LOCUS       NP_071560                349 aa            linear   ROD 28-APR-2025
DEFINITION  N-acetyltaurine hydrolase [Rattus norvegicus].
ACCESSION   NP_071560
VERSION     NP_071560.2
DBSOURCE    REFSEQ: accession NM_022224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 349)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   2  (residues 1 to 349)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (residues 1 to 349)
  AUTHORS   Davies,J.A., Buchman,V.L., Krylova,O. and Ninkina,N.N.
  TITLE     Molecular cloning and expression pattern of rpr-1, a
            resiniferatoxin-binding, phosphotriesterase-related protein,
            expressed in rat kidney tubules
  JOURNAL   FEBS Lett 410 (2-3), 378-382 (1997)
   PUBMED   9237666
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078833.1.
            
            On Mar 27, 2005 this sequence version replaced NP_071560.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132266, SAMD00132274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     Protein         1..349
                     /product="N-acetyltaurine hydrolase"
                     /note="phosphotriesterase-related protein; parathion
                     hydrolase-related protein; resiniferotoxin-binding
                     phosphotriesterase-related protein;
                     resiniferatoxin-binding, phosphotriesterase-related
                     protein"
                     /calculated_mol_wt=39014
     Region          15..347
                     /region_name="metallo-dependent_hydrolases"
                     /note="Superfamily of metallo-dependent hydrolases (also
                     called amidohydrolase superfamily) is a large group of
                     proteins that show conservation in their 3-dimensional
                     fold (TIM barrel) and in details of their active site. The
                     vast majority of the members have a...; cl00281"
                     /db_xref="CDD:469705"
     Site            order(26,28,168,201,230,298)
                     /site_type="active"
                     /db_xref="CDD:238295"
     Site            order(28,128,201,298)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238295"
     Site            order(33,101,140,144,151,158)
                     /site_type="other"
                     /note="homodimer interaction site [polypeptide binding]"
                     /db_xref="CDD:238295"
     CDS             1..349
                     /gene="Pter"
                     /gene_synonym="Rpr-1; Rpr1"
                     /coded_by="NM_022224.2:63..1112"
                     /db_xref="GeneID:63852"
                     /db_xref="RGD:61313"
ORIGIN      
        1 msslsgkvqt vlgpvepsql grtlthehlt mafdsfycpp ppcqeaasre pimmknlfwi
       61 qknpyshqen lqlnqeveav reellyfkak gggavventt tglsrdvrtl kwlaeqtgvh
      121 iiagagfyvd athsaatram sveqltdvli seilhgadgt sikcgvigei gcswpltdse
      181 rkvlqataha qaqlgcpvii hpgrnpgapf qiirvlqeag adisktvmsh ldrsifdkke
      241 llefaqlgcy leydlfgtel lnyqlspdid mpddnkrirr vrflvnegye drilmahdih
      301 tkhrlmkygg hgyshiltnv vpkmllrglt ervldkilre npkqwltfk
//
