LOCUS       NM_031606               2388 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus phosphatase and tensin homolog (Pten), mRNA.
ACCESSION   NM_031606
VERSION     NM_031606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2388)
  AUTHORS   Liu,H., Wang,X., He,K., Chen,Z., Li,X., Ren,J., Zhao,X., Liu,S.,
            Zhou,T. and Chen,H.
  TITLE     Oxidized DJ-1 activates the p-IKK/NF-kappaB/Beclin1 pathway by
            binding PTEN to induce autophagy and exacerbate myocardial
            ischemia-reperfusion injury
  JOURNAL   Eur J Pharmacol 971, 176496 (2024)
   PUBMED   38508437
  REMARK    GeneRIF: Oxidized DJ-1 activates the p-IKK/NF-kappaB/Beclin1
            pathway by binding PTEN to induce autophagy and exacerbate
            myocardial ischemia-reperfusion injury.
REFERENCE   2  (bases 1 to 2388)
  AUTHORS   Zhang,Y. and Hao,J.
  TITLE     Anti-tumor effect of PTEN and its effect on inhibition of the bone
            tumor through the CD47-SIRPalpha signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 40-44 (2023)
   PUBMED   38279488
  REMARK    GeneRIF: Anti-tumor effect of PTEN and its effect on inhibition of
            the bone tumor through the CD47-SIRPalpha signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2388)
  AUTHORS   Deng,J., Liao,Y., Chen,J., Chen,A., Wu,S., Huang,Y., Qian,H.,
            Gao,F., Wu,G., Chen,Y., Chen,X. and Zheng,X.
  TITLE     N6-methyladenosine demethylase FTO regulates synaptic and cognitive
            impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal
            rats
  JOURNAL   Cell Death Dis 14 (12), 820 (2023)
   PUBMED   38092760
  REMARK    GeneRIF: N6-methyladenosine demethylase FTO regulates synaptic and
            cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic
            neonatal rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2388)
  AUTHORS   Gong,Q., Luo,D., Wang,H., Xu,X., Fan,Y., Zheng,Z. and Qian,T.
  TITLE     Inhibiting autophagy by miR-19a-3p/PTEN regulation protected
            retinal pigment epithelial cells from hyperglycemic damage
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (7), 119530 (2023)
   PUBMED   37393018
  REMARK    GeneRIF: Inhibiting autophagy by miR-19a-3p/PTEN regulation
            protected retinal pigment epithelial cells from hyperglycemic
            damage.
REFERENCE   5  (bases 1 to 2388)
  AUTHORS   Johnson,A.M., Jose,S., Palakkott,A.R., Khan,F.B., Jayabalan,N.,
            Kizhakkayil,J., AlNaqbi,S.A.A., Scott,M.G., Ayoub,M.A., Gordon,R.
            and Saminathan,H.
  TITLE     Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by
            Attenuating Apoptotic and Neuroinflammatory Signaling Events
  JOURNAL   J Neuroimmune Pharmacol 18 (3), 462-475 (2023)
   PUBMED   37589761
  REMARK    GeneRIF: Pharmacological Inhibition of PTEN Rescues Dopaminergic
            Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling
            Events.
REFERENCE   6  (bases 1 to 2388)
  AUTHORS   Myers,M.P., Stolarov,J.P., Eng,C., Li,J., Wang,S.I., Wigler,M.H.,
            Parsons,R. and Tonks,N.K.
  TITLE     P-TEN, the tumor suppressor from human chromosome 10q23, is a
            dual-specificity phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9052-9057 (1997)
   PUBMED   9256433
REFERENCE   7  (bases 1 to 2388)
  AUTHORS   Li,D.M. and Sun,H.
  TITLE     TEP1, encoded by a candidate tumor suppressor locus, is a novel
            protein tyrosine phosphatase regulated by transforming growth
            factor beta
  JOURNAL   Cancer Res 57 (11), 2124-2129 (1997)
   PUBMED   9187108
REFERENCE   8  (bases 1 to 2388)
  AUTHORS   Liaw,D., Marsh,D.J., Li,J., Dahia,P.L., Wang,S.I., Zheng,Z.,
            Bose,S., Call,K.M., Tsou,H.C., Peacocke,M., Eng,C. and Parsons,R.
  TITLE     Germline mutations of the PTEN gene in Cowden disease, an inherited
            breast and thyroid cancer syndrome
  JOURNAL   Nat Genet 16 (1), 64-67 (1997)
   PUBMED   9140396
REFERENCE   9  (bases 1 to 2388)
  AUTHORS   Steck,P.A., Pershouse,M.A., Jasser,S.A., Yung,W.K., Lin,H.,
            Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T.,
            Frye,C., Hu,R., Swedlund,B., Teng,D.H. and Tavtigian,S.V.
  TITLE     Identification of a candidate tumour suppressor gene, MMAC1, at
            chromosome 10q23.3 that is mutated in multiple advanced cancers
  JOURNAL   Nat Genet 15 (4), 356-362 (1997)
   PUBMED   9090379
REFERENCE   10 (bases 1 to 2388)
  AUTHORS   Snary,D., Barnstable,C., Bodmer,W.F., Goodfellow,P. and
            Crumpton,M.J.
  TITLE     Human Ia antigens--purification and molecular structure
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 1, 379-386 (1977)
   PUBMED   70315
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 3, 2022 this sequence version replaced NM_031606.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF455569.1, AF017185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               JAXUCZ010000001.1  240043707-240044645
            940-1024            JAXUCZ010000001.1  240062971-240063055
            1025-1069           JAXUCZ010000001.1  240078298-240078342
            1070-1113           JAXUCZ010000001.1  240084000-240084043
            1114-1352           JAXUCZ010000001.1  240085890-240086128
            1353-1494           JAXUCZ010000001.1  240099487-240099628
            1495-1661           JAXUCZ010000001.1  240105036-240105202
            1662-1886           JAXUCZ010000001.1  240107636-240107860
            1887-2388           JAXUCZ010000001.1  240109829-240110330
FEATURES             Location/Qualifiers
     source          1..2388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..2388
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /note="phosphatase and tensin homolog"
                     /db_xref="GeneID:50557"
                     /db_xref="RGD:61995"
     exon            1..939
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             861..2072
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /EC_number="3.1.3.67"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="protein tyrosine phosphatase and tensin-like
                     protein; phosphatase and tensin homolog deleted on
                     chromosome ten; mutated in multiple advanced cancers 1;
                     inositol polyphosphate 3-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     3-phosphatase and dual-specificity protein phosphatase
                     PTEN"
                     /protein_id="NP_113794.1"
                     /db_xref="GeneID:50557"
                     /db_xref="RGD:61995"
                     /translation="MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEG
                     VYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIK
                     PFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRT
                     RDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC
                     QLKVKIYSSNSGPTRREDKLMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVN
                     TFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKAN
                     RYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPF
                     DEDQHSQITKV"
     exon            940..1024
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1069
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1113
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1352
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1494
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1661
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1886
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2388
                     /gene="Pten"
                     /gene_synonym="Mmac; MMAC1; TEP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggatatgcg cttgggcgtc gggacgcggc tgcgctcagc tctctcctct cggaagctgc
       61 agccatgatg gaagtttgag agttgagccg ctgtgaggcc aggcccggcg caggcgaggg
      121 agatgagaga cggcggcggc cgcggcccag agcccctctc agcgcctgtg agcagccgcg
      181 ggggcagcgc cctcggggag ccggccgggc ggcggcggcg gcagcggcgg cgggcctcgc
      241 ctcctcgtcg tctgttctaa ccgggcagcc tctgagcagc ttcggaaaga gacggtggaa
      301 gccgtgggct cgggcgggag ccggcgcagg ctcggcggct gcacctcccg ctcctggagc
      361 gggggggaga agcggcggcg gcggccgcgg ctccggggag ggggtcggag tcgcctgtca
      421 ccattgccag ggctgggaac gccggagagt tgctctctcc ccttctcctg cctccaacac
      481 ggcggcggcg gcggcggcac gtccagggac ccgggccggt gttaagcctc ccgtccgccg
      541 ccgccgcacc ccccctggcc cgggctccgg aggccgccgg aggaggcagc cgctgcgagg
      601 attatccgtc ttctccccat tccgctgctt cggctgccag gcctctggct gctgaggaga
      661 agcaggccca gtcgctgcaa ccatccagca gccgccgcag cagccattac ccggctgcgg
      721 tccagggcca agcggcagca gagcgagggg catcagcgac cgccaagtcc agagccattt
      781 ccatcctgca gaagaagcct cgccaccagc agcttctgcc atctctctcc tcctttttct
      841 tcagccacag gctcccagac atgacagcca tcatcaaaga gatcgttagc agaaacaaaa
      901 ggagatatca agaggatgga ttcgacttag acttgaccta tatttatcca aatattattg
      961 ctatgggatt tcctgcagaa agacttgaag gtgtatacag gaacaatatt gatgatgtag
     1021 taaggttttt ggattcaaag cataaaaacc attacaagat atacaatcta tgtgctgaga
     1081 gacattatga caccgccaaa tttaactgca gagttgcaca gtatcctttt gaagaccata
     1141 acccaccaca gctagaactt atcaaaccct tttgtgaaga tcttgaccaa tggctaagtg
     1201 aagacgacaa tcatgttgca gcaattcact gtaaagctgg gaaaggacgg actggtgtaa
     1261 tgatttgtgc atatttattg catcggggca agtttttaaa ggcacaagag gccctggatt
     1321 tttatgggga agtaaggacc agagataaaa agggagtaac tattcccagt cagaggcgct
     1381 atgtatatta ttatagctac ctgttaaaga atcacctgga ttacagacca gtggcactgt
     1441 tgtttcacaa gatgatgttt gaaactattc caatgttcag tggcggaact tgcaatcccc
     1501 agtttgtggt ctgccagcta aaggtgaaga tctactcctc caactcagga cccacgcggc
     1561 gggaggacaa gctcatgtac tttgagttcc ctcagccatt gcctgtgtgt ggtgacatca
     1621 aagtagagtt cttccacaaa cagaacaaga tgctcaaaaa ggacaaaatg tttcactttt
     1681 gggtaaatac gttcttcata ccaggaccag aggaaacctc agaaaaagtg gaaaatggaa
     1741 gtctttgtga tcaggaaatc gatagcattt gtagtataga gcgtgcggat aatgacaagg
     1801 agtatcttgt gctcaccctg acaaaaaatg atcttgacaa agcaaacaaa gacaaggcca
     1861 accgatactt ctctccaaat tttaaggtga aattatactt tacaaaaaca gtagaggaac
     1921 catcaaatcc agaggctagc agttcaactt ctgtgactcc agacgttagt gacaatgaac
     1981 ctgatcatta tagatattct gacaccactg actctgatcc agagaatgaa ccttttgatg
     2041 aagatcagca ttcacaaatt acaaaagtct gatttttttt ttcttatcaa gagggataaa
     2101 ataccaagaa aaaaaacttg aataaactga aatggacctt tttttttttt tttttaatgg
     2161 caataggaca ttgtgtcaga ttgcagttat aggaacaatt ctcttctcct gaccaatctt
     2221 gtttcaccct atacatccac agggttttga cacttgttgt ccagttaaaa aaggttgtgt
     2281 agctgtgtca tgtatatacc tttttgtgtc aaaaggacat ttaaaattca attaggataa
     2341 ataaaagatg gcactttccc attttattcc agttttataa aacgtgga
//
