LOCUS       NM_022241               1315 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus prostaglandin D2 receptor (Ptgdr), mRNA.
ACCESSION   NM_022241 XM_223897 XM_346474
VERSION     NM_022241.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1315)
  AUTHORS   He,Y., Zuo,C., Jia,D., Bai,P., Kong,D., Chen,D., Liu,G., Li,J.,
            Wang,Y., Chen,G., Yan,S., Xiao,B., Zhang,J., Piao,L., Li,Y.,
            Deng,Y., Li,B., Roux,P.P., Andreasson,K.I., Breyer,R.M., Su,Y.,
            Wang,J., Lyu,A., Shen,Y. and Yu,Y.
  TITLE     Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial
            Hypertension via mTORC1 Signaling
  JOURNAL   Am J Respir Crit Care Med 201 (10), 1263-1276 (2020)
   PUBMED   31917615
  REMARK    GeneRIF: Loss of DP1 Aggravates Vascular Remodeling in Pulmonary
            Arterial Hypertension via mTORC1 Signaling.
REFERENCE   2  (bases 1 to 1315)
  AUTHORS   Parent,A., Roy,S.J., Iorio-Morin,C., Lepine,M.C., Labrecque,P.,
            Gallant,M.A., Slipetz,D. and Parent,J.L.
  TITLE     ANKRD13C acts as a molecular chaperone for G protein-coupled
            receptors
  JOURNAL   J Biol Chem 285 (52), 40838-40851 (2010)
   PUBMED   20959461
REFERENCE   3  (bases 1 to 1315)
  AUTHORS   Thura,M., Hokamura,K., Yamamoto,S., Maeda,M., Furuta,K., Suzuki,M.,
            Ibaraki,K. and Umemura,K.
  TITLE     GIF-0173 protects against cerebral infarction through DP1 receptor
            activation
  JOURNAL   Exp Neurol 219 (2), 481-491 (2009)
   PUBMED   19576888
REFERENCE   4  (bases 1 to 1315)
  AUTHORS   Brugger,N., Kim,N.N., Araldi,G.L., Traish,A.M. and Palmer,S.S.
  TITLE     Pharmacological and functional characterization of novel EP and DP
            receptor agonists: DP1 receptor mediates penile erection in
            multiple species
  JOURNAL   J Sex Med 5 (2), 344-356 (2008)
   PUBMED   18047485
REFERENCE   5  (bases 1 to 1315)
  AUTHORS   Prenn,C., Heinemann,A., Schuligoi,R. and Peskar,B.A.
  TITLE     CRTH2 is not involved in the anti-enteropooling effect of PGD2 in
            the small intestine
  JOURNAL   Pharmacology 81 (3), 236-240 (2008)
   PUBMED   18212515
  REMARK    GeneRIF: PGD2 receptor does not seem to be involved in the
            anti-enteropooling effect of PGD(2), since the selective agonists
            13,14-dihydro-15-keto-PGD(2) and 15(R)-15-methyl-PGD(2) were
            without effect
REFERENCE   6  (bases 1 to 1315)
  AUTHORS   Hirai,H., Abe,H., Tanaka,K., Takatsu,K., Sugamura,K., Nakamura,M.
            and Nagata,K.
  TITLE     Gene structure and functional properties of mouse CRTH2, a
            prostaglandin D2 receptor
  JOURNAL   Biochem Biophys Res Commun 307 (4), 797-802 (2003)
   PUBMED   12878180
REFERENCE   7  (bases 1 to 1315)
  AUTHORS   Boyce,J.A.
  TITLE     The role of mast cells in asthma
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 69 (2-3), 195-205 (2003)
   PUBMED   12895603
  REMARK    GeneRIF: amino acid sequence alignment of human, mouse and rat DP
            receptors (also called prostaglandin D2 receptor)
            Review article
REFERENCE   8  (bases 1 to 1315)
  AUTHORS   Mizoguchi,A., Eguchi,N., Kimura,K., Kiyohara,Y., Qu,W.M.,
            Huang,Z.L., Mochizuki,T., Lazarus,M., Kobayashi,T., Kaneko,T.,
            Narumiya,S., Urade,Y. and Hayaishi,O.
  TITLE     Dominant localization of prostaglandin D receptors on arachnoid
            trabecular cells in mouse basal forebrain and their involvement in
            the regulation of non-rapid eye movement sleep
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11674-11679 (2001)
   PUBMED   11562489
REFERENCE   9  (bases 1 to 1315)
  AUTHORS   Wright,D.H., Nantel,F., Metters,K.M. and Ford-Hutchinson,A.W.
  TITLE     A novel biological role for prostaglandin D2 is suggested by
            distribution studies of the rat DP prostanoid receptor
  JOURNAL   Eur J Pharmacol 377 (1), 101-115 (1999)
   PUBMED   10448933
REFERENCE   10 (bases 1 to 1315)
  AUTHORS   Gerashchenko,D., Beuckmann,C.T., Kanaoka,Y., Eguchi,N.,
            Gordon,W.C., Urade,Y., Bazan,N.G. and Hayaishi,O.
  TITLE     Dominant expression of rat prostanoid DP receptor mRNA in
            leptomeninges, inner segments of photoreceptor cells, iris
            epithelium, and ciliary processes
  JOURNAL   J Neurochem 71 (3), 937-945 (1998)
   PUBMED   9721719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Aug 10, 2022 this sequence version replaced NM_022241.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U92289.1, SRR26360194.567157.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-903               JAXUCZ010000015.1  19790499-19791401
            904-1315            JAXUCZ010000015.1  19797462-19797873
FEATURES             Location/Qualifiers
     source          1..1315
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1315
                     /gene="Ptgdr"
                     /gene_synonym="Ptgdr2; Ptgdrl"
                     /note="prostaglandin D2 receptor"
                     /db_xref="GeneID:63889"
                     /db_xref="RGD:619707"
     exon            1..903
                     /gene="Ptgdr"
                     /gene_synonym="Ptgdr2; Ptgdrl"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1134
                     /gene="Ptgdr"
                     /gene_synonym="Ptgdr2; Ptgdrl"
                     /note="prostaglandin D receptor"
                     /codon_start=1
                     /product="prostaglandin D2 receptor-like"
                     /protein_id="NP_071577.2"
                     /db_xref="GeneID:63889"
                     /db_xref="RGD:619707"
                     /translation="MNESYRCQAATWVERGSSATMGGVLFSAGLLGNLLALVLLARSG
                     LGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNRSLKELLPASGNQ
                     LCEAFAFLMSFFGLASTLQLLAMALECWLSLGHPFFYQRHITARRGVLVAPVAGAFSL
                     AFCALPFAGFGKFVQYCPGTWCFIQMIHKKRSFSVIGFSVLYSSLMALLVLATVVCNL
                     GAMSNLYAMHRRQRHHPRRCSRDRAQSGSDYRHGSPNPLEELDHFVLLALTTVLFTMC
                     SLPLIYRAYYGAFKLVDRADGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKT
                     FTRPLIYRNWCSHSWQTNMESTL"
     exon            904..1315
                     /gene="Ptgdr"
                     /gene_synonym="Ptgdr2; Ptgdrl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccttcaca gctgtcctgg ctgcagcctt ccctccaggc agacgtggca agggctagct
       61 atgaatgagt cctatcgctg tcaggcagcc acctgggtgg aacggggctc ctcagcgaca
      121 atgggtggtg tgctcttcag tgcagggctg ctgggcaacc tcctggcgct ggtgctgctg
      181 gcgcgatccg ggctggggtc ctgccggcca gggccactgc atccgccgcc ctcggtcttt
      241 tatgtgctag tgtgcggctt gacggtcacc gacttgctgg gcaagtgtct gatcagcccg
      301 atggtcctgg ctgcctacgc acaaaatcgg agcctaaagg aactgctgcc tgcctcaggc
      361 aatcagttat gtgaagcctt cgccttcctg atgtccttct ttgggttagc ctcgacctta
      421 cagctactgg ctatggcact agagtgctgg ctgtctctgg gacacccttt cttctaccaa
      481 aggcacatca ccgcccgccg gggagtgctg gtggcgccag tcgcaggcgc cttctctttg
      541 gctttctgtg cgctcccctt tgctggcttt gggaagttcg tccagtactg tccgggtacc
      601 tggtgcttca tccagatgat ccacaagaag cgctcattct cggtaatagg cttctctgtg
      661 ctctactcca gcctcatggc gctgctggtc ctcgcaactg tggtgtgcaa cctgggtgcc
      721 atgtccaacc tctatgccat gcacaggcgc cagaggcacc atccccgccg ctgctccagg
      781 gaccgcgccc agtcaggctc agactacagg catgggtccc cgaatccttt ggaggagctg
      841 gaccactttg ttctgctggc tctcacgaca gtgctcttca ccatgtgttc cctgccttta
      901 atttatcgtg cttactatgg agcctttaaa cttgtggaca gagctgacgg agactcggaa
      961 gacctccaag ccttgcgttt tctgtctgtg atttccatcg tggacccctg gatcttcatc
     1021 attttcagga cttcagtatt ccggatgtta tttcacaaga ctttcacaag acctctgatc
     1081 tacagaaact ggtgcagcca ttcctggcag actaacatgg aatccacttt gtgagggctt
     1141 tgcatgttct ggcaagctga aaatacagca cacattcgga caaagaactg tggttgaaaa
     1201 agccttacaa ttgaaatcct taaaaaatac ctcccacggg gagctagaga gatgcatcgg
     1261 ccctgaaaga gcatttactt ttcttccaga agaccggagt tcatttccca gcacc
//
