)
   PUBMED   11208866
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY228550.1.
            
            On Feb 11, 2005 this sequence version replaced XM_219584.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY228550.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1297
                     /gene="Ptgdr2"
                     /gene_synonym="Gpr44"
                     /note="prostaglandin D2 receptor 2"
                     /db_xref="GeneID:309212"
                     /db_xref="RGD:1311986"
     exon            1..1297
                     /gene="Ptgdr2"
                     /gene_synonym="Gpr44"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1249
                     /gene="Ptgdr2"
                     /gene_synonym="Gpr44"
                     /note="G protein-coupled receptor 44"
                     /codon_start=1
                     /product="prostaglandin D2 receptor 2"
                     /protein_id="NP_001012070.1"
                     /db_xref="GeneID:309212"
                     /db_xref="RGD:1311986"
                     /translation="MANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLL
                     GLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTF
                     CKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVL
                     NTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPL
                     AIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTT
                     LRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLST
                     GPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQ
                     EKQGSLSCTLD"
ORIGIN      
        1 gggtgccagg ttcagctctc ctttcttcca cctggccatg gccaacatca cactgaagcc
       61 gctctgtcca ctcttggagg agatggtcca gcttccaaac cacagcaact ctagcctccg
      121 ctatattgac cacgtgtcgg tgctgttgca cgggctggcc tccctgctgg gcctggtgga
      181 aaacggactc atcctgtttg tggtgggctg tcgcatgcgc cagacggtgg tcactacctg
      241 ggtgctgcac ctggcgctgt ccgacttgtt agccgctgcc tctctgcctt tcttcaccta
      301 ctttctggca gtgggccact cgtgggaact gggcaccact ttctgcaagc tacattcctc
      361 ggtcttcttc ctcaacatgt ttgccagcgg cttcctgctc agcgccatca gcctggatcg
      421 ctgcctgcag gtggtgaggc cagtgtgggc acagaaccac cgcacggtgg cggccgcgca
      481 cagagtctgc ctgatgctct gggctctggc ggtgctcaac acagtaccct atttcgtgtt
      541 cagggacacc atcccgcggc gtgatggccg catcatgtgc tattacaaca tgctgctctt
      601 gaatccaggg tctgaccgcg acaccacgtg cgactaccgt cagaaggccc tggcggtcag
      661 caagttcctg ttggccttca tggtacctct ggccatcatc gcctcgagcc acgtggctgt
      721 gagcctacaa ctgcatcacc gtggtcgcca gaggacaggc cgtttcgtgc gtctggtggc
      781 agccatagtg gtggccttca tactctgctg ggggccctac cacatcttca gtctgttgga
      841 ggcgcgtgcc cattctgtca ccacgctacg gcagctcgcg tcacgtgggc tgccctttgt
      901 caccagcctg gccttcttca acagcgtggt caacccacta ctctatgtgc tcacttgtcc
      961 cgacatgttg cacaagctga ggcgctcgct actcacggtg cttgaaagcg tgctggtgga
     1021 ggacagcgac ctgagtactg ggcccggcaa gcgctgtcgc cgccgccatc gccgccgcgc
     1081 ctcctccacc accaccccag cctctacctt actgctggct gaccgatttc cccaactgcg
     1141 tcctgctcgc ttaatcggct ggatgaggcg tggcagtgca gagctcccac ggagggtccg
     1201 agagcagtcc caggagaagc agggctcatt gagctgtact ttggattaga tgggcacagc
     1261 ccagaagctg tgccaacaca tcccaggcct ctcccat
//
