LOCUS       NM_053566               7634 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus patched 1 (Ptch1), transcript variant 1, mRNA.
ACCESSION   NM_053566 XM_214413
VERSION     NM_053566.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7634)
  AUTHORS   Salem,G.A., Mohamed,A.A., Khater,S.I., Noreldin,A.E., Alosaimi,M.,
            Alansari,W.S., Shamlan,G., Eskandrani,A.A., Awad,M.M.,
            El-Shaer,R.A.A., Nassan,M.A., Mostafa,M. and Khamis,T.
  TITLE     Enhancement of biochemical and genomic pathways through
            lycopene-loaded nano-liposomes: Alleviating insulin resistance,
            hepatic steatosis, and autophagy in obese rats with non-alcoholic
            fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes
  JOURNAL   Gene 883, 147670 (2023)
   PUBMED   37516284
  REMARK    GeneRIF: Enhancement of biochemical and genomic pathways through
            lycopene-loaded nano-liposomes: Alleviating insulin resistance,
            hepatic steatosis, and autophagy in obese rats with non-alcoholic
            fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes.
REFERENCE   2  (bases 1 to 7634)
  AUTHORS   Yang,L., Xu,X., Chen,Z., Zhang,Y., Chen,H. and Wang,X.
  TITLE     miR-511-3p promotes hepatic sinusoidal obstruction syndrome by
            activating hedgehog pathway via targeting Ptch1
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 321 (3), G344-G354 (2021)
   PUBMED   34287088
  REMARK    GeneRIF: miR-511-3p promotes hepatic sinusoidal obstruction
            syndrome by activating hedgehog pathway via targeting Ptch1.
REFERENCE   3  (bases 1 to 7634)
  AUTHORS   Peregud,D., Stepanichev,M. and Gulyaeva,N.
  TITLE     Expression of the hippocampal PTCH during early abstinence is
            associated with drinking patterns in a rat model of voluntary
            alcohol intake
  JOURNAL   Neuroreport 32 (9), 757-761 (2021)
   PUBMED   33994522
  REMARK    GeneRIF: Expression of the hippocampal PTCH during early abstinence
            is associated with drinking patterns in a rat model of voluntary
            alcohol intake.
REFERENCE   4  (bases 1 to 7634)
  AUTHORS   Choi,J.Y., Lee,Y.S., Shim,D.M. and Seo,S.W.
  TITLE     PTCH1 regulates anchorage-independent growth and bone invasion of
            non-small cell lung cancer cells
  JOURNAL   Bone 144, 115829 (2021)
   PUBMED   33359005
  REMARK    Erratum:[Bone. 2022 Jul;160:116398. PMID: 35501249]
REFERENCE   5  (bases 1 to 7634)
  AUTHORS   Li,S.H., Zhang,Y.Y., Sun,Y.L., Zhao,H.J. and Wang,Y.
  TITLE     Inhibition of microRNA-802-5p inhibits myocardial apoptosis after
            myocardial infarction via Sonic Hedgehog signaling pathway by
            targeting PTCH1
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (1), 326-334 (2021)
   PUBMED   33506921
  REMARK    GeneRIF: Inhibition of microRNA-802-5p inhibits myocardial
            apoptosis after myocardial infarction via Sonic Hedgehog signaling
            pathway by targeting PTCH1.
REFERENCE   6  (bases 1 to 7634)
  AUTHORS   Xie,J., Murone,M., Luoh,S.M., Ryan,A., Gu,Q., Zhang,C.,
            Bonifas,J.M., Lam,C.W., Hynes,M., Goddard,A., Rosenthal,A.,
            Epstein,E.H. Jr. and de Sauvage,F.J.
  TITLE     Activating Smoothened mutations in sporadic basal-cell carcinoma
  JOURNAL   Nature 391 (6662), 90-92 (1998)
   PUBMED   9422511
REFERENCE   7  (bases 1 to 7634)
  AUTHORS   Goodrich,L.V., Milenkovic,L., Higgins,K.M. and Scott,M.P.
  TITLE     Altered neural cell fates and medulloblastoma in mouse patched
            mutants
  JOURNAL   Science 277 (5329), 1109-1113 (1997)
   PUBMED   9262482
REFERENCE   8  (bases 1 to 7634)
  AUTHORS   Bellusci,S., Furuta,Y., Rush,M.G., Henderson,R., Winnier,G. and
            Hogan,B.L.
  TITLE     Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth
            and morphogenesis
  JOURNAL   Development 124 (1), 53-63 (1997)
   PUBMED   9006067
REFERENCE   9  (bases 1 to 7634)
  AUTHORS   Wicking,C., Shanley,S., Smyth,I., Gillies,S., Negus,K., Graham,S.,
            Suthers,G., Haites,N., Edwards,M., Wainwright,B. and
            Chenevix-Trench,G.
  TITLE     Most germ-line mutations in the nevoid basal cell carcinoma
            syndrome lead to a premature termination of the PATCHED protein,
            and no genotype-phenotype correlations are evident
  JOURNAL   Am J Hum Genet 60 (1), 21-26 (1997)
   PUBMED   8981943
REFERENCE   10 (bases 1 to 7634)
  AUTHORS   Hahn,H., Wicking,C., Zaphiropoulous,P.G., Gailani,M.R., Shanley,S.,
            Chidambaram,A., Vorechovsky,I., Holmberg,E., Unden,A.B.,
            Gillies,S., Negus,K., Smyth,I., Pressman,C., Leffell,D.J.,
            Gerrard,B., Goldstein,A.M., Dean,M., Toftgard,R.,
            Chenevix-Trench,G., Wainwright,B. and Bale,A.E.
  TITLE     Mutations of the human homolog of Drosophila patched in the nevoid
            basal cell carcinoma syndrome
  JOURNAL   Cell 85 (6), 841-851 (1996)
   PUBMED   8681379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Feb 10, 2021 this sequence version replaced NM_053566.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY357891.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-907               JAXUCZ010000017.1  1555571-1556477
            908-1100            JAXUCZ010000017.1  1558024-1558216
            1101-1290           JAXUCZ010000017.1  1574289-1574478
            1291-1360           JAXUCZ010000017.1  1576742-1576811
            1361-1452           JAXUCZ010000017.1  1576954-1577045
            1453-1651           JAXUCZ010000017.1  1578436-1578634
            1652-1773           JAXUCZ010000017.1  1578938-1579059
            1774-1921           JAXUCZ010000017.1  1579829-1579976
            1922-2053           JAXUCZ010000017.1  1580795-1580926
            2054-2209           JAXUCZ010000017.1  1581247-1581402
            2210-2308           JAXUCZ010000017.1  1582211-1582309
            2309-2434           JAXUCZ010000017.1  1582793-1582918
            2435-2553           JAXUCZ010000017.1  1588690-1588808
            2554-2956           JAXUCZ010000017.1  1589412-1589814
            2957-3266           JAXUCZ010000017.1  1590163-1590472
            3267-3409           JAXUCZ010000017.1  1595573-1595715
            3410-3593           JAXUCZ010000017.1  1597736-1597919
            3594-3874           JAXUCZ010000017.1  1599604-1599884
            3875-4012           JAXUCZ010000017.1  1602072-1602209
            4013-4155           JAXUCZ010000017.1  1603873-1604015
            4156-4255           JAXUCZ010000017.1  1607628-1607727
            4256-4510           JAXUCZ010000017.1  1608163-1608417
            4511-5054           JAXUCZ010000017.1  1609921-1610464
            5055-7634           JAXUCZ010000017.1  1610882-1613461
FEATURES             Location/Qualifiers
     source          1..7634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..7634
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /note="patched 1"
                     /db_xref="GeneID:89830"
                     /db_xref="RGD:621425"
     exon            1..907
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     CDS             749..5053
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     patched homolog 2; protein patched homolog 1"
                     /codon_start=1
                     /product="protein patched homolog 1 isoform 1"
                     /protein_id="NP_446018.1"
                     /db_xref="GeneID:89830"
                     /db_xref="RGD:621425"
                     /translation="MASAGNAAGALGRQAGGGRRRRTGGPHRAAPDRDYLHRPSYCDA
                     AFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGL
                     KAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEA
                     LLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPL
                     DCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHG
                     YMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVK
                     NATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEV
                     VHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSK
                     SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF
                     SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVV
                     VVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHSNTR
                     YSPPPPYSSHSFAHETHITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTITQDT
                     LSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVI
                     LLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADY
                     PNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMP
                     NNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVS
                     NDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSD
                     FVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCA
                     VFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVAL
                     AFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILT
                     VLGVLNGLVLLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVRFAVPPGHTNNGS
                     DSSDSEYSSQTTVSGISEELRHYEAQQGTGGPAHQVIVEATENPVFARSTVVHPDSRH
                     QPPLNSRQQPHLDSGSLSPGRQGQQPRRDPPREGLRPPPYRPRRDAFEISTEGHSGPS
                     NRDRSGPHGARSHNPRNPTSTAMGSSVPSYCQPITTVTASASVTVAVHPPPGPGRNPR
                     GGPCPGYESYPETDHGVFEDPHVPFHVRCERRDSKVEVIELQDVECEERPWGSSSN"
     exon            908..1100
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1290
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1360
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1452
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1651
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1773
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1921
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2053
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2209
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2308
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2434
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2553
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2956
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3266
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3409
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3593
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3874
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..4012
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..4155
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4255
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..4510
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..5054
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
     exon            5055..7634
                     /gene="Ptch1"
                     /gene_synonym="Ptch; Ptch2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accccctccc ctcctcctcc tctttctcca aatggagaga gttctttttt ttcttcttcc
       61 atctcatcta ttgagtcaag gagctgctgc ggccgctgcc cgctgcacac acacagagcg
      121 gagtcctcag gtcccggtag cgagagaggc gcgcggcgcg ggggcagaat ggtccagcgg
      181 gtcggtgagg agaacaagaa agcagagtcc gggaccgagc agccaccgcg aacccagcag
      241 cccgagagcg agcagccgct tcagaagccg ccaccgccaa ctccagccgc agccgcacca
      301 gcagcagcag cggcggcagc cccggcccgg catcgctgag acccgccggg caccgtcgcg
      361 tcgcccgcag cgggcgccga gggagccggc gcaagcggcg ggggtctgcg cgcgccttct
      421 gccgtgaagg ggtcgcggcg cggggcgggg acgtctgggg gggacttggg gaccgcgagg
      481 cgcgccctgg aagtgccggc tctcgccttc ccgcgagctg gatgtgggca gcggcggccg
      541 caaagacctc gggactcacg cgcaatgtgg caatggaagg ctcagggtct gagtccccgg
      601 cagcggccac ggccgcagca cccgcagcgc ccgccgtgtg agcggcagca gcgggtctgt
      661 cacccggagc cggagtcccc ggccgccagc agcgtcctcg cgagccgagc gcccaggcgc
      721 gcccggagcc cgcggcggcg gcggcaacat ggcctcggct ggtaacgccg ccggggccct
      781 gggcaggcag gccggcggcg ggaggcgcag acggaccggg ggaccgcacc gcgccgcgcc
      841 ggaccgggac tatctgcacc ggcccagcta ctgcgacgcc gccttcgctc tggagcagat
      901 ttccaagggg aaggctactg gccggaaagc gccgctgtgg ctgagagcga agtttcaaag
      961 actcttattt aaactgggtt gttacattca aaagaactgc ggcaagtttt tggttgtggg
     1021 tctcctcata tttggggcct tcgctgtggg attaaaggca gctaatctcg agaccaacgt
     1081 ggaggagctg tgggtggaag ttggtggacg agtgagtcga gaattaaatt atacccgcca
     1141 gaagatagga gaagaggcta tgtttaatcc tcaactcatg attcagactc caaaagaaga
     1201 aggcgctaat gtcctgacca cagaggccct actacaacac ctggactcag cactccaggc
     1261 cagccgtgtg cacgtctaca tgtataacag gcaatggaag ttggaacatt tatgctacaa
     1321 atcaggggaa cttatcacag agacaggcta catggatcag ataatagaat acctttaccc
     1381 ttgcttaatc attacacctt tggactgctt ctgggaaggg gcaaagctac agtccgggac
     1441 agcgtacctc ctaggtaagc ctcctttacg gtggacaaac tttgacccct tggaattcct
     1501 agaagagtta aagaaaataa actaccaagt ggacagttgg gaggaaatgc tgaataaagc
     1561 cgaagttggc catgggtaca tggaccggcc ttgcctcaat ccagccgacc cagattgccc
     1621 tgccacagcc cccaacaaaa attcaaccaa acctcttgat gtggcccttg ttttgaacgg
     1681 tggatgtcaa ggtttatcca ggaagtatat gcattggcag gaggagttga ttgtgggtgg
     1741 caccgtcaag aacgccactg gaaagcttgt cagcgctcat gccctgcaaa ccatgttcca
     1801 gttaatgact cccaagcaaa tgtatgaaca cttcaggggc tacgactatg tctctcacat
     1861 caactggaat gaggataggg cagccgccat cctggaggca tggcagagga cttacgtgga
     1921 ggtggttcat caaagtgttg ccccaaactc cactcaaaag gtgctttcct tcaccaccac
     1981 gaccctggac gacatcctaa aatccttctc tgatgtcagt gtcatccgag tggccagtgg
     2041 ctacctactg atgcttgcct atgcctgttt aaccatgctg cgctgggact gctccaagtc
     2101 ccagggtgcc gtggggttgg ctggtgtcct gttggttgca ctgtcagtgg ctgcaggatt
     2161 gggcctctgc tccttgattg gcatttcctt taatgctgca acaactcagg ttttgccatt
     2221 tcttgccctt ggtgttggtg tggacgacgt ctttctcctg gcccatgcat tcagtgaaac
     2281 gggacagaat aagaggattc catttgagga caggactggg gagtgcctca agcgcacggg
     2341 agccagcgtg gccctcacct ccatcagcaa tgtcactgcc ttcttcatgg ctgcattaat
     2401 ccctattcct gcactgcgag cgttctccct ccaggctgct gtggtggtgg tattcaattt
     2461 tgccatggtt ctactcattt tccctgcaat tctcagcatg gatttataca gacgtgagga
     2521 cagaagattg gatattttct gctgtttcac aagcccctgt gtcagccggg tgattcaagt
     2581 tgaaccgcag gcctacacag agcctcatag taacacccgg tacagccccc cacccccgta
     2641 cagcagccac agcttcgccc atgaaaccca catcaccatg cagtccaccg ttcagctccg
     2701 cacagaatat gaccctcaca cacacgtcta ctacaccacc gccgagccgc gctctgagat
     2761 ctctgtacag cctgtcacca tcacccagga caccctcagc tgtcagagcc ctgagagcac
     2821 cagttccacc cgggacctgc tttctcaatt ctctgactcc agcctccact gccttgagcc
     2881 cccctgcacc aagtggacac tttcttcgtt tgcagagaag cactacgctc ctttcctctt
     2941 gagacccaaa gccaaggttg tggtaatcct tcttttcctg ggcttgctgg gcgtcagcct
     3001 ttatgggacc acccgagtga gagacgggct ggacctcacg gacattgtcc cccgggaaac
     3061 cagagaatat gacttcatag ctgcccagtt caagtacttc tctttctaca acatgtatat
     3121 agtcacccag aaagcagact acccaaatat ccaacacctg ctttacgacc ttcataagag
     3181 tttcagcagt gtgaagtatg tcatgctgga ggagaacaag caacttcccc aaatgtggct
     3241 gcattacttt agagactggc tccaaggact tcaggatgca tttgacagtg actgggaaac
     3301 cgggaggatc atgccaaaca attataaaaa tggatctgat gatggggtcc tcgcttacaa
     3361 actcctggtg cagactggca gccgagacaa gcccatcgac attagtcagt tgactaaaca
     3421 gcgtctggtg gacgcagatg gcatcattaa tccgagcgct ttctacatct acctgaccgc
     3481 ttgggtcagc aatgaccctg tagcttacgc tgcctcccag gccaacatcc ggcctcacag
     3541 accagagtgg gtgcacgaca aagctgacta catgccagag accaggctga gaatcccagc
     3601 agcagagccc atagagtacg ctcagttccc tttctacctc aacggcctac gggacacctc
     3661 agactttgtg gaagccatag aaaaagtgag agtcatctgt aacaactaca cgagtctggg
     3721 gctgtccagc taccccaatg gctacccctt cctgttctgg gagcagtaca tcagcctgcg
     3781 tcactggctg ctgctagcca tcagcgtggt gctggcctgc acatttctag tgtgcgcagt
     3841 cttcctcctg aacccctgga cggccgggat cattgtcatg gtcctggctt tgatgaccgt
     3901 tgagctcttc ggcatgatgg gcctcattgg gatcaagctg agtgctgtgc cggtggtcat
     3961 cctgattgcg tctgttggca ttggagtaga attcaccgtc cacgtggctt tggcctttct
     4021 gacagccatt ggggacaaga accacagggc tatgctcgcc ctggagcaca tgttcgctcc
     4081 tgttctggac ggtgctgtgt ccactctgct gggtgtactg atgcttgcgg gatccgaatt
     4141 tgacttcatt gtcagatact tctttgccgt cctggccatc ctcaccgtct tgggagttct
     4201 caacggactg gttctgctgc ctgtactctt atccttcttc ggaccatgtc ctgaggtgtc
     4261 tccagccaac ggcctaaacc ggctgcccac tccttcgcct gagccgcccc caagcgtcgt
     4321 ccggtttgcc gtgcctcctg gtcacacgaa caatgggtct gattcctccg actccgagta
     4381 cagctctcag accacggtgt ctggcatcag tgaggagctc aggcactatg aagcacagca
     4441 gggcaccgga ggtcctgccc accaagtgat tgtggaagcc acagaaaacc ccgtctttgc
     4501 ccggtccact gtggtgcatc ctgactccag acatcagcct cccttgaact ctcggcaaca
     4561 gccccacctg gactctggct ccctgtcccc tggacggcaa ggccagcagc ctcgaaggga
     4621 tccccccaga gaaggcttgc ggccaccccc ctacagaccg cgcagagacg cttttgaaat
     4681 ttctactgaa gggcattctg gccctagcaa tagggaccgc tcgggccccc atggggcccg
     4741 ttctcacaac cctcggaacc caacgtccac tgccatgggc agctctgtgc ccagctactg
     4801 ccagcctatc accactgtga cggcttccgc ttctgtaact gtcgctgtgc accccccacc
     4861 tggacctggg cgcaaccccc gagggggacc ctgtccaggc tacgagagct accccgagac
     4921 tgatcacggg gtgttcgagg atccccatgt gccttttcat gtcaggtgtg agaggaggga
     4981 ctcgaaggtg gaggttatag aactacagga cgtggagtgt gaggagaggc cgtgggggag
     5041 cagctccaac tgagggtaat taaaatctga agcaaagagg ccaaagattg gaaagccccg
     5101 ccccccccac ctctttccag aactgactgc ttgaagacaa ctgcttggaa ttatgggaaa
     5161 gcagttcatt gttactgtaa ctgattgtat tattttgtga aatatttcta taaatattta
     5221 agaggtgtac acatgtaata tacatggaaa tgttgtacag tctattgcct ggggcctctc
     5281 cactcctgcc ccagagtggg gagaccacag gggtcctctc ccctgtgtac attggtctct
     5341 gtgctgcaac caagcttaac ctagttttta aaaaagaaat ctcccagcat atgtcgctgc
     5401 tgcttaaata ttgtataatt tacttgtata attctatgca aatattgctt atgtaatagg
     5461 attgtttgta aaggtttctg tttaaaatat tttaaatttg catatcacaa ccctgtggta
     5521 ggatgaattg ttactgttaa ctttcgaaca cgctatgcgt ggttattgtt taacgagcag
     5581 acatgaagag aacaggttaa tcccagtggc ttctctaggg gtagtttgta tgcggttcgc
     5641 atgggtgggt gggtgtgtgc atgtgacttt ccaatgtact gtactgtgat tttgttgttg
     5701 tagttgttct tctttgtgtt tttctttgct ttgtatgatc ttagctctgg cctaggtgag
     5761 ctaagacggt ctgggtcttt ttcctgtctt gatgctggta gaagggtaac cccaatcatc
     5821 cgtcttattc tctgggactg ttcagagaaa gccagatttg cttcatgcct atggctgctt
     5881 ctgaggtcat gggtagccct ccaagcacct ctccttatgt ttcaaagaca agatgttctc
     5941 acagacatag tgttgcctat taaggcctct atactcagca atcatccctg gtggtgaaaa
     6001 attggacaac attgccttgt ggtgagtctc agctgggtca tgagattacc ctctaggaac
     6061 atgtggttgt ccctttctga tgatcacaca tgcacatagc ctcccagatg cagaccaaaa
     6121 agccctattt cattgaaagt ctatattaaa gcctttacaa ataagagtcc ctccttgctg
     6181 tgactgcctg gctggggcat gctagtagtt gtacagtctg ccatgtgggg tgagtttcta
     6241 aggacgcttt cctacatgtc ttaccctgtg cacacttcct tctccactgt tagcatccat
     6301 ccatgaaagg gcaggaagat gcccccctgt aacagtatat agaggaagga aactcgtgcc
     6361 tgtggaagct gtcgtgagga gtgtattctg tgtgcagctt ccctggatcc ctcctatcct
     6421 tcatggaaaa atttaaggtg atgagtctct agtagtacca gcaatctagt gccctcagac
     6481 tctaaagcgt atcccccata ctgtaaggtt ctaattggaa gccacctgtg actaccgtgt
     6541 gtgtgtgtgt gtgtgtgtgt gtgtgtctgt ctgtctgtct gtctgtctgt gtgtacacca
     6601 gaggccctgg ccattgactg ctactgtctt aatgcctgtc aagccactgt ctgcctaccg
     6661 aacaccagct ctgctcaggt atcttgcacc ctgagtcgag gagggagacg taatttgccg
     6721 aagccgtttt tggcggtagt tcttggttgt gtcccttacc cccgagcctt gcgcatgtga
     6781 cagaaggaat tccgtacagc ctcttggctt ccgtgcatca tgaatcacat cagccagggc
     6841 aggaaggaca cggagctggc aggagactaa agtcagagtg tgtgtctctt gtctgtctct
     6901 ctcgtagttt tattttgtct gtattgtttg ttcatttgga tgttttaatt tttaaaagaa
     6961 aagatctttg ctgatattta taattttgta tcataagaat gtcctccaga atttgtcatg
     7021 ccagtttata acagaaaaaa aaattgcagg gattttattt ctattggaaa cactattgca
     7081 gttatgtttt acttttgaac agaagtttta tttgtataga gtgcttacta atgttaaata
     7141 gttcagagta tataacattt atgttaagga ctcaatggta ggttttagtg taaggagttt
     7201 aaaggaaata aatattcaaa ctgggtctcg tctgccaatt tgggtggaaa tgagtttgtg
     7261 tcatttcaat tacaaagacg aaagtatgcc atataattta tttatatgaa aatttatttt
     7321 tgtagtgtac atagtagtca tcaagtcttt tgacagaagt atatttttaa agaatttata
     7381 tgtgatgaaa tccgtaatgt ctggggcttt gctgagacat gggtgtgagg acacatttca
     7441 ttgcaaacga cagcaaggga gagggagttg tgtttaacag tgttaagaga gtccacgtga
     7501 ttggaaaggg ttggtgtgag cgtggtgacc tagtgtggtt ctcagatgaa aatgtacaaa
     7561 actctctaaa tattaatgtt caaacactga tagaaattct aacatgaata aagataatat
     7621 aacttgtcgg ttta
//
