LOCUS       NM_001005555            1842 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus polypyrimidine tract binding protein 2 (Ptbp2),
            mRNA.
ACCESSION   NM_001005555 XM_227635
VERSION     NM_001005555.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1842)
  AUTHORS   Braunschweig,U., Gueroussov,S., Plocik,A.M., Graveley,B.R. and
            Blencowe,B.J.
  TITLE     Dynamic integration of splicing within gene regulatory pathways
  JOURNAL   Cell 152 (6), 1252-1269 (2013)
   PUBMED   23498935
  REMARK    Review article
REFERENCE   2  (bases 1 to 1842)
  AUTHORS   Licatalosi,D.D., Yano,M., Fak,J.J., Mele,A., Grabinski,S.E.,
            Zhang,C. and Darnell,R.B.
  TITLE     Ptbp2 represses adult-specific splicing to regulate the generation
            of neuronal precursors in the embryonic brain
  JOURNAL   Genes Dev 26 (14), 1626-1642 (2012)
   PUBMED   22802532
REFERENCE   3  (bases 1 to 1842)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1842)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1842)
  AUTHORS   Bitel,C.L., Perrone-Bizzozero,N.I. and Frederikse,P.H.
  TITLE     HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell
            identity are also utilized in the lens
  JOURNAL   Mol Vis 16, 2301-2316 (2010)
   PUBMED   21139978
  REMARK    GeneRIF: The predominant expression of REST4, HuB/C/D and nPTB in
            post-mitotic fiber cells, together with miR-124 expression in
            vertebrate lenses, was shown.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1842)
  AUTHORS   Tateiwa,H., Gotoh,N., Ichikawa,M., Kikuchi,T. and Yoshimura,N.
  TITLE     Molecular cloning and characterization of human PTB-like protein: a
            possible retinal autoantigen of cancer-associated retinopathy
  JOURNAL   J Neuroimmunol 120 (1-2), 161-169 (2001)
   PUBMED   11694331
REFERENCE   7  (bases 1 to 1842)
  AUTHORS   Kikuchi,T., Ichikawa,M., Arai,J., Tateiwa,H., Fu,L., Higuchi,K. and
            Yoshimura,N.
  TITLE     Molecular cloning and characterization of a new neuron-specific
            homologue of rat polypyrimidine tract binding protein
  JOURNAL   J Biochem 128 (5), 811-821 (2000)
   PUBMED   11056394
REFERENCE   8  (bases 1 to 1842)
  AUTHORS   Polydorides,A.D., Okano,H.J., Yang,Y.Y., Stefani,G. and
            Darnell,R.B.
  TITLE     A brain-enriched polypyrimidine tract-binding protein antagonizes
            the ability of Nova to regulate neuron-specific alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6350-6355 (2000)
   PUBMED   10829067
REFERENCE   9  (bases 1 to 1842)
  AUTHORS   Zhang,L., Liu,W. and Grabowski,P.J.
  TITLE     Coordinate repression of a trio of neuron-specific splicing events
            by the splicing regulator PTB
  JOURNAL   RNA 5 (1), 117-130 (1999)
   PUBMED   9917071
REFERENCE   10 (bases 1 to 1842)
  AUTHORS   Ashiya,M. and Grabowski,P.J.
  TITLE     A neuron-specific splicing switch mediated by an array of pre-mRNA
            repressor sites: evidence of a regulatory role for the
            polypyrimidine tract binding protein and a brain-specific PTB
            counterpart
  JOURNAL   RNA 3 (9), 996-1015 (1997)
   PUBMED   9292499
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082076.1.
            
            On Oct 8, 2004 this sequence version replaced XM_227635.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1842
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /note="polypyrimidine tract binding protein 2"
                     /db_xref="GeneID:310820"
                     /db_xref="RGD:1359267"
     exon            1..92
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1680
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /note="PTB-like protein; neural polypyrimidine
                     tract-binding protein"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 2"
                     /protein_id="NP_001005555.1"
                     /db_xref="GeneID:310820"
                     /db_xref="RGD:1359267"
                     /translation="MDGIVTEVAVGVKRGSDELLSGSVLSSPNSNMSGMVVTANGNDS
                     KKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELA
                     TEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKTDNTLNQRAQVVLQAVTAVQTAN
                     TPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKNNQ
                     FQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPD
                     LPSGDGQPALDPAIAAAFAKETSLLAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSA
                     GGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAM
                     NHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQNI
                     FPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQDHKMALLQMATVEEAIQAL
                     IDLHNYNLGENHHLRVSFSKSTI"
     exon            93..123
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            124..199
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            200..372
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            373..516
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            517..681
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            682..792
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            793..988
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1128
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1162
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1255
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1472
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1550
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1817
                     /gene="Ptbp2"
                     /gene_synonym="Ptb2; PTBLP; PTBLP-L; PTBLP-S"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggccgcc attttctcgc cgcttgtgtg gctcgctggc tgcgtggctc ggttcttggg
       61 agcgaagctt tgtccggttc ggcaatggac ggaattgtca ctgaggttgc tgttggtgtg
      121 aagagaggat ctgacgagct actctcaggc agtgttctca gtagtcccaa ctctaatatg
      181 agtggcatgg tagttacagc caatggtaac gacagtaaga aatttaaagg agaagataag
      241 atggacgggg cgccctctcg tgtgcttcac attcgaaagt tacctggtga agtgactgag
      301 accgaagtaa ttgcgttagg cttacctttt ggtaaggtga ctaacatcct tatgctgaaa
      361 ggaaagaacc aggcattttt ggaactggca acagaggaag cagctattac tatggttaat
      421 tactattctg ctgtgacacc tcatcttcgt aaccaaccaa tttacattca gtactccaat
      481 cacaaagaac taaagacaga taacacatta aaccaacgtg ctcaagtagt tcttcaagct
      541 gtgacagctg tccagacagc aaatacacct ctcagtggca ccacagtcag tgagagtgcg
      601 gtgactccag ctcagagtcc agtgcttaga ataattattg acaatatgta ctaccctgta
      661 acacttgatg tccttcacca aatattttct aagtttggtg ctgtattgaa gataatcaca
      721 tttacaaaaa acaaccagtt tcaggctttg ctccagtatg gtgatccagt aaacgctcaa
      781 caggcaaagc tagccctaga tggtcaaaat atttataatg cttgctgtac cctaaggatt
      841 gatttttcca aacttgtgaa tttgaatgta aaatacaaca atgataaaag tagggattat
      901 acacgacctg atcttccatc tggagacggc cagcctgcat tagacccagc tattgctgca
      961 gcatttgcca aggagacgtc ccttttagct gtcccaggag ctctcagtcc tttggctatt
     1021 cctaatgctg ctgcggcagc tgctgccgct gccgctggcc gagtgggcat gcctggagtc
     1081 tcagctggtg gcaacacagt cctgttggtt agcaatttaa atgaagagat ggttacgccc
     1141 caaagtctgt ttaccctctt cggtgtttat ggcgatgtgc agcgcgtgaa gattttgtac
     1201 aataagaaag acagtgctct gatacaaatg gccgatggga accagtcaca gcttgccatg
     1261 aatcatctta atgggcagaa gatgtatgga aaaattattc gtgttactct ctctaaacat
     1321 cagactgtgc aactacctcg agagggactt gatgatcaag ggctaacaaa agattttggg
     1381 aattcacccc tgcaccgttt taaaaaaccg ggatccaaaa actttcagaa cattttccct
     1441 ccttctgcaa cccttcacct gtccaacatc cctccttctg tagcagaaga ggatctgcga
     1501 actctgtttg ccaacaccgg gggcactgtg aaagcattta agttttttca agatcacaaa
     1561 atggctcttc ttcagatggc aacagtggag gaagctattc aggctttgat tgatcttcat
     1621 aattataacc ttggtgaaaa ccatcatctg agagtgtctt tctccaaatc aacaatttaa
     1681 ggacgggaga tgaagatggc gggcagatcc cattgtttgg tgtcatcacc tattgactgt
     1741 tcagaaaagt ggggaccaga gtttgatttt ttcatgctgt tctcattcct tggttataaa
     1801 tgaaatggcg tatgtaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
