LOCUS       NM_031346               6777 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus polypyrimidine tract binding protein 3 (Ptbp3),
            mRNA.
ACCESSION   NM_031346
VERSION     NM_031346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6777)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   2  (bases 1 to 6777)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 6777)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 6777)
  AUTHORS   Robinson,F., Jackson,R.J. and Smith,C.W.
  TITLE     Expression of human nPTB is limited by extreme suboptimal codon
            content
  JOURNAL   PLoS One 3 (3), e1801 (2008)
   PUBMED   18335065
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6777)
  AUTHORS   Yamamoto,H., Tsukahara,K., Kanaoka,Y., Jinno,S. and Okayama,H.
  TITLE     Isolation of a mammalian homologue of a fission yeast
            differentiation regulator
  JOURNAL   Mol Cell Biol 19 (5), 3829-3841 (1999)
   PUBMED   10207106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_031346.3.
            
            On Feb 26, 2021 this sequence version replaced NM_031346.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023966.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JACYVU010000161.1  49823425-49823567   c
            144-225             JACYVU010000161.1  49795616-49795697   c
            226-395             JACYVU010000161.1  49785217-49785386   c
            396-542             JACYVU010000161.1  49779172-49779318   c
            543-707             JACYVU010000161.1  49767204-49767368   c
            708-818             JACYVU010000161.1  49761204-49761314   c
            819-993             JACYVU010000161.1  49759960-49760134   c
            994-1071            JACYVU010000161.1  49752296-49752373   c
            1072-1211           JACYVU010000161.1  49749678-49749817   c
            1212-1245           JACYVU010000161.1  49749436-49749469   c
            1246-1338           JACYVU010000161.1  49746971-49747063   c
            1339-1555           JACYVU010000161.1  49745678-49745894   c
            1556-1633           JACYVU010000161.1  49742770-49742847   c
            1634-6777           JACYVU010000161.1  49737496-49742639   c
FEATURES             Location/Qualifiers
     source          1..6777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..6777
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /note="polypyrimidine tract binding protein 3"
                     /db_xref="GeneID:83515"
                     /db_xref="RGD:621671"
     exon            1..143
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..225
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1766
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /note="regulator of differentiation 1; regulator of
                     differentiation (in S. pombe) 1; ROD1 regulator of
                     differentiation 1"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 3"
                     /protein_id="NP_112636.1"
                     /db_xref="GeneID:83515"
                     /db_xref="RGD:621671"
                     /translation="MNNSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEA
                     EVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYS
                     NHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATSNEGTLLPGQSPVLRIIIENL
                     FYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNA
                     CCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIMSSPY
                     AGAAGFAPAIAFPQAAGLSVSAVPGALGPLTLTSSAVSGRMAIPGASGIPGNSVLLVT
                     NLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQIAMNHLSGQRLY
                     GKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHL
                     SNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDL
                     GENHHLRVSFSKSTI"
     exon            226..395
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..542
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..707
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..818
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..993
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1071
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1211
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1245
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1338
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1555
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1633
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..6777
                     /gene="Ptbp3"
                     /gene_synonym="Rod1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcttccct tccaccctct gaccggccgg cctgcggagc ggcctccgct cgcaggtccc
       61 gggagccggc cgcccgcttc ctccgcccgc ggtgagcccg tcaatccccg cacaacgcgc
      121 tcctccatct gggccatgga tggcggggat ctgatgagct tcttccttct ggtgtcatta
      181 acggaccttc taccatgaac aattctactt ctgcaggtgt gtatgctaat gggaatgaca
      241 acaagaaatt taaaggagat agacctccct gttcgccttc ccgtgttctc catcttcgaa
      301 aaattccatg tgatgtcacc gaagcagagg tcatatcatt aggtctacca tttggcaaag
      361 taactaatct tttgatgttg aaaggaaaaa gccaggcctt tttggaaatg gcttctgaag
      421 aagctgctgt tactatgata aattattaca ctcccgttac tcctcacctt cgaagtcagc
      481 ctgtttatat ccagtattcc aatcaccgag aacttaagac tgacaatctg cccaatcagg
      541 ctagagccca agctgcactg caggctgtca gtgcagtcca gtcaggaaac ctgtcccttc
      601 ctggagctac ttccaatgaa ggcacattgc tacctgggca gagccctgtg ctccggataa
      661 ttattgaaaa cctattttac cctgtcactc tggaagttct ccatcagata ttttctaaat
      721 ttggcacggt gttgaagatt atcaccttta caaagaataa tcagtttcaa gccttgcttc
      781 agtatgctga cccagtgaat gcgcagtatg ccaaaatggc tctggatggc cagaatatct
      841 ataatgcgtg ctgcactctc cgtatcgact tctccaagct caccagcctt aatgtgaaat
      901 acaataatga caaaagcaga gacttcactc gcttagacct tcctactggt gatggtcagc
      961 catctcttga acctcctatg gctgctgcat tcggtgcacc gggtataatg tcctctccat
     1021 atgcaggggc tgctggattt gccccagcca ttgcatttcc tcaagcagca ggtctgtccg
     1081 tctcggctgt tcctggagcc cttggtcctc tcacacttac ttcctctgct gtcagtggaa
     1141 ggatggccat tcctggggca agtggtatac cagggaattc cgttctgctg gtcaccaacc
     1201 tcaatcctga ctttatcaca ccacatgggc tttttatcct atttggagtg tatggtgatg
     1261 tacatcgagt gaagattatg tttaacaaga aagaaaatgc cttggtgcag atggccgatg
     1321 cgagtcaagc ccagatagca atgaaccacc taagtggtca gagactttat ggaaaagtac
     1381 ttcgggctac actgtccaaa catcaagctg tccagctccc tagagaggga caagaagacc
     1441 aaggtctgac caaggacttc agcaatagtc ccctgcatcg ctttaaaaag cctggctcaa
     1501 agaacttcca aaacatcttc cctccgtcag ccacactgca tctctccaac attcctcctt
     1561 ctgttacaat ggatgatctg aagaacctgt tcacggaagc tggatgttca gtgaaggctt
     1621 ttaaattctt tcagaaggac cgtaagatgg cactcattca gttgggatct gtggaggaag
     1681 caatccaggc ccttattgag cttcacaatc atgaccttgg agaaaatcac cacctcagag
     1741 tttccttctc aaaatccacc atctgatctg tctgtgaaat tctctccttg tattggacca
     1801 taatttctgt aaatcttcag gcacagactg aagcagttca ggaccagctc tgcctcttcc
     1861 ataaaagtaa ctcttggagt ctgactgata ctcaagtacg acagctactc ctttcctctc
     1921 atttccccta ccactgtatg atcaaaagtt tgcttttcct ttgtattgtg gtttctatga
     1981 aaataacttt caggaaaaaa aatcaggaaa gtatatttta aataatttaa ttccctgaat
     2041 tagatttcag aaggacagac tttctttatg tttgggtcca gatcagcctt acatgacatt
     2101 tctaaactcc tttgtacttt gagaaattta aacatacagc cttttgcaat ttcttgatgt
     2161 aatttaaatc accttctact aagtttttaa ctttatgatt cagaagtttc cctgtagaac
     2221 gtgacattca ttcacttgta agacttgtac cagatgtttg cacctattga tagcttatta
     2281 tacacaacca cacggagttg tattggaaac aggtctatag acatgcatgc ttcctttagt
     2341 cttctttccc cctcctgtgt tacactcctt tgaataatgc atatcttctc tttttaagac
     2401 tatttggaaa agcaaagtgt tgcaactgtc cccagggaaa tagaagtgaa attcagcctg
     2461 gatctattac aatatcagca taattagtca ttttagaaaa aaaaatcatg ttttaaattt
     2521 caaaatgaca tttgtctagt aatgtaatgt gatcttggaa aattttaaaa gaaaataatc
     2581 ctactttttt ataattgttt tcagaaaaaa gtttacagtc ttaaggaaaa atattcaggt
     2641 ctatcatatg gtttgacaga gtttttaaaa gttatttttg gtaaggtctt cttttagaaa
     2701 aaaaaatctc aagggttttt tgtaccacta taatctctaa tactcagaat tactgtgtac
     2761 ttacttaatt tcttattatg tgccttatta tgtgcttaag atataatagg ttaggatttt
     2821 atctaaatat ctaggaagat aaattgtggg cttggtgagc attctgttat ttctttcctt
     2881 gtcttggatt ttaaggggtt tggttgtttt gttttgtttt tctttttcat cacagtttta
     2941 agtggttttc aataagtaat cgtttctatt cagatctttg gtgctttggt atagtgatgg
     3001 gatagagaag ggtgagggtt tgggaataaa taactcagtg tgcacctgta ggcctctaca
     3061 tcatgactgc tggttactgc cagcgtcagt gtagtcagag ctgtagaact gcagcctccg
     3121 ttctgaatct gcctaacctt tactgcccgt tagaactcgt ctcaggacta cttgattctt
     3181 tcttagtgct caagtgagaa cttgatcttc tttgttaatg cgacttcctt acagctagct
     3241 agcacacaga tttggagtgt tagaagtggg ttatttttta tattctgacc ctcttactgt
     3301 tttggttgag tgtaaaagta catgttaatg ttgcctcagt gattgtgtca tgtaaattta
     3361 ttcttttaat atgagactgc tttttttaat tcttcagtgc ttgattggtt tttaaaatac
     3421 agaatttgtc agagggatca attttgtcca ccccttctca cttttaataa tctcagagtg
     3481 gatcatctca tctttgaaaa agtatatcag tctttacttt cagctattaa tttgaacatt
     3541 actttttttt taaagaaagg aagaaaattt tcatagaagc tgaaagaggt aactataggt
     3601 tggttagagt caaatcagaa ttccctcagt gcagagcaac tgctggtagg ctaggcaggg
     3661 aaatgctaga cggggcattt cacatggctc acctccatgt tggctgaata gatcggtgtg
     3721 acagttctcc agtgggtgtt ttcccactta catttgaggt gtattttcac ctgaatactg
     3781 aataagggag ggaaaaaatt aggactgtct cctcaaattt gcttttcttt ttttctcaca
     3841 cagacattat tttcagtgtc attttaaatt ggattgcttc ctttattttg agttgggaac
     3901 tactatgtaa tttattaatt cttggcattc gtaacatcca gcataagtgt agcaaaagtt
     3961 attgagaaca gaagggaaat catagtggtg ttgaatgtaa ttttgaacta gggatggcct
     4021 ttaatttgag agagaacatt gaaatccttt tcagggattt gtgtagatat gtgtgtgtgt
     4081 gtatgtgtgt gtataaataa gtgtatatac atacatatac tcttttaatg ttatatatac
     4141 atatgcacat tacgtacatt ttaatttatt gacaaaatta acaatgattt gagaacgtag
     4201 gatatgcttg ttttaaaaga gcatgtttga agccatcaga ttgtgtctaa aattagctgt
     4261 agcatatgga tgctgtccat atttgagctc tttactgttt gaattataga ggtctacagt
     4321 atttgtgtta aatatcaggg tggtggagaa atttggtctg tgtattttta ttttggcatg
     4381 cgctgattca ggatctttta agcagtggtt tatttgtgct gttgacctgt gacgacttgc
     4441 agagataatt tactttgttt tgtcactttt gggtgtcctg actttacttc ataaagcata
     4501 tacattcagg acttaaggaa atagcagtgc accttcaata atatcattac atgtcaagat
     4561 gtcttacttt gggatttgga tgtgttttgt gacaggtgag aatatattct cttagttgac
     4621 agtttgttac accttcagga ttacctggta cccccacaga atgtcatgag atctttggga
     4681 ctaaatgcca gctcttagtg tttgcactga atgtttcaga gtcatggttg cagcttcctc
     4741 ctttgtcttt ccccactgtg gtgagtaagg gtcctgttga ggtttggaat gagcccttat
     4801 gatccaggca tagtagcaca cagctgcagt tgaagcactg gaggaagatg atggttgtga
     4861 ctttaaaccc agcctggacc gaaggccatg gtccgtgcta gtcttggcat tacagaagac
     4921 cggtgccttc ctttccccaa ttaatctact gtcaactttt aagtcttcat catgtcattt
     4981 acttgagtat attaatgtgc agttccttgt ttagtcccat taaatatttt tgcattaaaa
     5041 aaacgacaag ctcagaaata atgattttgt gtgtgtgtgt gtgtgtgtgt gtgcctcagt
     5101 gaatctactt gtaaacccca aacttatctc ttagaaaact cagtgtgtat tgctattttt
     5161 ataaccaaaa agcatggcta tgatcggagc atttttctta gcctttcttt tgtcttgatc
     5221 tcttgtccat gggaataaaa ctgccagact taaatcctca ctattgtgct aaagcagaca
     5281 caatttagat tgtacataac cttgccatgt aactcagctg tctctttaag gatcgtgtta
     5341 gggttagact gtttgcagtc ctttttcaga gcaaatccga acaggtactt gtgaattgtt
     5401 taaaaaatag aaaattacag aaatcttaat ttggggcggg tcttaaaggg agaaaacaaa
     5461 ccaggaccaa agtttatgtg cctttttcag tagtcttaat tgatcttttc ttcctatttg
     5521 agactaaggt aacattcgga ttttggtttt caggaaatat ctactatata gattaaagga
     5581 atgttgttct acaaactgtt cacacaagcg aatagttaga actgaataaa aagttacact
     5641 cttgccttca gcacctaatg ccgagcattg aaccaaacaa gagcagagct gctccatctt
     5701 catgttggtc acttggctgt cacagctcgt cagggacctt ggtgttgata gcagccataa
     5761 ccgaaagctg cctgtggcaa acttcactta acactgtcag cagtgcattg tcatgttctc
     5821 tgtagtagtt gtaagaacag gtattttagg taggagagtt ttggggggtt ttttggagcc
     5881 attaagacta tcatactcta gtcctttttg tttcttgctt gtcttttgtt gtttgttttt
     5941 gttttttcct tgccactcat tgttacccag atctttaaaa acatcccata tccaggaagt
     6001 actaattaca aagattgctg accacaccaa gttttacatt gaaatttcac ctcattgctc
     6061 tgaccaaaga ctgcttgttc tggttttaac tcattttccc tgagctcttt tctgaaagat
     6121 aacatgcaga gcggccttga cttttcattt tctattggtg aatagactgc ttagagaaaa
     6181 tgggagttta ctatgaacag agtgggacag caacgatgga tagttatttt cagtactgta
     6241 tttgaggggg gcaaatagca cagctagaag cctctaacat tgtctagtgt tttacatggt
     6301 ctgttcataa aattcccttt ttctgtttgt aagaatgttc atctaacaga agaaaatgct
     6361 gtaaatattt gtaacaactt tttttaaaac caggccaaaa aagaaaaaaa aaggttttcg
     6421 ggaacaagtt aacatataaa gtggttttat ataaaacagc gattgtcttg tatattttga
     6481 taaacagcag taccagattt catttgtaat acagtttgtg gtattggaag aaaaggattc
     6541 tgtgattgtc taagtgaatt atgttataaa tgcaaaaagg agaaaatatt aaaaaccata
     6601 ttttctaact gtgtagtgca tggttaattt aagcttctgt acactacaat attgattccg
     6661 tttcccttcg gtttgtatat ttgataactg tttcttggaa tctcagtctc ttttcctaac
     6721 acgtatagca ttgtagcatg ccttttaata aatgtcatgg catctgtact ctcttaa
//
