LOCUS       NM_001108975            4304 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus patched 2 (Ptch2), mRNA.
ACCESSION   NM_001108975 XM_001071653 XM_008764050 XM_345570
VERSION     NM_001108975.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4304)
  AUTHORS   Zhang,Y.D., Zhu,Z.S., Zhang,D., Zhang,Z., Ma,B., Zhao,S.C. and
            Xue,F.
  TITLE     Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes
            recovery from spinal cord injury by activating the Hedgehog
            signaling pathway in a rat model
  JOURNAL   Exp Mol Med 49 (12), e412 (2017)
   PUBMED   29244790
  REMARK    GeneRIF: Activation of the Hh signaling pathway by silencing PTC1
            and PTC2 may reduce inflammation and may ultimately promote spinal
            cord injury recovery
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4304)
  AUTHORS   Adolphe,C., Nieuwenhuis,E., Villani,R., Li,Z.J., Kaur,P., Hui,C.C.
            and Wainwright,B.J.
  TITLE     Patched 1 and patched 2 redundancy has a key role in regulating
            epidermal differentiation
  JOURNAL   J Invest Dermatol 134 (7), 1981-1990 (2014)
   PUBMED   24492243
REFERENCE   3  (bases 1 to 4304)
  AUTHORS   Fan,Z., Li,J., Du,J., Zhang,H., Shen,Y., Wang,C.Y. and Wang,S.
  TITLE     A missense mutation in PTCH2 underlies dominantly inherited NBCCS
            in a Chinese family
  JOURNAL   J Med Genet 45 (5), 303-308 (2008)
   PUBMED   18285427
REFERENCE   4  (bases 1 to 4304)
  AUTHORS   Nieuwenhuis,E., Motoyama,J., Barnfield,P.C., Yoshikawa,Y.,
            Zhang,X., Mo,R., Crackower,M.A. and Hui,C.C.
  TITLE     Mice with a targeted mutation of patched2 are viable but develop
            alopecia and epidermal hyperplasia
  JOURNAL   Mol Cell Biol 26 (17), 6609-6622 (2006)
   PUBMED   16914743
REFERENCE   5  (bases 1 to 4304)
  AUTHORS   Carpenter,D., Stone,D.M., Brush,J., Ryan,A., Armanini,M.,
            Frantz,G., Rosenthal,A. and de Sauvage,F.J.
  TITLE     Characterization of two patched receptors for the vertebrate
            hedgehog protein family
  JOURNAL   Proc Natl Acad Sci U S A 95 (23), 13630-13634 (1998)
   PUBMED   9811851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Sep 6, 2019 this sequence version replaced
            XM_008764050.2, NM_001108975.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.29478.1,
                                           SRR26643429.20502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               JAXUCZ010000005.1  135808895-135809255
            362-554             JAXUCZ010000005.1  135809636-135809828
            555-744             JAXUCZ010000005.1  135817910-135818099
            745-814             JAXUCZ010000005.1  135818204-135818273
            815-906             JAXUCZ010000005.1  135818391-135818482
            907-1102            JAXUCZ010000005.1  135819088-135819283
            1103-1224           JAXUCZ010000005.1  135820361-135820482
            1225-1372           JAXUCZ010000005.1  135820617-135820764
            1373-1504           JAXUCZ010000005.1  135820836-135820967
            1505-1660           JAXUCZ010000005.1  135821057-135821212
            1661-1753           JAXUCZ010000005.1  135821307-135821399
            1754-1879           JAXUCZ010000005.1  135821745-135821870
            1880-1998           JAXUCZ010000005.1  135821952-135822070
            1999-2347           JAXUCZ010000005.1  135822170-135822518
            2348-2660           JAXUCZ010000005.1  135822615-135822927
            2661-2803           JAXUCZ010000005.1  135823020-135823162
            2804-2984           JAXUCZ010000005.1  135823250-135823430
            2985-3265           JAXUCZ010000005.1  135823552-135823832
            3266-3403           JAXUCZ010000005.1  135823942-135824079
            3404-3546           JAXUCZ010000005.1  135827693-135827835
            3547-3646           JAXUCZ010000005.1  135827922-135828021
            3647-4304           JAXUCZ010000005.1  135828329-135828986
FEATURES             Location/Qualifiers
     source          1..4304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4304
                     /gene="Ptch2"
                     /note="patched 2"
                     /db_xref="GeneID:366452"
                     /db_xref="RGD:1309039"
     exon            1..361
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..3838
                     /gene="Ptch2"
                     /note="patched homolog 1; patched homolog 2"
                     /codon_start=1
                     /product="protein patched homolog 2"
                     /protein_id="NP_001102445.2"
                     /db_xref="GeneID:366452"
                     /db_xref="RGD:1309039"
                     /translation="MVRPLSLGELPPSYTPPARSSAPQILAGSLQAPLWLRAYFQGLL
                     FSLGCRIQKHCGKVLFLGLVALGALALGLRVAVIETDLEQLWVEVGSRVSQELHYTKE
                     KLGEEAAYTSQMLIQTARQEGANILTPEALGFHLQAALTASKVQVSLYGKSWDLNKIC
                     YKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDP
                     QQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPNVA
                     QELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEAFQSTFLLMSPRQLYEHFRG
                     DYQTHDIGWSEEQASMVLQAWQRRFVQLAQEALPANASQQIHAFSSTTLDDILQAFSE
                     VSATRVVGGYLLMLAYACITMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGIT
                     FNAATTQVLPFLALGIGVDDIFLLAHAFTKAPPNTPLPERMGECLRRTGTSVALTSIN
                     NMVAFFMAVLVPIPALRAFSLQAAIVVGCNFAAVMLVFPAVLSLDLRRRHRQRLDVLC
                     CFSSPCSAQVIQMLPQELGDRAVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLL
                     SPTSDPLGSELYSPGGSTRDLLGQEEGTRPKASCRSLLCAHWTLAHFARYQFAPLLLQ
                     TQAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVA
                     LVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPAAQAPRTWLHYYRSWLQGIQTAFDQ
                     DWASGRITRNSYRNGSEDGALAYKLLIQTGNAQEPLDFNQLTTRKLVDKEGLIPPELF
                     YMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPAAQPLEFAQFPFLL
                     HGLQKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILL
                     LCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGV
                     EFTVHVALGFLTSHGSRNLRAARALEQTFAPVTDGAVSTLLGLLMLAGSNFDFIIRYF
                     FVVLTVLTLLGLLHGLLLLPVLLSILGPPPQVVQIYKESPQALSSTAPQRGGLRWGVS
                     PTLPQSFARVTTSMTVALHPPPLPGAYVHPASDEPT"
     exon            362..554
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..744
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..814
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..906
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1102
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1224
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1372
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1504
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1660
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1753
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1879
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1998
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2347
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2660
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2803
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2984
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3265
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3403
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3546
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3646
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..4304
                     /gene="Ptch2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccacagtc gccaccttga gctgtgaggt gcttcacagc ccggcgggtc tacccacacg
       61 tggagcccac tttagaccac ggcccaccga tccagagggg cttagggcca ccacccagca
      121 ccgttgctcc gggctactcc tgtgcatctg cacccgcgtc tcacccacga ccgcacgttc
      181 accgccctta cgaattccca ggtgaaaccg ggcggcacaa gggccaagcc agcctatggc
      241 agcgctcaga taacgcaggt tgggggcgct cgcccccatc ctcaccagca tggttcggcc
      301 actgtccctt ggagagctgc ctcccagcta cacacctcca gctcggtcct ccgcacctca
      361 aatcctagct gggagcctgc aggctcctct ctggcttcgt gcttacttcc aaggtctact
      421 cttctccctg gggtgcagga tccagaaaca ctgcggcaaa gtgctcttcc taggactggt
      481 ggctttgggg gctctggcac tgggtctccg agtggctgta attgagacag acctagaaca
      541 gctctgggta gaagtgggca gcagggtgag ccaggagctg cattacacca aagagaagct
      601 gggggaggag gctgcctaca cctcccagat gttgattcag actgcacgcc aggagggggc
      661 aaacatcctc acccccgagg cgcttggctt tcacctccag gcagccctca ccgccagtaa
      721 agtacaagtc tcactttatg ggaagtcctg ggatttgaac aaaatctgct acaaatcagg
      781 ggttcccctt attgaaaatg gaatgatcga gcggatgatt gagaagctgt ttccctgtgt
      841 gatcctcacc ccgcttgact gcttctggga aggagccaaa ctccaagggg gttctgccta
      901 cttgccgggc cgccctgata tccagtggac caacctggat ccccagcagc tcctagagga
      961 gctgggcccc tttgcctctc tggagggctt ccgggagctg ctagacaagg cacaggtggg
     1021 ccaggcctat gtggggcgac cctgtctgga ccctgatgac ccccactgtc cacctagtgc
     1081 tcccaaccgt cacagcaggc aggctcccaa tgtggctcag gagctgagtg ggggctgcca
     1141 tggcttctcc cacaagttca tgcactggca ggaggaactg ctactggggg gcacagccag
     1201 agatctccaa ggacagctgc tgagggcgga ggccttccag agcaccttcc tgctgatgag
     1261 cccccgtcag ctgtatgagc acttccgggg cgactaccag acacatgaca tcggctggag
     1321 tgaggagcag gccagcatgg tgctgcaggc ctggcagagg cgctttgtgc agctagccca
     1381 ggaggctctg ccagccaacg catcccagca gatccatgct ttctcctcca ccaccctgga
     1441 tgacatcctg caggcgttct cggaagtcag tgccacccgt gtggtaggag gctatctgct
     1501 catgctggcc tatgcctgca taacaatgct acggtgggac tgcgcccagt cccagggtgc
     1561 cgtcggtctt gctggggtgt tgctcgtggc cctggcggtg gcctcaggtc ttgggctttg
     1621 tgccctactt ggcatcactt tcaatgctgc cactactcag gtactgccct tcttagctct
     1681 gggcatcggt gtggatgaca tcttcctgct ggcacatgca ttcacaaagg ccccacccaa
     1741 cactcctctc ccagagcgca tgggtgagtg tttgcgacgc accggcacca gtgtggcact
     1801 cacgtccatc aacaacatgg tcgccttctt catggctgtt ctggttccca tccctgcgct
     1861 gcgggctttc tccctgcagg cagccatagt ggtcggctgc aactttgcag cggtaatgct
     1921 tgtcttcccc gctgtcctca gcctcgacct gcgccggcgc caccgccagc gcctcgacgt
     1981 tctctgctgc ttttctagcc cctgctctgc tcaggtcatt cagatgctgc cccaggaact
     2041 aggggacaga gccgtaccag tgggcattgc ccacctgact gccactgtgc aagcttttac
     2101 ccactgcgaa gccagcagcc agcacgtagt caccattttg cctcctcaag cccacctgct
     2161 gtctccaact tctgacccac tgggctctga actctacagc cctggggggt ccacacggga
     2221 ccttctcggt caggaggagg ggacgaggcc aaaggcgtcc tgcaggtctc tgctctgtgc
     2281 ccactggact ctcgcccatt ttgcccgcta tcagtttgcg cctttactgc tccagacaca
     2341 agccaaggcc ctggtgttgc tgttcttcgg ggctcttttg ggtctgagcc tctatggagc
     2401 caccttggtc caagatgggc tggccctgac agatgtggtc cctcggggca ctaaggaaca
     2461 tgctttcctg agcgcccagc tcaggtactt ctccctgtac gaggtggccc tggtgacaca
     2521 gggtggcttt gactacgccc actcccaacg cgccctcttt gatctgcacc agcgcttcag
     2581 ttccctcaag gctgtgctcc ccccacctgc ggcccaggcc ccccgcacct ggctgcacta
     2641 ctaccgcagc tggctacagg gtatccagac cgcatttgac caagactggg cttctgggcg
     2701 catcacccgc aactcttacc gcaacggctc tgaagatggc gccctggcct acaagctgct
     2761 catccaaacc gggaatgccc aggaacctct ggatttcaac cagctgacca caaggaaact
     2821 ggtggacaag gagggactca ttcccccaga actcttctac atggggctaa ccgtgtgggt
     2881 gagcagcgac cccctgggcc tagcagcctc tcaggccaac ttctaccccc cacctccgga
     2941 atggctgcat gacaagtacg ataccactgg agagaacctt cgcatcccgg cagcccagcc
     3001 cttggagttt gcccagttcc ccttcctgtt gcatggactc cagaagactg cagactttgt
     3061 ggaagccatc gaaggggccc gggcggcatg cacagaggca ggccaggcag gggtgcacgc
     3121 ctaccccagt ggctctccct ttctcttctg ggagcagtac ctgggccttc ggcgctgctt
     3181 cctcttggcg gtctgcatct tgctgctctg caccttcctc gtctgtgctc tgctcttact
     3241 caacccgtgg acagctggcc tcatagtgct ggtcctggcg atgatgactg tggagctctt
     3301 tggtatcatg ggattcctgg gcatcaaact gagtgccatc cccgtggtaa tcctcgtggc
     3361 ctctgtaggc atcggtgttg aattcacggt tcatgtggct ctgggcttcc tgaccagcca
     3421 tggtagccgg aacctgcggg ctgctcgcgc tctggagcag acctttgccc cagtgactga
     3481 tggagctgtc tctacattgc tgggtctgct catgcttgct ggttctaact ttgacttcat
     3541 cataaggtac ttcttcgtgg tgctgacggt gctgacactc ttgggcctgc tccatggact
     3601 cctgctgctt cctgtgctgc tgtccatcct gggcccccca ccacaggtgg tccagatata
     3661 caaggagagt ccacaggccc taagctccac agccccacag aggggtgggc tcaggtgggg
     3721 cgtgtccccc accctgcccc agagttttgc cagagtgact acctccatga ctgtggccct
     3781 ccacccacca ccactacctg gagcatacgt ccacccagcc tccgatgagc ccacgtagtc
     3841 tgccgctgcc aacttatcaa cagctctagc aacctcagtt ctagaggacc ggactagcca
     3901 ctgagtggaa gagtatcaga atcacagaga cctcacaggg ccacacagag tccctgggaa
     3961 gcagtgggtg aggtatgaaa tgcaggctgg accccagagg gctacatgct gctatctgtc
     4021 tcctctccta actcagttac tgcaacctta gctgatcccc aaagagaaca gctcctgctc
     4081 agacaagagc ctcctcacac ataggaactc acgggagttc atgtctgtat gcaggttggg
     4141 ccaaaaggct acattctggc tgcagtgcag ccctgtcctg tcctgtccca cactgacacc
     4201 tcagtagacc aagcctgagg gttcctagtt cattctccca tccctggcct ttcattgctt
     4261 gatgactcct agggaggccc tctgtacccc tccctccctc ctac
//
