LOCUS       NM_053964               1531 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus pancreas associated transcription factor 1a
            (Ptf1a), mRNA.
ACCESSION   NM_053964 XM_346504
VERSION     NM_053964.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Hale,M.A., Swift,G.H., Hoang,C.Q., Deering,T.G., Masui,T.,
            Lee,Y.K., Xue,J. and MacDonald,R.J.
  TITLE     The nuclear hormone receptor family member NR5A2 controls aspects
            of multipotent progenitor cell formation and acinar differentiation
            during pancreatic organogenesis
  JOURNAL   Development 141 (16), 3123-3133 (2014)
   PUBMED   25063451
REFERENCE   2  (bases 1 to 1531)
  AUTHORS   Chang,J.C., Meredith,D.M., Mayer,P.R., Borromeo,M.D., Lai,H.C.,
            Ou,Y.H. and Johnson,J.E.
  TITLE     Prdm13 mediates the balance of inhibitory and excitatory neurons in
            somatosensory circuits
  JOURNAL   Dev Cell 25 (2), 182-195 (2013)
   PUBMED   23639443
REFERENCE   3  (bases 1 to 1531)
  AUTHORS   Wildner,H., Das Gupta,R., Brohl,D., Heppenstall,P.A.,
            Zeilhofer,H.U. and Birchmeier,C.
  TITLE     Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice
            reveals new markers for distinct dorsal horn interneuron
            populations contributing to nociceptive reflex plasticity
  JOURNAL   J Neurosci 33 (17), 7299-7307 (2013)
   PUBMED   23616538
REFERENCE   4  (bases 1 to 1531)
  AUTHORS   Thompson,N., Gesina,E., Scheinert,P., Bucher,P. and
            Grapin-Botton,A.
  TITLE     RNA profiling and chromatin immunoprecipitation-sequencing reveal
            that PTF1a stabilizes pancreas progenitor identity via the control
            of MNX1/HLXB9 and a network of other transcription factors
  JOURNAL   Mol Cell Biol 32 (6), 1189-1199 (2012)
   PUBMED   22232429
REFERENCE   5  (bases 1 to 1531)
  AUTHORS   Nishida,K., Hoshino,M., Kawaguchi,Y. and Murakami,F.
  TITLE     Ptf1a directly controls expression of immunoglobulin superfamily
            molecules Nephrin and Neph3 in the developing central nervous
            system
  JOURNAL   J Biol Chem 285 (1), 373-380 (2010)
   PUBMED   19887377
REFERENCE   6  (bases 1 to 1531)
  AUTHORS   Knofler,M., Krapp,A., Hagenbuchle,O. and Wellauer,P.K.
  TITLE     Constitutive expression of the gene for the cell-specific p48
            DNA-binding subunit of pancreas transcription factor 1 in cultured
            cells is under control of binding sites for transcription factors
            Sp1 and alphaCbf
  JOURNAL   J Biol Chem 271 (36), 21993-22002 (1996)
   PUBMED   8703005
REFERENCE   7  (bases 1 to 1531)
  AUTHORS   Samuelson,L.C., Wiebauer,K., Howard,G., Schmid,R.M., Koeplin,D. and
            Meisler,M.H.
  TITLE     Isolation of the murine ribonuclease gene Rib-1: structure and
            tissue specific expression in pancreas and parotid gland
  JOURNAL   Nucleic Acids Res 19 (24), 6935-6941 (1991)
   PUBMED   1840677
REFERENCE   8  (bases 1 to 1531)
  AUTHORS   Sommer,L., Hagenbuchle,O., Wellauer,P.K. and Strubin,M.
  TITLE     Nuclear targeting of the transcription factor PTF1 is mediated by a
            protein subunit that does not bind to the PTF1 cognate sequence
  JOURNAL   Cell 67 (5), 987-994 (1991)
   PUBMED   1720355
REFERENCE   9  (bases 1 to 1531)
  AUTHORS   Petrucco,S., Wellauer,P.K. and Hagenbuchle,O.
  TITLE     The DNA-binding activity of transcription factor PTF1 parallels the
            synthesis of pancreas-specific mRNAs during mouse development
  JOURNAL   Mol Cell Biol 10 (1), 254-264 (1990)
   PUBMED   2294404
REFERENCE   10 (bases 1 to 1531)
  AUTHORS   Cockell,M., Stevenson,B.J., Strubin,M., Hagenbuchle,O. and
            Wellauer,P.K.
  TITLE     Identification of a cell-specific DNA-binding activity that
            interacts with a transcriptional activator of genes expressed in
            the acinar pancreas
  JOURNAL   Mol Cell Biol 9 (6), 2464-2476 (1989)
   PUBMED   2788241
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053964.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X98170.1, BE107609.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1014              JAXUCZ010000017.1  86959621-86960634
            1015-1531           JAXUCZ010000017.1  86960959-86961475
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..1531
                     /gene="Ptf1a"
                     /note="pancreas associated transcription factor 1a"
                     /db_xref="GeneID:117034"
                     /db_xref="RGD:621709"
     exon            1..1014
                     /gene="Ptf1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1214
                     /gene="Ptf1a"
                     /note="PTF1-p48; bHLH transcription factor p48; pancreas
                     specific transcription factor, 1a; p48 DNA-binding subunit
                     of transcription factor PTF1"
                     /codon_start=1
                     /product="pancreas transcription factor 1 subunit alpha"
                     /protein_id="NP_446416.1"
                     /db_xref="GeneID:117034"
                     /db_xref="RGD:621709"
                     /translation="MDAVLLEHFPGALDTFPSSYFDEEDFFTDQSSRDPLEDGDELLG
                     DEQAEVEFLSHQLHEYCYRDGACLLLQPAPSAAPHALAPPPLGDPGEPEDSGSYCCDA
                     GAPLGAFPYSPGSPPSCLAYPCTAVLSPGTRLRGLNGAAAAAAAAARRRRRVRSEAEL
                     QQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELV
                     QADLPLRGSGTGGCGGPGGSRHLGGDSPGNQAQKVIICHRGTRSPSPSDPDYGLPPLA
                     GHSLSWADEKQLKEQNIIRTAKVWTPEDPRKLNSKSFDNIENEPPFEFVS"
     exon            1015..1531
                     /gene="Ptf1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactccagca agcgggtccc agccctcccc agtgcatccc cagagccagt cagagccaga
       61 ggccgtcgcg cactccaggg aggccccggg gcggggaccc gtggcgcctc gccatctcca
      121 acgccaaccc cacgagggag gggctgcggg acctacccga actgccacag atcacgcaca
      181 aagcgtcacc cggagcagcc catcagtccc ttgaggcctc agtggcggac gacatggacg
      241 ccgtgctcct ggagcatttt cccggggccc tggacacctt cccgtcctct tacttcgatg
      301 aggaagattt cttcaccgat cagtcctctc gggacccact ggaggacggc gacgagctgc
      361 tgggggatga gcaggcggag gtagagttcc tcagtcacca gctgcacgaa tactgctacc
      421 gcgacggggc gtgcctgctg ctgcaacctg cgccctcggc ggccccgcac gcgctcgccc
      481 cgccgccttt gggggaccct ggcgagcccg aggacagcgg cagctattgc tgcgatgcag
      541 gggcgcctct tggtgccttc ccctactcgc ccggctcacc gccctcctgt ctcgcctacc
      601 cttgcaccgc ggtactgtcc cccggtacgc ggctccgtgg tttgaacgga gcagcggcag
      661 cggcggcggc ggccgcaagg cggcggcgac gcgtgcgctc cgaggcagag ctgcagcagc
      721 tgcgacaagc ggccaacgtg cgagagcggc gccgcatgca gtctatcaac gacgccttcg
      781 aggggctgcg ttcgcacatc cccacgctgc cctacgaaaa gcgcctctcc aaggtagaca
      841 cgctgcgctt agccataggc tacattaact tcctcagcga gctggtgcaa gccgacttgc
      901 cactgcgcgg gagtggcaca ggtggttgcg ggggcccagg tggcagccgg cacctcggag
      961 gggacagccc aggtaaccag gcccagaagg tcatcatctg ccatcgaggc acccgttcgc
     1021 cctcccccag cgacccggac tacggtctcc ctcctcttgc agggcactcc ctttcctggg
     1081 ctgatgaaaa acagctcaaa gaacaaaata ttattcgtac agctaaagtg tggaccccag
     1141 aggaccccag aaaactcaac agtaaatctt ttgacaacat agagaacgaa ccaccttttg
     1201 agtttgtgtc ctgagaaagc tctcacaggc cggctgtgtc tttgtgcata ttgtacgtgt
     1261 aaatacctat aatgtaaatg taatttaaag accacatttt tctaatggca atcaactgtt
     1321 tgttatttat ctatttatta tgctgttgag ttaatggaaa tagattgtct ttttaaaaat
     1381 atataattta tataatttaa cgtgatattc tataatatga tttccccaga acctttggca
     1441 gaactctgaa ctggaagatc tctgtcgtgc ttatttaatg tcggaattgg tttacttctg
     1501 agtgttgcta ataaatgcta ttcacacggg t
//
