LOCUS       NM_001191734            2676 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus patched domain containing 1 (Ptchd1), mRNA.
ACCESSION   NM_001191734 XM_228985
VERSION     NM_001191734.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2676)
  AUTHORS   Tora,D., Gomez,A.M., Michaud,J.F., Yam,P.T., Charron,F. and
            Scheiffele,P.
  TITLE     Cellular Functions of the Autism Risk Factor PTCHD1 in Mice
  JOURNAL   J Neurosci 37 (49), 11993-12005 (2017)
   PUBMED   29118110
REFERENCE   2  (bases 1 to 2676)
  AUTHORS   Wells,M.F., Wimmer,R.D., Schmitt,L.I., Feng,G. and Halassa,M.M.
  TITLE     Thalamic reticular impairment underlies attention deficit in
            Ptchd1(Y/-) mice
  JOURNAL   Nature 532 (7597), 58-63 (2016)
   PUBMED   27007844
REFERENCE   3  (bases 1 to 2676)
  AUTHORS   Noor,A., Whibley,A., Marshall,C.R., Gianakopoulos,P.J., Piton,A.,
            Carson,A.R., Orlic-Milacic,M., Lionel,A.C., Sato,D., Pinto,D.,
            Drmic,I., Noakes,C., Senman,L., Zhang,X., Mo,R., Gauthier,J.,
            Crosbie,J., Pagnamenta,A.T., Munson,J., Estes,A.M., Fiebig,A.,
            Franke,A., Schreiber,S., Stewart,A.F., Roberts,R., McPherson,R.,
            Guter,S.J., Cook,E.H. Jr., Dawson,G., Schellenberg,G.D.,
            Battaglia,A., Maestrini,E., Jeng,L., Hutchison,T.,
            Rajcan-Separovic,E., Chudley,A.E., Lewis,S.M., Liu,X., Holden,J.J.,
            Fernandez,B., Zwaigenbaum,L., Bryson,S.E., Roberts,W., Szatmari,P.,
            Gallagher,L., Stratton,M.R., Gecz,J., Brady,A.F., Schwartz,C.E.,
            Schachar,R.J., Monaco,A.P., Rouleau,G.A., Hui,C.C., Lucy
            Raymond,F., Scherer,S.W. and Vincent,J.B.
  CONSRTM   Autism Genome Project Consortium
  TITLE     Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum
            disorder and intellectual disability
  JOURNAL   Sci Transl Med 2 (49), 49ra68 (2010)
   PUBMED   20844286
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XM_228985.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.31932.1,
                                           SRR26360176.996656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               JAXUCZ010000021.1  43496907-43497266
            361-1021            JAXUCZ010000021.1  43533291-43533951
            1022-2676           JAXUCZ010000021.1  43546759-43548413
FEATURES             Location/Qualifiers
     source          1..2676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..2676
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /note="patched domain containing 1"
                     /db_xref="GeneID:317517"
                     /db_xref="RGD:1564527"
     exon            1..360
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2676
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /codon_start=1
                     /product="patched domain-containing protein 1"
                     /protein_id="NP_001178663.1"
                     /db_xref="GeneID:317517"
                     /db_xref="RGD:1564527"
                     /translation="MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFS
                     RYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSYQ
                     KANMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDIVHVLEEL
                     KNARATNRTNFAITYPITHLKDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSI
                     NSLNDMVAERWESSFCDTVKLFQKSNSKVKIYPYTSSSLREDFQKTSRVSERYLVTSL
                     ILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPF
                     VMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGASP
                     FTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEVL
                     QEKPAWYRFLLTARFSEDTAEGEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFY
                     LIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSPVIGFYIYESIEY
                     WNSSVQEDVLEYTKGFVRISWFESYLNYLRKLNVSTDLPKKNFTDMLRNSFLKAPQFS
                     HFQEDIIFSKKYNDEVDVVASRMFLVAKTMETNREELYDLLETLRRLSVTSKVKFIVF
                     NPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIG
                     FMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAI
                     LQSYLCYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPPSKKKR
                     KEKKNPENREEIECVEMLDIDSTRVVDQITTV"
     exon            361..1021
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..2676
                     /gene="Ptchd1"
                     /gene_synonym="RGD1564527"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctctagga tgctgcggca ggttctgcac aggggcttga ggacgtgttt ctcccggctt
       61 ggccacttca ttgccagtca cccggtcttc ttcgcttcgg cgccggtgct catctccatc
      121 ctgctcggcg ccagcttcag ccgctaccag gtggaagaga gcgtggagca cctgctggcg
      181 ccccagcaca gcctagccaa gatcgagcgc aacctagtca acagcctatt cccggtcaac
      241 cgctccaagc accggctcta ctcggacctg cagacccctg ggcgctacgg ccgggtcatt
      301 gtcacctcct accagaaagc caacatgcta gaccagcatc acacggacct gatcttaaag
      361 ttgcacactg ctgtaaccaa gatccaggtt ccaaggcctg gctttaacta tacatttgcc
      421 cacatatgtg tcctgaataa tgataagact tgcattgtgg atgacatagt acacgtcctg
      481 gaagagctaa agaatgctcg ggccaccaat cggaccaatt ttgctatcac atatccgatc
      541 actcacttaa aggatggaag ggctgtctat aatgggcacc aacttggagg tgtcactgtg
      601 cacagcaagg atcgggtgaa atctgcggag gccattcagc tcacctacta tctgcaatca
      661 atcaacagtc tcaatgacat ggtagctgag aggtgggagt ccagcttctg cgacactgtc
      721 aaattattcc agaaatccaa cagcaaagtc aaaatatacc cgtacacatc ctcatcactg
      781 agggaagatt tccagaagac cagccgtgtg tcagaacgtt acctggtcac cagtctgatc
      841 cttgtagtca ccatggccat tctgtgctgc tctatgcagg actgtgtccg cagcaaaccc
      901 tggttaggcc tacttgggtt ggtgaccata agcctagcca ctctcactgc agctggaatc
      961 atcaatctta ctggtggaaa atacaattcc accttcctgg gagtcccttt cgtcatgcta
     1021 ggtcatggat tatacgggac ttttgaaatg ttatcctcgt ggagaaaaac tagagaggac
     1081 caacatgtta aagagcgaac tgcagaagtc tatgcagact ccatgctctc cttctctctc
     1141 accactgcca tgtacttggt cacctttggc ataggggcca gccctttcac gaacattgag
     1201 gcagccagga ttttctgctg caattcctgt attgcaatcc tcttcaacta cctctatgta
     1261 ctctcatttt acggttccag ccttgtgttc actggctaca tagaaaacaa ttaccagcat
     1321 agtatattct gtagaaaagt tccaaagcct gaggtattac aggagaagcc agcatggtat
     1381 aggtttcttc tgacagctag attcagtgag gacacagctg aaggtgagga agcaaacact
     1441 tatgagagtc atttattggt atgtttcctc aaacgttatt actgtgactg gataaccaac
     1501 acctatgtca agccttttgt agtcctcttt taccttattt atatttcctt tgccttaatg
     1561 ggctatctgc aggtcagtga agggtcagac cttagtaaca tcgtagcaac tgcaacacaa
     1621 accattgagt acactactgc ccaccaaaag tactttaaca actacagtcc tgttattggg
     1681 ttttacatat atgagtccat agaatattgg aactctagtg tccaagaaga tgttctagag
     1741 tacactaagg gttttgtgcg gatatcctgg tttgaaagct atttaaatta tcttcggaaa
     1801 ctcaatgtgt ccactgactt gcctaagaaa aatttcacag acatgttgag aaattccttc
     1861 ctgaaagctc ctcaattttc acattttcaa gaggacatca tcttctctaa aaaatacaat
     1921 gatgaggttg acgtagtggc ctctagaatg tttttggtgg ccaagactat ggaaacaaac
     1981 agagaagaac tttatgatct cttggagacc ctgaggaggc tttcagtcac ctccaaggtg
     2041 aagttcattg tctttaatcc gtcttttgtg tacatggatc gatatgcctc ctctctggga
     2101 gcccccctgc acaactcctg catcagtgct ttgttcctgc tcttcttctc ggcattcctg
     2161 gtagcagatt cgctgattaa tgtctggatc actctaacgg ttgtgtctgt ggagtttgga
     2221 gtgataggct tcatgacatt atggaaggtc gaactggatt gtatttctgt gctatgctta
     2281 atttatggaa ttaactacac aattgataac tgtgctccac tgttatccac atttgtccta
     2341 ggcaaggatt ttacaagaac taaatgggta aaaaatgccc tggaagtgca tggggtagct
     2401 attttacaga gttacctctg ttatattgtt ggtctatttc ctctcgcagc tgtgccttca
     2461 aatctgacct gtacactgtt caggtgcttg tttttaatag catttgtcac cttctttcac
     2521 tgctttgcca ttttacctgt gatactgact ttcctgccac cctctaagaa aaaaaggaaa
     2581 gagaagaaaa atcctgaaaa ccgggaggaa attgagtgtg tagaaatgtt ggatattgac
     2641 agtactcgag tggttgacca aattaccaca gtgtga
//
